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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4eevL1XHepatocyte growth factor receptor2.7.10.1

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
4eevL1XHepatocyte growth factor receptor2.7.10.11.000
3ctj320Hepatocyte growth factor receptor2.7.10.10.555
3ce31FNHepatocyte growth factor receptor2.7.10.10.537
4agwNG7Proto-oncogene tyrosine-protein kinase Src2.7.10.20.477
4eyjN61Mitogen-activated protein kinase 132.7.11.240.462