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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4deeADPAurora kinase A2.7.11.1

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
4deeADPAurora kinase A2.7.11.11.000
5dosATPAurora kinase A2.7.11.10.494
5dnrATPAurora kinase A2.7.11.10.481
4jbpYPHAurora kinase A2.7.11.10.460
4jboWPHAurora kinase A2.7.11.10.453
4o0wADNAurora kinase A2.7.11.10.453