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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4dfn0K1Tyrosine-protein kinase SYK2.7.10.2

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
4dfn0K1Tyrosine-protein kinase SYK2.7.10.21.000
4i0t1B6Tyrosine-protein kinase SYK2.7.10.20.540
4f4p0SBTyrosine-protein kinase SYK2.7.10.20.500
4jia1K3Tyrosine-protein kinase JAK2/0.493
1stcSTUcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.492
4i0r1B4Tyrosine-protein kinase SYK2.7.10.20.483
2xvdAS6Ephrin type-B receptor 42.7.10.10.474
4o0rX4ZSerine/threonine-protein kinase PAK 12.7.11.10.468
1qpjSTUTyrosine-protein kinase Lck2.7.10.20.466
3i4bZ48Glycogen synthase kinase-3 beta2.7.11.260.460
2hxl422Serine/threonine-protein kinase Chk12.7.11.10.458
3vs2VSBTyrosine-protein kinase HCK2.7.10.20.456
4b8mVX6Aurora kinase B-A2.7.11.10.455
4fsnA58Serine/threonine-protein kinase Chk12.7.11.10.455
4bgq38RCyclin-dependent kinase-like 52.7.11.220.453
2ym6YM6Serine/threonine-protein kinase Chk12.7.11.10.452
3zc6VFCTyrosine-protein kinase JAK32.7.10.20.449
4c3pACPAurora kinase A2.7.11.10.448
5av2KMPDeath-associated protein kinase 12.7.11.10.448
2ckeIQUDeath-associated protein kinase 2/0.445
3orzBI43-phosphoinositide-dependent protein kinase 12.7.11.10.445
4qo9627Serine/threonine-protein kinase 242.7.11.10.445
4grb0XGCasein kinase II subunit alpha2.7.11.10.443
2cgu3A3Serine/threonine-protein kinase Chk12.7.11.10.442
3v8w0G2Tyrosine-protein kinase ITK/TSK2.7.10.20.442
3axwTIDCasein kinase II subunit alpha2.7.11.10.441
3e5aVX6Aurora kinase A2.7.11.10.441
4fsuHK5Serine/threonine-protein kinase Chk12.7.11.10.441
3c0g3AMPeripheral plasma membrane protein CASK2.7.11.10.440
3gu7ADPDeath-associated protein kinase 12.7.11.10.440