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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4fkg4CKCyclin-dependent kinase 22.7.11.22

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
4fkg4CKCyclin-dependent kinase 22.7.11.221.000
4ek610KCyclin-dependent kinase 22.7.11.220.720
4fkt48KCyclin-dependent kinase 22.7.11.220.660
4fkj11KCyclin-dependent kinase 22.7.11.220.636
1pxlCK4Cyclin-dependent kinase 22.7.11.220.617
3rk708ZCyclin-dependent kinase 22.7.11.220.600
4ek816KCyclin-dependent kinase 22.7.11.220.599
1oirHDYCyclin-dependent kinase 22.7.11.220.597
2btrU73Cyclin-dependent kinase 22.7.11.220.591
3rni21ZCyclin-dependent kinase 22.7.11.220.585
1b38ATPCyclin-dependent kinase 22.7.11.220.583
3s2pPMUCyclin-dependent kinase 22.7.11.220.583
2w06FRVCyclin-dependent kinase 22.7.11.220.582
1h0w207Cyclin-dependent kinase 22.7.11.220.581
3rmf20ZCyclin-dependent kinase 22.7.11.220.581
1oitHDTCyclin-dependent kinase 22.7.11.220.580
2r3jSCJCyclin-dependent kinase 22.7.11.220.578
3lfqA28Cyclin-dependent kinase 22.7.11.220.576
4fki09KCyclin-dependent kinase 22.7.11.220.570
4fkq42KCyclin-dependent kinase 22.7.11.220.569
3lfnA27Cyclin-dependent kinase 22.7.11.220.568
1pxmCK5Cyclin-dependent kinase 22.7.11.220.566
2c6o4SPCyclin-dependent kinase 22.7.11.220.566
3iggEFQCyclin-dependent kinase 22.7.11.220.565
4fklCK2Cyclin-dependent kinase 22.7.11.220.565
4fkpLS5Cyclin-dependent kinase 22.7.11.220.562
2vthLZ2Cyclin-dependent kinase 22.7.11.220.561
1ykr628Cyclin-dependent kinase 22.7.11.220.559
2vtpLZ9Cyclin-dependent kinase 22.7.11.220.558
3r8lZ30Cyclin-dependent kinase 22.7.11.220.558
2a0cCK9Cyclin-dependent kinase 22.7.11.220.554
1aq1STUCyclin-dependent kinase 22.7.11.220.553
1e1xNW1Cyclin-dependent kinase 22.7.11.220.553
4fkv61KCyclin-dependent kinase 22.7.11.220.552
1w8cN69Cyclin-dependent kinase 22.7.11.220.551
3rpy27ZCyclin-dependent kinase 22.7.11.220.551
3rk909ZCyclin-dependent kinase 22.7.11.220.550
2vtoLZ8Cyclin-dependent kinase 22.7.11.220.548
3sqq99ZCyclin-dependent kinase 22.7.11.220.548
4fkr45KCyclin-dependent kinase 22.7.11.220.547
1pxoCK7Cyclin-dependent kinase 22.7.11.220.546
2uzoC62Cyclin-dependent kinase 22.7.11.220.546
2w17I19Cyclin-dependent kinase 22.7.11.220.546
3r83Z14Cyclin-dependent kinase 22.7.11.220.546
2xmyCDKCyclin-dependent kinase 22.7.11.220.544
3rjc06ZCyclin-dependent kinase 22.7.11.220.544
2r3lSCWCyclin-dependent kinase 22.7.11.220.543
1gih1PUCyclin-dependent kinase 22.7.11.220.541
3qzgX67Cyclin-dependent kinase 22.7.11.220.541
1ke5LS1Cyclin-dependent kinase 22.7.11.220.540
3r1yX76Cyclin-dependent kinase 22.7.11.220.539
1g5sI17Cyclin-dependent kinase 22.7.11.220.538
2exmZIPCyclin-dependent kinase 22.7.11.220.538
3r73X87Cyclin-dependent kinase 22.7.11.220.538
4ez30S0Cyclin-dependent kinase 22.7.11.220.538
2r3gSC9Cyclin-dependent kinase 22.7.11.220.537
2r3iSCFCyclin-dependent kinase 22.7.11.220.537
3s1h56ZCyclin-dependent kinase 22.7.11.220.537
1y91CT9Cyclin-dependent kinase 22.7.11.220.535
2vtsLZCCyclin-dependent kinase 22.7.11.220.535
1w0xOLOCyclin-dependent kinase 22.7.11.220.533
2a4lRRCCyclin-dependent kinase 22.7.11.220.533
3r8vZ62Cyclin-dependent kinase 22.7.11.220.533
2vtiLZ3Cyclin-dependent kinase 22.7.11.220.532
2vtjLZ4Cyclin-dependent kinase 22.7.11.220.532
1ke7LS3Cyclin-dependent kinase 22.7.11.220.530
2bhhRYUCyclin-dependent kinase 22.7.11.220.530
3qu0X40Cyclin-dependent kinase 22.7.11.220.530
3qtzX42Cyclin-dependent kinase 22.7.11.220.529
1ckpPVBCyclin-dependent kinase 22.7.11.220.528
2w1hL0FCyclin-dependent kinase 22.7.11.220.528
3rk507ZCyclin-dependent kinase 22.7.11.220.526
3rm719ZCyclin-dependent kinase 22.7.11.220.526
3rpo24ZCyclin-dependent kinase 22.7.11.220.526
3qxoX65Cyclin-dependent kinase 22.7.11.220.525
3rak03ZCyclin-dependent kinase 22.7.11.220.525
1v1k3FPCyclin-dependent kinase 22.7.11.220.523
1h1s4SPCyclin-dependent kinase 22.7.11.220.521
3r71X86Cyclin-dependent kinase 22.7.11.220.521
1ke6LS2Cyclin-dependent kinase 22.7.11.220.518
1p2a5BNCyclin-dependent kinase 22.7.11.220.518
3qqkX02Cyclin-dependent kinase 22.7.11.220.518
2btsU32Cyclin-dependent kinase 22.7.11.220.517
2r3fSC8Cyclin-dependent kinase 22.7.11.220.515
2vv9IM9Cyclin-dependent kinase 22.7.11.220.515
4acm7YGCyclin-dependent kinase 22.7.11.220.515
2c6lDT4Cyclin-dependent kinase 22.7.11.220.514
4fkw62KCyclin-dependent kinase 22.7.11.220.513
2b54D05Cyclin-dependent kinase 22.7.11.220.512
2r3kSCQCyclin-dependent kinase 22.7.11.220.512
3qqhX0ACyclin-dependent kinase 22.7.11.220.512
3ral04ZCyclin-dependent kinase 22.7.11.220.512
4fks46KCyclin-dependent kinase 22.7.11.220.512
3qqlX03Cyclin-dependent kinase 22.7.11.220.511
3s0o50ZCyclin-dependent kinase 22.7.11.220.511
4bgh3I6Cyclin-dependent kinase 22.7.11.220.511
2ds11CDCyclin-dependent kinase 22.7.11.220.510
2r3p3SCCyclin-dependent kinase 22.7.11.220.510
4kd11QKCyclin-dependent kinase 22.7.11.220.509
2b53D23Cyclin-dependent kinase 22.7.11.220.508
4eor4SPCyclin-dependent kinase 22.7.11.220.508
1vyzN5BCyclin-dependent kinase 22.7.11.220.507
1pyePM1Cyclin-dependent kinase 22.7.11.220.505
3qtxX43Cyclin-dependent kinase 22.7.11.220.504
2uznC96Cyclin-dependent kinase 22.7.11.220.503
1y8yCT7Cyclin-dependent kinase 22.7.11.220.502
2j9mPY8Cyclin-dependent kinase 22.7.11.220.501
4fko20KCyclin-dependent kinase 22.7.11.220.501
1h1r6CPCyclin-dependent kinase 22.7.11.220.500
2r3r6SCCyclin-dependent kinase 22.7.11.220.500
3r9oZ71Cyclin-dependent kinase 22.7.11.220.499
3roy22ZCyclin-dependent kinase 22.7.11.220.499
1ke9LS5Cyclin-dependent kinase 22.7.11.220.498
1urwI1PCyclin-dependent kinase 22.7.11.220.498
3ezvEZVCyclin-dependent kinase 22.7.11.220.496
3lfsA07Cyclin-dependent kinase 22.7.11.220.495
3uli1N3Cyclin-dependent kinase 22.7.11.220.495
3ig7EFPCyclin-dependent kinase 22.7.11.220.494
3ti1B49Cyclin-dependent kinase 22.7.11.220.494
2vtlLZ5Cyclin-dependent kinase 22.7.11.220.493
2duv371Cyclin-dependent kinase 22.7.11.220.492
1b39ATPCyclin-dependent kinase 22.7.11.220.491
1h0vUN4Cyclin-dependent kinase 22.7.11.220.491
3r6xX84Cyclin-dependent kinase 22.7.11.220.490
3r7uX96Cyclin-dependent kinase 22.7.11.220.490
3sw719KCyclin-dependent kinase 22.7.11.220.490
3bhtMFRCyclin-dependent kinase 22.7.11.220.489
3rahO1ZCyclin-dependent kinase 22.7.11.220.489
3unk0BYCyclin-dependent kinase 22.7.11.220.489
3raiX85Cyclin-dependent kinase 22.7.11.220.488
2c5yMTWCyclin-dependent kinase 22.7.11.220.487
2c6kDT2Cyclin-dependent kinase 22.7.11.220.487
2vttLZDCyclin-dependent kinase 22.7.11.220.487
3qtuX44Cyclin-dependent kinase 22.7.11.220.487
3qzhX69Cyclin-dependent kinase 22.7.11.220.487
3r9hZ67Cyclin-dependent kinase 22.7.11.220.487
4eon1ROCyclin-dependent kinase 22.7.11.220.487
4fx360KCyclin-dependent kinase 22.7.11.220.487
1oguST8Cyclin-dependent kinase 22.7.11.220.486
2b55D31Cyclin-dependent kinase 22.7.11.220.486
2vtnLZ7Cyclin-dependent kinase 22.7.11.220.486
3qqfX07Cyclin-dependent kinase 22.7.11.220.485
3r7vZ02Cyclin-dependent kinase 22.7.11.220.485
3rpv26ZCyclin-dependent kinase 22.7.11.220.485
2b52D42Cyclin-dependent kinase 22.7.11.220.484
1di8DTQCyclin-dependent kinase 22.7.11.220.483
3pj8404Cyclin-dependent kinase 22.7.11.220.483
3wblPDYCyclin-dependent kinase 22.7.11.220.483
1gii1PUCyclin-dependent kinase 22.7.11.220.482
1hckATPCyclin-dependent kinase 22.7.11.220.480
3ddpRC8Cyclin-dependent kinase 22.7.11.220.480
1dm2HMDCyclin-dependent kinase 22.7.11.220.479
4lyn1YGCyclin-dependent kinase 22.7.11.220.478
3qtrX36Cyclin-dependent kinase 22.7.11.220.477
1pxpCK8Cyclin-dependent kinase 22.7.11.220.476
3r1sX73Cyclin-dependent kinase 22.7.11.220.476
4eomATPCyclin-dependent kinase 22.7.11.220.476
3sw418KCyclin-dependent kinase 22.7.11.220.475
4nj32KDCyclin-dependent kinase 22.7.11.220.475
3nynSGVG protein-coupled receptor kinase 62.7.11.160.474
3unj0BXCyclin-dependent kinase 22.7.11.220.474
1ke8LS4Cyclin-dependent kinase 22.7.11.220.472
2wotZZGTGF-beta receptor type-12.7.11.300.472
3ezrEZRCyclin-dependent kinase 22.7.11.220.471
3sheI85MAP kinase-activated protein kinase 32.7.11.10.471
3hmm855TGF-beta receptor type-12.7.11.300.470
2vz6FEFCalcium/calmodulin-dependent protein kinase type II subunit alpha2.7.11.170.469
3qwjX6ACyclin-dependent kinase 22.7.11.220.469
2iw84SPCyclin-dependent kinase 22.7.11.220.467
2wpa889Cyclin-dependent kinase 22.7.11.220.467
2c6mDT5Cyclin-dependent kinase 22.7.11.220.466
3qwkX62Cyclin-dependent kinase 22.7.11.220.466
3r7yZ04Cyclin-dependent kinase 22.7.11.220.466
1xjdSTUProtein kinase C theta type2.7.11.130.465
2c5nCK8Cyclin-dependent kinase 22.7.11.220.465
3rkb12ZCyclin-dependent kinase 22.7.11.220.465
1h1q2A6Cyclin-dependent kinase 22.7.11.220.464
1vyw292Cyclin-dependent kinase 22.7.11.220.464
2r3o2SCCyclin-dependent kinase 22.7.11.220.462
3r8pZ46Cyclin-dependent kinase 22.7.11.220.461
4gih0X5Non-receptor tyrosine-protein kinase TYK22.7.10.20.461
1oi9N20Cyclin-dependent kinase 22.7.11.220.460
4jboWPHAurora kinase A2.7.11.10.460
5aniES4Cyclin-dependent kinase 22.7.11.220.460
1unlRRCCyclin-dependent-like kinase 52.7.11.10.459
2c6iDT1Cyclin-dependent kinase 22.7.11.220.459
3ddqRRCCyclin-dependent kinase 22.7.11.220.459
3qxpX64Cyclin-dependent kinase 22.7.11.220.459
1oiqHDUCyclin-dependent kinase 22.7.11.220.458
3pxyJWSCyclin-dependent kinase 22.7.11.220.458
3qx2X63Cyclin-dependent kinase 22.7.11.220.458
2iw94SPCyclin-dependent kinase 22.7.11.220.457
3ql8X01Cyclin-dependent kinase 22.7.11.220.457
1oiuN76Cyclin-dependent kinase 22.7.11.220.455
4ii5ADPCyclin-dependent kinase 22.7.11.220.455
1fvv107Cyclin-dependent kinase 22.7.11.220.454
2c69CT8Cyclin-dependent kinase 22.7.11.220.454
2iw6QQ2Cyclin-dependent kinase 22.7.11.220.454
2r3q5SCCyclin-dependent kinase 22.7.11.220.454
2uzdC85Cyclin-dependent kinase 22.7.11.220.454
3fz1B98Cyclin-dependent kinase 22.7.11.220.454
4bcpT3CCyclin-dependent kinase 22.7.11.220.454
2pvnP63Casein kinase II subunit alpha2.7.11.10.453
3kgaLX9MAP kinase-activated protein kinase 22.7.11.10.453
1pxkCK3Cyclin-dependent kinase 22.7.11.220.452
1qmzATPCyclin-dependent kinase 22.7.11.220.452
1v0pPVBCell division control protein 2 homolog2.7.11.220.452
1vjy460TGF-beta receptor type-12.7.11.300.452
1oiyN41Cyclin-dependent kinase 22.7.11.220.451
3rm618ZCyclin-dependent kinase 22.7.11.220.451
4eok4SPCyclin-dependent kinase 22.7.11.220.451
1eh4IC1Casein kinase I homolog 12.7.11.10.450
2eufLQQCyclin-dependent kinase 62.7.11.220.450
3qtqX35Cyclin-dependent kinase 22.7.11.220.450
3r28XA0Cyclin-dependent kinase 22.7.11.220.450
3r9nZ68Cyclin-dependent kinase 22.7.11.220.450
1gz8MBPCyclin-dependent kinase 22.7.11.220.449
3qtwX3ACyclin-dependent kinase 22.7.11.220.449
2xnbY8LCyclin-dependent kinase 22.7.11.220.448
2c6tDT5Cyclin-dependent kinase 22.7.11.220.447
2uzbC75Cyclin-dependent kinase 22.7.11.220.447
2dwbANPAurora kinase A2.7.11.10.446
3gxlQIGTGF-beta receptor type-12.7.11.300.446
4ks8B49Serine/threonine-protein kinase PAK 62.7.11.10.446
2phkATPPhosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform2.7.11.190.445
3r1qX75Cyclin-dependent kinase 22.7.11.220.444
2nrySTUInterleukin-1 receptor-associated kinase 42.7.11.10.443
2wxvWXVCyclin-dependent kinase 22.7.11.220.441
3tnwF18Cyclin-dependent kinase 22.7.11.220.441
1pkdUCNCyclin-dependent kinase 22.7.11.220.440
2x1nX1NCyclin-dependent kinase 22.7.11.220.440