sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

Distribution of Cavity similarities measured by Shaper

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Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :

PDB ID	HET	Uniprot Name	EC Number
4fk6	0UJ	Tyrosine-protein kinase JAK1

Complex with similar cavities

PDB ID	HET	Uniprot Name	EC Number	Cavity Similarity	Align
4fk6	0UJ	Tyrosine-protein kinase JAK1	/	1.000
4ehz	JAK	Tyrosine-protein kinase JAK1	/	0.604
4i5c	C5I	Tyrosine-protein kinase JAK1	/	0.556
4e4n	0NL	Tyrosine-protein kinase JAK1	/	0.548
4f08	1RS	Tyrosine-protein kinase JAK2	/	0.516
4e6q	0NV	Tyrosine-protein kinase JAK2	/	0.508
4e6d	0NU	Tyrosine-protein kinase JAK2	/	0.504
4aqc	88A	Tyrosine-protein kinase JAK2	/	0.501
4hge	15V	Tyrosine-protein kinase JAK2	/	0.500
3lpb	NVB	Tyrosine-protein kinase JAK2	/	0.470
4ji9	1M3	Tyrosine-protein kinase JAK2	/	0.470
4hvi	19S	Tyrosine-protein kinase JAK3	2.7.10.2	0.460
3zc6	VFC	Tyrosine-protein kinase JAK3	2.7.10.2	0.455