sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Cavities are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 4fag | GTQ | Gentisate 1,2-dioxygenase |
| PDB ID | HET | Uniprot Name | EC Number | Cavity Similarity |
Align |
|---|---|---|---|---|---|
| 4fag | GTQ | Gentisate 1,2-dioxygenase | / | 1.000 | |
| 3nkt | 1HN | Gentisate 1,2-dioxygenase | / | 0.667 | |
| 3nw4 | GTQ | Gentisate 1,2-dioxygenase | / | 0.655 | |
| 3nl1 | GTQ | Gentisate 1,2-dioxygenase | / | 0.503 | |
| 3uud | EST | Estrogen receptor | / | 0.500 | |
| 4mv3 | ACP | Biotin carboxylase | 6.3.4.14 | 0.492 | |
| 2pir | DHT | Androgen receptor | / | 0.491 | |
| 2b1z | 17M | Estrogen receptor | / | 0.488 | |
| 2piw | DHT | Androgen receptor | / | 0.488 | |
| 3c14 | FOK | Adenylate cyclase type 2 | / | 0.488 | |
| 3c14 | FOK | Adenylate cyclase type 5 | / | 0.488 | |
| 4bfr | J82 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform | 2.7.1.153 | 0.487 | |
| 4lga | A2O | Abscisic acid receptor PYL2 | / | 0.486 | |
| 3zvu | A8S | Abscisic acid receptor PYR1 | / | 0.485 | |
| 3aos | JH2 | Hemolymph juvenile hormone binding protein | / | 0.484 | |
| 1tow | CRZ | Fatty acid-binding protein, adipocyte | / | 0.483 | |
| 2bfm | TOP | Pteridine reductase 1 | 1.5.1.33 | 0.483 | |
| 3zxz | KRW | Hepatocyte growth factor receptor | 2.7.10.1 | 0.483 | |
| 2o1s | TDP | 1-deoxy-D-xylulose-5-phosphate synthase | 2.2.1.7 | 0.481 | |
| 4bbx | LKF | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.481 | |
| 2ouu | 35G | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.479 | |
| 1s4e | ADP | Galactokinase | / | 0.478 | |
| 3rbq | GLY_ALA_GLY_ALA_DAO | Protein unc-119 homolog A | / | 0.478 | |
| 1zzl | TZY | Mitogen-activated protein kinase 14 | / | 0.477 | |
| 2yx6 | ADP | Uncharacterized protein | / | 0.477 | |
| 3kdi | A8S | Abscisic acid receptor PYL2 | / | 0.477 | |
| 3utd | 0CJ | 4-hydroxy-3-methylbut-2-enyl diphosphate reductase | / | 0.476 | |
| 4euf | NAD | Trans-2-enoyl-CoA reductase [NADH] | / | 0.475 | |
| 2w6z | L21 | Biotin carboxylase | 6.3.4.14 | 0.474 | |
| 3ed1 | GA3 | Gibberellin receptor GID1 | / | 0.474 | |
| 4j03 | FVS | Bifunctional epoxide hydrolase 2 | 3.1.3.76 | 0.474 | |
| 5ez4 | NAD | Betaine-aldehyde dehydrogenase | / | 0.474 | |
| 1ddt | APU | Diphtheria toxin | / | 0.472 | |
| 4mv4 | ACP | Biotin carboxylase | 6.3.4.14 | 0.472 | |
| 1lke | DOG | Bilin-binding protein | / | 0.471 | |
| 3tr9 | PT1 | Dihydropteroate synthase | / | 0.471 | |
| 3zku | HCV | Isopenicillin N synthase | 1.21.3.1 | 0.471 | |
| 1rkh | VD2 | Vitamin D3 receptor | / | 0.470 | |
| 2pg0 | FAD | Acyl-CoA dehydrogenase | / | 0.470 | |
| 2w6n | OA2 | Biotin carboxylase | 6.3.4.14 | 0.470 | |
| 4zn7 | DES | Estrogen receptor | / | 0.470 | |
| 5ai5 | BSU | Bifunctional epoxide hydrolase 2 | 3.1.3.76 | 0.470 | |
| 5hyr | EST | Estrogen receptor | / | 0.470 | |
| 1toi | HCI | Aspartate aminotransferase | 2.6.1.1 | 0.469 | |
| 2v59 | LZK | Biotin carboxylase | 6.3.4.14 | 0.469 | |
| 2zba | ZBA | Trichothecene 3-O-acetyltransferase | / | 0.469 | |
| 3nef | PYV | Abscisic acid receptor PYL1 | / | 0.469 | |
| 1dtp | APU | Diphtheria toxin | / | 0.468 | |
| 2aq8 | NAI | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.468 | |
| 3vgn | FNN | Steroid Delta-isomerase | 5.3.3.1 | 0.468 | |
| 4ap1 | NAP | Steroid monooxygenase | / | 0.468 | |
| 1cjt | FOK | Adenylate cyclase type 2 | / | 0.467 | |
| 1cjt | FOK | Adenylate cyclase type 5 | / | 0.467 | |
| 2vss | ACO | Hydroxycinnamoyl-CoA hydratase-lyase | 4.1.2.41 | 0.467 | |
| 4b63 | NAP | L-ornithine N(5)-monooxygenase | / | 0.467 | |
| 1toj | HCI | Aspartate aminotransferase | 2.6.1.1 | 0.466 | |
| 2piu | DHT | Androgen receptor | / | 0.466 | |
| 2w6p | OA4 | Biotin carboxylase | 6.3.4.14 | 0.466 | |
| 4fgc | PQ0 | NADPH-dependent 7-cyano-7-deazaguanine reductase | 1.7.1.13 | 0.466 | |
| 1kzj | CB3 | Thymidylate synthase | / | 0.465 | |
| 2ama | DHT | Androgen receptor | / | 0.465 | |
| 3itu | IBM | cGMP-dependent 3',5'-cyclic phosphodiesterase | 3.1.4.17 | 0.465 | |
| 3lfz | ADP | Uncharacterized protein MJ1225 | / | 0.465 | |
| 4bb3 | KKA | Isopenicillin N synthase | 1.21.3.1 | 0.465 | |
| 4jql | VJ6 | Heat shock protein HSP 90-alpha | / | 0.465 | |
| 1qk3 | 5GP | Hypoxanthine-guanine-xanthine phosphoribosyltransferase | 2.4.2.22 | 0.464 | |
| 2fdu | D1G | Cytochrome P450 2A6 | 1.14.13 | 0.464 | |
| 3h3s | H15 | Collagen type IV alpha-3-binding protein | / | 0.464 | |
| 3l03 | 4OH | Estrogen receptor | / | 0.464 | |
| 1xbt | TTP | Thymidine kinase, cytosolic | 2.7.1.21 | 0.463 | |
| 1xj7 | DHT | Androgen receptor | / | 0.463 | |
| 1yqj | 6NP | Mitogen-activated protein kinase 14 | / | 0.463 | |
| 2pk3 | A2R | GDP-6-deoxy-D-mannose reductase | / | 0.463 | |
| 3itz | P66 | Mitogen-activated protein kinase 14 | / | 0.463 | |
| 3o73 | O73 | Ribosyldihydronicotinamide dehydrogenase [quinone] | / | 0.463 | |
| 1e2j | THM | Thymidine kinase | / | 0.462 | |
| 1zxn | ADP | DNA topoisomerase 2-alpha | 5.99.1.3 | 0.462 | |
| 2z4y | 252 | Geranylgeranyl pyrophosphate synthase | / | 0.462 | |
| 3nj0 | PYV | Abscisic acid receptor PYL2 | / | 0.462 | |
| 3uhm | RFN | UDP-3-O-acyl-N-acetylglucosamine deacetylase | / | 0.462 | |
| 4jda | A9S | Abscisic acid receptor PYL3 | / | 0.462 | |
| 5ccc | DDF | Dihydrofolate reductase | 1.5.1.3 | 0.462 | |
| 1equ | EQI | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.461 | |
| 1pq9 | 44B | Oxysterols receptor LXR-beta | / | 0.461 | |
| 1r0e | DFN | Glycogen synthase kinase-3 beta | 2.7.11.26 | 0.461 | |
| 1v3q | 2DI | Purine nucleoside phosphorylase | 2.4.2.1 | 0.461 | |
| 3fp0 | FP0 | 15-O-acetyltransferase | / | 0.461 | |
| 3hk1 | B64 | Fatty acid-binding protein, adipocyte | / | 0.461 | |
| 4c3y | ANB | 3-ketosteroid dehydrogenase | / | 0.461 | |
| 4h97 | 53S | Dihydrofolate reductase | 1.5.1.3 | 0.461 | |
| 5akk | 1P8 | Bifunctional epoxide hydrolase 2 | 3.1.3.76 | 0.461 | |
| 5cuq | NSC | Genome polyprotein | / | 0.461 | |
| 1cju | FOK | Adenylate cyclase type 2 | / | 0.460 | |
| 1cju | FOK | Adenylate cyclase type 5 | / | 0.460 | |
| 1d3h | A26 | Dihydroorotate dehydrogenase (quinone), mitochondrial | 1.3.5.2 | 0.460 | |
| 1gs3 | EQU | Steroid Delta-isomerase | 5.3.3.1 | 0.460 | |
| 1ove | 358 | Mitogen-activated protein kinase 14 | / | 0.460 | |
| 1p44 | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.460 | |
| 2ea4 | F79 | Methionine aminopeptidase 2 | / | 0.460 | |
| 2rhr | EMO | Putative ketoacyl reductase | 1.3.1 | 0.460 | |
| 2vr1 | ATF | Biotin carboxylase | 6.3.4.14 | 0.460 | |
| 4b4d | FAD | Ferredoxin-NADP reductase | / | 0.460 | |
| 4h4e | 10G | 4-hydroxy-3-methylbut-2-enyl diphosphate reductase | / | 0.460 | |
| 4nmc | FAD | Bifunctional protein PutA | / | 0.460 | |
| 4xvr | GNP | GTPase HRas | / | 0.460 | |
| 1cul | FOK | Adenylate cyclase type 2 | / | 0.459 | |
| 1cul | FOK | Adenylate cyclase type 5 | / | 0.459 | |
| 1d0l | BLG | Membrane-bound lytic murein transglycosylase B | 4.2.2.n1 | 0.459 | |
| 1fnd | A2P | Ferredoxin--NADP reductase, chloroplastic | 1.18.1.2 | 0.459 | |
| 1xxj | UNC | Uricase | 1.7.3.3 | 0.459 | |
| 3b9l | AZZ | Serum albumin | / | 0.459 | |
| 3juq | AJD | Phenazine biosynthesis protein A/B | / | 0.459 | |
| 3pn1 | IVH | DNA ligase | / | 0.459 | |
| 4py6 | R78 | Bromodomain protein, putative | / | 0.459 | |
| 1cjk | FOK | Adenylate cyclase type 2 | / | 0.458 | |
| 1cjk | FOK | Adenylate cyclase type 5 | / | 0.458 | |
| 1ogx | EQU | Steroid Delta-isomerase | 5.3.3.1 | 0.458 | |
| 1trk | TPP | Transketolase 1 | 2.2.1.1 | 0.458 | |
| 3q2j | CKI | Aminoglycoside 3'-phosphotransferase | 2.7.1.95 | 0.458 | |
| 3zu2 | NAI | Enoyl-[acyl-carrier-protein] reductase [NADH] | / | 0.458 | |
| 4cju | JNS | Integrase | / | 0.458 | |
| 4r3a | ANP | Blue-light-activated histidine kinase 2 | 2.7.13.3 | 0.458 | |
| 4uyg | 73B | Bromodomain-containing protein 2 | / | 0.458 | |
| 4z1f | H71 | Heat shock protein 75 kDa, mitochondrial | / | 0.458 | |
| 1ikg | REX | D-alanyl-D-alanine carboxypeptidase | 3.4.16.4 | 0.457 | |
| 1krh | FAD | Benzoate 1,2-dioxygenase electron transfer component | 1.18.1.3 | 0.457 | |
| 2zsi | GA4 | Gibberellin receptor GID1A | 3 | 0.457 | |
| 3evb | SAH | Genome polyprotein | 2.1.1.56 | 0.457 | |
| 3lfc | Z86 | Mitogen-activated protein kinase 14 | / | 0.457 | |
| 5alu | HD2 | Bifunctional epoxide hydrolase 2 | 3.1.3.76 | 0.457 | |
| 1cs4 | FOK | Adenylate cyclase type 2 | / | 0.456 | |
| 1cs4 | FOK | Adenylate cyclase type 5 | / | 0.456 | |
| 1u0h | FOK | Adenylate cyclase type 2 | / | 0.456 | |
| 1u0h | FOK | Adenylate cyclase type 5 | / | 0.456 | |
| 1zky | 689 | Estrogen receptor | / | 0.456 | |
| 2a2d | ANP | N-acetylgalactosamine kinase | 2.7.1.157 | 0.456 | |
| 2b36 | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.456 | |
| 2j7y | E3O | Estrogen receptor beta | / | 0.456 | |
| 3eku | CY9 | Actin-5C | / | 0.456 | |
| 3h03 | UBP | Glutamate receptor 2 | / | 0.456 | |
| 3nxo | D2B | Dihydrofolate reductase | 1.5.1.3 | 0.456 | |
| 3oll | EST | Estrogen receptor beta | / | 0.456 | |
| 4dru | 0LN | Genome polyprotein | 2.7.7.48 | 0.456 | |
| 4fvr | ATP | Tyrosine-protein kinase JAK2 | / | 0.456 | |
| 4g1z | 0VP | Vitamin D3 receptor A | / | 0.456 | |
| 4pah | LNR | Phenylalanine-4-hydroxylase | 1.14.16.1 | 0.456 | |
| 4y1b | NAP | AntE | / | 0.456 | |
| 2g78 | REA | Cellular retinoic acid-binding protein 2 | / | 0.455 | |
| 2w6q | OA5 | Biotin carboxylase | 6.3.4.14 | 0.455 | |
| 3ewk | FAD | Sensory box histidine kinase/response regulator | / | 0.455 | |
| 3irm | 1CY | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.455 | |
| 3ke8 | EIP | 4-hydroxy-3-methylbut-2-enyl diphosphate reductase | / | 0.455 | |
| 3ld6 | BCD | Lanosterol 14-alpha demethylase | 1.14.13.70 | 0.455 | |
| 5k2c | ZMA | Adenosine receptor A2a | / | 0.455 | |
| 1q19 | SSC | Carbapenam-3-carboxylate synthase | 6.3.3.6 | 0.454 | |
| 1z5c | ADP | Type 2 DNA topoisomerase 6 subunit B | / | 0.454 | |
| 2buf | ADP | Acetylglutamate kinase | / | 0.454 | |
| 2bxm | IMN | Serum albumin | / | 0.454 | |
| 2ouy | CMP | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.454 | |
| 2prh | 238 | Dihydroorotate dehydrogenase (quinone), mitochondrial | 1.3.5.2 | 0.454 | |
| 2yg4 | FAD | Putrescine oxidase | / | 0.454 | |
| 3f88 | 3HT | Glycogen synthase kinase-3 beta | 2.7.11.26 | 0.454 | |
| 3gkj | HC3 | Niemann-Pick C1 protein | / | 0.454 | |
| 3h23 | B54 | Dihydropteroate synthase | / | 0.454 | |
| 3iqe | H4M | F420-dependent methylenetetrahydromethanopterin dehydrogenase | 1.5.98.1 | 0.454 | |
| 4dpd | DHF | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.454 | |
| 4iw8 | KN3 | Estrogen receptor | / | 0.454 | |
| 5iu8 | 6DZ | Adenosine receptor A2a | / | 0.454 | |
| 1j78 | VDY | Vitamin D-binding protein | / | 0.453 | |
| 2aax | PDN | Mineralocorticoid receptor | / | 0.453 | |
| 2piq | DHT | Androgen receptor | / | 0.453 | |
| 2zsh | GA3 | Gibberellin receptor GID1A | 3 | 0.453 | |
| 3a6q | FMN | FMN-binding protein | / | 0.453 | |
| 3ebl | GA4 | Gibberellin receptor GID1 | / | 0.453 | |
| 3hgs | FMN | 12-oxophytodienoate reductase 3 | 1.3.1.42 | 0.453 | |
| 3uic | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | / | 0.453 | |
| 3umv | FAD | Deoxyribodipyrimidine photo-lyase | 4.1.99.3 | 0.453 | |
| 4b66 | NAP | L-ornithine N(5)-monooxygenase | / | 0.453 | |
| 4cf2 | 3GM | Integrase | / | 0.453 | |
| 4i11 | 1CH | Beta-secretase 1 | 3.4.23.46 | 0.453 | |
| 4z63 | ILE_THR_GLN_TYS_TYS | Phytosulfokine receptor 1 | 2.7.11.1 | 0.453 | |
| 1hfq | MOT | Dihydrofolate reductase | 1.5.1.3 | 0.452 | |
| 1klk | PMD | Dihydrofolate reductase | 1.5.1.3 | 0.452 | |
| 1r2j | FAD | FkbI | / | 0.452 | |
| 1xow | R18 | Androgen receptor | / | 0.452 | |
| 2ea1 | GPG | Ribonuclease I | 3.1.27.6 | 0.452 | |
| 2i0y | 5CN | Macrophage colony-stimulating factor 1 receptor | 2.7.10.1 | 0.452 | |
| 2o1x | TDP | 1-deoxy-D-xylulose-5-phosphate synthase | 2.2.1.7 | 0.452 | |
| 2qzs | ADP | Glycogen synthase | 2.4.1.21 | 0.452 | |
| 3cls | FAD | Electron transfer flavoprotein subunit alpha | / | 0.452 | |
| 3e92 | G6A | Mitogen-activated protein kinase 14 | / | 0.452 | |
| 3ge7 | AFQ | Queuine tRNA-ribosyltransferase | 2.4.2.29 | 0.452 | |
| 3kb3 | A8S | Abscisic acid receptor PYL2 | / | 0.452 | |
| 3kdj | A8S | Abscisic acid receptor PYL1 | / | 0.452 | |
| 4nbt | NAD | 3-oxoacyl-[acyl-carrier-protein] reductase | / | 0.452 | |
| 4oxi | GAP | Enterobactin synthetase component F-related protein | / | 0.452 | |
| 4zju | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | / | 0.452 | |
| 1fko | EFZ | Gag-Pol polyprotein | 2.7.7.49 | 0.451 | |
| 1gwr | EST | Estrogen receptor | / | 0.451 | |
| 2bn4 | NAP | NADPH--cytochrome P450 reductase | / | 0.451 | |
| 2fdv | D2G | Cytochrome P450 2A6 | 1.14.13 | 0.451 | |
| 2ij7 | TPF | Mycocyclosin synthase | 1.14.21.9 | 0.451 | |
| 2iw6 | QQ2 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.451 | |
| 2qgt | EED | Estrogen receptor | / | 0.451 | |
| 2y3p | SM8 | DNA gyrase subunit A | / | 0.451 | |
| 3dys | 5GP | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.451 | |
| 3erd | DES | Estrogen receptor | / | 0.451 | |
| 3i6q | NDP | Putative leucoanthocyanidin reductase 1 | / | 0.451 | |
| 4cee | B0T | Integrase | / | 0.451 | |
| 1c1c | 612 | Gag-Pol polyprotein | 2.7.7.49 | 0.450 | |
| 1h51 | FMN | Pentaerythritol tetranitrate reductase | / | 0.450 | |
| 1zid | ZID | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.450 | |
| 2cah | NDP | Catalase | 1.11.1.6 | 0.450 | |
| 2wge | TLM | 3-oxoacyl-[acyl-carrier-protein] synthase 1 | 2.3.1.41 | 0.450 | |
| 3g5s | FAD | Methylenetetrahydrofolate--tRNA-(uracil-5-)-methyltransferase TrmFO | / | 0.450 | |
| 3hz1 | 42C | Heat shock protein HSP 90-alpha | / | 0.450 | |
| 4ek1 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.450 | |
| 4f6w | 0SS | Cyclin-dependent kinase 8 | 2.7.11.22 | 0.450 | |
| 4je5 | PLP | Aromatic/aminoadipate aminotransferase 1 | 2.6.1.39 | 0.450 | |
| 4mv1 | ADP | Biotin carboxylase | 6.3.4.14 | 0.450 | |
| 4oac | ADP | Protein BRASSINOSTEROID INSENSITIVE 1 | 2.7.10.1 | 0.450 | |
| 4oal | 245 | Cytokinin dehydrogenase 4 | / | 0.450 | |
| 1dmw | HBI | Phenylalanine-4-hydroxylase | 1.14.16.1 | 0.449 | |
| 1opb | RET | Retinol-binding protein 2 | / | 0.449 | |
| 1srj | NAB | Streptavidin | / | 0.449 | |
| 1x7e | 244 | Estrogen receptor | / | 0.449 | |
| 2w6o | OA3 | Biotin carboxylase | 6.3.4.14 | 0.449 | |
| 2wo7 | ASV | Isopenicillin N synthase | 1.21.3.1 | 0.449 | |
| 2xnc | FAD | Ferredoxin--NADP reductase, leaf isozyme, chloroplastic | 1.18.1.2 | 0.449 | |
| 3bxx | QUE | Dihydroflavonol 4-reductase | 1.1.1.219 | 0.449 | |
| 3dyl | PCG | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.449 | |
| 3nxr | D2D | Dihydrofolate reductase | 1.5.1.3 | 0.449 | |
| 3of2 | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.449 | |
| 3oji | PYV | Abscisic acid receptor PYL3 | / | 0.449 | |
| 3zgl | 10E | 4-hydroxy-3-methylbut-2-enyl diphosphate reductase | / | 0.449 | |
| 4dk7 | 0KS | Oxysterols receptor LXR-beta | / | 0.449 | |
| 4oey | DHT | Androgen receptor | / | 0.449 | |
| 1dr4 | HBI | Dihydrofolate reductase | 1.5.1.3 | 0.448 | |
| 1ezv | UQ6 | Cytochrome b | / | 0.448 | |
| 1gwq | ZTW | Estrogen receptor | / | 0.448 | |
| 1mma | ADP | Myosin-2 heavy chain | / | 0.448 | |
| 1t13 | INI | 6,7-dimethyl-8-ribityllumazine synthase 2 | / | 0.448 | |
| 1t7r | DHT | Androgen receptor | / | 0.448 | |
| 2a5u | QYT | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.448 | |
| 2chz | 093 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.448 | |
| 2cy0 | NAP | Shikimate dehydrogenase (NADP(+)) | / | 0.448 | |
| 2v4l | ABJ | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.448 | |
| 2w93 | TPP | Pyruvate decarboxylase isozyme 1 | / | 0.448 | |
| 2z1x | PRF | Queuine tRNA-ribosyltransferase | 2.4.2.29 | 0.448 | |
| 3c16 | FOK | Adenylate cyclase type 2 | / | 0.448 | |
| 3c16 | FOK | Adenylate cyclase type 5 | / | 0.448 | |
| 3ozc | 4CT | S-methyl-5'-thioadenosine phosphorylase | / | 0.448 | |
| 3qfc | NAP | NADPH--cytochrome P450 reductase | / | 0.448 | |
| 3w0j | T08 | Vitamin D3 receptor | / | 0.448 | |
| 4at3 | LTI | BDNF/NT-3 growth factors receptor | 2.7.10.1 | 0.448 | |
| 4dpy | 2P0 | Mevalonate diphosphate decarboxylase | / | 0.448 | |
| 4gg7 | 0J8 | Hepatocyte growth factor receptor | 2.7.10.1 | 0.448 | |
| 4hbm | 0Y7 | E3 ubiquitin-protein ligase Mdm2 | 6.3.2 | 0.448 | |
| 4jhz | 1KV | Beta-glucuronidase | 3.2.1.31 | 0.448 | |
| 4kne | 1CY | Dihydrofolate reductase | 1.5.1.3 | 0.448 | |
| 4oic | A8S | Bet v I allergen-like | / | 0.448 | |
| 5ecc | NAP | Dehydrofolate reductase type I | / | 0.448 | |
| 1ia1 | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.447 | |
| 1mvs | DTM | Dihydrofolate reductase | 1.5.1.3 | 0.447 | |
| 1tl7 | FOK | Adenylate cyclase type 2 | / | 0.447 | |
| 1tl7 | FOK | Adenylate cyclase type 5 | / | 0.447 | |
| 2fai | 459 | Estrogen receptor | / | 0.447 | |
| 2qxx | TTP | dCTP deaminase | 3.5.4.13 | 0.447 | |
| 2w0h | NDP | Trypanothione reductase | / | 0.447 | |
| 2x06 | NAD | L-sulfolactate dehydrogenase | / | 0.447 | |
| 3eva | SAH | Genome polyprotein | 2.1.1.56 | 0.447 | |
| 3o8g | O8G | HTH-type transcriptional regulator EthR | / | 0.447 | |
| 4a4x | JUP | Serine/threonine-protein kinase Nek2 | 2.7.11.1 | 0.447 | |
| 4an4 | DUD | Putative glycosyl transferase | / | 0.447 | |
| 4ku5 | DCC | 3-oxoacyl-[ACP] synthase III | / | 0.447 | |
| 4njo | NAD | D-3-phosphoglycerate dehydrogenase, putative | / | 0.447 | |
| 4twn | B96 | Ephrin type-A receptor 3 | 2.7.10.1 | 0.447 | |
| 1dfo | PLG | Serine hydroxymethyltransferase | 2.1.2.1 | 0.446 | |
| 1xq3 | R18 | Androgen receptor | / | 0.446 | |
| 2bf7 | HBI | Pteridine reductase 1 | 1.5.1.33 | 0.446 | |
| 2ejv | NAD | L-threonine 3-dehydrogenase | / | 0.446 | |
| 2gfs | PQB | Mitogen-activated protein kinase 14 | / | 0.446 | |
| 2pbz | ATP | Uncharacterized protein | / | 0.446 | |
| 2pit | DHT | Androgen receptor | / | 0.446 | |
| 2rc6 | NAP | Ferredoxin--NADP reductase | / | 0.446 | |
| 2y60 | M8F | Isopenicillin N synthase | 1.21.3.1 | 0.446 | |
| 2yat | EEU | Estrogen receptor | / | 0.446 | |
| 2zev | B71 | Geranylgeranyl pyrophosphate synthase | / | 0.446 | |
| 3djf | BC3 | Purine nucleoside phosphorylase | / | 0.446 | |
| 3fr5 | I4A | Fatty acid-binding protein, adipocyte | / | 0.446 | |
| 3nr4 | PYV | Abscisic acid receptor PYL2 | / | 0.446 | |
| 3t3q | 9PL | Cytochrome P450 2A6 | 1.14.13 | 0.446 | |
| 3zky | WT4 | Isopenicillin N synthase | 1.21.3.1 | 0.446 | |
| 4a39 | GEM | Uncharacterized protein | / | 0.446 | |
| 4bii | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.446 | |
| 4du6 | GTP | GTP cyclohydrolase 1 | / | 0.446 | |
| 4qer | STL | Phospholipase A2 VRV-PL-VIIIa | / | 0.446 | |
| 4zm6 | ACO | N-acetyl-beta-D glucosaminidase | / | 0.446 | |
| 1a8p | FAD | Ferredoxin--NADP reductase | / | 0.445 | |
| 1b2l | NDC | Alcohol dehydrogenase | 1.1.1.1 | 0.445 | |
| 1cqs | EQU | Steroid Delta-isomerase | 5.3.3.1 | 0.445 | |
| 1nbi | SAM | Glycine N-methyltransferase | 2.1.1.20 | 0.445 | |
| 1p8d | CO1 | Oxysterols receptor LXR-beta | / | 0.445 | |
| 2p7z | OHT | Estrogen-related receptor gamma | / | 0.445 | |
| 2q66 | ATP | Poly(A) polymerase | 2.7.7.19 | 0.445 | |
| 3cgd | COA | Coenzyme A disulfide reductase | / | 0.445 | |
| 3elm | 24F | Collagenase 3 | 3.4.24 | 0.445 | |
| 3jun | AJD | Phenazine biosynthesis protein A/B | / | 0.445 | |
| 3k3k | A8S | Abscisic acid receptor PYR1 | / | 0.445 | |
| 3keq | NAD | Redox-sensing transcriptional repressor Rex | / | 0.445 | |
| 3oik | WZB | Carbonic anhydrase 2 | 4.2.1.1 | 0.445 | |
| 3zgn | 10G | 4-hydroxy-3-methylbut-2-enyl diphosphate reductase | / | 0.445 | |
| 4ap7 | F47 | Hepatocyte growth factor receptor | 2.7.10.1 | 0.445 | |
| 4dqu | NAI | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.445 | |
| 4fox | UMP | Thymidylate synthase ThyA | / | 0.445 | |
| 4g8z | TOP | Dihydrofolate reductase | 1.5.1.3 | 0.445 | |
| 4j8t | DOG | Uncharacterized PhzA/B-like protein PA3332 | / | 0.445 | |
| 4ozt | P1A | Ecdysone receptor, putative | / | 0.445 | |
| 4wh3 | ATP | N-acetylhexosamine 1-kinase | 2.7.1.162 | 0.445 | |
| 5koi | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | / | 0.445 | |
| 1fkx | PRH | Adenosine deaminase | 3.5.4.4 | 0.444 | |
| 1kmv | LII | Dihydrofolate reductase | 1.5.1.3 | 0.444 | |
| 1l2i | ETC | Estrogen receptor | / | 0.444 | |
| 1ozq | PRF | Queuine tRNA-ribosyltransferase | 2.4.2.29 | 0.444 | |
| 1pw1 | HEL | D-alanyl-D-alanine carboxypeptidase | 3.4.16.4 | 0.444 | |
| 2gvd | FKP | Adenylate cyclase type 2 | / | 0.444 | |
| 2gvd | FKP | Adenylate cyclase type 5 | / | 0.444 | |
| 2pix | DHT | Androgen receptor | / | 0.444 | |
| 2zsc | BTN | Tamavidin2 | / | 0.444 | |
| 3ada | NAD | Subunit alpha of sarocosine oxidase | / | 0.444 | |
| 3dmj | GWE | Pol protein | / | 0.444 | |
| 3gc9 | B45 | Mitogen-activated protein kinase 11 | 2.7.11.24 | 0.444 | |
| 3h06 | VBP | Glutamate receptor 2 | / | 0.444 | |
| 3i6i | NDP | Putative leucoanthocyanidin reductase 1 | / | 0.444 | |
| 3ml8 | ML8 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.444 | |
| 3nhp | HGZ | Ribosyldihydronicotinamide dehydrogenase [quinone] | / | 0.444 | |
| 3qg2 | CP6 | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.444 | |
| 3to3 | ATP | Petrobactin biosynthesis protein AsbB | / | 0.444 | |
| 4dbc | 3QP | Aspartate aminotransferase | 2.6.1.1 | 0.444 | |
| 4h4c | 10D | 4-hydroxy-3-methylbut-2-enyl diphosphate reductase | / | 0.444 | |
| 4ysw | NAI | Xanthine dehydrogenase/oxidase | / | 0.444 | |
| 1b9i | PXG | 3-amino-5-hydroxybenzoate synthase | 4.2.1.144 | 0.443 | |
| 1coy | AND | Cholesterol oxidase | 1.1.3.6 | 0.443 | |
| 1gpe | FAD | Glucose oxidase | 1.1.3.4 | 0.443 | |
| 1kwq | SG1 | Carbonic anhydrase 2 | 4.2.1.1 | 0.443 | |
| 2z4s | ADP | Chromosomal replication initiator protein DnaA | / | 0.443 | |
| 3c0i | 3AM | Peripheral plasma membrane protein CASK | 2.7.11.1 | 0.443 | |
| 3hub | 469 | Mitogen-activated protein kinase 14 | / | 0.443 | |
| 3pd4 | A3G | Threonine--tRNA ligase | 6.1.1.3 | 0.443 | |
| 3q95 | ESL | Estrogen receptor | / | 0.443 | |
| 4ds8 | A8S | Abscisic acid receptor PYL3 | / | 0.443 | |
| 4e2b | FMN | Dehydrogenase | / | 0.443 | |
| 4iwf | 15Q | Estrogen receptor | / | 0.443 | |
| 4juf | TPP | Benzoylformate decarboxylase | 4.1.1.7 | 0.443 | |
| 4pxm | EST | Estrogen receptor | / | 0.443 | |
| 4r20 | AER | Cytochrome P450 family 17 polypeptide 2 | / | 0.443 | |
| 1i58 | ADP | Chemotaxis protein CheA | 2.7.13.3 | 0.442 | |
| 1itz | TPP | Transketolase, chloroplastic | 2.2.1.1 | 0.442 | |
| 1nas | ASE | Sepiapterin reductase | 1.1.1.153 | 0.442 | |
| 1p7t | ACO | Malate synthase G | / | 0.442 | |
| 2blc | CP7 | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.442 | |
| 2g44 | T3O | Estrogen receptor | / | 0.442 | |
| 2v58 | LZJ | Biotin carboxylase | 6.3.4.14 | 0.442 | |
| 2ydx | STL | Methionine adenosyltransferase 2 subunit beta | / | 0.442 | |
| 3da1 | FAD | Glycerol-3-phosphate dehydrogenase | / | 0.442 | |
| 3dys | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.442 | |
| 3gdv | TYR_GLN_PHE | Serine endoprotease DegS | 3.4.21.107 | 0.442 | |
| 3hxc | BD6 | Geranylgeranyl transferase type-2 subunit beta | 2.5.1.60 | 0.442 | |
| 3k47 | D09 | Dihydrofolate reductase | 1.5.1.3 | 0.442 | |
| 3kem | IPE | 4-hydroxy-3-methylbut-2-enyl diphosphate reductase | / | 0.442 | |
| 3lkh | LT6 | Genome polyprotein | 2.7.7.48 | 0.442 | |
| 3o9p | MHI | Periplasmic murein peptide-binding protein | / | 0.442 | |
| 3w0h | W12 | Vitamin D3 receptor | / | 0.442 | |
| 3wd9 | QPC | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.442 | |
| 3zrb | OR8 | Progesterone receptor | / | 0.442 | |
| 4c71 | 7RD | 3-oxoacyl-ACP synthase | / | 0.442 | |
| 4ho8 | THM | Glucose-1-phosphate thymidylyltransferase | / | 0.442 | |
| 4jln | 18V | Deoxycytidine kinase | 2.7.1.74 | 0.442 | |
| 4la7 | A1O | Abscisic acid receptor PYL2 | / | 0.442 | |
| 4lvg | 20O | Nicotinamide phosphoribosyltransferase | 2.4.2.12 | 0.442 | |
| 4oed | DHT | Androgen receptor | / | 0.442 | |
| 4rup | H97 | Vitamin D3 receptor A | / | 0.442 | |
| 4wfr | 2AM | 2',3'-cyclic-nucleotide 3'-phosphodiesterase | 3.1.4.37 | 0.442 | |
| 1cg6 | MTA | S-methyl-5'-thioadenosine phosphorylase | / | 0.441 | |
| 1iol | EST | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.441 | |
| 1rt9 | IMH | Purine nucleoside phosphorylase | 2.4.2.1 | 0.441 | |
| 1uy7 | PU4 | Heat shock protein HSP 90-alpha | / | 0.441 | |
| 2b9w | FAD | Putative aminooxidase | / | 0.441 | |
| 2ddo | ATP | Pyridoxine/pyridoxal/pyridoxamine kinase | / | 0.441 | |
| 2npn | SAM | Putative cobalamin synthesis related protein | / | 0.441 | |
| 2vbp | VB1 | Isopenicillin N synthase | 1.21.3.1 | 0.441 | |
| 2y6o | 1N1 | Ephrin type-A receptor 4 | 2.7.10.1 | 0.441 | |
| 2yg5 | FAD | Putrescine oxidase | / | 0.441 | |
| 2ywv | ADP | Phosphoribosylaminoimidazole-succinocarboxamide synthase | / | 0.441 | |
| 3e6c | 3C4 | Cyclic nucleotide-binding protein | / | 0.441 | |
| 3hz1 | 37D | Heat shock protein HSP 90-alpha | / | 0.441 | |
| 3mt8 | 17T | Glycogen phosphorylase, muscle form | 2.4.1.1 | 0.441 | |
| 3pd5 | TSB | Threonine--tRNA ligase | 6.1.1.3 | 0.441 | |
| 3vf6 | 0H6 | Glucokinase | 2.7.1.2 | 0.441 | |
| 4cdm | FO1 | Deoxyribodipyrimidine photolyase | / | 0.441 | |
| 4f32 | N32 | 3-oxoacyl-[acyl-carrier-protein] synthase 2 | / | 0.441 | |
| 4nmd | FDA | Bifunctional protein PutA | / | 0.441 | |
| 4y0k | NAP | AntE | / | 0.441 | |
| 5buk | FAD | FADH2-dependent halogenase | / | 0.441 | |
| 1fm7 | DFV | Chalcone--flavonone isomerase 1 | 5.5.1.6 | 0.440 | |
| 1ia2 | TQ4 | Dihydrofolate reductase | 1.5.1.3 | 0.440 | |
| 1jnr | FAD | Adenylylsulfate reductase, subunit A (AprA) | / | 0.440 | |
| 1n2v | BDI | Queuine tRNA-ribosyltransferase | 2.4.2.29 | 0.440 | |
| 1qyx | ASD | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.440 | |
| 1y2b | DEE | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.440 | |
| 1yw8 | A75 | Methionine aminopeptidase 2 | / | 0.440 | |
| 2ban | 357 | Gag-Pol polyprotein | 2.7.7.49 | 0.440 | |
| 2bu2 | TF1 | [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial | 2.7.11.2 | 0.440 | |
| 2dw4 | FAD | Lysine-specific histone demethylase 1A | 1 | 0.440 | |
| 2f0y | 3MN | Protein farnesyltransferase subunit beta | 2.5.1.58 | 0.440 | |
| 2ido | TMP | DNA polymerase III subunit epsilon | 2.7.7.7 | 0.440 | |
| 2ior | ADP | Chaperone protein HtpG | / | 0.440 | |
| 2qpy | DHT | Androgen receptor | / | 0.440 | |
| 2wyv | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | / | 0.440 | |
| 2xk3 | XK3 | Serine/threonine-protein kinase Nek2 | 2.7.11.1 | 0.440 | |
| 2zb4 | 5OP | Prostaglandin reductase 2 | 1.3.1.48 | 0.440 | |
| 3otb | DGT | Probable tRNA(His) guanylyltransferase | 2.7.7.79 | 0.440 | |
| 3th8 | TH9 | Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific) | 2.5.1.31 | 0.440 | |
| 3w0i | O11 | Vitamin D3 receptor | / | 0.440 | |
| 3zrb | ORC | Progesterone receptor | / | 0.440 | |
| 4ajj | 88R | L-lactate dehydrogenase A chain | 1.1.1.27 | 0.440 | |
| 4bew | ACP | Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 | 3.6.3.8 | 0.440 | |
| 4lk3 | NAD | UDP-glucuronic acid decarboxylase 1 | 4.1.1.35 | 0.440 | |
| 5bt9 | NAP | 3-oxoacyl-(Acyl-carrier-protein) reductase | / | 0.440 | |
| 5pah | LDP | Phenylalanine-4-hydroxylase | 1.14.16.1 | 0.440 |