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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4dwb0M7Farnesyl pyrophosphate synthase

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
4dwb0M7Farnesyl pyrophosphate synthase/1.000
3dyh721Farnesyl pyrophosphate synthase/0.528
2f94BFQFarnesyl pyrophosphate synthase2.5.1.100.518
4lfvYS4Farnesyl pyrophosphate synthase2.5.1.100.516
3ez3IPEFarnesyl pyrophosphate synthase, putative/0.511
2i191BYFarnesyl pyrophosphate synthase/0.510
1zw5ZOLFarnesyl pyrophosphate synthase2.5.1.100.503
3rywK9HFarnesyl pyrophosphate synthase, putative/0.501
3rbmB73Farnesyl pyrophosphate synthase, putative/0.496
3ryeUNRFarnesyl pyrophosphate synthase2.5.1.100.494
3ldwIPEFarnesyl pyrophosphate synthase, putative/0.492
3egt722Farnesyl pyrophosphate synthase/0.487
4q23RISFarnesyl pyrophosphate synthase2.5.1.100.481
3ldwZOLFarnesyl pyrophosphate synthase, putative/0.480
4dxj0M9Farnesyl pyrophosphate synthase/0.477
3ez3ZOLFarnesyl pyrophosphate synthase, putative/0.475
3krfIPEGeranyl diphosphate synthase large subunit/0.474
4nkeIPEFarnesyl pyrophosphate synthase2.5.1.100.470
3krfDSTGeranyl diphosphate synthase large subunit/0.469
1yq7RISFarnesyl pyrophosphate synthase2.5.1.100.468
1yv5RISFarnesyl pyrophosphate synthase2.5.1.100.463
4nkeRISFarnesyl pyrophosphate synthase2.5.1.100.463
4lfgIPEPutative geranyltranstransferase/0.456
1rqjIPEFarnesyl diphosphate synthase2.5.1.100.452
2opmNI9Farnesyl pyrophosphate synthase2.5.1.100.451
4kqsIPEFarnesyl pyrophosphate synthase2.5.1.100.445
1rqjRISFarnesyl diphosphate synthase2.5.1.100.444