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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4f9c0SXCell division cycle 7-related protein kinase2.7.11.1

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
4f9c0SXCell division cycle 7-related protein kinase2.7.11.11.000
4f9b0SYCell division cycle 7-related protein kinase2.7.11.10.576
4dgnLU2Casein kinase II subunit alpha2.7.11.10.535
2jdsL20cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.519
4hge15VTyrosine-protein kinase JAK2/0.510
4aqc88ATyrosine-protein kinase JAK2/0.507
1q8uH52cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.502
1dayGNPCasein kinase II subunit alpha2.7.11.10.499
3rak03ZCyclin-dependent kinase 22.7.11.220.498
1om1IQACasein kinase II subunit alpha2.7.11.10.497
2uw0GVKcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.496
5e8ySTUTGF-beta receptor type-22.7.11.300.496
2f7e2EAcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.495
3i5zZ48Mitogen-activated protein kinase 12.7.11.240.495
2pvhP19Casein kinase II subunit alpha2.7.11.10.494
3be9P04Casein kinase II subunit alpha2.7.11.10.494
4bgg844Activin receptor type-12.7.11.300.494
2f7x4EAcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.492
4dgmAGICasein kinase II subunit alpha2.7.11.10.490
2uzuL20cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.489
2vo0M03cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.488
3zc6VFCTyrosine-protein kinase JAK32.7.10.20.488
2ckeIQUDeath-associated protein kinase 2/0.487
4hvi19STyrosine-protein kinase JAK32.7.10.20.487
4lfiGNPCasein kinase II subunit alpha2.7.11.10.486
3rkb12ZCyclin-dependent kinase 22.7.11.220.485
3zo1SIJcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.484
2vo6M05cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.483
3hmm855TGF-beta receptor type-12.7.11.300.483
4anmWULCasein kinase II subunit alpha2.7.11.10.483
1m2pHNACasein kinase II subunit alpha2.7.11.10.482
4f081RSTyrosine-protein kinase JAK2/0.482
4i5cC5ITyrosine-protein kinase JAK1/0.482
1q41IXMGlycogen synthase kinase-3 beta2.7.11.260.480
3gu83GUDeath-associated protein kinase 12.7.11.10.479
3s1h56ZCyclin-dependent kinase 22.7.11.220.479
2pvnP63Casein kinase II subunit alpha2.7.11.10.475
4e6d0NUTyrosine-protein kinase JAK2/0.475
4jia1K3Tyrosine-protein kinase JAK2/0.474
4y93746Tyrosine-protein kinase/0.474
1j1cADPGlycogen synthase kinase-3 beta2.7.11.260.473
1dawANPCasein kinase II subunit alpha2.7.11.10.472
1gii1PUCyclin-dependent kinase 22.7.11.220.472
2h8hH8HProto-oncogene tyrosine-protein kinase Src2.7.10.20.472
1pmn984Mitogen-activated protein kinase 102.7.11.240.470
2gu8796cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.470
5cvfATPCasein kinase II subunit alpha2.7.11.10.470
2qs1UB1Glutamate receptor ionotropic, kainate 1/0.469
2yxuATPPyridoxal kinase2.7.1.350.469
3ofm4B0Casein kinase II subunit alpha'2.7.11.10.469
3sayOFTGlycogen synthase kinase-3 beta2.7.11.260.469
3at4CCKCasein kinase II subunit alpha2.7.11.10.468
3lpbNVBTyrosine-protein kinase JAK2/0.468
3uyt0CKCasein kinase I isoform delta2.7.11.10.468
4bgh3I6Cyclin-dependent kinase 22.7.11.220.467
4ix6ADPUncharacterized protein/0.467
1w6hTITPlasmepsin-23.4.23.390.464
2pvlP55Casein kinase II subunit alpha2.7.11.10.464
3ezvEZVCyclin-dependent kinase 22.7.11.220.464
1qcfPP1Tyrosine-protein kinase HCK2.7.10.20.463
2czfXMPOrotidine 5'-phosphate decarboxylase4.1.1.230.463
3q9xEMOCasein kinase II subunit alpha2.7.11.10.463
4bznUGXSerine/threonine-protein kinase pim-12.7.11.10.463
4dymIYZActivin receptor type-12.7.11.300.463
2cf6NAPCinnamyl alcohol dehydrogenase 51.1.1.1950.462
2uztSS3cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.462
3mtfA3FActivin receptor type-12.7.11.300.462
2vo3M04cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.461
2x2lX2LProto-oncogene tyrosine-protein kinase receptor Ret2.7.10.10.461
3efwAK8Aurora kinase A2.7.11.10.461
4kz01UJPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.461
4fg9ATPCalcium/calmodulin-dependent protein kinase type 12.7.11.170.460
2ifaFMNUncharacterized protein/0.458
1rx8NAPDihydrofolate reductase1.5.1.30.457
2jdtI5ScAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.457
3l1sZ92Glycogen synthase kinase-3 beta2.7.11.260.457
4c58824Cyclin-G-associated kinase2.7.11.10.457
1xddAAYIntegrin alpha-L/0.456
2ztmNADD(-)-3-hydroxybutyrate dehydrogenase/0.456
1ydtIQBcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.455
4j99ACPFibroblast growth factor receptor 2/0.455
4ji91M3Tyrosine-protein kinase JAK2/0.455
2ojf4PYcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.454
2pvmP29Casein kinase II subunit alpha2.7.11.10.454
3cosNADAlcohol dehydrogenase 41.1.1.10.454
1e3eNAIAlcohol dehydrogenase 41.1.1.10.453
2w17I19Cyclin-dependent kinase 22.7.11.220.453
4hwkNAPSepiapterin reductase1.1.1.1530.453
4m69ANPReceptor-interacting serine/threonine-protein kinase 32.7.11.10.453
4ux9ANPMitogen-activated protein kinase 82.7.11.240.453
4y95746Tyrosine-protein kinase/0.453
1u8vFAD4-hydroxybutyryl-CoA dehydratase/vinylacetyl-CoA-Delta-isomerase/0.452
1xe55FEPlasmepsin-23.4.23.390.452
2b9jADPMitogen-activated protein kinase FUS32.7.11.240.452
3ambVX6cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.452
3ljtLA3A disintegrin and metalloproteinase with thrombospondin motifs 53.4.240.452
3rk909ZCyclin-dependent kinase 22.7.11.220.452
4btjADPTau-tubulin kinase 12.7.11.10.452
1q8tY27cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.451
4grb0XGCasein kinase II subunit alpha2.7.11.10.451
2c1bCQPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.450
4mq12C3Dual specificity tyrosine-phosphorylation-regulated kinase 1A2.7.12.10.450
2objVRVSerine/threonine-protein kinase pim-12.7.11.10.449
2uw4L15cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.449
3kvxFMYMitogen-activated protein kinase 102.7.11.240.449
3oroAGSSerine/threonine protein kinase/0.449
1vjy460TGF-beta receptor type-12.7.11.300.448
2oapANPType II secretion system protein (GspE-2)/0.448
3fwgCAMCamphor 5-monooxygenase1.14.15.10.448
1rfvADPPyridoxal kinase2.7.1.350.447
2vv9IM9Cyclin-dependent kinase 22.7.11.220.447
4ks8B49Serine/threonine-protein kinase PAK 62.7.11.10.447
4u03GTPCyclic GMP-AMP synthase/0.447
1pd9CO4Dihydrofolate reductase1.5.1.30.446
2gjlFMNNitronate monooxygenase1.13.12.160.446
3hyoADPPyridoxal kinase/0.446
3nxxNDPDihydrofolate reductase1.5.1.30.446
3qtxX43Cyclin-dependent kinase 22.7.11.220.446
4anx534Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.446
4awiAQ2Mitogen-activated protein kinase 82.7.11.240.446
4bibIEOMitogen-activated protein kinase kinase kinase 52.7.11.250.446
4ful0VUPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.446
4ly91YYGlucokinase regulatory protein/0.446
4pl4ADPSerine/threonine-protein kinase/endoribonuclease IRE12.7.11.10.446
1aq1STUCyclin-dependent kinase 22.7.11.220.445
2j5xGSPADP-ribosylation factor 6/0.445
2pmoHMDProtein kinase 7/0.445
3oriAGSSerine/threonine protein kinase/0.445
3pe2E1BCasein kinase II subunit alpha2.7.11.10.445
1y91CT9Cyclin-dependent kinase 22.7.11.220.444
2jdvL20cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.444
2nrySTUInterleukin-1 receptor-associated kinase 42.7.11.10.444
3eyhIZATyrosine-protein kinase JAK1/0.444
3oogYTPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.444
3tscNADUncharacterized protein/0.444
4ijp1EHSerine/threonine-protein kinase PRP4 homolog2.7.11.10.444
1jnkANPMitogen-activated protein kinase 102.7.11.240.443
2uzwSS4cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.443
2x8iX8ISerine/threonine-protein kinase Chk12.7.11.10.443
3fhyATPPyridoxal kinase2.7.1.350.443
3ow3SMYcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.443
4c34STUcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.443
4pd6URINucleoside permease/0.443
4xf7ACPCarbohydrate/pyrimidine kinase, PfkB family/0.443
2b9iADPMitogen-activated protein kinase FUS32.7.11.240.442
2gnhH52cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.442
2uw7GVPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.442
2vnwM01cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.442
3qlsNDPDihydrofolate reductase1.5.1.30.442
4ehzJAKTyrosine-protein kinase JAK1/0.442
4lv7ADPInositol-pentakisphosphate 2-kinase2.7.1.1580.442
1q5kTMUGlycogen synthase kinase-3 beta2.7.11.260.441
1r6uTYMTryptophan--tRNA ligase, cytoplasmic6.1.1.20.441
1tj0FADBifunctional protein PutA1.5.5.20.441
1w0xOLOCyclin-dependent kinase 22.7.11.220.441
1ydrIQPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.441
2aa0MTPAdenosine kinase2.7.1.200.441
2ivnANPtRNA N6-adenosine threonylcarbamoyltransferase/0.441
2v2qNVG4-diphosphocytidyl-2-C-methyl-D-erythritol kinase/0.441
4a33MYAGlycylpeptide N-tetradecanoyltransferase/0.441
4bieIE6Mitogen-activated protein kinase kinase kinase 52.7.11.250.441
4c59FEFCyclin-G-associated kinase2.7.11.10.441
4fkv61KCyclin-dependent kinase 22.7.11.220.441
4gh5NADShort-chain dehydrogenase/reductase SDR/0.441
1pxoCK7Cyclin-dependent kinase 22.7.11.220.440
2y05NAPProstaglandin reductase 1/0.440
2y99NADCis-2,3-dihydrobiphenyl-2,3-diol dehydrogenase1.3.1.560.440
3jxwLXGSerine/threonine-protein kinase pim-12.7.11.10.440
3r8lZ30Cyclin-dependent kinase 22.7.11.220.440
3u33FADPutative acyl-CoA dehydrogenase AidB1.3.990.440
3udn09BBeta-secretase 13.4.23.460.440
4k110J9Proto-oncogene tyrosine-protein kinase Src2.7.10.20.440
4l4xNDPAmphI/0.440
5cnoANPEpidermal growth factor receptor2.7.10.10.440