sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

Distribution of Cavity similarities measured by Shaper

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Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :

PDB ID	HET	Uniprot Name	EC Number
4dtc	D5C	Dipeptidyl peptidase 4

Complex with similar cavities

PDB ID	HET	Uniprot Name	EC Number	Cavity Similarity	Align
4dtc	D5C	Dipeptidyl peptidase 4	/	1.000
3d0b	SNX	Heat shock protein HSP 90-alpha	/	0.470
3hyz	42C	Heat shock protein HSP 90-alpha	/	0.464
2cgp	CMP	cAMP-activated global transcriptional regulator CRP	/	0.459
4lnk	ADP	Glutamine synthetase	6.3.1.2	0.459
1nhh	ANP	DNA mismatch repair protein MutL	/	0.457
1w2x	RCP	Acetyl-CoA carboxylase	/	0.454
1uy8	PU5	Heat shock protein HSP 90-alpha	/	0.444
5iqi	GNP	Bifunctional AAC/APH	2.3.1	0.442
2ibz	UQ6	Cytochrome b	/	0.441
3ibq	ATP	Pyridoxal kinase	/	0.441
2bpo	NAP	NADPH--cytochrome P450 reductase	/	0.440
3daw	ATP	Actin, alpha skeletal muscle	/	0.440