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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4f9b0SYCell division cycle 7-related protein kinase2.7.11.1

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
4f9b0SYCell division cycle 7-related protein kinase2.7.11.11.000
5cvfATPCasein kinase II subunit alpha2.7.11.10.521
4dgnLU2Casein kinase II subunit alpha2.7.11.10.504
4hvi19STyrosine-protein kinase JAK32.7.10.20.497
4f9c0SXCell division cycle 7-related protein kinase2.7.11.10.495
3zc6VFCTyrosine-protein kinase JAK32.7.10.20.489
3ofm4B0Casein kinase II subunit alpha'2.7.11.10.483
2vu3LZECyclin-dependent kinase 22.7.11.220.481
3lltANPProtein serine/threonine kinase-1/0.479
5av2KMPDeath-associated protein kinase 12.7.11.10.478
4jia1K3Tyrosine-protein kinase JAK2/0.477
2gnhH52cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.475
2jdsL20cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.474
2pvlP55Casein kinase II subunit alpha2.7.11.10.473
4aqc88ATyrosine-protein kinase JAK2/0.472
1q8uH52cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.471
2uzuL20cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.471
5av3KMPDeath-associated protein kinase 12.7.11.10.471
3be9P04Casein kinase II subunit alpha2.7.11.10.468
3mb714ICasein kinase II subunit alpha2.7.11.10.467
3q9xEMOCasein kinase II subunit alpha2.7.11.10.465
2f7e2EAcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.462
2uw0GVKcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.462
1om1IQACasein kinase II subunit alpha2.7.11.10.461
1m2pHNACasein kinase II subunit alpha2.7.11.10.458
2ckeIQUDeath-associated protein kinase 2/0.458
2f7z6EAcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.456
3rkb12ZCyclin-dependent kinase 22.7.11.220.456
4anmWULCasein kinase II subunit alpha2.7.11.10.456
2uztSS3cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.455
4ji91M3Tyrosine-protein kinase JAK2/0.453
2uw4L15cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.452
3at4CCKCasein kinase II subunit alpha2.7.11.10.452
2pvhP19Casein kinase II subunit alpha2.7.11.10.451
3i4bZ48Glycogen synthase kinase-3 beta2.7.11.260.451
2f7x4EAcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.450
2oh02PYcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.449
3qxpX64Cyclin-dependent kinase 22.7.11.220.449
1dayGNPCasein kinase II subunit alpha2.7.11.10.448
1jklANPDeath-associated protein kinase 12.7.11.10.448
3gu83GUDeath-associated protein kinase 12.7.11.10.448
2gnfY27cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.446
3pe2E1BCasein kinase II subunit alpha2.7.11.10.445
3rak03ZCyclin-dependent kinase 22.7.11.220.445
4hge15VTyrosine-protein kinase JAK2/0.445
4dgmAGICasein kinase II subunit alpha2.7.11.10.444
4mq12C3Dual specificity tyrosine-phosphorylation-regulated kinase 1A2.7.12.10.444
4qnyANPMitogen activated protein kinase, putative/0.442
3lpbNVBTyrosine-protein kinase JAK2/0.440