sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Cavities are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 4cjp | 4D2 | Integrase |
| PDB ID | HET | Uniprot Name | EC Number | Cavity Similarity |
Align |
|---|---|---|---|---|---|
| 4cjp | 4D2 | Integrase | / | 1.000 | |
| 4cef | D0T | Integrase | / | 0.704 | |
| 4cf2 | 3GM | Integrase | / | 0.673 | |
| 4cgj | NZL | Integrase | / | 0.653 | |
| 4cjq | VXO | Integrase | / | 0.646 | |
| 3zsw | ZSW | Integrase | / | 0.640 | |
| 4cea | ZSW | Integrase | / | 0.633 | |
| 4cjf | RVN | Integrase | / | 0.624 | |
| 4ck2 | NVU | Integrase | / | 0.624 | |
| 3zsr | O3N | Integrase | / | 0.621 | |
| 4cez | O3N | Integrase | / | 0.621 | |
| 4cfc | 7NV | Integrase | / | 0.616 | |
| 4cgg | K5Q | Integrase | / | 0.613 | |
| 4ced | 9NS | Integrase | / | 0.607 | |
| 4cj5 | 4VW | Integrase | / | 0.607 | |
| 4ceq | QCH | Integrase | / | 0.606 | |
| 4cfa | WOP | Integrase | / | 0.603 | |
| 4ce9 | O3N | Integrase | / | 0.602 | |
| 3zt0 | ZT0 | Integrase | / | 0.598 | |
| 4cfb | OM3 | Integrase | / | 0.592 | |
| 4cif | JDX | Integrase | / | 0.592 | |
| 4cie | Y7N | Integrase | / | 0.590 | |
| 4ces | NFW | Integrase | / | 0.588 | |
| 4cf0 | O5U | Integrase | / | 0.586 | |
| 4cer | VL4 | Integrase | / | 0.581 | |
| 3zt3 | ZT4 | Integrase | / | 0.580 | |
| 4cf8 | V7H | Integrase | / | 0.580 | |
| 4cig | X0P | Integrase | / | 0.579 | |
| 4cje | Q31 | Integrase | / | 0.578 | |
| 4cju | JNS | Integrase | / | 0.578 | |
| 4cfd | S8Y | Integrase | / | 0.577 | |
| 4cjk | H39 | Integrase | / | 0.575 | |
| 4cj3 | E4F | Integrase | / | 0.573 | |
| 4ck3 | K1T | Integrase | / | 0.573 | |
| 4cee | B0T | Integrase | / | 0.572 | |
| 4cgi | NZL | Integrase | / | 0.572 | |
| 4cgd | 8P3 | Integrase | / | 0.571 | |
| 4cj4 | S3G | Integrase | / | 0.569 | |
| 3zsv | ZSV | Integrase | / | 0.567 | |
| 4ceb | ZSV | Integrase | / | 0.567 | |
| 4cgh | LOZ | Integrase | / | 0.564 | |
| 3zsy | OM3 | Integrase | / | 0.557 | |
| 4ceo | G0T | Integrase | / | 0.556 | |
| 4cec | 2SS | Integrase | / | 0.555 | |
| 3zsz | OM2 | Integrase | / | 0.552 | |
| 4chy | C5Q | Integrase | / | 0.543 | |
| 4cjs | L0Y | Integrase | / | 0.541 | |
| 4ck1 | OM1 | Integrase | / | 0.540 | |
| 3zsq | O4N | Integrase | / | 0.538 | |
| 3zt2 | ZT2 | Integrase | / | 0.536 | |
| 3zcm | PX3 | Integrase | / | 0.530 | |
| 4cjr | FYM | Integrase | / | 0.530 | |
| 4chq | CWU | Integrase | / | 0.524 | |
| 3zt1 | OM1 | Integrase | / | 0.523 | |
| 4cf1 | IY7 | Integrase | / | 0.511 | |
| 3zsx | N44 | Integrase | / | 0.503 | |
| 2h2q | NAP | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.500 | |
| 2xck | MH4 | 3-phosphoinositide-dependent protein kinase 1 | 2.7.11.1 | 0.493 | |
| 4eh9 | IRG | Mitogen-activated protein kinase 14 | / | 0.487 | |
| 1ia1 | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.486 | |
| 1drh | NAP | Dihydrofolate reductase | 1.5.1.3 | 0.485 | |
| 1y5r | C0R | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.485 | |
| 3c0i | 3AM | Peripheral plasma membrane protein CASK | 2.7.11.1 | 0.484 | |
| 3iae | D7K | Benzaldehyde lyase | / | 0.482 | |
| 4l4x | NDP | AmphI | / | 0.482 | |
| 5byl | GCP | Bifunctional AAC/APH | 2.3.1 | 0.482 | |
| 1cqp | 803 | Integrin alpha-L | / | 0.477 | |
| 1rx1 | NAP | Dihydrofolate reductase | 1.5.1.3 | 0.477 | |
| 1crb | RTL | Retinol-binding protein 1 | / | 0.476 | |
| 2xf3 | J01 | Uncharacterized protein | / | 0.476 | |
| 1rx8 | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.475 | |
| 2x6o | 2TC | Tetracycline repressor protein class D | / | 0.475 | |
| 1dr3 | TAP | Dihydrofolate reductase | 1.5.1.3 | 0.474 | |
| 3lqf | NAD | Galactitol dehydrogenase | / | 0.474 | |
| 2pvn | P63 | Casein kinase II subunit alpha | 2.7.11.1 | 0.473 | |
| 1pox | FAD | Pyruvate oxidase | 1.2.3.3 | 0.472 | |
| 3d7k | D7K | Benzaldehyde lyase | / | 0.472 | |
| 4nfs | NAJ | Alcohol dehydrogenase E chain | 1.1.1.1 | 0.471 | |
| 1ahi | CHO | 7-alpha-hydroxysteroid dehydrogenase | 1.1.1.159 | 0.470 | |
| 3dhe | AND | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.469 | |
| 3had | NAD | Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial | 1.1.1.35 | 0.469 | |
| 5cb3 | APR | O-acetyl-ADP-ribose deacetylase | / | 0.469 | |
| 2zev | B71 | Geranylgeranyl pyrophosphate synthase | / | 0.468 | |
| 3be9 | P04 | Casein kinase II subunit alpha | 2.7.11.1 | 0.467 | |
| 4ks8 | B49 | Serine/threonine-protein kinase PAK 6 | 2.7.11.1 | 0.467 | |
| 3iw1 | ASD | Steroid C26-monooxygenase | 1.14.13.141 | 0.466 | |
| 4fsq | HK3 | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.466 | |
| 4iwq | 1FV | Serine/threonine-protein kinase TBK1 | 2.7.11.1 | 0.466 | |
| 5hwr | COA | Hydroxymethylglutaryl-CoA synthase | / | 0.466 | |
| 3w0c | 6DS | Vitamin D3 receptor | / | 0.465 | |
| 4bdf | H3R | Serine/threonine-protein kinase Chk2 | 2.7.11.1 | 0.465 | |
| 2c3k | ABO | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.464 | |
| 3bht | MFR | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.464 | |
| 4q72 | FAD | Bifunctional protein PutA | / | 0.464 | |
| 1sxj | ADP | Replication factor C subunit 5 | / | 0.463 | |
| 1u7t | NAD | 3-hydroxyacyl-CoA dehydrogenase type-2 | 1.1.1.35 | 0.463 | |
| 1uuo | BRF | Dihydroorotate dehydrogenase (quinone), mitochondrial | 1.3.5.2 | 0.463 | |
| 2vbd | V10 | Isopenicillin N synthase | 1.21.3.1 | 0.463 | |
| 4kfq | KFQ | Glutamate receptor ionotropic, NMDA 1 | / | 0.463 | |
| 5ack | ATP | 3-phosphoinositide-dependent protein kinase 1 | 2.7.11.1 | 0.463 | |
| 1c1d | NAI | Phenylalanine dehydrogenase | / | 0.462 | |
| 2qo9 | ANP | Ephrin type-A receptor 3 | 2.7.10.1 | 0.462 | |
| 4i4b | 1CV | 3-hydroxy-3-methylglutaryl-coenzyme A reductase | 1.1.1.88 | 0.462 | |
| 1nhh | ANP | DNA mismatch repair protein MutL | / | 0.461 | |
| 2e08 | SAH | Diphthine synthase | / | 0.461 | |
| 3gbu | ATP | Uncharacterized sugar kinase PH1459 | 2.7.1 | 0.461 | |
| 3hl7 | I47 | Mitogen-activated protein kinase 14 | / | 0.461 | |
| 3zh8 | C58 | Protein kinase C iota type | 2.7.11.13 | 0.461 | |
| 4bcr | WY1 | Peroxisome proliferator-activated receptor alpha | / | 0.461 | |
| 4dxh | NAJ | Alcohol dehydrogenase E chain | 1.1.1.1 | 0.461 | |
| 4qer | STL | Phospholipase A2 VRV-PL-VIIIa | / | 0.461 | |
| 1rx8 | NAP | Dihydrofolate reductase | 1.5.1.3 | 0.460 | |
| 1zrz | BI1 | Protein kinase C iota type | 2.7.11.13 | 0.460 | |
| 2cf6 | NAP | Cinnamyl alcohol dehydrogenase 5 | 1.1.1.195 | 0.460 | |
| 2ji9 | ADP | Oxalyl-CoA decarboxylase | 4.1.1.8 | 0.460 | |
| 2nry | STU | Interleukin-1 receptor-associated kinase 4 | 2.7.11.1 | 0.460 | |
| 4c02 | TAK | Activin receptor type-1 | 2.7.11.30 | 0.460 | |
| 3bv3 | P39 | Mitogen-activated protein kinase 14 | / | 0.459 | |
| 3gyt | DL4 | Nuclear hormone receptor of the steroid/thyroid hormone receptors superfamily | / | 0.459 | |
| 3lsi | FAD | Pyranose 2-oxidase | / | 0.459 | |
| 3o4r | NAP | Dehydrogenase/reductase SDR family member 4 | 1.1.1.184 | 0.459 | |
| 3vfq | AR6 | Poly [ADP-ribose] polymerase 14 | 2.4.2.30 | 0.459 | |
| 1fds | EST | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.458 | |
| 1szm | BI4 | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.458 | |
| 2w6n | OA2 | Biotin carboxylase | 6.3.4.14 | 0.458 | |
| 2w71 | L23 | Biotin carboxylase | 6.3.4.14 | 0.458 | |
| 4bdc | ODH | Serine/threonine-protein kinase Chk2 | 2.7.11.1 | 0.458 | |
| 1llu | NAD | Alcohol dehydrogenase | / | 0.457 | |
| 2e9n | 76A | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.457 | |
| 3fly | FLY | Mitogen-activated protein kinase 14 | / | 0.457 | |
| 3kpz | ZNE | Vitamin D3 receptor | / | 0.457 | |
| 4ftn | 2HK | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.457 | |
| 4u9a | STU | Interleukin-1 receptor-associated kinase 4 | 2.7.11.1 | 0.457 | |
| 1db4 | 8IN | Phospholipase A2, membrane associated | / | 0.456 | |
| 1db5 | 6IN | Phospholipase A2, membrane associated | / | 0.456 | |
| 1kc1 | NDP | dTDP-4-dehydrorhamnose reductase | 1.1.1.133 | 0.456 | |
| 2b0m | 201 | Dihydroorotate dehydrogenase (quinone), mitochondrial | 1.3.5.2 | 0.456 | |
| 2bjh | FER | Feruloyl esterase A | 3.1.1.73 | 0.456 | |
| 3qlr | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.456 | |
| 3vf8 | 0JE | Tyrosine-protein kinase SYK | 2.7.10.2 | 0.456 | |
| 4bb4 | 32W | Ephrin type-B receptor 4 | 2.7.10.1 | 0.456 | |
| 1k8y | 13P | Tryptophan synthase alpha chain | / | 0.455 | |
| 2tps | TPS | Thiamine-phosphate synthase | / | 0.455 | |
| 3b8r | 887 | Vascular endothelial growth factor receptor 2 | 2.7.10.1 | 0.455 | |
| 3kjs | NAP | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.455 | |
| 3nww | 3NW | Mitogen-activated protein kinase 14 | / | 0.455 | |
| 3q5d | GDP | Atlastin-1 | 3.6.5 | 0.455 | |
| 3q5k | D1U | Heat shock protein 83-1 | / | 0.455 | |
| 3v8w | 0G2 | Tyrosine-protein kinase ITK/TSK | 2.7.10.2 | 0.455 | |
| 4bdh | WVI | Serine/threonine-protein kinase Chk2 | 2.7.11.1 | 0.455 | |
| 4bdi | HAU | Serine/threonine-protein kinase Chk2 | 2.7.11.1 | 0.455 | |
| 4e8y | IHA | D-beta-D-heptose 7-phosphate kinase | / | 0.455 | |
| 4gyy | 12V | UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit | / | 0.455 | |
| 4jb1 | FAD | UDP-N-acetylenolpyruvoylglucosamine reductase | / | 0.455 | |
| 4ozt | P1A | Ecdysone receptor, putative | / | 0.455 | |
| 4rqu | NAD | Alcohol dehydrogenase class-P | / | 0.455 | |
| 5ar4 | SB2 | Receptor-interacting serine/threonine-protein kinase 2 | 2.7.11.1 | 0.455 | |
| 1iol | EST | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.454 | |
| 2vwx | 7X4 | Ephrin type-B receptor 4 | 2.7.10.1 | 0.454 | |
| 2w0j | ZAT | Serine/threonine-protein kinase Chk2 | 2.7.11.1 | 0.454 | |
| 3fhx | PLP | Pyridoxal kinase | 2.7.1.35 | 0.454 | |
| 4g2f | C07 | Ephrin type-A receptor 3 | 2.7.10.1 | 0.454 | |
| 4m6j | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.454 | |
| 4wfr | 2AM | 2',3'-cyclic-nucleotide 3'-phosphodiesterase | 3.1.4.37 | 0.454 | |
| 1b15 | NAE | Alcohol dehydrogenase | 1.1.1.1 | 0.453 | |
| 1mzs | 669 | 3-oxoacyl-[acyl-carrier-protein] synthase 3 | / | 0.453 | |
| 1o76 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.453 | |
| 2x06 | NAD | L-sulfolactate dehydrogenase | / | 0.453 | |
| 2zjw | REF | Casein kinase II subunit alpha | 2.7.11.1 | 0.453 | |
| 4g2l | 0WL | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.453 | |
| 4g95 | OAG | Dihydrofolate reductase | 1.5.1.3 | 0.453 | |
| 4prv | ADP | DNA gyrase subunit B | / | 0.453 | |
| 1a72 | PAD | Alcohol dehydrogenase E chain | 1.1.1.1 | 0.452 | |
| 1dcy | I3N | Phospholipase A2, membrane associated | / | 0.452 | |
| 1ef9 | 2CP | Methylmalonyl-CoA decarboxylase | 4.1.1.41 | 0.452 | |
| 1pjk | ANP | Casein kinase II subunit alpha | 2.7.11.1 | 0.452 | |
| 2aa0 | MTP | Adenosine kinase | 2.7.1.20 | 0.452 | |
| 2hdh | NAD | Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial | 1.1.1.35 | 0.452 | |
| 2vig | FAD | Short-chain specific acyl-CoA dehydrogenase, mitochondrial | 1.3.8.1 | 0.452 | |
| 3ad6 | KSC | Tyrosine-protein kinase Lck | 2.7.10.2 | 0.452 | |
| 3dop | NAP | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.452 | |
| 3nga | 3NG | Casein kinase II subunit alpha | 2.7.11.1 | 0.452 | |
| 3nx2 | FER | Ferulic acid decarboxylase | / | 0.452 | |
| 3r5y | F42 | Uncharacterized protein | / | 0.452 | |
| 3wle | NAD | (R)-specific carbonyl reductase | / | 0.452 | |
| 4bfz | ZVZ | Pantothenate kinase | 2.7.1.33 | 0.452 | |
| 4fv7 | E94 | Mitogen-activated protein kinase 1 | 2.7.11.24 | 0.452 | |
| 4iwo | 1H4 | Serine/threonine-protein kinase TBK1 | 2.7.11.1 | 0.452 | |
| 4kip | 1R9 | Mitogen-activated protein kinase 14 | / | 0.452 | |
| 4mv8 | ACP | Biotin carboxylase | 6.3.4.14 | 0.452 | |
| 5ai5 | BSU | Bifunctional epoxide hydrolase 2 | 3.1.3.76 | 0.452 | |
| 1dtp | APU | Diphtheria toxin | / | 0.451 | |
| 1osv | CHC | Bile acid receptor | / | 0.451 | |
| 1qbg | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.451 | |
| 1ra8 | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.451 | |
| 1upc | TPP | N(2)-(2-carboxyethyl)arginine synthase | / | 0.451 | |
| 1uyc | PU7 | Heat shock protein HSP 90-alpha | / | 0.451 | |
| 3flw | FLW | Mitogen-activated protein kinase 14 | / | 0.451 | |
| 3zdu | 38R | Cyclin-dependent kinase-like 3 | 2.7.11.22 | 0.451 | |
| 4f6w | 0SS | Cyclin-dependent kinase 8 | 2.7.11.22 | 0.451 | |
| 1dkf | BMS | Retinoic acid receptor alpha | / | 0.450 | |
| 1e1l | NAP | NADPH:adrenodoxin oxidoreductase, mitochondrial | 1.18.1.6 | 0.450 | |
| 1hbv | GAN | Gag-Pol polyprotein | / | 0.450 | |
| 1yjq | NAP | 2-dehydropantoate 2-reductase | 1.1.1.169 | 0.450 | |
| 2nru | T12 | Interleukin-1 receptor-associated kinase 4 | 2.7.11.1 | 0.450 | |
| 2w9h | TOP | Dihydrofolate reductase | 1.5.1.3 | 0.450 | |
| 2xj2 | 985 | Serine/threonine-protein kinase pim-1 | 2.7.11.1 | 0.450 | |
| 3kjr | NAP | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.450 | |
| 3uic | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | / | 0.450 | |
| 3up3 | XCA | aceDAF-12 | / | 0.450 | |
| 4qem | HC4 | Phospholipase A2 VRV-PL-VIIIa | / | 0.450 | |
| 1bdl | IM1 | Gag-Pol polyprotein | 3.4.23.16 | 0.449 | |
| 1pvg | ANP | DNA topoisomerase 2 | 5.99.1.3 | 0.449 | |
| 1pw6 | FRB | Interleukin-2 | / | 0.449 | |
| 1tqf | 32P | Beta-secretase 1 | 3.4.23.46 | 0.449 | |
| 1z7y | AA5 | Cysteine synthase 1 | 2.5.1.47 | 0.449 | |
| 2bri | ANP | Uridylate kinase | 2.7.4.22 | 0.449 | |
| 2qd4 | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.449 | |
| 3p8z | SAH | Genome polyprotein | 2.1.1.56 | 0.449 | |
| 4bca | FAD | Alkyldihydroxyacetonephosphate synthase, peroxisomal | 2.5.1.26 | 0.449 | |
| 4hmv | WUB | Phenazine biosynthesis protein PhzG | 1.4 | 0.449 | |
| 4kl9 | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.449 | |
| 4pmj | NAP | Putative oxidoreductase | / | 0.449 | |
| 5dp2 | NAP | CurF | / | 0.449 | |
| 1e8x | ATP | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.448 | |
| 1fdu | EST | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.448 | |
| 1qyx | ASD | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.448 | |
| 1rsz | DIH | Purine nucleoside phosphorylase | 2.4.2.1 | 0.448 | |
| 2gtm | LID | Mitogen-activated protein kinase 14 | / | 0.448 | |
| 2qhm | 7CS | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.448 | |
| 2xf0 | 4UB | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.448 | |
| 3bv2 | P38 | Mitogen-activated protein kinase 14 | / | 0.448 | |
| 3cjf | SAV | Vascular endothelial growth factor receptor 2 | 2.7.10.1 | 0.448 | |
| 3elm | 24F | Collagenase 3 | 3.4.24 | 0.448 | |
| 3nmp | PYV | Abscisic acid receptor PYL2 | / | 0.448 | |
| 3pqb | VGP | Putative oxidoreductase | / | 0.448 | |
| 3rai | X85 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.448 | |
| 4dpt | AGS | Mevalonate diphosphate decarboxylase | / | 0.448 | |
| 4f0e | 0RU | Poly [ADP-ribose] polymerase 15 | 2.4.2.30 | 0.448 | |
| 4olf | HFG | Proline--tRNA ligase | 6.1.1.15 | 0.448 | |
| 1lso | NAD | Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial | 1.1.1.35 | 0.447 | |
| 2oxi | NAD | Alcohol dehydrogenase E chain | 1.1.1.1 | 0.447 | |
| 2prh | 238 | Dihydroorotate dehydrogenase (quinone), mitochondrial | 1.3.5.2 | 0.447 | |
| 3caq | NDP | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.447 | |
| 3ixp | 834 | Ecdysone receptor | / | 0.447 | |
| 3maa | FKP | Adenylate cyclase type 2 | / | 0.447 | |
| 3maa | FKP | Adenylate cyclase type 5 | / | 0.447 | |
| 3t3c | 017 | Gag-Pol polyprotein | 3.4.23.16 | 0.447 | |
| 3up0 | D7S | aceDAF-12 | / | 0.447 | |
| 4epl | JAI | Jasmonic acid-amido synthetase JAR1 | 6.3.2 | 0.447 | |
| 4euf | NAD | Trans-2-enoyl-CoA reductase [NADH] | / | 0.447 | |
| 4fhk | 0U0 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.447 | |
| 4ftm | 1HK | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.447 | |
| 4mcd | 22L | tRNA (guanine-N(1)-)-methyltransferase | 2.1.1.228 | 0.447 | |
| 4mxo | DB8 | Proto-oncogene tyrosine-protein kinase Src | 2.7.10.2 | 0.447 | |
| 4qzu | RTL | Retinol-binding protein 2 | / | 0.447 | |
| 5cwa | 0GA | Anthranilate synthase component 1 | 4.1.3.27 | 0.447 | |
| 5e8w | STU | TGF-beta receptor type-1 | 2.7.11.30 | 0.447 | |
| 1jtv | TES | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.446 | |
| 1kqu | BR4 | Phospholipase A2, membrane associated | / | 0.446 | |
| 1n6l | GTP | Ras-related protein Rab-5A | / | 0.446 | |
| 1p0p | BCH | Cholinesterase | 3.1.1.8 | 0.446 | |
| 1x15 | NAD | NAD(P) transhydrogenase subunit alpha | 1.6.1.2 | 0.446 | |
| 1z6t | ADP | Apoptotic protease-activating factor 1 | / | 0.446 | |
| 2cgu | 3A3 | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.446 | |
| 2e0n | SAH | Precorrin-2 C20-methyltransferase | / | 0.446 | |
| 2gmh | FAD | Electron transfer flavoprotein-ubiquinone oxidoreductase, mitochondrial | 1.5.5.1 | 0.446 | |
| 2hcd | BIV | Vitamin D3 receptor A | / | 0.446 | |
| 2o7p | NAP | Riboflavin biosynthesis protein RibD | / | 0.446 | |
| 2p8u | COA | Hydroxymethylglutaryl-CoA synthase, cytoplasmic | 2.3.3.10 | 0.446 | |
| 3b9l | AZZ | Serum albumin | / | 0.446 | |
| 3c16 | FOK | Adenylate cyclase type 2 | / | 0.446 | |
| 3c16 | FOK | Adenylate cyclase type 5 | / | 0.446 | |
| 3clb | NAP | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.446 | |
| 3cps | NAD | Glyceraldehyde-3-phosphate dehydrogenase | / | 0.446 | |
| 3o9g | F53 | Gag-Pol polyprotein | / | 0.446 | |
| 3otf | CMP | Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 | / | 0.446 | |
| 3w0a | DS5 | Vitamin D3 receptor | / | 0.446 | |
| 4a83 | DXC | Major pollen allergen Bet v 1-A | / | 0.446 | |
| 4bqp | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.446 | |
| 4k5o | 1OT | M1 family aminopeptidase | 3.4.11 | 0.446 | |
| 4mf0 | 29Z | Tyrosine-protein kinase ITK/TSK | 2.7.10.2 | 0.446 | |
| 5h8t | RTL | Retinol-binding protein 1 | / | 0.446 | |
| 1di8 | DTQ | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.445 | |
| 1dr2 | TAP | Dihydrofolate reductase | 1.5.1.3 | 0.445 | |
| 1h1r | 6CP | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.445 | |
| 1jpa | ANP | Ephrin type-B receptor 2 | 2.7.10.1 | 0.445 | |
| 1you | PFD | Collagenase 3 | 3.4.24 | 0.445 | |
| 2acx | ANP | G protein-coupled receptor kinase 6 | 2.7.11.16 | 0.445 | |
| 2wip | P49 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.445 | |
| 3dt1 | P40 | Mitogen-activated protein kinase 14 | / | 0.445 | |
| 3qiz | QI2 | Botulinum neurotoxin type A | 3.4.24.69 | 0.445 | |
| 3u9n | 09H | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.445 | |
| 4btm | F8E | Tau-tubulin kinase 1 | 2.7.11.1 | 0.445 | |
| 4cgf | UJ6 | Integrase | / | 0.445 | |
| 4dfl | 0K0 | Tyrosine-protein kinase SYK | 2.7.10.2 | 0.445 | |
| 4ftl | H0K | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.445 | |
| 4ie6 | UN9 | Alpha-ketoglutarate-dependent dioxygenase FTO | / | 0.445 | |
| 4kug | NAD | 3-hydroxybutyryl-CoA dehydrogenase | / | 0.445 | |
| 4u97 | STU | Interleukin-1 receptor-associated kinase 4 | 2.7.11.1 | 0.445 | |
| 4wuo | NAD | 3-isopropylmalate dehydrogenase | 1.1.1.85 | 0.445 | |
| 4xq9 | NAD | Homospermidine synthase | 2.5.1.44 | 0.445 | |
| 5kcz | NAJ | Alcohol dehydrogenase E chain | 1.1.1.1 | 0.445 | |
| 1ewy | FAD | Ferredoxin--NADP reductase | 1.18.1.2 | 0.444 | |
| 1m78 | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.444 | |
| 1qvn | FRI | Interleukin-2 | / | 0.444 | |
| 2rhr | EMO | Putative ketoacyl reductase | 1.3.1 | 0.444 | |
| 2ydb | NAP | 2',3'-cyclic-nucleotide 3'-phosphodiesterase | 3.1.4.37 | 0.444 | |
| 3fwj | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.444 | |
| 3r2b | 05B | MAP kinase-activated protein kinase 2 | 2.7.11.1 | 0.444 | |
| 3uoz | FAD | 2-oxo-Delta(3)-4,5,5-trimethylcyclopentenylacetyl-CoA monooxygenase | 1.14.13.160 | 0.444 | |
| 4anq | VGH | ALK tyrosine kinase receptor | 2.7.10.1 | 0.444 | |
| 4g34 | 924 | Eukaryotic translation initiation factor 2-alpha kinase 3 | 2.7.11.1 | 0.444 | |
| 4jaj | XU1 | Aurora kinase A | 2.7.11.1 | 0.444 | |
| 4jx1 | CAH | Camphor 5-monooxygenase | 1.14.15.1 | 0.444 | |
| 4l7f | 1V5 | Mitogen-activated protein kinase 8 | 2.7.11.24 | 0.444 | |
| 1eio | GCH | Gastrotropin | / | 0.443 | |
| 1fdo | MGD | Formate dehydrogenase H | 1.1.99.33 | 0.443 | |
| 1kbq | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.443 | |
| 1q41 | IXM | Glycogen synthase kinase-3 beta | 2.7.11.26 | 0.443 | |
| 2cda | NAP | Glucose 1-dehydrogenase | / | 0.443 | |
| 2fzn | FAD | Bifunctional protein PutA | 1.5.5.2 | 0.443 | |
| 2ham | C33 | Vitamin D3 receptor | / | 0.443 | |
| 2hl2 | SSA | Threonine--tRNA ligase | 6.1.1.3 | 0.443 | |
| 2po7 | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.443 | |
| 2uzw | SS4 | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.443 | |
| 3byz | H11 | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.443 | |
| 3hmm | 855 | TGF-beta receptor type-1 | 2.7.11.30 | 0.443 | |
| 3n4m | CMP | cAMP-activated global transcriptional regulator CRP | / | 0.443 | |
| 3nr4 | PYV | Abscisic acid receptor PYL2 | / | 0.443 | |
| 4bc7 | FAD | Alkyldihydroxyacetonephosphate synthase, peroxisomal | 2.5.1.26 | 0.443 | |
| 4bkz | 1WS | Maternal embryonic leucine zipper kinase | 2.7.11.1 | 0.443 | |
| 4ew2 | DXY | Trifunctional purine biosynthetic protein adenosine-3 | 2.1.2.2 | 0.443 | |
| 4fqs | LYA | Thymidylate synthase ThyA | / | 0.443 | |
| 4nbt | NAD | 3-oxoacyl-[acyl-carrier-protein] reductase | / | 0.443 | |
| 4y35 | F90 | Endothiapepsin | 3.4.23.22 | 0.443 | |
| 3sn6 | P0G | Beta-2 adrenergic receptor | / | 0.443 | |
| 1h66 | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.442 | |
| 1kzu | RG1 | Light-harvesting protein B-800/850 alpha chain | / | 0.442 | |
| 1kzu | RG1 | Light-harvesting protein B-800/850 beta chain | / | 0.442 | |
| 1mrx | K57 | Gag-Pol polyprotein | 3.4.23.16 | 0.442 | |
| 1msn | JE2 | Gag-Pol polyprotein | 3.4.23.16 | 0.442 | |
| 1v35 | NAI | Enoyl-ACP reductase | / | 0.442 | |
| 2bik | BI1 | Serine/threonine-protein kinase pim-1 | 2.7.11.1 | 0.442 | |
| 2brb | PFQ | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.442 | |
| 2lfo | GCH | Fatty acid-binding protein, liver | / | 0.442 | |
| 2ozu | ACO | Histone acetyltransferase KAT6A | / | 0.442 | |
| 2pk3 | A2R | GDP-6-deoxy-D-mannose reductase | / | 0.442 | |
| 2xaa | NAD | Secondary alcohol dehydrogenase | / | 0.442 | |
| 3a62 | STU | Ribosomal protein S6 kinase beta-1 | 2.7.11.1 | 0.442 | |
| 3iph | G11 | Mitogen-activated protein kinase 14 | / | 0.442 | |
| 3kb6 | NAD | D-lactate dehydrogenase | / | 0.442 | |
| 3pe2 | E1B | Casein kinase II subunit alpha | 2.7.11.1 | 0.442 | |
| 3uhm | RFN | UDP-3-O-acyl-N-acetylglucosamine deacetylase | / | 0.442 | |
| 3vt9 | YI4 | Vitamin D3 receptor | / | 0.442 | |
| 4anm | WUL | Casein kinase II subunit alpha | 2.7.11.1 | 0.442 | |
| 4ftk | H9K | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.442 | |
| 4jin | 1L7 | RIO-type serine/threonine-protein kinase Rio1 | 2.7.11.1 | 0.442 | |
| 4xzj | NAD | Putative NAD(+)--arginine ADP-ribosyltransferase Vis | 2.4.2.31 | 0.442 | |
| 4yai | NAI | C alpha-dehydrogenase | / | 0.442 | |
| 4yt5 | H4M | H(2)-forming methylenetetrahydromethanopterin dehydrogenase-related protein MJ1338 | / | 0.442 | |
| 4z61 | ILE_THR_GLN_TYS_TYS | Phytosulfokine receptor 1 | 2.7.11.1 | 0.442 | |
| 5ajq | DB8 | Serine/threonine-protein kinase 10 | 2.7.11.1 | 0.442 | |
| 5ch7 | MD1 | DMSO reductase family type II enzyme, molybdopterin subunit | / | 0.442 | |
| 5hes | 032 | Mitogen-activated protein kinase kinase kinase 20 | 2.7.11.25 | 0.442 | |
| 1d8f | SPI | Stromelysin-1 | 3.4.24.17 | 0.441 | |
| 1gqt | ACP | Ribokinase | / | 0.441 | |
| 1jbp | ADP | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.441 | |
| 1q6t | 600 | Tyrosine-protein phosphatase non-receptor type 1 | 3.1.3.48 | 0.441 | |
| 1sd2 | MTH | S-methyl-5'-thioadenosine phosphorylase | / | 0.441 | |
| 1u2y | GOX | Pancreatic alpha-amylase | / | 0.441 | |
| 2bfq | AR6 | [Protein ADP-ribosylglutamate] hydrolase AF_1521 | 3.2.2 | 0.441 | |
| 2chz | 093 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.441 | |
| 2f2s | COA | Acetyl-CoA acetyltransferase, mitochondrial | 2.3.1.9 | 0.441 | |
| 2zfn | ACO | Histone acetyltransferase RTT109 | 2.3.1.48 | 0.441 | |
| 3cd3 | STU | Tyrosine-protein kinase Fes/Fps | 2.7.10.2 | 0.441 | |
| 3cd5 | 7HI | 3-hydroxy-3-methylglutaryl-coenzyme A reductase | 1.1.1.34 | 0.441 | |
| 3d7z | GK5 | Mitogen-activated protein kinase 14 | / | 0.441 | |
| 3da1 | FAD | Glycerol-3-phosphate dehydrogenase | / | 0.441 | |
| 3fkl | FKL | Mitogen-activated protein kinase 14 | / | 0.441 | |
| 3fp0 | FP0 | 15-O-acetyltransferase | / | 0.441 | |
| 3gxl | QIG | TGF-beta receptor type-1 | 2.7.11.30 | 0.441 | |
| 3mgd | ACO | Predicted acetyltransferase | / | 0.441 | |
| 3roc | 29B | Mitogen-activated protein kinase 14 | / | 0.441 | |
| 3v1s | 0LH | Strictosidine synthase | 4.3.3.2 | 0.441 | |
| 3vey | 0H5 | Glucokinase | 2.7.1.2 | 0.441 | |
| 3w5p | 4OA | Vitamin D3 receptor | / | 0.441 | |
| 4gyz | D5M | Tyrosyl-DNA phosphodiesterase 2 | 3.1.4 | 0.441 | |
| 4kin | 1M8 | Mitogen-activated protein kinase 14 | / | 0.441 | |
| 4mok | FAD | Pyranose 2-oxidase | / | 0.441 | |
| 4mzu | COA | WxcM-like protein | / | 0.441 | |
| 4ea3 | 0NN | Nociceptin receptor | / | 0.441 | |
| 1drf | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.440 | |
| 1me6 | IVS | Plasmepsin-2 | 3.4.23.39 | 0.440 | |
| 1s3u | TQD | Dihydrofolate reductase | 1.5.1.3 | 0.440 | |
| 1srf | MTB | Streptavidin | / | 0.440 | |
| 2b8t | THM | Thymidine kinase | / | 0.440 | |
| 2c31 | ADP | Oxalyl-CoA decarboxylase | 4.1.1.8 | 0.440 | |
| 2ghl | LIB | Mitogen-activated protein kinase 14 | / | 0.440 | |
| 2iml | FMN | Uncharacterized protein | / | 0.440 | |
| 2oh0 | 2PY | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.440 | |
| 2r3w | G3G | Gag-Pol polyprotein | 3.4.23.16 | 0.440 | |
| 2x8i | X8I | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.440 | |
| 2ycq | UPX | Serine/threonine-protein kinase Chk2 | 2.7.11.1 | 0.440 | |
| 3cmf | PDN | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.440 | |
| 3ndr | NAD | Pyridoxal 4-dehydrogenase | 1.1.1.107 | 0.440 | |
| 3vtd | TKD | Vitamin D3 receptor | / | 0.440 | |
| 3wrm | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.440 | |
| 4amb | DUD | Putative glycosyl transferase | / | 0.440 | |
| 4ans | VGH | ALK tyrosine kinase receptor | 2.7.10.1 | 0.440 | |
| 4bdd | Z0O | Serine/threonine-protein kinase Chk2 | 2.7.11.1 | 0.440 | |
| 4bfm | ANP | Maternal embryonic leucine zipper kinase | 2.7.11.1 | 0.440 | |
| 4c34 | STU | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.440 | |
| 4c4o | NAD | SADH | / | 0.440 | |
| 4f86 | SFG | Geranyl diphosphate 2-C-methyltransferase | 2.1.1.255 | 0.440 | |
| 4fe6 | 0TQ | Gag-Pol polyprotein | 3.4.23.16 | 0.440 | |
| 4fmx | CNL | 1,8-cineole 2-endo-monooxygenase | 1.14.13.156 | 0.440 | |
| 4fw8 | NAI | 3-oxoacyl-(Acyl-carrier-protein) reductase | / | 0.440 | |
| 4fxy | 0W2 | Neurolysin, mitochondrial | 3.4.24.16 | 0.440 | |
| 4j7d | I31 | E3 ubiquitin-protein ligase Mdm2 | 6.3.2 | 0.440 | |
| 4jvf | 17X | Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta | / | 0.440 | |
| 4k6f | NAP | Putative Acetoacetyl-CoA reductase | / | 0.440 | |
| 4mle | VO1 | Glucokinase | 2.7.1.2 | 0.440 | |
| 4wda | 2AM | 2',3'-cyclic-nucleotide 3'-phosphodiesterase | 3.1.4.37 | 0.440 |