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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4demYS4Farnesyl pyrophosphate synthase2.5.1.10

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
4demYS4Farnesyl pyrophosphate synthase2.5.1.101.000
4h5cYS4Farnesyl pyrophosphate synthase2.5.1.100.721
4h5eYS4Farnesyl pyrophosphate synthase2.5.1.100.706
4l2xYL2Farnesyl pyrophosphate synthase2.5.1.100.642
4h5dYS4Farnesyl pyrophosphate synthase2.5.1.100.631
4ga34GAFarnesyl pyrophosphate synthase2.5.1.100.559
4lfvYS4Farnesyl pyrophosphate synthase2.5.1.100.557
2opmNI9Farnesyl pyrophosphate synthase2.5.1.100.553
4jvj1MVFarnesyl pyrophosphate synthase2.5.1.100.553
3iczPB6Farnesyl pyrophosphate synthase/0.546
2opnSUFFarnesyl pyrophosphate synthase2.5.1.100.506
3ldwZOLFarnesyl pyrophosphate synthase, putative/0.500
1zw5ZOLFarnesyl pyrophosphate synthase2.5.1.100.498
3egt722Farnesyl pyrophosphate synthase/0.496
4kqsRISFarnesyl pyrophosphate synthase2.5.1.100.491
3dyh721Farnesyl pyrophosphate synthase/0.481
4nkeRISFarnesyl pyrophosphate synthase2.5.1.100.481
3ez3ZOLFarnesyl pyrophosphate synthase, putative/0.466
3up0D7SaceDAF-12/0.457
2zatNAPDehydrogenase/reductase SDR family member 41.1.1.1840.456
3wsbRWZFarnesyltransferase, putative/0.456
3gytDL4Nuclear hormone receptor of the steroid/thyroid hormone receptors superfamily/0.452
1rqjRISFarnesyl diphosphate synthase2.5.1.100.449
2ekaSAHDiphthine synthase/0.446
2iqgF2IBeta-secretase 13.4.23.460.443
3bgxMEFThymidylate synthase/0.443
1n83CLRNuclear receptor ROR-alpha/0.442
5iqiGNPBifunctional AAC/APH2.3.10.442
3rywK9HFarnesyl pyrophosphate synthase, putative/0.441