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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4dsuGDPGTPase KRas

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
4dsuGDPGTPase KRas/1.000
4dxaGSPRas-related protein Rap-1b/0.588
1uadGNPRas-related protein Ral-A/0.554
1zc3GNPRas-related protein Ral-A/0.545
1zc4GNPRas-related protein Ral-A/0.543
3oivGNPGTPase HRas/0.513
2cl6CAGGTPase HRas/0.507
5b2zGNPGTPase HRas/0.502
4nyiGNPGTPase HRas/0.496
3rs5GNPGTPase HRas/0.494
3v4fGNPGTPase HRas/0.493
3i3sGNPGTPase HRas/0.483
4kvgGTPRas-related protein Rap-1A/0.483
4dsoGSPGTPase KRas/0.478
1cxzGSPTransforming protein RhoA/0.476
1kmqGNPTransforming protein RhoA/0.474
3lbnGNPGTPase HRas/0.472
3x1wGDPRas-related protein Rap-1b/0.472
1mh1GNPRas-related C3 botulinum toxin substrate 1/0.471
1m7bGTPRho-related GTP-binding protein RhoE/0.470
3oiuGNPGTPase HRas/0.470
4xvrGNPGTPase HRas/0.465
2w2xGSPRas-related C3 botulinum toxin substrate 2/0.464
3eg5GNPCell division control protein 42 homolog/0.464
4nyjGNPGTPase HRas/0.462
5hpyGDPTransforming protein RhoA/0.458
4qo9627Serine/threonine-protein kinase 242.7.11.10.457
4uj3GNPRas-related protein Rab-11A/0.449
2gcpGSPRho-related GTP-binding protein RhoC/0.448
1ow3GDPTransforming protein RhoA/0.445
1g17GNPRas-related protein SEC4/0.444
3tsoGNPRas-related protein Rab-25/0.440
5dhaGNPGTP-binding nuclear protein Ran/0.440