Logo scPDB

sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

Logo CNRS Logo Unistra
Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4d58BI9Focal adhesion kinase 12.7.10.2

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
4d58BI9Focal adhesion kinase 12.7.10.21.000
4d4sBI9Focal adhesion kinase 12.7.10.20.555
2ijmATPFocal adhesion kinase 12.7.10.20.499
2jkoBIJFocal adhesion kinase 12.7.10.20.498
2phkATPPhosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform2.7.11.190.497
2ycrHCWSerine/threonine-protein kinase Chk22.7.11.10.497
4ftiH7KSerine/threonine-protein kinase Chk12.7.11.10.496
4brxKGWFocal adhesion kinase 12.7.10.20.491
1h1wATP3-phosphoinositide-dependent protein kinase 12.7.11.10.488
2yitYITSerine/threonine-protein kinase Chk22.7.11.10.488
3hrfATP3-phosphoinositide-dependent protein kinase 12.7.11.10.487
4i22IREEpidermal growth factor receptor2.7.10.10.484
2y7jB49Phosphorylase b kinase gamma catalytic chain, liver/testis isoform2.7.11.190.483
2c3lIDZSerine/threonine-protein kinase Chk12.7.11.10.482
2yiqYIQSerine/threonine-protein kinase Chk22.7.11.10.482
3rwpABQ3-phosphoinositide-dependent protein kinase 12.7.11.10.482
2pe24643-phosphoinositide-dependent protein kinase 12.7.11.10.481
2xk9XK9Serine/threonine-protein kinase Chk22.7.11.10.481
3ambVX6cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.480
2zb3NDPProstaglandin reductase 21.3.1.480.479
2wtiWTISerine/threonine-protein kinase Chk22.7.11.10.478
2wtjWTJSerine/threonine-protein kinase Chk22.7.11.10.476
4xx9ATP3-phosphoinositide-dependent protein kinase 12.7.11.10.476
2yirYIRSerine/threonine-protein kinase Chk22.7.11.10.475
4fsnA58Serine/threonine-protein kinase Chk12.7.11.10.475
2cgu3A3Serine/threonine-protein kinase Chk12.7.11.10.474
2jkqVG8Focal adhesion kinase 12.7.10.20.474
4bcmT7ZCyclin-dependent kinase 22.7.11.220.474
4l3j5FIRibosomal protein S6 kinase beta-12.7.11.10.473
2wmqZYQSerine/threonine-protein kinase Chk12.7.11.10.472
3et7349Protein-tyrosine kinase 2-beta2.7.10.20.472
3nux3NVCyclin-dependent kinase 62.7.11.220.472
4enxZ20Serine/threonine-protein kinase pim-12.7.11.10.472
3my5RFZCyclin-dependent kinase 22.7.11.220.471
1h0w207Cyclin-dependent kinase 22.7.11.220.470
2wtdZZKSerine/threonine-protein kinase Chk22.7.11.10.470
4aw1ATP3-phosphoinositide-dependent protein kinase 12.7.11.10.470
4flh14KPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.470
4fv1EK4Mitogen-activated protein kinase 12.7.11.240.470
1z5mLI83-phosphoinositide-dependent protein kinase 12.7.11.10.469
2br1PFPSerine/threonine-protein kinase Chk12.7.11.10.469
2hog710Serine/threonine-protein kinase Chk12.7.11.10.469
2pe15173-phosphoinositide-dependent protein kinase 12.7.11.10.469
2xbjXBJSerine/threonine-protein kinase Chk22.7.11.10.469
3eb0DRKUncharacterized protein/0.469
4g1wG1WMitogen-activated protein kinase 82.7.11.240.469
4yduADPtRNA N6-adenosine threonylcarbamoyltransferase/0.469
2w7xD1ASerine/threonine-protein kinase Chk22.7.11.10.468
2ydjYDJSerine/threonine-protein kinase Chk12.7.11.10.468
3amaSKEcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.468
2e9v85ASerine/threonine-protein kinase Chk12.7.11.10.467
2xp2VGHALK tyrosine kinase receptor2.7.10.10.467
1tqmANPRIO-type serine/threonine-protein kinase Rio22.7.11.10.466
1u54ACPActivated CDC42 kinase 1/0.466
3zdu38RCyclin-dependent kinase-like 32.7.11.220.466
4bkz1WSMaternal embryonic leucine zipper kinase2.7.11.10.466
4bdaVFBSerine/threonine-protein kinase Chk22.7.11.10.465
4kz01UJPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.465
2hxl422Serine/threonine-protein kinase Chk12.7.11.10.464
2ydiYDISerine/threonine-protein kinase Chk12.7.11.10.464
3nunJMZ3-phosphoinositide-dependent protein kinase 12.7.11.10.464
5auvAGIDeath-associated protein kinase 12.7.11.10.464
2brhDFWSerine/threonine-protein kinase Chk12.7.11.10.463
2c4g514Cyclin-dependent kinase 22.7.11.220.463
3gubGUBDeath-associated protein kinase 12.7.11.10.463
1oirHDYCyclin-dependent kinase 22.7.11.220.462
3hrcATP3-phosphoinositide-dependent protein kinase 12.7.11.10.462
3pxkPXKFocal adhesion kinase 12.7.10.20.462
4ez50RSCyclin-dependent kinase 62.7.11.220.462
5da9AGSUncharacterized protein/0.462
2wtcVGMSerine/threonine-protein kinase Chk22.7.11.10.461
2ycqUPXSerine/threonine-protein kinase Chk22.7.11.10.461
4k8aK8AFocal adhesion kinase 12.7.10.20.461
1bygSTUTyrosine-protein kinase CSK/0.460
2p33J07Mitogen-activated protein kinase 102.7.11.240.460
3qcs3Q13-phosphoinositide-dependent protein kinase 12.7.11.10.460
4rqkATP3-phosphoinositide-dependent protein kinase 12.7.11.10.460
2zjwREFCasein kinase II subunit alpha2.7.11.10.459
3tkh07SSerine/threonine-protein kinase Chk12.7.11.10.459
4gu610NFocal adhesion kinase 12.7.10.20.459
4a06ATP3-phosphoinositide-dependent protein kinase 12.7.11.10.458
2exmZIPCyclin-dependent kinase 22.7.11.220.457
2izsBRQCasein kinase I isoform gamma-32.7.11.10.457
2pe039Z3-phosphoinositide-dependent protein kinase 12.7.11.10.457
3cblSTUTyrosine-protein kinase Fes/Fps2.7.10.20.457
4fl2ANPTyrosine-protein kinase SYK2.7.10.20.457
4nka2K7Fibroblast growth factor receptor 1/0.457
1aq1STUCyclin-dependent kinase 22.7.11.220.456
1uu3LY43-phosphoinositide-dependent protein kinase 12.7.11.10.456
2brbPFQSerine/threonine-protein kinase Chk12.7.11.10.456
2brmDFZSerine/threonine-protein kinase Chk12.7.11.10.456
3at4CCKCasein kinase II subunit alpha2.7.11.10.456
2ckeIQUDeath-associated protein kinase 2/0.455
4a9uA9USerine/threonine-protein kinase Chk22.7.11.10.455
4wq5ATPtRNA N6-adenosine threonylcarbamoyltransferase/0.455
2e9oA58Serine/threonine-protein kinase Chk12.7.11.10.454
3lctADPALK tyrosine kinase receptor2.7.10.10.454
4fod0UVALK tyrosine kinase receptor2.7.10.10.454
1uu7BI23-phosphoinositide-dependent protein kinase 12.7.11.10.453
3l8p0CEAngiopoietin-1 receptor2.7.10.10.453
3nuuJOZ3-phosphoinositide-dependent protein kinase 12.7.11.10.453
4bl1ANPMaternal embryonic leucine zipper kinase2.7.11.10.453
4dk50KOPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.453
4fswHK6Serine/threonine-protein kinase Chk12.7.11.10.453
1xjdSTUProtein kinase C theta type2.7.11.130.452
5av4GENDeath-associated protein kinase 12.7.11.10.452
5dr9SKEAurora kinase A2.7.11.10.452
4ft7H3KSerine/threonine-protein kinase Chk12.7.11.10.451
1finATPCyclin-dependent kinase 22.7.11.220.450
1wvxBD4Death-associated protein kinase 12.7.11.10.450
2cgw3C3Serine/threonine-protein kinase Chk12.7.11.10.450
2xm9LWHSerine/threonine-protein kinase Chk22.7.11.10.450
3qwjX6ACyclin-dependent kinase 22.7.11.220.450
3sheI85MAP kinase-activated protein kinase 32.7.11.10.450
3ttiKBIMitogen-activated protein kinase 102.7.11.240.450
3ztxZTXAurora kinase B-A2.7.11.10.450
4c4iX20Dual specificity protein kinase TTK2.7.12.10.450
4deaNHIAurora kinase A2.7.11.10.450
4fx360KCyclin-dependent kinase 22.7.11.220.450
4hgs15GCasein kinase I isoform gamma-32.7.11.10.450
4nky3QZSteroid 17-alpha-hydroxylase/17,20 lyase/0.450
5dt0SKEAurora kinase A2.7.11.10.450
2e9uA25Serine/threonine-protein kinase Chk12.7.11.10.449
2w17I19Cyclin-dependent kinase 22.7.11.220.449
2yyuC5POrotidine 5'-phosphate decarboxylase/0.449
3fcoIIGCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.449
3nlb5BESerine/threonine-protein kinase Chk12.7.11.10.449
4ct2ATP3-phosphoinositide-dependent protein kinase 12.7.11.10.449
4fsrHKCSerine/threonine-protein kinase Chk12.7.11.10.449
5br4NADLactaldehyde reductase1.1.1.770.449
1pmn984Mitogen-activated protein kinase 102.7.11.240.448
1zaoATPRIO-type serine/threonine-protein kinase Rio22.7.11.10.448
3iok1P6Tyrosine-protein kinase JAK2/0.448
4dggI76Proto-oncogene tyrosine-protein kinase Src2.7.10.20.448
4ft0HK9Serine/threonine-protein kinase Chk12.7.11.10.448
4kuhCAA3-hydroxybutyryl-CoA dehydrogenase/0.448
4mcv29KProto-oncogene tyrosine-protein kinase Src2.7.10.20.448
1f123HCHydroxyacyl-coenzyme A dehydrogenase, mitochondrial1.1.1.350.447
2h8hH8HProto-oncogene tyrosine-protein kinase Src2.7.10.20.447
2vu3LZECyclin-dependent kinase 22.7.11.220.447
3fzpAGSProtein-tyrosine kinase 2-beta2.7.10.20.447
3q9xEMOCasein kinase II subunit alpha2.7.11.10.447
3zonIK1Non-receptor tyrosine-protein kinase TYK22.7.10.20.447
4fob0USALK tyrosine kinase receptor2.7.10.10.447
5auwQUEDeath-associated protein kinase 12.7.11.10.447
1ckpPVBCyclin-dependent kinase 22.7.11.220.446
2wmtZYTSerine/threonine-protein kinase Chk12.7.11.10.446
3f69XDRSerine/threonine-protein kinase PknB2.7.11.10.446
3qcq3Q03-phosphoinositide-dependent protein kinase 12.7.11.10.446
3r71X86Cyclin-dependent kinase 22.7.11.220.446
4anuEM7Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.446
4gih0X5Non-receptor tyrosine-protein kinase TYK22.7.10.20.446
4hgl0YOCasein kinase I isoform gamma-32.7.11.10.446
4o0wADNAurora kinase A2.7.11.10.446
4riyADPEpidermal growth factor receptor2.7.10.10.446
4xumIMNPeroxisome proliferator-activated receptor gamma/0.446
5av2KMPDeath-associated protein kinase 12.7.11.10.446
5av3KMPDeath-associated protein kinase 12.7.11.10.446
1e9hINRCyclin-dependent kinase 22.7.11.220.445
1nvrSTUSerine/threonine-protein kinase Chk12.7.11.10.445
1u3dFADCryptochrome-1/0.445
2ayp43ASerine/threonine-protein kinase Chk12.7.11.10.445
2biyATP3-phosphoinositide-dependent protein kinase 12.7.11.10.445
2btsU32Cyclin-dependent kinase 22.7.11.220.445
2hxq373Serine/threonine-protein kinase Chk12.7.11.10.445
2w05FRTCyclin-dependent kinase 22.7.11.220.445
3gxlQIGTGF-beta receptor type-12.7.11.300.445
3v04V04Dual specificity mitogen-activated protein kinase kinase 12.7.12.20.445
4l3l5FIRibosomal protein S6 kinase beta-12.7.11.10.445
5ackATP3-phosphoinositide-dependent protein kinase 12.7.11.10.445
1qpjSTUTyrosine-protein kinase Lck2.7.10.20.444
1rl8RITGag-Pol polyprotein3.4.23.160.444
1tvoFRZMitogen-activated protein kinase 12.7.11.240.444
2cgv3B3Serine/threonine-protein kinase Chk12.7.11.10.444
2vgpAD6Aurora kinase B-A2.7.11.10.444
3bhy7CPDeath-associated protein kinase 3/0.444
3nuyJPZ3-phosphoinositide-dependent protein kinase 12.7.11.10.444
4bdbODOSerine/threonine-protein kinase Chk22.7.11.10.444
4h4uNDPBiphenyl dioxygenase ferredoxin reductase subunit/0.444
1eh4IC1Casein kinase I homolog 12.7.11.10.443
1oitHDTCyclin-dependent kinase 22.7.11.220.443
1zarADPRIO-type serine/threonine-protein kinase Rio22.7.11.10.443
2a0cCK9Cyclin-dependent kinase 22.7.11.220.443
3otuBI43-phosphoinositide-dependent protein kinase 12.7.11.10.443
3qd43Q63-phosphoinositide-dependent protein kinase 12.7.11.10.443
3sc13S13-phosphoinositide-dependent protein kinase 12.7.11.10.443
4fkg4CKCyclin-dependent kinase 22.7.11.220.443
4fv8E63Mitogen-activated protein kinase 12.7.11.240.443
4hyu1BKMitogen-activated protein kinase 82.7.11.240.443
4yhjAN2G protein-coupled receptor kinase 42.7.11.160.443
5fl3ADPPili retraction protein PilT/0.443
2bxgIBPSerum albumin/0.442
2obyNAPQuinone oxidoreductase PIG310.442
2w0jZATSerine/threonine-protein kinase Chk22.7.11.10.442
3bqr4RBDeath-associated protein kinase 3/0.442
3ormAGSSerine/threonine protein kinase/0.442
3r1yX76Cyclin-dependent kinase 22.7.11.220.442
4a9sRU9Serine/threonine-protein kinase Chk22.7.11.10.442
4f4p0SBTyrosine-protein kinase SYK2.7.10.20.442
4fsmHK1Serine/threonine-protein kinase Chk12.7.11.10.442
4l425FIRibosomal protein S6 kinase beta-12.7.11.10.442
1e1xNW1Cyclin-dependent kinase 22.7.11.220.441
1k6tXN1Gag-Pol polyprotein3.4.23.160.441
2ijmADPFocal adhesion kinase 12.7.10.20.441
2ycfYCFSerine/threonine-protein kinase Chk22.7.11.10.441
3bu5ATPInsulin receptor2.7.10.10.441
3sqq99ZCyclin-dependent kinase 22.7.11.220.441
3t2zFADSulfide-quinone reductase/0.441
3w0sANPHygromycin-B 4-O-kinase2.7.1.1630.441
4a6bQG8Gag-Pol polyprotein3.4.23.160.441
4bdeCWSSerine/threonine-protein kinase Chk22.7.11.10.441
4eon1ROCyclin-dependent kinase 22.7.11.220.441
4hdfG52Gag-Pol polyprotein3.4.23.160.441
4wujFMNGlycoside hydrolase family 15, cellulose signaling associated protein envoy/0.441
1h1s4SPCyclin-dependent kinase 22.7.11.220.440
1rj6AZMCarbonic anhydrase 144.2.1.10.440
1uvrBI83-phosphoinositide-dependent protein kinase 12.7.11.10.440
2vgoAD5Aurora kinase B-A2.7.11.10.440
3rpo24ZCyclin-dependent kinase 22.7.11.220.440
4ia7BIVVitamin D3 receptor A/0.440
4jajXU1Aurora kinase A2.7.11.10.440
4rqvATP3-phosphoinositide-dependent protein kinase 12.7.11.10.440
5dr6SKEAurora kinase A2.7.11.10.440