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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4dltGNPGTPase HRas

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
4dltGNPGTPase HRas/1.000
3lbnGNPGTPase HRas/0.721
3lbhGNPGTPase HRas/0.704
4dlwGNPGTPase HRas/0.699
3rs4GNPGTPase HRas/0.684
3lbiGNPGTPase HRas/0.653
3i3sGNPGTPase HRas/0.639
3v4fGNPGTPase HRas/0.634
3ddcGNPGTPase HRas/0.624
3oiuGNPGTPase HRas/0.620
3rs7GNPGTPase HRas/0.608
5b2zGNPGTPase HRas/0.591
3k8yGNPGTPase HRas/0.588
5dhaGNPGTP-binding nuclear protein Ran/0.588
3oivGNPGTPase HRas/0.586
4lhwGNPRas-related protein Rab-8A/0.584
1ibrGNPGTP-binding nuclear protein Ran/0.583
4qxaGTPRas-related protein Rab-9A/0.582
3rslGNPGTPase HRas/0.580
4nyiGNPGTPase HRas/0.579
3oesGNPGTPase RhebL1/0.578
1zc4GNPRas-related protein Ral-A/0.575
3pitGNPRas-related protein M-Ras/0.574
3rabGNPRas-related protein Rab-3A/0.570
4mitGTPRho-related protein racC/0.569
5jljGNPGTP-binding nuclear protein Ran/0.568
3kucGDPRas-related protein Rap-1A/0.567
1xtsGTPGTP-binding protein Rheb/0.565
1kmqGNPTransforming protein RhoA/0.563
1xtrGNPGTP-binding protein Rheb/0.562
2rgeGNPGTPase HRas/0.561
1g17GNPRas-related protein SEC4/0.560
3tsoGNPRas-related protein Rab-25/0.558
4rkfGNPRas-related protein Rab-3/0.557
4l9sGDPGTPase HRas/0.555
4nyjGNPGTPase HRas/0.551
1yzqGNPRas-related protein Rab-6A/0.549
3e5hGNPRas-related protein Rab-28/0.549
2zetGTPRas-related protein Rab-27B/0.548
4cymGCPRas-related protein Rab-32/0.548
1zbdGTPRas-related protein Rab-3A/0.546
3l8yGNPGTPase HRas/0.541
2c5lGTPGTPase HRas/0.540
3nbzGTPGTP-binding nuclear protein Ran/0.539
4dsnGCPGTPase KRas/0.539
2rgcGNPGTPase HRas/0.538
1zc3GNPRas-related protein Ral-A/0.537
3sbeGNPRas-related C3 botulinum toxin substrate 1/0.537
1cxzGSPTransforming protein RhoA/0.536
1t91GTPRas-related protein Rab-7a/0.536
3rs5GNPGTPase HRas/0.534
4g0nGNPGTPase HRas/0.534
3kz1GSPTransforming protein RhoA/0.533
3kkoGNPRas-related protein M-Ras/0.532
1mh1GNPRas-related C3 botulinum toxin substrate 1/0.531
3a58GNPGTP-binding protein RHO1/0.531
1e96GTPRas-related C3 botulinum toxin substrate 1/0.529
3ea5GDPGTP-binding nuclear protein Ran/0.529
3oiwGNPGTPase HRas/0.529
3w3zGTPGTP-binding nuclear protein Ran/0.529
2fe4GDPRas-related protein Rab-6B/0.528
3bc1GNPRas-related protein Rab-27A/0.528
3rs0GNPGTPase HRas/0.526
3sbdGNPRas-related C3 botulinum toxin substrate 1/0.522
3x1zGNPRas-related protein Rap-1b/0.522
4o25GTPGTP-binding protein Rheb/0.520
5hpyGDPTransforming protein RhoA/0.520
1vg8GNPRas-related protein Rab-7a/0.519
3bbpGTPRas-related protein Rab-6A/0.518
4l9wGNPGTPase HRas/0.518
3a6pGTPGTP-binding nuclear protein Ran/0.515
1oixGDPRas-related protein Rab-11A/0.513
2gcpGSPRho-related GTP-binding protein RhoC/0.513
3qbtGNPRas-related protein Rab-8A/0.513
1uadGNPRas-related protein Ral-A/0.512
2clsGTPRho-related GTP-binding protein Rho6/0.512
1m7bGTPRho-related GTP-binding protein RhoE/0.510
3kudGDPGTPase HRas/0.510
4dxaGSPRas-related protein Rap-1b/0.507
1ow3GDPTransforming protein RhoA/0.505
1s1cGNPTransforming protein RhoA/0.504
2rgbGNPGTPase HRas/0.502
4uj3GNPRas-related protein Rab-11A/0.502
4hdoGNPRas-related protein Rap-1b/0.501
2ov2GCPRas-related C3 botulinum toxin substrate 3/0.500
2w2xGSPRas-related C3 botulinum toxin substrate 2/0.500
1a2bGSPTransforming protein RhoA/0.499
4kvgGTPRas-related protein Rap-1A/0.499
5difGNPGTP-binding nuclear protein Ran/0.498
1yhnGTPRas-related protein Rab-7a/0.497
1zd9GDPADP-ribosylation factor-like protein 8A/0.497
2cl6CAGGTPase HRas/0.492
2fjuGSPRas-related C3 botulinum toxin substrate 1/0.487
4dsuGDPGTPase KRas/0.487
2qmeGCPRas-related C3 botulinum toxin substrate 3/0.486
2bkuGTPGTP-binding nuclear protein Ran/0.485
3tklGTPRas-related protein Rab-1A/0.484
4dsoGSPGTPase KRas/0.484
4hdqGNPRas-related protein Rap-1b/0.481
4ol0GTPGTP-binding nuclear protein Ran/0.480
2ffqGSPRas-related protein Rab-6B/0.478
3tgpGNPGTPase HRas/0.478
1k5dGNPGTP-binding nuclear protein Ran/0.477
4tq9GDPGTPase KRas/0.477
4xoiGTPTransforming protein RhoA/0.475
4js0GNPCell division control protein 42 homolog/0.474
1z2cGNPRho-related GTP-binding protein RhoC/0.469
3eg5GNPCell division control protein 42 homolog/0.469
1lfdGNPGTPase HRas/0.468
4dlzGNPGTPase HRas/0.468
4o2rGDPGTP-binding protein Rheb/0.467
4dlsGNPGTPase HRas/0.465
2gvdGSPGuanine nucleotide-binding protein G(s) subunit alpha isoforms short/0.464
5c46GSPRas-related protein Rab-11A/0.464
4xvrGNPGTPase HRas/0.463
3wyfGTPGTP-binding nuclear protein/0.462
1x1rGDPRas-related protein M-Ras/0.461
4l8gGDPGTPase KRas/0.460
4lpkGDPGTPase KRas/0.460
3th5GNPRas-related C3 botulinum toxin substrate 1/0.459
4xvqGNPGTPase HRas/0.458
1z2aGDPRas-related protein Rab-23/0.456
4dlvGNPGTPase HRas/0.456
4dlxGNPGTPase HRas/0.455
4uj5GNPRas-related protein Rab-11A/0.455
4epxGDPGTPase KRas/0.454
1q12ATPMaltose/maltodextrin import ATP-binding protein MalK/0.453
4o2lGTPGTP-binding protein Rheb/0.453
4gzlGNPRas-related C3 botulinum toxin substrate 1/0.452
4q03GDPGTPase KRas/0.451
1yu9GNPRas-related protein Rab-4A/0.450
1gwnGTPRho-related GTP-binding protein RhoE/0.447
4lucGDPGTPase KRas/0.447
4gzmGSPRas-related C3 botulinum toxin substrate 1/0.446
3x1wGDPRas-related protein Rap-1b/0.444
4lv6GDPGTPase KRas/0.442
4ql3GDPGTPase KRas/0.442
2ce2GDPGTPase HRas/0.440