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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4dit0KDGlycogen synthase kinase-3 beta2.7.11.26

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
4dit0KDGlycogen synthase kinase-3 beta2.7.11.261.000
1j1cADPGlycogen synthase kinase-3 beta2.7.11.260.538
3i4bZ48Glycogen synthase kinase-3 beta2.7.11.260.533
1q41IXMGlycogen synthase kinase-3 beta2.7.11.260.523
1q5kTMUGlycogen synthase kinase-3 beta2.7.11.260.522
1q3wATUGlycogen synthase kinase-3 beta2.7.11.260.514
4acc7YGGlycogen synthase kinase-3 beta2.7.11.260.508
3l1sZ92Glycogen synthase kinase-3 beta2.7.11.260.502
4acdGR9Glycogen synthase kinase-3 beta2.7.11.260.501
3f7z34OGlycogen synthase kinase-3 beta2.7.11.260.500
1q3dSTUGlycogen synthase kinase-3 beta2.7.11.260.499
2hxl422Serine/threonine-protein kinase Chk12.7.11.10.497
3eb0DRKUncharacterized protein/0.494
4dgmAGICasein kinase II subunit alpha2.7.11.10.493
3sayOFTGlycogen synthase kinase-3 beta2.7.11.260.490
4acg6LQGlycogen synthase kinase-3 beta2.7.11.260.486
4aguD15Cyclin-dependent kinase-like 1/0.482
4k110J9Proto-oncogene tyrosine-protein kinase Src2.7.10.20.482
4afjSJJGlycogen synthase kinase-3 beta2.7.11.260.481
1j1bANPGlycogen synthase kinase-3 beta2.7.11.260.475
3a4oSTUTyrosine-protein kinase Lyn2.7.10.20.475
2pvlP55Casein kinase II subunit alpha2.7.11.10.474
4fsuHK5Serine/threonine-protein kinase Chk12.7.11.10.474
2wmqZYQSerine/threonine-protein kinase Chk12.7.11.10.472
4fv9E71Mitogen-activated protein kinase 12.7.11.240.472
1qcfPP1Tyrosine-protein kinase HCK2.7.10.20.468
4jbpYPHAurora kinase A2.7.11.10.468
3be9P04Casein kinase II subunit alpha2.7.11.10.466
3i5zZ48Mitogen-activated protein kinase 12.7.11.240.465
1uv5BRWGlycogen synthase kinase-3 beta2.7.11.260.464
3i60E86Mitogen-activated protein kinase 12.7.11.240.464
4yzcSTUSerine/threonine-protein kinase/endoribonuclease IRE12.7.11.10.464
2cdz23DSerine/threonine-protein kinase PAK 42.7.11.10.463
3sd0TSKGlycogen synthase kinase-3 beta2.7.11.260.463
3gb2G3BGlycogen synthase kinase-3 beta2.7.11.260.462
4fv6E57Mitogen-activated protein kinase 12.7.11.240.462
4o0wADNAurora kinase A2.7.11.10.461
5dpvSKEAurora kinase A2.7.11.10.460
3vrzVRZTyrosine-protein kinase HCK2.7.10.20.459
4achKDIGlycogen synthase kinase-3 beta2.7.11.260.458
2j7t274Serine/threonine-protein kinase 102.7.11.10.457
3vs2VSBTyrosine-protein kinase HCK2.7.10.20.457
3w2sW2REpidermal growth factor receptor2.7.10.10.457
4btjATPTau-tubulin kinase 12.7.11.10.457
4fg7ATPCalcium/calmodulin-dependent protein kinase type 12.7.11.170.457
1qpjSTUTyrosine-protein kinase Lck2.7.10.20.455
3bqr4RBDeath-associated protein kinase 3/0.455
3q9xEMOCasein kinase II subunit alpha2.7.11.10.455
4j95ACPFibroblast growth factor receptor 2/0.454
2cgu3A3Serine/threonine-protein kinase Chk12.7.11.10.453
4jia1K3Tyrosine-protein kinase JAK2/0.453
2h8hH8HProto-oncogene tyrosine-protein kinase Src2.7.10.20.452
2w05FRTCyclin-dependent kinase 22.7.11.220.452
2ym6YM6Serine/threonine-protein kinase Chk12.7.11.10.451
4bcmT7ZCyclin-dependent kinase 22.7.11.220.451
4grb0XGCasein kinase II subunit alpha2.7.11.10.451
2pvmP29Casein kinase II subunit alpha2.7.11.10.449
3ofm4B0Casein kinase II subunit alpha'2.7.11.10.449
4ftiH7KSerine/threonine-protein kinase Chk12.7.11.10.449
1fvv107Cyclin-dependent kinase 22.7.11.220.448
3vs5VSGTyrosine-protein kinase HCK2.7.10.20.448
4c34STUcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.448
4o0rX4ZSerine/threonine-protein kinase PAK 12.7.11.10.448
2hog710Serine/threonine-protein kinase Chk12.7.11.10.447
3kkvB99cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.447
5dr9SKEAurora kinase A2.7.11.10.447
2x8iX8ISerine/threonine-protein kinase Chk12.7.11.10.446
3vs3VSETyrosine-protein kinase HCK2.7.10.20.446
4jboWPHAurora kinase A2.7.11.10.446
2pvhP19Casein kinase II subunit alpha2.7.11.10.445
2wouZZFTGF-beta receptor type-12.7.11.300.445
2wtcVGMSerine/threonine-protein kinase Chk22.7.11.10.445
3at4CCKCasein kinase II subunit alpha2.7.11.10.445
2vu3LZECyclin-dependent kinase 22.7.11.220.444
2ayp43ASerine/threonine-protein kinase Chk12.7.11.10.443
2h96893Mitogen-activated protein kinase 82.7.11.240.443
2oh02PYcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.443
2uzuL20cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.443
4k1b1OCSerine/threonine-protein kinase pim-12.7.11.10.443
1wvxBD4Death-associated protein kinase 12.7.11.10.442
2ydiYDISerine/threonine-protein kinase Chk12.7.11.10.442
4ix6ADPUncharacterized protein/0.442
4jajXU1Aurora kinase A2.7.11.10.442
5dosATPAurora kinase A2.7.11.10.442
3zh8C58Protein kinase C iota type2.7.11.130.441
4dgnLU2Casein kinase II subunit alpha2.7.11.10.441
3r2b05BMAP kinase-activated protein kinase 22.7.11.10.440
5e8ySTUTGF-beta receptor type-22.7.11.300.440