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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4f7n0SVCyclin-dependent kinase 82.7.11.22

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
4f7n0SVCyclin-dependent kinase 82.7.11.221.000
4f6s0SQCyclin-dependent kinase 82.7.11.220.573
3npcB96Mitogen-activated protein kinase 92.7.11.240.484
4f7j0SUCyclin-dependent kinase 82.7.11.220.476
4h1m0YJProtein-tyrosine kinase 2-beta2.7.10.20.468
4z34ON7Lysophosphatidic acid receptor 1/0.467
3e8cG96cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.462
1kv1BMUMitogen-activated protein kinase 14/0.456
3w0sANPHygromycin-B 4-O-kinase2.7.1.1630.450