Logo scPDB

sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

Logo CNRS Logo Unistra
Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4dsnGCPGTPase KRas

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
4dsnGCPGTPase KRas/1.000
3pitGNPRas-related protein M-Ras/0.634
4g0nGNPGTPase HRas/0.622
3kkoGNPRas-related protein M-Ras/0.618
3ddcGNPGTPase HRas/0.614
3lbhGNPGTPase HRas/0.603
3k8yGNPGTPase HRas/0.602
2rgeGNPGTPase HRas/0.601
4nyjGNPGTPase HRas/0.601
3lbiGNPGTPase HRas/0.591
3x1zGNPRas-related protein Rap-1b/0.589
3lbnGNPGTPase HRas/0.583
3v4fGNPGTPase HRas/0.579
3kucGDPRas-related protein Rap-1A/0.576
2c5lGTPGTPase HRas/0.572
2rgcGNPGTPase HRas/0.568
4hdoGNPRas-related protein Rap-1b/0.567
3oiuGNPGTPase HRas/0.566
3oivGNPGTPase HRas/0.565
3l8yGNPGTPase HRas/0.561
4dltGNPGTPase HRas/0.561
3e5hGNPRas-related protein Rab-28/0.560
3i3sGNPGTPase HRas/0.559
4mitGTPRho-related protein racC/0.557
1zc4GNPRas-related protein Ral-A/0.556
3oiwGNPGTPase HRas/0.555
3oesGNPGTPase RhebL1/0.553
3rs5GNPGTPase HRas/0.553
3rs0GNPGTPase HRas/0.552
4dlxGNPGTPase HRas/0.552
2rgbGNPGTPase HRas/0.551
3rs4GNPGTPase HRas/0.549
4dlzGNPGTPase HRas/0.548
3rs7GNPGTPase HRas/0.545
4nyiGNPGTPase HRas/0.545
5difGNPGTP-binding nuclear protein Ran/0.545
1zbdGTPRas-related protein Rab-3A/0.544
3w3zGTPGTP-binding nuclear protein Ran/0.544
2qmeGCPRas-related C3 botulinum toxin substrate 3/0.541
1zc3GNPRas-related protein Ral-A/0.537
1kmqGNPTransforming protein RhoA/0.536
1xtsGTPGTP-binding protein Rheb/0.536
4dlwGNPGTPase HRas/0.535
4lhwGNPRas-related protein Rab-8A/0.535
5b2zGNPGTPase HRas/0.535
1t91GTPRas-related protein Rab-7a/0.534
3wyfGTPGTP-binding nuclear protein/0.534
3a6pGTPGTP-binding nuclear protein Ran/0.531
1zd9GDPADP-ribosylation factor-like protein 8A/0.529
3a58GNPGTP-binding protein RHO1/0.528
3sbdGNPRas-related C3 botulinum toxin substrate 1/0.528
1a2bGSPTransforming protein RhoA/0.527
2gcpGSPRho-related GTP-binding protein RhoC/0.527
1g17GNPRas-related protein SEC4/0.526
1yhnGTPRas-related protein Rab-7a/0.526
1e96GTPRas-related C3 botulinum toxin substrate 1/0.525
2ov2GCPRas-related C3 botulinum toxin substrate 3/0.525
3bbpGTPRas-related protein Rab-6A/0.524
1xtrGNPGTP-binding protein Rheb/0.523
2msdGNPMHC class I alpha chain/0.522
4dlsGNPGTPase HRas/0.522
2bkuGTPGTP-binding nuclear protein Ran/0.521
5dhaGNPGTP-binding nuclear protein Ran/0.521
5jljGNPGTP-binding nuclear protein Ran/0.520
1m7bGTPRho-related GTP-binding protein RhoE/0.519
3rabGNPRas-related protein Rab-3A/0.519
4dlvGNPGTPase HRas/0.519
3rslGNPGTPase HRas/0.516
4l9wGNPGTPase HRas/0.515
4ol0GTPGTP-binding nuclear protein Ran/0.515
4tq9GDPGTPase KRas/0.515
1gwnGTPRho-related GTP-binding protein RhoE/0.514
2fjuGSPRas-related C3 botulinum toxin substrate 1/0.514
2rggGNPGTPase HRas/0.514
3kudGDPGTPase HRas/0.514
1mh1GNPRas-related C3 botulinum toxin substrate 1/0.511
4o2lGTPGTP-binding protein Rheb/0.511
4rkfGNPRas-related protein Rab-3/0.509
3ea5GDPGTP-binding nuclear protein Ran/0.504
2fe4GDPRas-related protein Rab-6B/0.503
3tgpGNPGTPase HRas/0.503
1yzqGNPRas-related protein Rab-6A/0.502
3nbzGTPGTP-binding nuclear protein Ran/0.499
3kkqGDPRas-related protein M-Ras/0.495
1z2aGDPRas-related protein Rab-23/0.494
4dsoGSPGTPase KRas/0.494
4hdqGNPRas-related protein Rap-1b/0.493
4epxGDPGTPase KRas/0.492
4kvgGTPRas-related protein Rap-1A/0.490
1ibrGNPGTP-binding nuclear protein Ran/0.489
2mseGNPMHC class I alpha chain/0.489
3sbeGNPRas-related C3 botulinum toxin substrate 1/0.489
4q03GDPGTPase KRas/0.488
4xvqGNPGTPase HRas/0.487
3x1wGDPRas-related protein Rap-1b/0.485
1d5cGDPGTPase (Rab6)/0.484
4qxaGTPRas-related protein Rab-9A/0.483
4lpkGDPGTPase KRas/0.482
3k9lGNPGTPase HRas/0.481
4ql3GDPGTPase KRas/0.481
1yu9GNPRas-related protein Rab-4A/0.480
3mjhGTPRas-related protein Rab-5A/0.479
3kz1GSPTransforming protein RhoA/0.478
4l9sGDPGTPase HRas/0.478
1k5dGNPGTP-binding nuclear protein Ran/0.475
2ffqGSPRas-related protein Rab-6B/0.475
4xvrGNPGTPase HRas/0.475
4wa7GDPGTPase KRas/0.474
4o2rGDPGTP-binding protein Rheb/0.472
4xoiGTPTransforming protein RhoA/0.472
3th5GNPRas-related C3 botulinum toxin substrate 1/0.471
4o25GTPGTP-binding protein Rheb/0.471
3tsoGNPRas-related protein Rab-25/0.470
4lv6GDPGTPase KRas/0.470
1n6lGTPRas-related protein Rab-5A/0.469
2ce2GDPGTPase HRas/0.468
2fg5GNPRas-related protein Rab-31/0.468
4gzmGSPRas-related C3 botulinum toxin substrate 1/0.466
1vg8GNPRas-related protein Rab-7a/0.461
2x19GTPGTP-binding nuclear protein GSP1/CNR1/0.461
4epwGDPGTPase KRas/0.461
1ow3GDPTransforming protein RhoA/0.460
4l8gGDPGTPase KRas/0.459
3eg5GNPCell division control protein 42 homolog/0.458
4ldjGDPGTPase KRas/0.458
1lfdGNPGTPase HRas/0.457
2p2lGDPRas-related C3 botulinum toxin substrate 1/0.456
4uj3GNPRas-related protein Rab-11A/0.456
4js0GNPCell division control protein 42 homolog/0.455
4lrwGDPGTPase KRas/0.455
2ydbNAP2',3'-cyclic-nucleotide 3'-phosphodiesterase3.1.4.370.453
3exhTPPPyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial1.2.4.10.451
3exhTPPPyruvate dehydrogenase E1 component subunit beta, mitochondrial1.2.4.10.451
3wygGTPGTP-binding nuclear protein GSP1/CNR1/0.451
4d0lGSPRas-related protein Rab-11A/0.450
2clsGTPRho-related GTP-binding protein Rho6/0.449
3cphGDPRas-related protein SEC4/0.449
3qbtGNPRas-related protein Rab-8A/0.449
4g20484Vitamin D3 receptor A/0.448
4q02GDPGTPase KRas/0.448
4xymCOAAcyl-CoA synthetase (NDP forming)/0.448
1x1rGDPRas-related protein M-Ras/0.446
1g16GDPRas-related protein SEC4/0.445
4bc7FADAlkyldihydroxyacetonephosphate synthase, peroxisomal2.5.1.260.445
4obeGDPGTPase KRas/0.445
5hpyGDPTransforming protein RhoA/0.445
2bmeGNPRas-related protein Rab-4A/0.444
1upw444Oxysterols receptor LXR-beta/0.443
1h50FMNPentaerythritol tetranitrate reductase/0.442
1oixGDPRas-related protein Rab-11A/0.442
3w0jT08Vitamin D3 receptor/0.440
4bfvZVVPantothenate kinase2.7.1.330.440
4cidANPEH domain-containing protein 2/0.440
4zzi1NSNAD-dependent protein deacetylase sirtuin-13.5.10.440