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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4e200MYNon-receptor tyrosine-protein kinase TYK22.7.10.2

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
4e200MYNon-receptor tyrosine-protein kinase TYK22.7.10.21.000
4e1z0MXNon-receptor tyrosine-protein kinase TYK22.7.10.20.665
2b7aIZATyrosine-protein kinase JAK2/0.548
4gj20XHNon-receptor tyrosine-protein kinase TYK22.7.10.20.530
4k771Q4Tyrosine-protein kinase JAK1/0.524
4ivc1J6Tyrosine-protein kinase JAK1/0.523
4k6z1Q3Tyrosine-protein kinase JAK1/0.514
4qmpDKISerine/threonine-protein kinase 242.7.11.10.512
4e4l0NHTyrosine-protein kinase JAK1/0.507
4e4m0NHTyrosine-protein kinase JAK2/0.507
4ivd15TTyrosine-protein kinase JAK1/0.501
3lxkMI1Tyrosine-protein kinase JAK32.7.10.20.496
4ei40Q2Tyrosine-protein kinase JAK1/0.489
2nrySTUInterleukin-1 receptor-associated kinase 42.7.11.10.484
3zm422TDual specificity mitogen-activated protein kinase kinase 12.7.12.20.484
4gj30XPNon-receptor tyrosine-protein kinase TYK22.7.10.20.481
4e5w0NTTyrosine-protein kinase JAK1/0.480
4ivb1J5Tyrosine-protein kinase JAK1/0.480
4u9aSTUInterleukin-1 receptor-associated kinase 42.7.11.10.478
3r6xX84Cyclin-dependent kinase 22.7.11.220.477
3v8t477Tyrosine-protein kinase ITK/TSK2.7.10.20.477
4gii0X6Non-receptor tyrosine-protein kinase TYK22.7.10.20.476
4u97STUInterleukin-1 receptor-associated kinase 42.7.11.10.476
1g5sI17Cyclin-dependent kinase 22.7.11.220.475
3ggfGVDSerine/threonine-protein kinase 26/0.474
5drdATPAurora kinase A2.7.11.10.473
5dpvSKEAurora kinase A2.7.11.10.472
4fkr45KCyclin-dependent kinase 22.7.11.220.470
4acm7YGCyclin-dependent kinase 22.7.11.220.469
4fx360KCyclin-dependent kinase 22.7.11.220.468
4gfo0X2Non-receptor tyrosine-protein kinase TYK22.7.10.20.467
5dt0SKEAurora kinase A2.7.11.10.467
3zep1NXTyrosine-protein kinase JAK32.7.10.20.465
1h1r6CPCyclin-dependent kinase 22.7.11.220.463
2wotZZGTGF-beta receptor type-12.7.11.300.463
2x1nX1NCyclin-dependent kinase 22.7.11.220.463
4iwq1FVSerine/threonine-protein kinase TBK12.7.11.10.463
1p2a5BNCyclin-dependent kinase 22.7.11.220.461
4fkg4CKCyclin-dependent kinase 22.7.11.220.461
2xmyCDKCyclin-dependent kinase 22.7.11.220.460
4dgo0JWCasein kinase II subunit alpha2.7.11.10.460
4gih0X5Non-receptor tyrosine-protein kinase TYK22.7.10.20.460
4hge15VTyrosine-protein kinase JAK2/0.460
1rekB8LcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.459
2xikJ60Serine/threonine-protein kinase 252.7.11.10.459
3raiX85Cyclin-dependent kinase 22.7.11.220.459
4bbfO19Tyrosine-protein kinase JAK2/0.459
3zmmF9JTyrosine-protein kinase JAK2/0.458
3lxpIZANon-receptor tyrosine-protein kinase TYK22.7.10.20.456
4fkv61KCyclin-dependent kinase 22.7.11.220.456
2w06FRVCyclin-dependent kinase 22.7.11.220.455
3iok1P6Tyrosine-protein kinase JAK2/0.455
3qd03Q43-phosphoinositide-dependent protein kinase 12.7.11.10.455
3rmf20ZCyclin-dependent kinase 22.7.11.220.455
4o0sADNAurora kinase A2.7.11.10.455
3qu0X40Cyclin-dependent kinase 22.7.11.220.454
3sw418KCyclin-dependent kinase 22.7.11.220.454
3v5l0G1Tyrosine-protein kinase ITK/TSK2.7.10.20.454
1py5PY1TGF-beta receptor type-12.7.11.300.453
2vv9IM9Cyclin-dependent kinase 22.7.11.220.453
3kc3MK2MAP kinase-activated protein kinase 22.7.11.10.453
1dm2HMDCyclin-dependent kinase 22.7.11.220.452
1gih1PUCyclin-dependent kinase 22.7.11.220.452
2vtoLZ8Cyclin-dependent kinase 22.7.11.220.452
3rvg17PTyrosine-protein kinase JAK2/0.452
4idtT28Mitogen-activated protein kinase kinase kinase 142.7.11.250.452
3ti1B49Cyclin-dependent kinase 22.7.11.220.451
4f081RSTyrosine-protein kinase JAK2/0.451
2i40BLZCyclin-dependent kinase 22.7.11.220.450
5e8wSTUTGF-beta receptor type-12.7.11.300.450
3qd43Q63-phosphoinositide-dependent protein kinase 12.7.11.10.449
4kikKSAInhibitor of nuclear factor kappa-B kinase subunit beta2.7.11.100.449
1pkdUCNCyclin-dependent kinase 22.7.11.220.448
2uzlC94Cyclin-dependent kinase 22.7.11.220.448
3qqkX02Cyclin-dependent kinase 22.7.11.220.448
1h1s4SPCyclin-dependent kinase 22.7.11.220.447
2bkzSBCCyclin-dependent kinase 22.7.11.220.447
2eufLQQCyclin-dependent kinase 62.7.11.220.447
3rak03ZCyclin-dependent kinase 22.7.11.220.447
4fks46KCyclin-dependent kinase 22.7.11.220.447
1fvv107Cyclin-dependent kinase 22.7.11.220.446
1m2rMNYCasein kinase II subunit alpha2.7.11.10.446
3rk708ZCyclin-dependent kinase 22.7.11.220.446
3rni21ZCyclin-dependent kinase 22.7.11.220.446
3w18N13Aurora kinase A2.7.11.10.446
4mf129YTyrosine-protein kinase ITK/TSK2.7.10.20.446
3el51UNGag-Pol polyprotein/0.445
3qqhX0ACyclin-dependent kinase 22.7.11.220.445
4ewhT77Activated CDC42 kinase 1/0.445
1oguST8Cyclin-dependent kinase 22.7.11.220.444
1urwI1PCyclin-dependent kinase 22.7.11.220.444
2btrU73Cyclin-dependent kinase 22.7.11.220.444
3ckxSTUSerine/threonine-protein kinase 242.7.11.10.444
2ydiYDISerine/threonine-protein kinase Chk12.7.11.10.443
3a62STURibosomal protein S6 kinase beta-12.7.11.10.443
3qzgX67Cyclin-dependent kinase 22.7.11.220.443
3ral04ZCyclin-dependent kinase 22.7.11.220.443
3sc13S13-phosphoinositide-dependent protein kinase 12.7.11.10.443
4fkt48KCyclin-dependent kinase 22.7.11.220.443
4gh2HK0Serine/threonine-protein kinase Chk12.7.11.10.443
4gvjADPNon-receptor tyrosine-protein kinase TYK22.7.10.20.443
4hvi19STyrosine-protein kinase JAK32.7.10.20.443
1eh4IC1Casein kinase I homolog 12.7.11.10.442
1q41IXMGlycogen synthase kinase-3 beta2.7.11.260.442
3qx2X63Cyclin-dependent kinase 22.7.11.220.442
4hvh19RTyrosine-protein kinase JAK32.7.10.20.442
4oa9ANPProtein BRASSINOSTEROID INSENSITIVE 12.7.10.10.442
2r3lSCWCyclin-dependent kinase 22.7.11.220.441
3ddpRC8Cyclin-dependent kinase 22.7.11.220.441
3zc6VFCTyrosine-protein kinase JAK32.7.10.20.441
5dr6SKEAurora kinase A2.7.11.10.441
1ppm0P1Penicillopepsin-13.4.23.200.440
2c6tDT5Cyclin-dependent kinase 22.7.11.220.440
2pmoHMDProtein kinase 7/0.440
3r9oZ71Cyclin-dependent kinase 22.7.11.220.440
3s0o50ZCyclin-dependent kinase 22.7.11.220.440