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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4dg3ANPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.11

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
4dg3ANPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.111.000
4iacACPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.599
4xw4ANPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.583
3x2wATPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.579
1q24ATPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.578
3x2uATPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.576
3idbANPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.557
4dh5ADPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.548
3x2vATPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.545
1jbpADPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.533
4iakADPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.527
4ekkANPRAC-alpha serine/threonine-protein kinase2.7.11.10.522
4iazADPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.513
3o7lANPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.506
4iayADPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.504
2uw7GVPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.501
2c1aI5ScAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.500
2jdsL20cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.498
2c1bCQPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.497
2f7e2EAcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.497
3e8cG96cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.497
2uw5GVNcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.495
4qnyANPMitogen activated protein kinase, putative/0.493
3dndLL2cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.492
2f7z6EAcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.488
4wbbADPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.486
2gu8796cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.484
4ysjADPCalmodulin-like domain protein kinase/0.482
5dnrATPAurora kinase A2.7.11.10.481
4yxsEMUcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.480
1q8uH52cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.479
2vo6M05cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.479
5iqiGNPBifunctional AAC/APH2.3.10.477
3idcANPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.476
5iqgGDPBifunctional AAC/APH2.3.10.475
1dayGNPCasein kinase II subunit alpha2.7.11.10.473
1jkkANPDeath-associated protein kinase 12.7.11.10.469
1ydtIQBcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.469
1o6kANPRAC-beta serine/threonine-protein kinase2.7.11.10.467
4iafADPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.466
4deeADPAurora kinase A2.7.11.10.465
2gnhH52cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.464
5iqeGNPBifunctional AAC/APH2.3.10.464
3zo4QWIcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.463
2z7qACPRibosomal protein S6 kinase alpha-12.7.11.10.462
3qc9ADPRhodopsin kinase/0.462
2uzuL20cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.461
4hge15VTyrosine-protein kinase JAK2/0.461
2vo0M03cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.460
3dqwAGSProto-oncogene tyrosine-protein kinase Src2.7.10.20.460
1cdkANPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.459
1ydrIQPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.459
2uzvSS5cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.457
2uztSS3cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.456
3dneLL1cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.456
3ow3SMYcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.455
2jdtI5ScAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.454
2oh02PYcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.454
4dh7ANPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.454
4orkGDPBifunctional AAC/APH2.3.10.454
3orzBI43-phosphoinositide-dependent protein kinase 12.7.11.10.453
4wb6ATPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.453
2uw4L15cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.452
3zc6VFCTyrosine-protein kinase JAK32.7.10.20.452
4axaRKDcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.452
1qmzATPCyclin-dependent kinase 22.7.11.220.451
2uzwSS4cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.451
3aglA03cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.450
5iqhGNPBifunctional AAC/APH2.3.10.450
4k110J9Proto-oncogene tyrosine-protein kinase Src2.7.10.20.449
2vo3M04cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.448
3c4wATPRhodopsin kinase/0.447
3fjqATPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.447
4aqc88ATyrosine-protein kinase JAK2/0.447
4i3zADPCyclin-dependent kinase 22.7.11.220.447
3p23ADPSerine/threonine-protein kinase/endoribonuclease IRE12.7.11.10.446
4xlvACPInsulin receptor2.7.10.10.446
5bylGCPBifunctional AAC/APH2.3.10.446
5cvfATPCasein kinase II subunit alpha2.7.11.10.446
5kgpACOPredicted acetyltransferase/0.446
4crsAGSSerine/threonine-protein kinase N22.7.11.130.445
1ig1ANPDeath-associated protein kinase 12.7.11.10.443
4bbe3O4Tyrosine-protein kinase JAK2/0.443
1rejB1LcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.442
2uw6GVOcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.442
2ojf4PYcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.441
3gu7ADPDeath-associated protein kinase 12.7.11.10.441
3cqwCQWRAC-alpha serine/threonine-protein kinase2.7.11.10.440