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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4e6d0NUTyrosine-protein kinase JAK2

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
4e6d0NUTyrosine-protein kinase JAK2/1.000
4aqc88ATyrosine-protein kinase JAK2/0.603
4hge15VTyrosine-protein kinase JAK2/0.579
4i5cC5ITyrosine-protein kinase JAK1/0.573
4ehzJAKTyrosine-protein kinase JAK1/0.552
4f081RSTyrosine-protein kinase JAK2/0.550
3lpbNVBTyrosine-protein kinase JAK2/0.540
3zc6VFCTyrosine-protein kinase JAK32.7.10.20.540
4e4n0NLTyrosine-protein kinase JAK1/0.527
4fk60UJTyrosine-protein kinase JAK1/0.504
4e6q0NVTyrosine-protein kinase JAK2/0.492
4ivb1J5Tyrosine-protein kinase JAK1/0.483
4ji91M3Tyrosine-protein kinase JAK2/0.475
4hvi19STyrosine-protein kinase JAK32.7.10.20.473
4fv6E57Mitogen-activated protein kinase 12.7.11.240.469
2vv9IM9Cyclin-dependent kinase 22.7.11.220.468
1yvj4STTyrosine-protein kinase JAK32.7.10.20.463
3qxpX64Cyclin-dependent kinase 22.7.11.220.457
3i4bZ48Glycogen synthase kinase-3 beta2.7.11.260.456
4jia1K3Tyrosine-protein kinase JAK2/0.454
3rkb12ZCyclin-dependent kinase 22.7.11.220.453
4e5w0NTTyrosine-protein kinase JAK1/0.450
3rak03ZCyclin-dependent kinase 22.7.11.220.449
5dpvSKEAurora kinase A2.7.11.10.448
2vu3LZECyclin-dependent kinase 22.7.11.220.447
1fvv107Cyclin-dependent kinase 22.7.11.220.445
1om1IQACasein kinase II subunit alpha2.7.11.10.443
3i5zZ48Mitogen-activated protein kinase 12.7.11.240.442
4anmWULCasein kinase II subunit alpha2.7.11.10.442
3be9P04Casein kinase II subunit alpha2.7.11.10.440