Logo scPDB

sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

Logo CNRS Logo Unistra
Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4f4p0SBTyrosine-protein kinase SYK2.7.10.2

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
4f4p0SBTyrosine-protein kinase SYK2.7.10.21.000
1qpjSTUTyrosine-protein kinase Lck2.7.10.20.526
4dfn0K1Tyrosine-protein kinase SYK2.7.10.20.513
3a4oSTUTyrosine-protein kinase Lyn2.7.10.20.507
3w2sW2REpidermal growth factor receptor2.7.10.10.500
3bqr4RBDeath-associated protein kinase 3/0.497
4fv9E71Mitogen-activated protein kinase 12.7.11.240.493
4j95ACPFibroblast growth factor receptor 2/0.489
4yhjAN2G protein-coupled receptor kinase 42.7.11.160.486
2hxl422Serine/threonine-protein kinase Chk12.7.11.10.485
2yaaATPDeath-associated protein kinase 2/0.484
3orzBI43-phosphoinositide-dependent protein kinase 12.7.11.10.482
4j99ACPFibroblast growth factor receptor 2/0.482
3kkvB99cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.479
2pvmP29Casein kinase II subunit alpha2.7.11.10.478
3vs2VSBTyrosine-protein kinase HCK2.7.10.20.478
4l9i8PRRhodopsin kinase/0.478
3at4CCKCasein kinase II subunit alpha2.7.11.10.476
4i0t1B6Tyrosine-protein kinase SYK2.7.10.20.475
1q3wATUGlycogen synthase kinase-3 beta2.7.11.260.474
4c34STUcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.473
3vrzVRZTyrosine-protein kinase HCK2.7.10.20.472
5dt0SKEAurora kinase A2.7.11.10.471
3vs5VSGTyrosine-protein kinase HCK2.7.10.20.470
4l7sG7KTyrosine-protein kinase ITK/TSK2.7.10.20.468
4o0wADNAurora kinase A2.7.11.10.468
3nynSGVG protein-coupled receptor kinase 62.7.11.160.467
3axwTIDCasein kinase II subunit alpha2.7.11.10.465
5av2KMPDeath-associated protein kinase 12.7.11.10.465
2qoqANPEphrin type-A receptor 32.7.10.10.464
3dqwAGSProto-oncogene tyrosine-protein kinase Src2.7.10.20.464
2h8hH8HProto-oncogene tyrosine-protein kinase Src2.7.10.20.462
4bcmT7ZCyclin-dependent kinase 22.7.11.220.461
1j1cADPGlycogen synthase kinase-3 beta2.7.11.260.460
1pjkANPCasein kinase II subunit alpha2.7.11.10.460
4dit0KDGlycogen synthase kinase-3 beta2.7.11.260.460
4k110J9Proto-oncogene tyrosine-protein kinase Src2.7.10.20.460
2f7z6EAcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.459
3q9xEMOCasein kinase II subunit alpha2.7.11.10.459
4l3j5FIRibosomal protein S6 kinase beta-12.7.11.10.458
5av3KMPDeath-associated protein kinase 12.7.11.10.458
2vu3LZECyclin-dependent kinase 22.7.11.220.457
2c6eHPMAurora kinase A2.7.11.10.456
3i60E86Mitogen-activated protein kinase 12.7.11.240.456
2uzvSS5cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.455
2etrY27Rho-associated protein kinase 12.7.11.10.454
2j0m4STFocal adhesion kinase 12.7.10.20.454
4bfmANPMaternal embryonic leucine zipper kinase2.7.11.10.454
3qd03Q43-phosphoinositide-dependent protein kinase 12.7.11.10.453
4i0r1B4Tyrosine-protein kinase SYK2.7.10.20.453
1fvv107Cyclin-dependent kinase 22.7.11.220.452
2henADPEphrin type-B receptor 22.7.10.10.452
4ekl0RFRAC-alpha serine/threonine-protein kinase2.7.11.10.452
4fv2EK5Mitogen-activated protein kinase 12.7.11.240.452
4grb0XGCasein kinase II subunit alpha2.7.11.10.452
3zc6VFCTyrosine-protein kinase JAK32.7.10.20.451
2cgu3A3Serine/threonine-protein kinase Chk12.7.11.10.450
4yzcSTUSerine/threonine-protein kinase/endoribonuclease IRE12.7.11.10.450
2v7a627Tyrosine-protein kinase ABL12.7.10.20.449
3cblSTUTyrosine-protein kinase Fes/Fps2.7.10.20.449
3ofm4B0Casein kinase II subunit alpha'2.7.11.10.449
3vs0VS0Tyrosine-protein kinase HCK2.7.10.20.449
4fg7ATPCalcium/calmodulin-dependent protein kinase type 12.7.11.170.449
4ftiH7KSerine/threonine-protein kinase Chk12.7.11.10.449
2ojf4PYcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.448
3b2w9NHTyrosine-protein kinase Lck2.7.10.20.448
3lpbNVBTyrosine-protein kinase JAK2/0.448
3my5RFZCyclin-dependent kinase 22.7.11.220.448
2j7t274Serine/threonine-protein kinase 102.7.11.10.447
2uzuL20cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.447
4fv6E57Mitogen-activated protein kinase 12.7.11.240.447
3cqwCQWRAC-alpha serine/threonine-protein kinase2.7.11.10.446
4fsnA58Serine/threonine-protein kinase Chk12.7.11.10.446
4jia1K3Tyrosine-protein kinase JAK2/0.446
1jklANPDeath-associated protein kinase 12.7.11.10.445
2ojj82AMitogen-activated protein kinase 12.7.11.240.445
4o0rX4ZSerine/threonine-protein kinase PAK 12.7.11.10.445
2j0lANPFocal adhesion kinase 12.7.10.20.444
4gk4L90Ephrin type-A receptor 32.7.10.10.444
5d12G97Proto-oncogene tyrosine-protein kinase Src2.7.10.20.444
2xvdAS6Ephrin type-B receptor 42.7.10.10.443
3u4uLNHCasein kinase II subunit alpha2.7.11.10.443
4anmWULCasein kinase II subunit alpha2.7.11.10.443
4dgmAGICasein kinase II subunit alpha2.7.11.10.443
4gv10XZRAC-alpha serine/threonine-protein kinase2.7.11.10.443
1q8uH52cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.441
2vo0M03cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.441
3zewSTUEphrin type-B receptor 42.7.10.10.441
4h4zFADBiphenyl dioxygenase ferredoxin reductase subunit/0.441
2f7e2EAcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.440
2wmqZYQSerine/threonine-protein kinase Chk12.7.11.10.440
4hge15VTyrosine-protein kinase JAK2/0.440