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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4f1mACPProbable serine/threonine-protein kinase roco42.7.11.1

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
4f1mACPProbable serine/threonine-protein kinase roco42.7.11.11.000
4f0fACPProbable serine/threonine-protein kinase roco42.7.11.10.599
4f1oACPProbable serine/threonine-protein kinase roco42.7.11.10.565
3d5wADPSerine/threonine-protein kinase PLK/0.475
4yhjAN2G protein-coupled receptor kinase 42.7.11.160.459
4a4o664Serine/threonine-protein kinase PLK12.7.11.210.450
2in6839Wee1-like protein kinase2.7.10.20.446
2yac937Serine/threonine-protein kinase PLK12.7.11.210.441