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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4dce0JFALK tyrosine kinase receptor2.7.10.1

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
4dce0JFALK tyrosine kinase receptor2.7.10.11.000
4fnzNZFALK tyrosine kinase receptor2.7.10.10.647
4ccbOFGALK tyrosine kinase receptor2.7.10.10.590
2xp2VGHALK tyrosine kinase receptor2.7.10.10.550
4nks2M2Fibroblast growth factor receptor 1/0.547
3qlfPD5Proto-oncogene tyrosine-protein kinase Src2.7.10.20.546
3b2w9NHTyrosine-protein kinase Lck2.7.10.20.545
2p2h994Vascular endothelial growth factor receptor 22.7.10.10.535
3b8r887Vascular endothelial growth factor receptor 22.7.10.10.533
4f640S8Fibroblast growth factor receptor 1/0.529
4nka2K7Fibroblast growth factor receptor 1/0.528
3w2sW2REpidermal growth factor receptor2.7.10.10.527
3s4qNK0Mitogen-activated protein kinase 14/0.525
2hog710Serine/threonine-protein kinase Chk12.7.11.10.517
4fswHK6Serine/threonine-protein kinase Chk12.7.11.10.517
4xli1N1Abelson tyrosine-protein kinase 22.7.10.20.517
4eym0RXMitogen-activated protein kinase 132.7.11.240.516
4fic0ULProto-oncogene tyrosine-protein kinase Src2.7.10.20.515
4j97ACPFibroblast growth factor receptor 2/0.515
3qlg1N1Proto-oncogene tyrosine-protein kinase Src2.7.10.20.513
4k110J9Proto-oncogene tyrosine-protein kinase Src2.7.10.20.512
4fsqHK3Serine/threonine-protein kinase Chk12.7.11.10.510
2ivuZD6Proto-oncogene tyrosine-protein kinase receptor Ret2.7.10.10.509
2wmuZYUSerine/threonine-protein kinase Chk12.7.11.10.509
5aaaVGHALK tyrosine kinase receptor2.7.10.10.508
2ym3YM3Serine/threonine-protein kinase Chk12.7.11.10.507
3eta351Insulin receptor2.7.10.10.507
2itzIREEpidermal growth factor receptor2.7.10.10.506
4i231C9Epidermal growth factor receptor2.7.10.10.506
1zyjBI5Mitogen-activated protein kinase 14/0.505
2br1PFPSerine/threonine-protein kinase Chk12.7.11.10.505
2itqITQEpidermal growth factor receptor2.7.10.10.505
1xkkFMMEpidermal growth factor receptor2.7.10.10.504
2wmtZYTSerine/threonine-protein kinase Chk12.7.11.10.501
2bdf24AProto-oncogene tyrosine-protein kinase Src2.7.10.20.500
4an92P7Dual specificity mitogen-activated protein kinase kinase 12.7.12.20.500
4ftkH9KSerine/threonine-protein kinase Chk12.7.11.10.500
2ayp43ASerine/threonine-protein kinase Chk12.7.11.10.499
3mfrANPPeripheral plasma membrane protein CASK2.7.11.10.499
3tubFPUTyrosine-protein kinase SYK2.7.10.20.499
3vid4TTVascular endothelial growth factor receptor 22.7.10.10.499
4c62XWWTyrosine-protein kinase JAK2/0.499
4fob0USALK tyrosine kinase receptor2.7.10.10.499
4hyu1BKMitogen-activated protein kinase 82.7.11.240.499
3cjgKIMVascular endothelial growth factor receptor 22.7.10.10.497
5d12G97Proto-oncogene tyrosine-protein kinase Src2.7.10.20.497
2itwITQEpidermal growth factor receptor2.7.10.10.495
4ftiH7KSerine/threonine-protein kinase Chk12.7.11.10.495
4mxoDB8Proto-oncogene tyrosine-protein kinase Src2.7.10.20.495
4f630S7Fibroblast growth factor receptor 1/0.494
4jrvKJVEpidermal growth factor receptor2.7.10.10.494
1m17AQ4Epidermal growth factor receptor2.7.10.10.493
2pzrACPFibroblast growth factor receptor 2/0.493
2wmqZYQSerine/threonine-protein kinase Chk12.7.11.10.493
4fszHK8Serine/threonine-protein kinase Chk12.7.11.10.493
4ftlH0KSerine/threonine-protein kinase Chk12.7.11.10.493
4hvh19RTyrosine-protein kinase JAK32.7.10.20.493
2eb3ANPEpidermal growth factor receptor2.7.10.10.492
2qhm7CSSerine/threonine-protein kinase Chk12.7.11.10.492
3vs7KS1Tyrosine-protein kinase HCK2.7.10.20.492
4cd0AWJALK tyrosine kinase receptor2.7.10.10.492
2wmwZYWSerine/threonine-protein kinase Chk12.7.11.10.491
3uvqFS8Mitogen-activated protein kinase 14/0.490
4ftt6HKSerine/threonine-protein kinase Chk12.7.11.10.490
4an35Y0Dual specificity mitogen-activated protein kinase kinase 12.7.12.20.489
4ft9H4KSerine/threonine-protein kinase Chk12.7.11.10.489
4kaoKAOFocal adhesion kinase 12.7.10.20.489
3ctj320Hepatocyte growth factor receptor2.7.10.10.488
2brhDFWSerine/threonine-protein kinase Chk12.7.11.10.487
2c0iL1GTyrosine-protein kinase HCK2.7.10.20.487
2wmsZYSSerine/threonine-protein kinase Chk12.7.11.10.487
4fstHK4Serine/threonine-protein kinase Chk12.7.11.10.487
4ftcH6KSerine/threonine-protein kinase Chk12.7.11.10.487
2qhn582Serine/threonine-protein kinase Chk12.7.11.10.486
2wtcVGMSerine/threonine-protein kinase Chk22.7.11.10.486
3vjoANPEpidermal growth factor receptor2.7.10.10.486
2hy0306Serine/threonine-protein kinase Chk12.7.11.10.485
3c7qXINVascular endothelial growth factor receptor 22.7.10.10.485
4ic7ANPMitogen-activated protein kinase 72.7.11.240.485
1i7iAZ2Peroxisome proliferator-activated receptor gamma/0.484
1lhvNOGSex hormone-binding globulin/0.484
2yfxVGHALK tyrosine kinase receptor2.7.10.10.484
4bdhWVISerine/threonine-protein kinase Chk22.7.11.10.484
4fad0TBPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.484
4ftjH8KSerine/threonine-protein kinase Chk12.7.11.10.484
4jlcSU6Serine/threonine-protein kinase TBK12.7.11.10.484
4tv3ML9Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform/0.484
4y93746Tyrosine-protein kinase/0.484
1uu8BI13-phosphoinositide-dependent protein kinase 12.7.11.10.483
3w33W19Epidermal growth factor receptor2.7.10.10.483
4eevL1XHepatocyte growth factor receptor2.7.10.10.483
2x8eX8ESerine/threonine-protein kinase Chk12.7.11.10.482
2zv9PP2Tyrosine-protein kinase Lyn2.7.10.20.482
3emg685Tyrosine-protein kinase SYK2.7.10.20.482
4dk50KOPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.482
4rrvATP3-phosphoinositide-dependent protein kinase 12.7.11.10.482
2cgw3C3Serine/threonine-protein kinase Chk12.7.11.10.481
2wtdZZKSerine/threonine-protein kinase Chk22.7.11.10.481
2xf04UBSerine/threonine-protein kinase Chk12.7.11.10.481
2y7jB49Phosphorylase b kinase gamma catalytic chain, liver/testis isoform2.7.11.190.481
2ym5YM5Serine/threonine-protein kinase Chk12.7.11.10.481
1di9MSQMitogen-activated protein kinase 14/0.480
2brgDFYSerine/threonine-protein kinase Chk12.7.11.10.480
4ft0HK9Serine/threonine-protein kinase Chk12.7.11.10.480
2itpAEEEpidermal growth factor receptor2.7.10.10.479
4bdgP3JSerine/threonine-protein kinase Chk22.7.11.10.479
4fsyHK7Serine/threonine-protein kinase Chk12.7.11.10.479
3jy0LYGSerine/threonine-protein kinase pim-12.7.11.10.478
3poz03PEpidermal growth factor receptor2.7.10.10.478
2r0uM54Serine/threonine-protein kinase Chk12.7.11.10.477
2wmxZY6Serine/threonine-protein kinase Chk12.7.11.10.477
4uyaAGSMitogen-activated protein kinase kinase kinase 212.7.11.250.477
4fx360KCyclin-dependent kinase 22.7.11.220.475
4jq7KJQEpidermal growth factor receptor2.7.10.10.475
2xk9XK9Serine/threonine-protein kinase Chk22.7.11.10.474
2ydjYDJSerine/threonine-protein kinase Chk12.7.11.10.474
1nvsUCMSerine/threonine-protein kinase Chk12.7.11.10.473
2brnDF1Serine/threonine-protein kinase Chk12.7.11.10.473
2cgv3B3Serine/threonine-protein kinase Chk12.7.11.10.473
2wtiWTISerine/threonine-protein kinase Chk22.7.11.10.473
3uvp048Mitogen-activated protein kinase 14/0.473
3zw3ZW3Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.473
1w84L12Mitogen-activated protein kinase 14/0.472
3bheBZNGag-Pol polyprotein3.4.23.160.472
4jr3KJREpidermal growth factor receptor2.7.10.10.472
4wq4ATPtRNA N6-adenosine threonylcarbamoyltransferase/0.472
2itxANPEpidermal growth factor receptor2.7.10.10.471
3os33OSDual specificity mitogen-activated protein kinase kinase 12.7.12.20.471
3v04V04Dual specificity mitogen-activated protein kinase kinase 12.7.12.20.471
4ftaH5KSerine/threonine-protein kinase Chk12.7.11.10.471
4ftu7HKSerine/threonine-protein kinase Chk12.7.11.10.471
4gu94GUFocal adhesion kinase 12.7.10.20.471
2brmDFZSerine/threonine-protein kinase Chk12.7.11.10.470
4ezj0SCPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.470
4ib4ERM5-hydroxytryptamine receptor 2B/0.470
2hk51BMTyrosine-protein kinase HCK2.7.10.20.469
2vgpAD6Aurora kinase B-A2.7.11.10.469
3a62STURibosomal protein S6 kinase beta-12.7.11.10.469
3bhy7CPDeath-associated protein kinase 3/0.469
3vrzVRZTyrosine-protein kinase HCK2.7.10.20.469
4ft7H3KSerine/threonine-protein kinase Chk12.7.11.10.469
4gapFADRotenone-insensitive NADH-ubiquinone oxidoreductase, mitochondrial1.6.5.90.469
4h1j0YHProtein-tyrosine kinase 2-beta2.7.10.20.469
4izy1J2Mitogen-activated protein kinase 82.7.11.240.469
1agwSU2Fibroblast growth factor receptor 1/0.468
1nvqUCNSerine/threonine-protein kinase Chk12.7.11.10.468
1s9jBBMDual specificity mitogen-activated protein kinase kinase 12.7.12.20.468
1yw2PGJMitogen-activated protein kinase 14/0.468
2gcdSTUSerine/threonine-protein kinase TAO22.7.11.10.468
3v013V0Dual specificity mitogen-activated protein kinase kinase 12.7.12.20.468
3vjnANPEpidermal growth factor receptor2.7.10.10.468
4anqVGHALK tyrosine kinase receptor2.7.10.10.468
4fmqANPMitogen-activated protein kinase 12.7.11.240.468
4ftm1HKSerine/threonine-protein kinase Chk12.7.11.10.468
4fv9E71Mitogen-activated protein kinase 12.7.11.240.468
4h4qFADBiphenyl dioxygenase ferredoxin reductase subunit/0.468
2cgx3D3Serine/threonine-protein kinase Chk12.7.11.10.467
2ituITQEpidermal growth factor receptor2.7.10.10.467
2ycrHCWSerine/threonine-protein kinase Chk22.7.11.10.467
2yiqYIQSerine/threonine-protein kinase Chk22.7.11.10.467
2ym8YM8Serine/threonine-protein kinase Chk12.7.11.10.467
4hvg19QTyrosine-protein kinase JAK32.7.10.20.467
1qpdSTUTyrosine-protein kinase Lck2.7.10.20.466
2c0tL3GTyrosine-protein kinase HCK2.7.10.20.466
2dq7STUTyrosine-protein kinase Fyn2.7.10.20.466
2fvdLIACyclin-dependent kinase 22.7.11.220.466
2xchCKG3-phosphoinositide-dependent protein kinase 12.7.11.10.466
4ansVGHALK tyrosine kinase receptor2.7.10.10.466
4fsnA58Serine/threonine-protein kinase Chk12.7.11.10.466
4ftn2HKSerine/threonine-protein kinase Chk12.7.11.10.466
4jq8KJ8Epidermal growth factor receptor2.7.10.10.466
4k181OBSerine/threonine-protein kinase pim-12.7.11.10.466
4l455FIRibosomal protein S6 kinase beta-12.7.11.10.466
4yduADPtRNA N6-adenosine threonylcarbamoyltransferase/0.466
5amnDTQProto-oncogene tyrosine-protein kinase receptor Ret2.7.10.10.466
1k6pXN3Gag-Pol polyprotein3.4.23.160.465
2j0k4STFocal adhesion kinase 12.7.10.20.465
2pwlACPFibroblast growth factor receptor 2/0.465
3ac5KZMTyrosine-protein kinase Lck2.7.10.20.465
4ezk0SDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.465
4hys1BJMitogen-activated protein kinase 82.7.11.240.465
4k1b1OCSerine/threonine-protein kinase pim-12.7.11.10.465
1oecAA2Fibroblast growth factor receptor 2/0.464
1snuSTUTyrosine-protein kinase ITK/TSK2.7.10.20.464
1uu7BI23-phosphoinositide-dependent protein kinase 12.7.11.10.464
1uvrBI83-phosphoinositide-dependent protein kinase 12.7.11.10.464
3igoANPCalmodulin-domain protein kinase 1, putative/0.464
3tkiS25Serine/threonine-protein kinase Chk12.7.11.10.464
4ft5H2KSerine/threonine-protein kinase Chk12.7.11.10.464
3w0aDS5Vitamin D3 receptor/0.463
4bddZ0OSerine/threonine-protein kinase Chk22.7.11.10.463
4bdfH3RSerine/threonine-protein kinase Chk22.7.11.10.463
4fsrHKCSerine/threonine-protein kinase Chk12.7.11.10.463
2biyATP3-phosphoinositide-dependent protein kinase 12.7.11.10.462
2e9aB28Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific)2.5.1.310.462
2e9n76ASerine/threonine-protein kinase Chk12.7.11.10.462
3bbtFMMReceptor tyrosine-protein kinase erbB-42.7.10.10.462
3t8oATPRhodopsin kinase/0.462
4mxxDB8Proto-oncogene tyrosine-protein kinase Src2.7.10.20.462
4w9wYDJBMP-2-inducible protein kinase2.7.11.10.462
1t1rIMB1-deoxy-D-xylulose 5-phosphate reductoisomerase1.1.1.2670.461
2c6eHPMAurora kinase A2.7.11.10.461
2gr1FADFerredoxin reductase/0.461
2of2547Tyrosine-protein kinase Lck2.7.10.20.461
3lctADPALK tyrosine kinase receptor2.7.10.10.461
4wq5ATPtRNA N6-adenosine threonylcarbamoyltransferase/0.461
1ouy094Mitogen-activated protein kinase 14/0.460
2xba571ALK tyrosine kinase receptor2.7.10.10.460
3el8PD5Proto-oncogene tyrosine-protein kinase Src2.7.10.20.460
3nunJMZ3-phosphoinositide-dependent protein kinase 12.7.11.10.460
3nwxKVSGag-Pol polyprotein3.4.23.160.460
3vs6VSHTyrosine-protein kinase HCK2.7.10.20.460
4a06ATP3-phosphoinositide-dependent protein kinase 12.7.11.10.460
4bdiHAUSerine/threonine-protein kinase Chk22.7.11.10.460
4fnyI3KALK tyrosine kinase receptor2.7.10.10.460
4l3j5FIRibosomal protein S6 kinase beta-12.7.11.10.460
2duv371Cyclin-dependent kinase 22.7.11.220.459
2ym7YM7Serine/threonine-protein kinase Chk12.7.11.10.459
3hrfATP3-phosphoinositide-dependent protein kinase 12.7.11.10.459
3livE16Protease/0.459
3zk5Z18Cytochrome P450 monooxygenase PikC/0.459
1u59STUTyrosine-protein kinase ZAP-702.7.10.20.458
2bdjHETProto-oncogene tyrosine-protein kinase Src2.7.10.20.458
2x7gPVBSRSF protein kinase 22.7.11.10.458
2zva1N1Tyrosine-protein kinase Lyn2.7.10.20.458
3cukFADD-amino-acid oxidase1.4.3.30.458
3hllI45Mitogen-activated protein kinase 14/0.458
3liqE14Protease/0.458
3tu5ATPActin, alpha skeletal muscle/0.458
3w1wCHDFerrochelatase, mitochondrial4.99.1.10.458
4gh2HK0Serine/threonine-protein kinase Chk12.7.11.10.458
4i0r1B4Tyrosine-protein kinase SYK2.7.10.20.458
1zys199Serine/threonine-protein kinase Chk12.7.11.10.457
2itnANPEpidermal growth factor receptor2.7.10.10.457
2ym44YMSerine/threonine-protein kinase Chk12.7.11.10.457
3ac1KZITyrosine-protein kinase Lck2.7.10.20.457
3flkNAITartrate dehydrogenase/decarboxylase1.1.1.930.457
3ncgBK1Calmodulin-domain protein kinase 1, putative/0.457
4bdbODOSerine/threonine-protein kinase Chk22.7.11.10.457
4fto3HKSerine/threonine-protein kinase Chk12.7.11.10.457
4gmy0X5Tyrosine-protein kinase JAK2/0.457
4rqvATP3-phosphoinositide-dependent protein kinase 12.7.11.10.457
4u9aSTUInterleukin-1 receptor-associated kinase 42.7.11.10.457
4xey1N1Tyrosine-protein kinase ABL12.7.10.20.457
5ackATP3-phosphoinositide-dependent protein kinase 12.7.11.10.457
1k6tXN1Gag-Pol polyprotein3.4.23.160.456
1pkdUCNCyclin-dependent kinase 22.7.11.220.456
2hwrDRDPeroxisome proliferator-activated receptor gamma/0.456
4a9sRU9Serine/threonine-protein kinase Chk22.7.11.10.456
4bfmANPMaternal embryonic leucine zipper kinase2.7.11.10.456
4fr4STUSerine/threonine-protein kinase 32A2.7.11.10.456
4fv1EK4Mitogen-activated protein kinase 12.7.11.240.456
4fyo0VFTyrosine-protein kinase SYK2.7.10.20.456
4g1wG1WMitogen-activated protein kinase 82.7.11.240.456
4gk3L87Ephrin type-A receptor 32.7.10.10.456
4iaq2GM5-hydroxytryptamine receptor 1B/0.456
4iteTEYVitamin D3 receptor/0.456
1h1wATP3-phosphoinositide-dependent protein kinase 12.7.11.10.455
1rekB8LcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.455
2e9uA25Serine/threonine-protein kinase Chk12.7.11.10.455
2ittAEEEpidermal growth factor receptor2.7.10.10.455
2of4979Tyrosine-protein kinase Lck2.7.10.20.455
2r7b2533-phosphoinositide-dependent protein kinase 12.7.11.10.455
2vrx447Aurora kinase B-A2.7.11.10.455
2vtpLZ9Cyclin-dependent kinase 22.7.11.220.455
3a99ANPSerine/threonine-protein kinase pim-12.7.11.10.455
3ckxSTUSerine/threonine-protein kinase 242.7.11.10.455
3fzpAGSProtein-tyrosine kinase 2-beta2.7.10.20.455
3gstGPRGlutathione S-transferase Mu 12.5.1.180.455
4fjyFJYPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.455
4k41ATPActin, alpha skeletal muscle/0.455
2aquDR7Gag-Pol polyprotein3.4.23.160.454
2e9oA58Serine/threonine-protein kinase Chk12.7.11.10.454
3ml8ML8Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.454
3opdHIEHeat shock protein 83/0.454
3t113T1Gag-Pol polyprotein3.4.23.160.454
3w1f1O5Dual specificity protein kinase TTK2.7.12.10.454
3wd7COAAcridone synthase/0.454
1chwHXCChalcone synthase 22.3.1.740.453
1hncGDNGlutathione S-transferase Mu 22.5.1.180.453
1phkATPPhosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform2.7.11.190.453
1y57MPZProto-oncogene tyrosine-protein kinase Src2.7.10.20.453
2a5uQYTPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.453
2py3ACPFibroblast growth factor receptor 2/0.453
3gfeP37Mitogen-activated protein kinase 14/0.453
3swrSFGDNA (cytosine-5)-methyltransferase 12.1.1.370.453
3tnwF18Cyclin-dependent kinase 22.7.11.220.453
4a9mP9MBromodomain-containing protein 2/0.453
4bcqTJFCyclin-dependent kinase 22.7.11.220.453
4btkDTQTau-tubulin kinase 12.7.11.10.453
4kuhCAA3-hydroxybutyryl-CoA dehydrogenase/0.453
3uzaT4GAdenosine receptor A2a/0.453
1hckATPCyclin-dependent kinase 22.7.11.220.452
3dgaNDPBifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.452
3fzt4JZProtein-tyrosine kinase 2-beta2.7.10.20.452
3mfsANPPeripheral plasma membrane protein CASK2.7.11.10.452
3q92XNBKetohexokinase/0.452
3zrmZRMGlycogen synthase kinase-3 beta2.7.11.260.452
4jaqCOAAlpha-pyrone synthesis polyketide synthase-like Pks112.3.10.452
4u97STUInterleukin-1 receptor-associated kinase 42.7.11.10.452
5hes032Mitogen-activated protein kinase kinase kinase 202.7.11.250.452
3reyXACAdenosine receptor A2a/0.452
1ictT44Transthyretin/0.451
1k6cMK1Gag-Pol polyprotein3.4.23.160.451
1q41IXMGlycogen synthase kinase-3 beta2.7.11.260.451
2b0m201Dihydroorotate dehydrogenase (quinone), mitochondrial1.3.5.20.451
2j5nNAD1-pyrroline-5-carboxylate dehydrogenase/0.451
2vwu7X1Ephrin type-B receptor 42.7.10.10.451
3cd57HI3-hydroxy-3-methylglutaryl-coenzyme A reductase1.1.1.340.451
3krwBA1Beta-adrenergic receptor kinase 12.7.11.150.451
3q5iANPProtein kinase, putative/0.451
3wi6YRZMAP kinase-activated protein kinase 22.7.11.10.451
3wxyCOAUncharacterized protein/0.451
4aw0ATP3-phosphoinositide-dependent protein kinase 12.7.11.10.451
4c4h7RODual specificity protein kinase TTK2.7.12.10.451
4eh50OMMitogen-activated protein kinase 14/0.451
4ftr5HKSerine/threonine-protein kinase Chk12.7.11.10.451
4hjoAQ4Epidermal growth factor receptor2.7.10.10.451
4l4cCAMCamphor 5-monooxygenase1.14.15.10.451
1nvrSTUSerine/threonine-protein kinase Chk12.7.11.10.450
1q8wM77cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.450
1qcfPP1Tyrosine-protein kinase HCK2.7.10.20.450
1tqpATPRIO-type serine/threonine-protein kinase Rio22.7.11.10.450
3ma301ISerine/threonine-protein kinase pim-12.7.11.10.450
3q3b55EGlycogen synthase kinase-3 beta2.7.11.260.450
3vvh4BMDual specificity mitogen-activated protein kinase kinase 12.7.12.20.450
4brxKGWFocal adhesion kinase 12.7.10.20.450
4ftq4HKSerine/threonine-protein kinase Chk12.7.11.10.450
4h0xNADIota toxin component Ia/0.450
4mxyDB8Proto-oncogene tyrosine-protein kinase Src2.7.10.20.450
4mxzDB8Proto-oncogene tyrosine-protein kinase Src2.7.10.20.450
4njt017Protease/0.450
4u0i0LIMast/stem cell growth factor receptor Kit2.7.10.10.450
5awmANPStress-activated protein kinase JNK2.7.11.240.450
1dz6CAMCamphor 5-monooxygenase1.14.15.10.449
1qpePP2Tyrosine-protein kinase Lck2.7.10.20.449
1w2xRCPAcetyl-CoA carboxylase/0.449
1y0s331Peroxisome proliferator-activated receptor delta/0.449
2bheBRYCyclin-dependent kinase 22.7.11.220.449
2hasC3OVitamin D3 receptor/0.449
2jdsL20cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.449
2zmd537Dual specificity protein kinase TTK2.7.12.10.449
3bgqVX2Serine/threonine-protein kinase pim-12.7.11.10.449
3bhh5CPCalcium/calmodulin-dependent protein kinase type II subunit beta2.7.11.170.449
3gmd2M3Corticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.449
3gu6ADPDeath-associated protein kinase 12.7.11.10.449
3n0tOPYDipeptidyl peptidase 23.4.14.20.449
3oibFDAPutative acyl-CoA dehydrogenase/0.449
3u9n09HSerine/threonine-protein kinase Chk12.7.11.10.449
3vt7VDXVitamin D3 receptor/0.449
3zsh469Mitogen-activated protein kinase 14/0.449
4hdbG52Gag-Pol polyprotein3.4.23.160.449
4ix6ADPUncharacterized protein/0.449
2btsU32Cyclin-dependent kinase 22.7.11.220.448
2qe6SAMUncharacterized protein/0.448
2y3rTRKTamL/0.448
3bqr4RBDeath-associated protein kinase 3/0.448
3flyFLYMitogen-activated protein kinase 14/0.448
3fmn530Mitogen-activated protein kinase 14/0.448
3n8zFLPProstaglandin G/H synthase 11.14.99.10.448
3nwq2NCGag-Pol polyprotein3.4.23.160.448
3v8w0G2Tyrosine-protein kinase ITK/TSK2.7.10.20.448
4c9pCAMCytochrome P450/0.448
4ctaATPCinA-like protein/0.448
4f1mACPProbable serine/threonine-protein kinase roco42.7.11.10.448
4fki09KCyclin-dependent kinase 22.7.11.220.448
4i4e1BQFocal adhesion kinase 12.7.10.20.448
1r6g442Thyroid hormone receptor beta/0.447
1sh9RITGag-Pol polyprotein3.4.23.160.447
1uu3LY43-phosphoinositide-dependent protein kinase 12.7.11.10.447
1zrzBI1Protein kinase C iota type2.7.11.130.447
2p55MRADual specificity mitogen-activated protein kinase kinase 12.7.12.20.447
2qnpQN2Gag-Pol polyprotein3.4.23.160.447
2xru400Aurora kinase A2.7.11.10.447
2yitYITSerine/threonine-protein kinase Chk22.7.11.10.447
3l8p0CEAngiopoietin-1 receptor2.7.10.10.447
3nuyJPZ3-phosphoinositide-dependent protein kinase 12.7.11.10.447
3sa323XProtease/0.447
4agwNG7Proto-oncogene tyrosine-protein kinase Src2.7.10.20.447
4feq0T8Tyrosine-protein kinase receptor TYRO32.7.10.10.447
4gb90WRPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.447
4h4xFADBiphenyl dioxygenase ferredoxin reductase subunit/0.447
5e8xSTUTGF-beta receptor type-12.7.11.300.447
1kgjFL8Transthyretin/0.446
2acxANPG protein-coupled receptor kinase 62.7.11.160.446
2broDF2Serine/threonine-protein kinase Chk12.7.11.10.446
2chw039Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.446
2w7xD1ASerine/threonine-protein kinase Chk22.7.11.10.446
2xnn430Serine/threonine-protein kinase Nek22.7.11.10.446
2xrwANPMitogen-activated protein kinase 82.7.11.240.446
3ormAGSSerine/threonine protein kinase/0.446
4c9oCAMCytochrome P450/0.446
4f9mFCMPeroxisome proliferator-activated receptor gamma/0.446
4wloNAIMalate dehydrogenase, mitochondrial1.1.1.370.446
6cp4CAMCamphor 5-monooxygenase1.14.15.10.446
1d3gBREDihydroorotate dehydrogenase (quinone), mitochondrial1.3.5.20.445
2cciATPCyclin-dependent kinase 22.7.11.220.445
2ckeIQUDeath-associated protein kinase 2/0.445
2j0j4STFocal adhesion kinase 12.7.10.20.445
2ydkYDKSerine/threonine-protein kinase Chk12.7.11.10.445
2zm1KSFTyrosine-protein kinase Lck2.7.10.20.445
3mvhWFERAC-alpha serine/threonine-protein kinase2.7.11.10.445
3sc13S13-phosphoinositide-dependent protein kinase 12.7.11.10.445
3vt3VDXVitamin D3 receptor/0.445
3zrkZRKGlycogen synthase kinase-3 beta2.7.11.260.445
3ztxZTXAurora kinase B-A2.7.11.10.445
4c4g7RODual specificity protein kinase TTK2.7.12.10.445
4fk3325Serine/threonine-protein kinase B-raf2.7.11.10.445
4l8u9AZSerum albumin/0.445
4o4fATPKinase/0.445
1cx2S58Prostaglandin G/H synthase 21.14.99.10.444
1sm2STUTyrosine-protein kinase ITK/TSK2.7.10.20.444
1txiTX5Vitamin D3 receptor/0.444
1zarADPRIO-type serine/threonine-protein kinase Rio22.7.11.10.444
2ath3EAPeroxisome proliferator-activated receptor gamma/0.444
2c3kABOSerine/threonine-protein kinase Chk12.7.11.10.444
2i0dMUTProtease/0.444
2i4pDRHPeroxisome proliferator-activated receptor gamma/0.444
2pe24643-phosphoinositide-dependent protein kinase 12.7.11.10.444
2pywADPMethylthioribose kinase2.7.1.1000.444
3a4oSTUTyrosine-protein kinase Lyn2.7.10.20.444
3b2tM33Fibroblast growth factor receptor 2/0.444
3flsFLSMitogen-activated protein kinase 14/0.444
3sp6IL2Peroxisome proliferator-activated receptor alpha/0.444
3vbq0F5Serine/threonine-protein kinase pim-12.7.11.10.444
4ekl0RFRAC-alpha serine/threonine-protein kinase2.7.11.10.444
4fkpLS5Cyclin-dependent kinase 22.7.11.220.444
4h1m0YJProtein-tyrosine kinase 2-beta2.7.10.20.444
4hgl0YOCasein kinase I isoform gamma-32.7.11.10.444
4id71G0Activated CDC42 kinase 1/0.444
5auwQUEDeath-associated protein kinase 12.7.11.10.444
3uzcT4EAdenosine receptor A2a/0.444
1ie9VDXVitamin D3 receptor/0.443
1unlRRCCyclin-dependent-like kinase 52.7.11.10.443
2c1aI5ScAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.443
2h96893Mitogen-activated protein kinase 82.7.11.240.443
2i40BLZCyclin-dependent kinase 22.7.11.220.443
3ef6FADToluene 1,2-dioxygenase system ferredoxin--NAD(+) reductase component1.18.1.30.443
3l0lHC3Nuclear receptor ROR-gamma/0.443
3lcdBDYMacrophage colony-stimulating factor 1 receptor2.7.10.10.443
3nnwEDDMitogen-activated protein kinase 14/0.443
3otuBI43-phosphoinositide-dependent protein kinase 12.7.11.10.443
3uli1N3Cyclin-dependent kinase 22.7.11.220.443
3vt8YI3Vitamin D3 receptor/0.443
4e730NRMitogen-activated protein kinase 82.7.11.240.443
4iarERM5-hydroxytryptamine receptor 1B/0.443
4l98LRGPeroxisome proliferator-activated receptor gamma/0.443
4qpmADPMitotic checkpoint serine/threonine-protein kinase BUB12.7.11.10.443
4xlvACPInsulin receptor2.7.10.10.443
5auzGENDeath-associated protein kinase 12.7.11.10.443
1q3dSTUGlycogen synthase kinase-3 beta2.7.11.260.442
1uv5BRWGlycogen synthase kinase-3 beta2.7.11.260.442
1wvySTUDeath-associated protein kinase 12.7.11.10.442
1xl2189Gag-Pol polyprotein3.4.23.160.442
2fxeDR7Gag-Pol polyprotein3.4.23.160.442
2rg5279Mitogen-activated protein kinase 14/0.442
2rioADPSerine/threonine-protein kinase/endoribonuclease IRE12.7.11.10.442
2w05FRTCyclin-dependent kinase 22.7.11.220.442
3a7hATPSerine/threonine-protein kinase 242.7.11.10.442
3w18N13Aurora kinase A2.7.11.10.442
3w2o03PEpidermal growth factor receptor2.7.10.10.442
4djr0KJPol polyprotein/0.442
4fv7E94Mitogen-activated protein kinase 12.7.11.240.442
4g3rCAMCamphor 5-monooxygenase1.14.15.10.442
4ia3BIVVitamin D3 receptor A/0.442
4l445FIRibosomal protein S6 kinase beta-12.7.11.10.442
4q73FADBifunctional protein PutA/0.442
5ap57RODual specificity protein kinase TTK2.7.12.10.442
1d4aFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.441
1hvsA77Gag-Pol polyprotein/0.441
1nzwNAIAldehyde dehydrogenase, mitochondrial1.2.1.30.441
1ywrLI9Mitogen-activated protein kinase 14/0.441
2j3kNAPNADPH-dependent oxidoreductase 2-alkenal reductase1.3.1.740.441
2q5g1FAPeroxisome proliferator-activated receptor delta/0.441
2q61SF1Peroxisome proliferator-activated receptor gamma/0.441
2r5tANPSerine/threonine-protein kinase Sgk12.7.11.10.441
2vd5BI8Myotonin-protein kinase2.7.11.10.441
2zb0GK3Mitogen-activated protein kinase 14/0.441
3cisATPUniversal stress protein Rv2623/0.441
3mpt1GKMitogen-activated protein kinase 14/0.441
3qlrNDPDihydrofolate reductase1.5.1.30.441
3qlxQLRUncharacterized protein/0.441
4aacAAVMitogen-activated protein kinase 14/0.441
4g6hNAIRotenone-insensitive NADH-ubiquinone oxidoreductase, mitochondrial1.6.5.90.441
4h50NAPBiphenyl dioxygenase ferredoxin reductase subunit/0.441
4o0sADNAurora kinase A2.7.11.10.441
4s34ANPMitogen-activated protein kinase 12.7.11.240.441
1aq1STUCyclin-dependent kinase 22.7.11.220.440
1sn0T44Transthyretin/0.440
1t44ATPActin, alpha skeletal muscle/0.440
1vijBAYGag-Pol polyprotein/0.440
1yi3LY2Serine/threonine-protein kinase pim-12.7.11.10.440
2a0cCK9Cyclin-dependent kinase 22.7.11.220.440
2a4lRRCCyclin-dependent kinase 22.7.11.220.440
2cig1DGDihydrofolate reductase1.5.1.30.440
2hamC33Vitamin D3 receptor/0.440
2nnpROCProtease/0.440
2oyeIM8Prostaglandin G/H synthase 11.14.99.10.440
2qnqQN3Gag-Pol polyprotein3.4.23.160.440
2vo6M05cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.440
2w0jZATSerine/threonine-protein kinase Chk22.7.11.10.440
2y9qANPMitogen-activated protein kinase 12.7.11.240.440
3cktYDPGag-Pol polyprotein3.4.23.160.440
3crzFADFerredoxin--NADP+ reductase/0.440
3gbk2PQPeroxisome proliferator-activated receptor gamma/0.440
3nga3NGCasein kinase II subunit alpha2.7.11.10.440
3uleC69Actin-related protein 3/0.440
3v9v21LPeroxisome proliferator-activated receptor gamma/0.440
3vrwYS5Vitamin D3 receptor/0.440
4aa0AA0Mitogen-activated protein kinase 14/0.440
4aicNDP1-deoxy-D-xylulose 5-phosphate reductoisomerase/0.440
4bcmT7ZCyclin-dependent kinase 22.7.11.220.440
4c4iX20Dual specificity protein kinase TTK2.7.12.10.440
4e4m0NHTyrosine-protein kinase JAK2/0.440
4krcAGSCyclin-dependent protein kinase PHO852.7.11.220.440
4l2iFADElectron transfer flavoprotein alpha/beta-subunit/0.440
4m69ANPReceptor-interacting serine/threonine-protein kinase 32.7.11.10.440
4riyADPEpidermal growth factor receptor2.7.10.10.440
4x81MVIMycinamicin III 3''-O-methyltransferase2.1.1.2370.440
5bp9SAHPutative methyltransferase protein/0.440