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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4ele31IDihydrofolate reductase

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
4ele31IDihydrofolate reductase/1.000
3fl8RARDihydrofolate reductase/0.690
4elf35IDihydrofolate reductase/0.658
4elg52JDihydrofolate reductase/0.611
4elb34SDihydrofolate reductase/0.548
2w9sTOPDihydrofolate reductase type 1 from Tn40031.5.1.30.523
4elb34RDihydrofolate reductase/0.509
4elh53IDihydrofolate reductase/0.499
1diuBDMDihydrofolate reductase1.5.1.30.493
2qk8MTXDihydrofolate reductase/0.492
3och2MXDihydrofolate reductase1.5.1.30.483
4dfrMTXDihydrofolate reductase1.5.1.30.467
1dhjMTXDihydrofolate reductase1.5.1.30.466
1draMTXDihydrofolate reductase1.5.1.30.466
1disBDMDihydrofolate reductase1.5.1.30.458
2drcMTXDihydrofolate reductase1.5.1.30.457
1ddsMTXDihydrofolate reductase1.5.1.30.454
1jolFFODihydrofolate reductase1.5.1.30.454
2cig1DGDihydrofolate reductase1.5.1.30.454
3fl9TOPDihydrofolate reductase/0.445
1drbMTXDihydrofolate reductase1.5.1.30.444