sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

Distribution of Cavity similarities measured by Shaper

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Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :

PDB ID	HET	Uniprot Name	EC Number
4eil	CB3	Bifunctional dihydrofolate reductase-thymidylate synthase	1.5.1.3

Complex with similar cavities

PDB ID	HET	Uniprot Name	EC Number	Cavity Similarity	Align
4eil	CB3	Bifunctional dihydrofolate reductase-thymidylate synthase	1.5.1.3	1.000
1ju6	LYA	Thymidylate synthase	2.1.1.45	0.503
1juj	LYA	Thymidylate synthase	2.1.1.45	0.482
4ez8	DHF	Thymidylate synthase	2.1.1.45	0.475
1qzf	CB3	Bifunctional dihydrofolate reductase-thymidylate synthase	/	0.453
1tdu	CB3	Thymidylate synthase	/	0.445
1jut	LYD	Thymidylate synthase	/	0.443
1ci7	CB3	Thymidylate synthase	2.1.1.45	0.441
1hvy	D16	Thymidylate synthase	2.1.1.45	0.441