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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4fc00T2Serine/threonine-protein kinase B-raf2.7.11.1

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
4fc00T2Serine/threonine-protein kinase B-raf2.7.11.11.000
5hi2BAXSerine/threonine-protein kinase B-raf2.7.11.10.601
4ksp1SUSerine/threonine-protein kinase B-raf2.7.11.10.583
3hv5R24Mitogen-activated protein kinase 14/0.543
4c8b0LIReceptor-interacting serine/threonine-protein kinase 22.7.11.10.515
3dtwA96Vascular endothelial growth factor receptor 22.7.10.10.505
4agwNG7Proto-oncogene tyrosine-protein kinase Src2.7.10.20.502
3b8q900Vascular endothelial growth factor receptor 22.7.10.10.500
3kq7KQ7Mitogen-activated protein kinase 14/0.500
3efl706Vascular endothelial growth factor receptor 22.7.10.10.497
2hyySTITyrosine-protein kinase ABL12.7.10.20.495
2og81N8Tyrosine-protein kinase Lck2.7.10.20.491
4aa0AA0Mitogen-activated protein kinase 14/0.491
2xir00JVascular endothelial growth factor receptor 22.7.10.10.487
3vnt0JAVascular endothelial growth factor receptor 22.7.10.10.483
2oiqSTIProto-oncogene tyrosine-protein kinase Src2.7.10.20.480
3lfbZ87Mitogen-activated protein kinase 14/0.480
4o2z046Mitogen-activated protein kinase/0.478
4aseAV9Vascular endothelial growth factor receptor 22.7.10.10.475
2qu6857Vascular endothelial growth factor receptor 22.7.10.10.470
1iepSTITyrosine-protein kinase ABL12.7.10.20.466
4eyjN61Mitogen-activated protein kinase 132.7.11.240.463
3hng8STVascular endothelial growth factor receptor 12.7.10.10.456
3cp9C19Vascular endothelial growth factor receptor 22.7.10.10.455