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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4dxaGSPRas-related protein Rap-1b

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
4dxaGSPRas-related protein Rap-1b/1.000
1uadGNPRas-related protein Ral-A/0.544
1zc4GNPRas-related protein Ral-A/0.537
1zc3GNPRas-related protein Ral-A/0.535
4kvgGTPRas-related protein Rap-1A/0.533
4dsuGDPGTPase KRas/0.525
3v4fGNPGTPase HRas/0.505
4nyiGNPGTPase HRas/0.498
1cxzGSPTransforming protein RhoA/0.497
3oiuGNPGTPase HRas/0.493
1lfdGNPGTPase HRas/0.492
3lbnGNPGTPase HRas/0.489
3i3sGNPGTPase HRas/0.484
3oivGNPGTPase HRas/0.484
4nyjGNPGTPase HRas/0.482
3rs5GNPGTPase HRas/0.481
3kucGDPRas-related protein Rap-1A/0.479
1m7bGTPRho-related GTP-binding protein RhoE/0.478
5b2zGNPGTPase HRas/0.474
3tsoGNPRas-related protein Rab-25/0.462
1kmqGNPTransforming protein RhoA/0.461
1ow3GDPTransforming protein RhoA/0.461
2zetGTPRas-related protein Rab-27B/0.460
5hpyGDPTransforming protein RhoA/0.459
1xtrGNPGTP-binding protein Rheb/0.458
4qxaGTPRas-related protein Rab-9A/0.455
2cl6CAGGTPase HRas/0.450
4dltGNPGTPase HRas/0.450
2w2xGSPRas-related C3 botulinum toxin substrate 2/0.448
1xtsGTPGTP-binding protein Rheb/0.447
4dlwGNPGTPase HRas/0.444
1s1cGNPTransforming protein RhoA/0.443
3e5hGNPRas-related protein Rab-28/0.440