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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4dlwGNPGTPase HRas

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
4dlwGNPGTPase HRas/1.000
3v4fGNPGTPase HRas/0.724
4dltGNPGTPase HRas/0.709
3rs5GNPGTPase HRas/0.699
3lbnGNPGTPase HRas/0.689
3rs7GNPGTPase HRas/0.657
3oivGNPGTPase HRas/0.651
3rs0GNPGTPase HRas/0.647
3i3sGNPGTPase HRas/0.645
3rslGNPGTPase HRas/0.643
3oiuGNPGTPase HRas/0.639
4dlvGNPGTPase HRas/0.638
4dlxGNPGTPase HRas/0.630
2rgcGNPGTPase HRas/0.627
3ddcGNPGTPase HRas/0.619
5b2zGNPGTPase HRas/0.614
2rgeGNPGTPase HRas/0.613
4dlzGNPGTPase HRas/0.604
2rgbGNPGTPase HRas/0.599
3lbhGNPGTPase HRas/0.594
3kucGDPRas-related protein Rap-1A/0.586
4lhwGNPRas-related protein Rab-8A/0.585
4rkfGNPRas-related protein Rab-3/0.575
3rabGNPRas-related protein Rab-3A/0.571
4mitGTPRho-related protein racC/0.566
4qxaGTPRas-related protein Rab-9A/0.562
4nyiGNPGTPase HRas/0.561
2c5lGTPGTPase HRas/0.552
3rs4GNPGTPase HRas/0.547
3ea5GDPGTP-binding nuclear protein Ran/0.546
4nyjGNPGTPase HRas/0.545
3a6pGTPGTP-binding nuclear protein Ran/0.544
3pitGNPRas-related protein M-Ras/0.544
3x1zGNPRas-related protein Rap-1b/0.544
3tsoGNPRas-related protein Rab-25/0.542
4dxaGSPRas-related protein Rap-1b/0.541
4l9wGNPGTPase HRas/0.541
1ibrGNPGTP-binding nuclear protein Ran/0.540
1yzqGNPRas-related protein Rab-6A/0.538
4l9sGDPGTPase HRas/0.538
3k8yGNPGTPase HRas/0.537
1e96GTPRas-related C3 botulinum toxin substrate 1/0.534
1t91GTPRas-related protein Rab-7a/0.534
3lbiGNPGTPase HRas/0.534
5jljGNPGTP-binding nuclear protein Ran/0.534
1kmqGNPTransforming protein RhoA/0.533
3bc1GNPRas-related protein Rab-27A/0.533
3kkoGNPRas-related protein M-Ras/0.533
3l8yGNPGTPase HRas/0.532
1g17GNPRas-related protein SEC4/0.529
1yhnGTPRas-related protein Rab-7a/0.529
3oesGNPGTPase RhebL1/0.528
3w3zGTPGTP-binding nuclear protein Ran/0.527
4dsnGCPGTPase KRas/0.523
3kudGDPGTPase HRas/0.521
1vg8GNPRas-related protein Rab-7a/0.520
3bbpGTPRas-related protein Rab-6A/0.517
3oiwGNPGTPase HRas/0.517
1xtrGNPGTP-binding protein Rheb/0.515
5dhaGNPGTP-binding nuclear protein Ran/0.514
1ow3GDPTransforming protein RhoA/0.513
2gcpGSPRho-related GTP-binding protein RhoC/0.513
3e5hGNPRas-related protein Rab-28/0.513
1cxzGSPTransforming protein RhoA/0.512
4g0nGNPGTPase HRas/0.510
3sbeGNPRas-related C3 botulinum toxin substrate 1/0.509
1xtsGTPGTP-binding protein Rheb/0.508
3kz1GSPTransforming protein RhoA/0.507
4hdoGNPRas-related protein Rap-1b/0.506
4o25GTPGTP-binding protein Rheb/0.506
3a58GNPGTP-binding protein RHO1/0.505
1mh1GNPRas-related C3 botulinum toxin substrate 1/0.504
3nbzGTPGTP-binding nuclear protein Ran/0.504
1oixGDPRas-related protein Rab-11A/0.503
5hpyGDPTransforming protein RhoA/0.503
1m7bGTPRho-related GTP-binding protein RhoE/0.502
4kvgGTPRas-related protein Rap-1A/0.499
1zc4GNPRas-related protein Ral-A/0.498
3sbdGNPRas-related C3 botulinum toxin substrate 1/0.497
2zetGTPRas-related protein Rab-27B/0.496
5difGNPGTP-binding nuclear protein Ran/0.496
2gilGTPRas-related protein Rab-6A/0.491
4xoiGTPTransforming protein RhoA/0.488
1zbdGTPRas-related protein Rab-3A/0.487
4dsoGSPGTPase KRas/0.487
1k5dGNPGTP-binding nuclear protein Ran/0.485
2ffqGSPRas-related protein Rab-6B/0.484
4dlsGNPGTPase HRas/0.484
1zc3GNPRas-related protein Ral-A/0.483
2bkuGTPGTP-binding nuclear protein Ran/0.483
2w2xGSPRas-related C3 botulinum toxin substrate 2/0.483
2qmeGCPRas-related C3 botulinum toxin substrate 3/0.482
3th5GNPRas-related C3 botulinum toxin substrate 1/0.481
4dsuGDPGTPase KRas/0.481
1s1cGNPTransforming protein RhoA/0.477
2cl6CAGGTPase HRas/0.476
1zd9GDPADP-ribosylation factor-like protein 8A/0.475
4uj3GNPRas-related protein Rab-11A/0.475
1z2cGNPRho-related GTP-binding protein RhoC/0.472
1a2bGSPTransforming protein RhoA/0.471
1uadGNPRas-related protein Ral-A/0.467
2fe4GDPRas-related protein Rab-6B/0.467
2fjuGSPRas-related C3 botulinum toxin substrate 1/0.467
2ov2GCPRas-related C3 botulinum toxin substrate 3/0.466
4epwGDPGTPase KRas/0.466
4hdqGNPRas-related protein Rap-1b/0.460
3qbtGNPRas-related protein Rab-8A/0.459
1lfdGNPGTPase HRas/0.450
2msdGNPMHC class I alpha chain/0.449
4l8gGDPGTPase KRas/0.448
4uj5GNPRas-related protein Rab-11A/0.448
4gzlGNPRas-related C3 botulinum toxin substrate 1/0.447
4wa7GDPGTPase KRas/0.447
4js0GNPCell division control protein 42 homolog/0.446
1tkaN3TTransketolase 12.2.1.10.445
1z2aGDPRas-related protein Rab-23/0.445
4obeGDPGTPase KRas/0.445
3wyfGTPGTP-binding nuclear protein/0.444
1d5cGDPGTPase (Rab6)/0.443
4o2lGTPGTP-binding protein Rheb/0.443
4tq9GDPGTPase KRas/0.440