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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4chzH75Integrase

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity
Align
4chzH75Integrase/1.000
2xf3J01Uncharacterized protein/0.521
3vt5YI2Vitamin D3 receptor/0.514
3vtcTK3Vitamin D3 receptor/0.499
3vt65YIVitamin D3 receptor/0.498
1rkhVD2Vitamin D3 receptor/0.496
3w5rLOAVitamin D3 receptor/0.495
4bfwZVWPantothenate kinase2.7.1.330.495
1wuuANPGalactokinase2.7.1.60.493
4ddrMMVDihydrofolate reductase1.5.1.30.493
4g210VPVitamin D3 receptor A/0.493
4fhd0TTSpore photoproduct lyase/0.492
2bxqIMNSerum albumin/0.491
3qge26FGenome polyprotein2.7.7.480.488
1cqp803Integrin alpha-L/0.487
1hlk113Metallo-beta-lactamase type 2/0.487
1rkgVD1Vitamin D3 receptor/0.487
4fhf0TTSpore photoproduct lyase/0.487
1ove358Mitogen-activated protein kinase 14/0.486
1rftPXMPyridoxal kinase2.7.1.350.486
2xvw9NRSerum albumin/0.486
3lcjCOAPhosphopantetheine adenylyltransferase/0.486
4q0a4OAVitamin D3 receptor A/0.485
1ej3CZHAequorin-2/0.484
4lsjLSJGlucocorticoid receptor/0.484
4qx5CMPcGMP-dependent protein kinase 12.7.11.120.484
2a9y26AAdenosine kinase2.7.1.200.482
2hamC33Vitamin D3 receptor/0.481
2hasC3OVitamin D3 receptor/0.480
2j9gADPBiotin carboxylase6.3.4.140.480
3d73NBBPheromone-binding protein ASP1/0.480
4ap1NAPSteroid monooxygenase/0.480
1i58ADPChemotaxis protein CheA2.7.13.30.479
2e16SAHDiphthine synthase/0.479
2hb7O1CVitamin D3 receptor/0.479
3dr1C5DVitamin D3 receptor A/0.478
3pn1IVHDNA ligase/0.478
3smkCW714-3-3 protein sigma/0.478
4g20484Vitamin D3 receptor A/0.478
2dsgSAHDiphthine synthase/0.477
2e8hSAHDiphthine synthase/0.477
2zbaZBATrichothecene 3-O-acetyltransferase/0.477
4qe6JN3Bile acid receptor/0.477
4v0s2HN3-dehydroquinate dehydratase4.2.1.100.477
1cq8PY6Aspartate aminotransferase2.6.1.10.476
1xjqADPBifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 12.7.1.250.476
2fa3ACOHydroxymethylglutaryl-CoA synthase/0.476
3angDCCTranscriptional repressor, TetR family/0.476
3dysIBMHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.476
4bb5HD2Corticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.476
4l9q9TPSerum albumin/0.476
4mv1ADPBiotin carboxylase6.3.4.140.476
1dr4HBIDihydrofolate reductase1.5.1.30.475
1ie8KH1Vitamin D3 receptor/0.475
1v8kANPKinesin-like protein KIF2C/0.475
2cjfRP43-dehydroquinate dehydratase4.2.1.100.475
2e08SAHDiphthine synthase/0.475
2wo7ASVIsopenicillin N synthase1.21.3.10.475
3bbfGDPNucleoside diphosphate kinase B2.7.4.60.475
3i0pNADMalate dehydrogenase, putative/0.475
3i6rJ5ZDihydroorotate dehydrogenase (quinone), mitochondrial1.3.5.20.475
3wv9FEGHmd co-occurring protein HcgE/0.475
4x81MVIMycinamicin III 3''-O-methyltransferase2.1.1.2370.475
1h9zRWFSerum albumin/0.474
2dsiSAHDiphthine synthase/0.474
2p6lSAHDiphthine synthase/0.474
2x06NADL-sulfolactate dehydrogenase/0.474
4j8tDOGUncharacterized PhzA/B-like protein PA3332/0.474
4qms1N1Serine/threonine-protein kinase 242.7.11.10.474
4rh10TTSpore photoproduct lyase/0.474
4rujVDXVitamin D3 receptor A/0.474
4xbfFADLysine-specific histone demethylase 1A10.474
1nbmADPATP synthase subunit beta, mitochondrial3.6.3.140.473
2ab8MTPAdenosine kinase2.7.1.200.473
2dv5SAHDiphthine synthase/0.473
2dv7SAHDiphthine synthase/0.473
3b9lAZZSerum albumin/0.473
3q7dNPXProstaglandin G/H synthase 21.14.99.10.473
3sl2ATPSensor histidine kinase WalK/0.473
3vrwYS5Vitamin D3 receptor/0.473
3zze6XPHepatocyte growth factor receptor2.7.10.10.473
4eqrCOACoenzyme A disulfide reductase/0.473
4h6zACOAlpha-tubulin N-acetyltransferase 1/0.473
4jqh1MFAlr2278 protein/0.473
4u9zCOAAlpha-tubulin N-acetyltransferase 1/0.473
1szmBI4cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.472
2dw4FADLysine-specific histone demethylase 1A10.472
2q46NAPUncharacterized protein At5g02240/0.472
1kqwRTLCellular retinol-binding protein type II/0.471
1n5vNOMActVA 6 protein/0.471
1s0zEB1Vitamin D3 receptor/0.471
1vgrCOAFormyl-CoA:oxalate CoA-transferase/0.471
3h3qH13Collagen type IV alpha-3-binding protein/0.471
4ead0NPThymidine phosphorylase2.4.2.40.471
4iae1DXAlr2278 protein/0.471
1fm7DFVChalcone--flavonone isomerase 15.5.1.60.470
1i59ANPChemotaxis protein CheA2.7.13.30.470
1i59ADPChemotaxis protein CheA2.7.13.30.470
1rd4L08Integrin alpha-L/0.470
2pb6SAHDiphthine synthase/0.470
2qzsADPGlycogen synthase2.4.1.210.470
2w6pOA4Biotin carboxylase6.3.4.140.470
2z4sADPChromosomal replication initiator protein DnaA/0.470
2zl9VDAVitamin D3 receptor/0.470
4aosNAPSteroid monooxygenase/0.470
1wxjIPLTryptophan synthase alpha chain/0.469
2ncdADPProtein claret segregational/0.469
2z7hGG3Geranylgeranyl pyrophosphate synthase/0.469
3dyqPCGHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.469
4dhyS41Glucokinase2.7.1.20.469
4g1y0VOVitamin D3 receptor A/0.469
3c3dFO12-phospho-L-lactate transferase/0.468
3jswJARHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.468
3zlmANPAdenosine monophosphate-protein transferase NmFic2.7.7.n10.468
4mv8ACPBiotin carboxylase6.3.4.140.468
1i58ACPChemotaxis protein CheA2.7.13.30.467
2a9z26AAdenosine kinase2.7.1.200.467
2eh4SAHDiphthine synthase/0.467
2wmwZYWSerine/threonine-protein kinase Chk12.7.11.10.467
3dhaC6LN-acyl homoserine lactonase AiiA3.1.1.810.467
3l6jZ90Alr2278 protein/0.467
3w5p4OAVitamin D3 receptor/0.467
4ckrDI1Epithelial discoidin domain-containing receptor 12.7.10.10.467
4mv3ACPBiotin carboxylase6.3.4.140.467
1vbiNADMalate/L-lactate dehydrogenase family protein/0.466
2xdaJPS3-dehydroquinate dehydratase4.2.1.100.466
3gncQQQGlutaryl-CoA dehydrogenase/0.466
3v1s0LHStrictosidine synthase4.3.3.20.466
1i5cADPChemotaxis protein CheA2.7.13.30.465
1ne4RP1cAMP-dependent protein kinase type I-alpha regulatory subunit/0.465
1po7TZDBenzoylformate decarboxylase4.1.1.70.465
2bbqPFGThymidylate synthase/0.465
3dcsMZMCarbonic anhydrase 24.2.1.10.465
3l034OHEstrogen receptor/0.465
3x04GNPPhosphatidylinositol 5-phosphate 4-kinase type-2 beta2.7.1.1490.465
4gusFADLysine-specific histone demethylase 1B10.465
4oew5IOcGMP-specific 3',5'-cyclic phosphodiesterase/0.465
4yp05IQHistidyl-tRNA synthetase, putative/0.465
5a88ADPRiboflavin biosynthesis protein RibF2.7.1.260.465
5iotUMPFlavin-dependent thymidylate synthase2.1.1.1480.465
2dshSAHDiphthine synthase/0.464
2hc4VDXVitamin D3 receptor A/0.464
2rehFADNitroalkane oxidase1.7.3.10.464
3s41S41Glucokinase2.7.1.20.464
3vrtYS2Vitamin D3 receptor/0.464
4iah1DXAlr2278 protein/0.464
1kqgMGDFormate dehydrogenase, nitrate-inducible, major subunit1.1.5.60.463
1qyxASDEstradiol 17-beta-dehydrogenase 11.1.1.620.463
2iypNAP6-phosphogluconate dehydrogenase, decarboxylating1.1.1.440.463
2jlbUDMUncharacterized protein/0.463
2oaxSNLMineralocorticoid receptor/0.463
2pk3A2RGDP-6-deoxy-D-mannose reductase/0.463
3p0fBAUUridine phosphorylase 22.4.2.30.463
3vt45YIVitamin D3 receptor/0.463
3zoiM2WIsopenicillin N synthase1.21.3.10.463
4g8zTOPDihydrofolate reductase1.5.1.30.463
1f0yCAAHydroxyacyl-coenzyme A dehydrogenase, mitochondrial1.1.1.350.462
1n3sGTPGTP cyclohydrolase 13.5.4.160.462
1pwuGM6Lethal factor3.4.24.830.462
1uaeUD1UDP-N-acetylglucosamine 1-carboxyvinyltransferase/0.462
1xddAAYIntegrin alpha-L/0.462
1y56FMNUncharacterized protein/0.462
1y56FMN382aa long hypothetical sarcosine oxidase/0.462
1yw7A41Methionine aminopeptidase 2/0.462
2b0qADPAminoglycoside 3'-phosphotransferase2.7.1.950.462
2dxwSAHDiphthine synthase/0.462
2e17SAHDiphthine synthase/0.462
4bfxZVXPantothenate kinase2.7.1.330.462
4eh3IRGMitogen-activated protein kinase 14/0.462
4x7wMVIMycinamicin III 3''-O-methyltransferase2.1.1.2370.462
1cg6MTAS-methyl-5'-thioadenosine phosphorylase/0.461
1i91INQCarbonic anhydrase 24.2.1.10.461
2hkoFADLysine-specific histone demethylase 1A10.461
2o4rVD5Vitamin D3 receptor/0.461
2owvSAHDiphthine synthase/0.461
2pb4SAHDiphthine synthase/0.461
2qu6857Vascular endothelial growth factor receptor 22.7.10.10.461
2w6zL21Biotin carboxylase6.3.4.140.461
2yx6ADPUncharacterized protein/0.461
3apwDP0Alpha-1-acid glycoprotein 2/0.461
3qvrFADGlucose oxidase1.1.3.40.461
3vtdTKDVitamin D3 receptor/0.461
4mprTPPBenzoylformate decarboxylase4.1.1.70.461
4u9yCOAAlpha-tubulin N-acetyltransferase 1/0.461
1ahiCHO7-alpha-hydroxysteroid dehydrogenase1.1.1.1590.460
1dd6MCIMetallo-beta-lactamase type 2/0.460
1l8tADPAminoglycoside 3'-phosphotransferase2.7.1.950.460
3af1GDPPantothenate kinase2.7.1.330.460
3h3r14HCollagen type IV alpha-3-binding protein/0.460
3n8wFLPProstaglandin G/H synthase 11.14.99.10.460
3v3m0ENReplicase polyprotein 1a3.4.19.120.460
4eqwCOACoenzyme A disulfide reductase/0.460
4zo3C6LAcylhomoserine lactonase/0.460
1m78NDPDihydrofolate reductase1.5.1.30.459
2bb3SAHCobalamin biosynthesis precorrin-6Y methylase (CbiE)/0.459
2eglSAHDiphthine synthase/0.459
2huxSAHDiphthine synthase/0.459
2p9dSAHDiphthine synthase/0.459
3gb4D3MDdmC/0.459
3gcq1BUMitogen-activated protein kinase 14/0.459
3h23B54Dihydropteroate synthase/0.459
4gi40EXQueuine tRNA-ribosyltransferase2.4.2.290.459
4tx9AMZPhosphoribosyl isomerase A/0.459
4xivACPChemotaxis protein CheA2.7.13.30.459
4yekTHMThymidine phosphorylase/0.459
1e2jTHMThymidine kinase/0.458
1gs4ZK5Androgen receptor/0.458
1rszDIHPurine nucleoside phosphorylase2.4.2.10.458
2emuSAHDiphthine synthase/0.458
3n3zIBMHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.458
4a51ADPKinesin-like protein KIF11/0.458
1qy2IPZMajor urinary protein 1/0.457
1w2cANPInositol-trisphosphate 3-kinase A2.7.1.1270.457
1ysx4EBSerum albumin/0.457
2bxmIMNSerum albumin/0.457
2fr3REACellular retinoic acid-binding protein 2/0.457
2gtbAZPOrf1ab polyprotein/0.457
2p6iSAHDiphthine synthase/0.457
2pcaSAHDiphthine synthase/0.457
2v5aLZLBiotin carboxylase6.3.4.140.457
2zshGA3Gibberellin receptor GID1A30.457
3d74NBBPheromone-binding protein ASP1/0.457
3w5tLHPVitamin D3 receptor/0.457
4bkjSTIEpithelial discoidin domain-containing receptor 12.7.10.10.457
5ab7MLCNonspecific lipid-transfer protein, putative/0.457
5epvACPBlue-light-activated histidine kinase2.7.13.30.457
1bk0ACVIsopenicillin N synthase1.21.3.10.456
1h50FMNPentaerythritol tetranitrate reductase/0.456
1zydATPeIF-2-alpha kinase GCN2/0.456
2eldSAHDiphthine synthase/0.456
2z52H23Geranylgeranyl pyrophosphate synthase/0.456
2zfiADPKinesin-like protein KIF1A/0.456
3fsjD7KBenzoylformate decarboxylase4.1.1.70.456
3vruYS3Vitamin D3 receptor/0.456
3wnzADPAlanine--anticapsin ligase/0.456
3zvuA8SAbscisic acid receptor PYR1/0.456
4fl1ANPTyrosine-protein kinase SYK2.7.10.20.456
4j24ESTEstrogen receptor beta/0.456
5hwpCOAHydroxymethylglutaryl-CoA synthase/0.456
1dghNDPCatalase1.11.1.60.455
1e79ADPATP synthase subunit alpha, mitochondrial/0.455
1e79ADPATP synthase subunit beta, mitochondrial3.6.3.140.455
1eqhFLPProstaglandin G/H synthase 11.14.99.10.455
1m8jNADNicotinamide-nucleotide adenylyltransferase2.7.7.10.455
2ek2SAHDiphthine synthase/0.455
2qd4CHDFerrochelatase, mitochondrial4.99.1.10.455
3d5wADPSerine/threonine-protein kinase PLK/0.455
3fkoFKOMitogen-activated protein kinase 14/0.455
3jyoNADQuinate/shikimate dehydrogenase (NAD(+))/0.455
3o3jBB4Peptide deformylase 1B, chloroplastic/mitochondrial3.5.1.880.455
4iteTEYVitamin D3 receptor/0.455
4x7zZM3Mycinamicin III 3''-O-methyltransferase2.1.1.2370.455
4xugF9FTryptophan synthase alpha chain/0.455
1gwrESTEstrogen receptor/0.454
1rgsCMPcAMP-dependent protein kinase type I-alpha regulatory subunit/0.454
2bfmTOPPteridine reductase 11.5.1.330.454
2i5nUQ1Reaction center protein L chain/0.454
2idkC2FGlycine N-methyltransferase2.1.1.200.454
2z4y252Geranylgeranyl pyrophosphate synthase/0.454
3c14FOKAdenylate cyclase type 2/0.454
3c14FOKAdenylate cyclase type 5/0.454
3cgyRDCVirulence sensor histidine kinase PhoQ2.7.13.30.454
3ns2PYVAbscisic acid receptor PYL2/0.454
3qi4IBMHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.454
4cdmFO1Deoxyribodipyrimidine photolyase/0.454
4fhh0U3Vitamin D3 receptor A/0.454
4l0oPLPCystathionine gamma-synthase2.5.1.480.454
5k2aZMAAdenosine receptor A2a/0.454
1ht834CProstaglandin G/H synthase 11.14.99.10.453
1synF89Thymidylate synthase/0.453
1towCRZFatty acid-binding protein, adipocyte/0.453
1xve3BBMethane monooxygenase component A beta chain1.14.13.250.453
1zz1SHHHistone deacetylase-like amidohydrolase3.5.10.453
2a5kAZPReplicase polyprotein 1ab3.4.220.453
2e20B4PPropionate kinase/0.453
2ed5SAHDiphthine synthase/0.453
2ejzSAHDiphthine synthase/0.453
2iviACWIsopenicillin N synthase1.21.3.10.453
2pchSAHDiphthine synthase/0.453
2qtaTDPPyruvate dehydrogenase E1 component1.2.4.10.453
3ahiHTLProbable phosphoketolase/0.453
3d78NBBPheromone-binding protein ASP1/0.453
3sgy06WDihydrofolate reductase1.5.1.30.453
3vf60H6Glucokinase2.7.1.20.453
3vtbTKAVitamin D3 receptor/0.453
4fcr0TMHeat shock protein HSP 90-alpha/0.453
4gukP2GNeuronal calcium sensor 1/0.453
4jbxSK7Thymidine kinase/0.453
4lzwTHMUridine phosphorylase/0.453
4pk4ADPUnconventional myosin-VI/0.453
1o5rFR9Adenosine deaminase3.5.4.40.452
2hcdBIVVitamin D3 receptor A/0.452
2z6rSAHDiphthine synthase/0.452
2zs8ADPPantothenate kinase2.7.1.330.452
3l3rOAGDihydrofolate reductase1.5.1.30.452
3new3NEMitogen-activated protein kinase 14/0.452
4i231C9Epidermal growth factor receptor2.7.10.10.452
4mv4ACPBiotin carboxylase6.3.4.140.452
4oeaDHTAndrogen receptor/0.452
4q5jANPProtein BRASSINOSTEROID INSENSITIVE 12.7.10.10.452
4qzuRTLRetinol-binding protein 2/0.452
4ytnFD8Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial/0.452
4ytnFD8Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial/0.452
4ytnFD8Succinate dehydrogenase cytochrome b560/0.452
1crbRTLRetinol-binding protein 1/0.451
1upaTPPN(2)-(2-carboxyethyl)arginine synthase/0.451
1xlsREARetinoic acid receptor RXR-alpha/0.451
1zrzBI1Protein kinase C iota type2.7.11.130.451
2belCBOCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.451
2g78REACellular retinoic acid-binding protein 2/0.451
2kt4EB4Extracellular fatty acid-binding protein/0.451
2prh238Dihydroorotate dehydrogenase (quinone), mitochondrial1.3.5.20.451
2v58LZJBiotin carboxylase6.3.4.140.451
2w6qOA5Biotin carboxylase6.3.4.140.451
2x7hPFNProstaglandin reductase 310.451
2y60M8FIsopenicillin N synthase1.21.3.10.451
3fhxPLPPyridoxal kinase2.7.1.350.451
3jsiWTCHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.451
3mvm39PMitogen-activated protein kinase 14/0.451
3qgi33FGenome polyprotein2.7.7.480.451
3rl35GPMetallophosphoesterase MPPED23.10.451
4fgcPQ0NADPH-dependent 7-cyano-7-deazaguanine reductase1.7.1.130.451
4j7uYTZSepiapterin reductase1.1.1.1530.451
4l5b1UXDeoxycytidine kinase2.7.1.740.451
4m2xTMQDihydrofolate reductase1.5.1.30.451
4x7uZM3Mycinamicin III 3''-O-methyltransferase2.1.1.2370.451
4y17LAETranscriptional regulator of ftsQAZ gene cluster/0.451
5hwrCOAHydroxymethylglutaryl-CoA synthase/0.451
3emlZMAAdenosine receptor A2a/0.451
1g1aNADdTDP-glucose 4,6-dehydratase/0.450
1gc5ADPADP-dependent glucokinase2.7.1.1470.450
1i2lDCSAminodeoxychorismate lyase4.1.3.380.450
1ivrCBAAspartate aminotransferase, mitochondrial2.6.1.10.450
1n2vBDIQueuine tRNA-ribosyltransferase2.4.2.290.450
1ne6SP1cAMP-dependent protein kinase type I-alpha regulatory subunit/0.450
1xpcAITEstrogen receptor/0.450
2b35TCLEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.450
2dxvSAHDiphthine synthase/0.450
2g1n1IGRenin3.4.23.150.450
2msdGNPMHC class I alpha chain/0.450
2o1xTDP1-deoxy-D-xylulose-5-phosphate synthase2.2.1.70.450
2xvv9DNSerum albumin/0.450
2ym7YM7Serine/threonine-protein kinase Chk12.7.11.10.450
3elm24FCollagenase 33.4.240.450
3jpuTY4Transcriptional activator protein LasR/0.450
3rr3FLRProstaglandin G/H synthase 21.14.99.10.450
4coxIMNProstaglandin G/H synthase 21.14.99.10.450
4ixd1HVIntegrin alpha-L/0.450
4q71FADBifunctional protein PutA/0.450
5fm7ADPRuvB-like helicase/0.450
1culFOKAdenylate cyclase type 2/0.449
1culFOKAdenylate cyclase type 5/0.449
1e94ANPATP-dependent protease ATPase subunit HslU/0.449
1h8hADPATP synthase subunit alpha, mitochondrial/0.449
1h8hADPATP synthase subunit beta, mitochondrial3.6.3.140.449
1hb1OCVIsopenicillin N synthase1.21.3.10.449
1mf0GDPAdenylosuccinate synthetase isozyme 1/0.449
1pnqNDPNAD(P) transhydrogenase subunit beta1.6.1.20.449
1ro98BRcAMP-specific 3',5'-cyclic phosphodiesterase 4B3.1.4.530.449
1wngSAHDiphthine synthase/0.449
1xdkREARetinoic acid receptor beta/0.449
1xuoLA1Integrin alpha-L/0.449
2acxANPG protein-coupled receptor kinase 62.7.11.160.449
2ed3SAHDiphthine synthase/0.449
2i0v6C3Macrophage colony-stimulating factor 1 receptor2.7.10.10.449
2yk2YJWHeat shock protein HSP 90-alpha/0.449
2z2dHSIMacrophage metalloelastase3.4.24.650.449
2zlaVDBVitamin D3 receptor/0.449
3byzH11Corticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.449
3e92G6AMitogen-activated protein kinase 14/0.449
3hdmMMGSerine/threonine-protein kinase Sgk12.7.11.10.449
3r5yF42Uncharacterized protein/0.449
4aoaIK2Beta-phenylalanine transaminase2.6.10.449
4bftZVTPantothenate kinase2.7.1.330.449
4iyg1HUStrictosidine synthase4.3.3.20.449
4mxxDB8Proto-oncogene tyrosine-protein kinase Src2.7.10.20.449
4twnB96Ephrin type-A receptor 32.7.10.10.449
4u0sADPAdenosine monophosphate-protein transferase FICD2.7.7.n10.449
5e5h0T1Succinyl-CoA:acetate CoA-transferase/0.449
6stdMS2Scytalone dehydratase4.2.1.940.449
1i05LTLMajor urinary protein 6/0.448
2aq7TL53-oxoacyl-[acyl-carrier-protein] synthase 12.3.1.410.448
2x7cKZ9Kinesin-like protein KIF11/0.448
2xk6EQHSerine/threonine-protein kinase Nek22.7.11.10.448
2z6iFMN2-nitropropane dioxygenase/0.448
3be2RAJVascular endothelial growth factor receptor 22.7.10.10.448
3c0i3AMPeripheral plasma membrane protein CASK2.7.11.10.448
3dntATPSerine/threonine-protein kinase toxin HipA/0.448
3nmnPYVAbscisic acid receptor PYL1/0.448
3w0hW12Vitamin D3 receptor/0.448
4h6uACOAlpha-tubulin N-acetyltransferase 1/0.448
4jju1MBGenome polyprotein2.7.7.480.448
4ubtCOASteroid 3-ketoacyl-CoA thiolase/0.448
1f9aATPNicotinamide-nucleotide adenylyltransferase/0.447
1fmjRTLRetinol dehydratase/0.447
1zzlTZYMitogen-activated protein kinase 14/0.447
2r2nKYNKynurenine/alpha-aminoadipate aminotransferase, mitochondrial2.6.1.390.447
2y71CB63-dehydroquinate dehydratase4.2.1.100.447
2zva1N1Tyrosine-protein kinase Lyn2.7.10.20.447
3e8xNAPBH1520 protein/0.447
3epsATPIsocitrate dehydrogenase kinase/phosphatase/0.447
3ix4TX1Transcriptional activator protein LasR/0.447
3sqwANPATP-dependent RNA helicase MSS116, mitochondrial3.6.4.130.447
4a2aATPCell division protein FtsA/0.447
4bfyZVYPantothenate kinase2.7.1.330.447
4dptAGSMevalonate diphosphate decarboxylase/0.447
4jv81M1Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta/0.447
4ubfADPKinesin-like protein KIF2C/0.447
1ay0TPPTransketolase 12.2.1.10.446
1jdzFMBPurine nucleoside phosphorylase/0.446
1nhhANPDNA mismatch repair protein MutL/0.446
1sd2MTHS-methyl-5'-thioadenosine phosphorylase/0.446
1u4sBIHL-lactate dehydrogenase1.1.1.270.446
1xp9AIJEstrogen receptor/0.446
1ybgTAVUDP-N-acetylglucosamine 1-carboxyvinyltransferase/0.446
2ij7TPFMycocyclosin synthase1.14.21.90.446
2jb4A14Isopenicillin N synthase1.21.3.10.446
2qtvGNPSmall COPII coat GTPase SAR13.6.50.446
2rdn1PL1-deoxypentalenic acid 11-beta-hydroxylase1.14.11.350.446
2rgeGNPGTPase HRas/0.446
2rkvZBATrichothecene 3-O-acetyltransferase/0.446
2xkeWI2Serine/threonine-protein kinase Nek22.7.11.10.446
3hv3R49Mitogen-activated protein kinase 14/0.446
3oiaA31Camphor 5-monooxygenase1.14.15.10.446
3rs4GNPGTPase HRas/0.446
3ungADPCRISPR system Cmr subunit Cmr2/0.446
4bewACPSarcoplasmic/endoplasmic reticulum calcium ATPase 13.6.3.80.446
4eqsCOACoenzyme A disulfide reductase/0.446
4ha6PXMPyridoxine 4-oxidase/0.446
4iv0SAMPhosphoethanolamine N-methyltransferase, putative/0.446
4j531J4Serine/threonine-protein kinase PLK12.7.11.210.446
5bt9NAP3-oxoacyl-(Acyl-carrier-protein) reductase/0.446
5jtbZMAAdenosine receptor A2a/0.446
4ug2NGIAdenosine receptor A2a/0.446
1a4lDCFAdenosine deaminase3.5.4.40.445
1cnfFADNitrate reductase [NADH]1.7.1.10.445
1cq7PY5Aspartate aminotransferase2.6.1.10.445
1dliUDXUDP-glucose 6-dehydrogenase/0.445
1esvLARActin, alpha skeletal muscle/0.445
1j7lADPAminoglycoside 3'-phosphotransferase2.7.1.950.445
1lhoAOMSex hormone-binding globulin/0.445
1mraAPGMandelate racemase/0.445
1rzuADPGlycogen synthase 12.4.1.210.445
1x8lOXRRetinol dehydratase/0.445
1z6lFADPolyamine oxidase FMS1/0.445
2bglNAJSecoisolariciresinol dehydrogenase1.1.1.3310.445
2e1zB4PPropionate kinase/0.445
2emrSAHDiphthine synthase/0.445
2gevCOKPantothenate kinase2.7.1.330.445
2itnANPEpidermal growth factor receptor2.7.10.10.445
2p5fSAHDiphthine synthase/0.445
2pupADPMethylthioribose kinase2.7.1.1000.445
2vssACOHydroxycinnamoyl-CoA hydratase-lyase4.1.2.410.445
2ym44YMSerine/threonine-protein kinase Chk12.7.11.10.445
2zsiGA4Gibberellin receptor GID1A30.445
3ae4FADSuccinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial/0.445
3e6yCW114-3-3-like protein C/0.445
3f8kCOAUncharacterized protein/0.445
3iktNADRedox-sensing transcriptional repressor Rex/0.445
3sgv2BJDitrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific)2.5.1.310.445
3t3iGPWGlycogen phosphorylase, muscle form2.4.1.10.445
3v0n4GWHisto-blood group ABO system transferase/0.445
4biwANPSensor histidine kinase CpxA/0.445
4equG6ISerine/threonine-protein kinase 102.7.11.10.445
4hbgNDP3-oxoacyl-[acyl-carrier-protein] reductase1.1.1.1000.445
4hp8NAP2-deoxy-D-gluconate 3-dehydrogenase/0.445
4ia7BIVVitamin D3 receptor A/0.445
4tjy3GNTankyrase-22.4.2.300.445
4yx6FMNOmega-3 polyunsaturated fatty acid synthase subunit PfaD/0.445
5difGNPGTP-binding nuclear protein Ran/0.445
1d3hA26Dihydroorotate dehydrogenase (quinone), mitochondrial1.3.5.20.444
1obnASVIsopenicillin N synthase1.21.3.10.444
1xngDNDNH(3)-dependent NAD(+) synthetase6.3.1.50.444
1yqzCOACoenzyme A disulfide reductase/0.444
2fb8215Serine/threonine-protein kinase B-raf2.7.11.10.444
2g44T3OEstrogen receptor/0.444
2qgtEEDEstrogen receptor/0.444
2vbpVB1Isopenicillin N synthase1.21.3.10.444
2ztvNADD(-)-3-hydroxybutyrate dehydrogenase/0.444
3d76NBBPheromone-binding protein ASP1/0.444
3ibqATPPyridoxal kinase/0.444
3k3ePDBHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.444
3rbaCODPhosphopantetheine adenylyltransferase/0.444
3up0D7SaceDAF-12/0.444
3zy6GFBGDP-fucose protein O-fucosyltransferase 12.4.1.2210.444
4bbxLKFcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.444
4emrMGPRibosome inactivating protein/0.444
4gh6LUOHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.444
4jq4IMNAldo-keto reductase family 1 member C2/0.444
4rraA3TProbable threonine--tRNA ligase 26.1.1.30.444
4uugPXGBranched-chain amino acid aminotransferase, putative/0.444
4xymCOAAcyl-CoA synthetase (NDP forming)/0.444
5i4nATPTyrosine-protein kinase JAK2/0.444
1a8t061Metallo-beta-lactamase type 2/0.443
1dkfBMSRetinoic acid receptor alpha/0.443
1dxrMSTReaction center protein L chain/0.443
1eqgIBPProstaglandin G/H synthase 11.14.99.10.443
1gky5GPGuanylate kinase2.7.4.80.443
1m8gNADNicotinamide-nucleotide adenylyltransferase2.7.7.10.443
1prcUQ1Reaction center protein L chain/0.443
1qjfACSIsopenicillin N synthase1.21.3.10.443
1qjgEQUSteroid Delta-isomerase5.3.3.10.443
1wpgADPSarcoplasmic/endoplasmic reticulum calcium ATPase 13.6.3.80.443
2b1z17MEstrogen receptor/0.443
2pckSAHDiphthine synthase/0.443
2v1aFMNNPH1-1/0.443
2w6oOA3Biotin carboxylase6.3.4.140.443
2xnmWGZSerine/threonine-protein kinase Nek22.7.11.10.443
3fw3ETSCarbonic anhydrase 44.2.1.10.443
3mneDEXGlucocorticoid receptor/0.443
3pvwQRXBeta-adrenergic receptor kinase 12.7.11.150.443
3ssnMVIMycinamicin VI 2''-O-methyltransferase/0.443
3vev0H4Glucokinase2.7.1.20.443
3w0iO11Vitamin D3 receptor/0.443
3zrrPXGSerine-pyruvate aminotransferase (AgxT)/0.443
3zu2NAIEnoyl-[acyl-carrier-protein] reductase [NADH]/0.443
4b42942Glucose-1-phosphate thymidylyltransferase/0.443
4bl5GFBGDP-L-fucose synthase1.1.1.2710.443
4fxy0W2Neurolysin, mitochondrial3.4.24.160.443
4iqlFMNEnoyl-(Acyl-carrier-protein) reductase II/0.443
4itxIN5Cystathionine beta-lyase MetC4.4.1.80.443
4z63ILE_THR_GLN_TYS_TYSPhytosulfokine receptor 12.7.11.10.443
1dljUGAUDP-glucose 6-dehydrogenase/0.442
1hb3SCVIsopenicillin N synthase1.21.3.10.442
1m8kNADNicotinamide-nucleotide adenylyltransferase2.7.7.10.442
1mdrAPGMandelate racemase/0.442
1mznBM6Retinoic acid receptor RXR-alpha/0.442
1pjcNADAlanine dehydrogenase/0.442
1w0kADPATP synthase subunit alpha, mitochondrial/0.442
1w0kADPATP synthase subunit beta, mitochondrial3.6.3.140.442
1yw8A75Methionine aminopeptidase 2/0.442
2apcUDMAlpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase2.4.1.1010.442
2atiIHUGlycogen phosphorylase, liver form2.4.1.10.442
2dekSAHDiphthine synthase/0.442
2dv4SAHDiphthine synthase/0.442
2ea2F77Methionine aminopeptidase 2/0.442
2vyxFMNDodecin/0.442
2x2rX2OKinesin-like protein KIF11/0.442
2ywvADPPhosphoribosylaminoimidazole-succinocarboxamide synthase/0.442
3h3t16HCollagen type IV alpha-3-binding protein/0.442
3m2vCOMMethyl-coenzyme M reductase I subunit alpha2.8.4.10.442
3nxyD2HDihydrofolate reductase1.5.1.30.442
3p2oNADBifunctional protein FolD/0.442
3vi5M4MHematopoietic prostaglandin D synthase/0.442
3vjoANPEpidermal growth factor receptor2.7.10.10.442
3wv7ADPHmd co-occurring protein HcgE/0.442
3zh8C58Protein kinase C iota type2.7.11.130.442
3zo7K6HMuconolactone Delta-isomerase/0.442
4e03ADPPlasmid partitioning protein ParF/0.442
4f6w0SSCyclin-dependent kinase 82.7.11.220.442
4feu537Aminoglycoside 3'-phosphotransferase AphA1-IAB/0.442
4gutFADLysine-specific histone demethylase 1B10.442
4i6gFADCryptochrome-2/0.442
4j521J3Serine/threonine-protein kinase PLK12.7.11.210.442
4jauADPSensor histidine kinase/0.442
4k9yK9YFocal adhesion kinase 12.7.10.20.442
4ku2MYA3-oxoacyl-[ACP] synthase III/0.442
4stdBFSScytalone dehydratase4.2.1.940.442
4x7vMIVMycinamicin III 3''-O-methyltransferase2.1.1.2370.442
4z64ILE_THR_GLN_TYS_TYSPhytosulfokine receptor 12.7.11.10.442
5ab6CAANonspecific lipid-transfer protein, putative/0.442
5iu86DZAdenosine receptor A2a/0.442
1kquBR4Phospholipase A2, membrane associated/0.441
1xpz4TZCarbonic anhydrase 24.2.1.10.441
2beiACODiamine acetyltransferase 22.3.1.570.441
2e8sSAHDiphthine synthase/0.441
2el0SAHDiphthine synthase/0.441
2hxzH7JCathepsin S3.4.22.270.441
2ioaADPBifunctional glutathionylspermidine synthetase/amidase/0.441
2lbvEB4Extracellular fatty acid-binding protein/0.441
2oo7AP5Adenylate kinase/0.441
2p1v5TNRetinoic acid receptor RXR-alpha/0.441
2piuDHTAndrogen receptor/0.441
2w5bAGSSerine/threonine-protein kinase Nek22.7.11.10.441
2w6mOA1Biotin carboxylase6.3.4.140.441
2zatNAPDehydrogenase/reductase SDR family member 41.1.1.1840.441
2zs9ADPPantothenate kinase2.7.1.330.441
3bx5304Mitogen-activated protein kinase 14/0.441
3cmpDBHNeutrophil gelatinase-associated lipocalin/0.441
3pvuQRWBeta-adrenergic receptor kinase 12.7.11.150.441
3qizQI2Botulinum neurotoxin type A3.4.24.690.441
3qviK95HAP protein/0.441
3tm0ANPAminoglycoside 3'-phosphotransferase2.7.1.950.441
4aw0ATP3-phosphoinositide-dependent protein kinase 12.7.11.10.441
4c72TLG3-oxoacyl-ACP synthase/0.441
4g2l0WLHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.441
4gt8ADPSensor protein VraS2.7.13.30.441
4n57ADPAPH(2'')-Id/0.441
4wqmFADToluene-4-monooxygenase electron transfer component1.18.1.30.441
4ycpFMNtRNA-dihydrouridine(16) synthase/0.441
5c88COAN-alpha-acetyltransferase/0.441
5ej9TPP2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase/0.441
5kf2COAPredicted acetyltransferase/0.441
1gwqZTWEstrogen receptor/0.440
1n71COAAac(6')-Ii protein/0.440
1oc1ASVIsopenicillin N synthase1.21.3.10.440
1sreHABStreptavidin/0.440
1toiHCIAspartate aminotransferase2.6.1.10.440
1tojHCIAspartate aminotransferase2.6.1.10.440
1w2dADPInositol-trisphosphate 3-kinase A2.7.1.1270.440
1ycgFMNNitric oxide reductase10.440
2a57CRM6,7-dimethyl-8-ribityllumazine synthase2.5.1.780.440
2amaDHTAndrogen receptor/0.440
2ejkSAHDiphthine synthase/0.440
2jblSMAReaction center protein L chain/0.440
2p8uCOAHydroxymethylglutaryl-CoA synthase, cytoplasmic2.3.3.100.440
2q7kTESAndrogen receptor/0.440
2rhrEMOPutative ketoacyl reductase1.3.10.440
2wmxZY6Serine/threonine-protein kinase Chk12.7.11.10.440
2y1oT26UDP-N-acetylmuramoylalanine--D-glutamate ligase6.3.2.90.440
2zm4KSMTyrosine-protein kinase Lck2.7.10.20.440
3biz61EWee1-like protein kinase2.7.10.20.440
3dogNNNCyclin-dependent kinase 22.7.11.220.440
3gytDL4Nuclear hormone receptor of the steroid/thyroid hormone receptors superfamily/0.440
3m34TPPTransketolase/0.440
3nu03TUDihydrofolate reductase1.5.1.30.440
3q23G2PVirion DNA-directed RNA polymerase/0.440
4ap7F47Hepatocyte growth factor receptor2.7.10.10.440
4cukNAID-lactate dehydrogenase/0.440
4du82P0Mevalonate diphosphate decarboxylase/0.440
4l9zCOAL-malyl-CoA/beta-methylmalyl-CoA lyase4.1.3.240.440
4o63NADGlyceraldehyde-3-phosphate dehydrogenase1.2.1.120.440
4rrmA3TProbable threonine--tRNA ligase 26.1.1.30.440
4yao2AMNADPH--cytochrome P450 reductase/0.440
5cpbNADEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.440
6gsuGPSGlutathione S-transferase Mu 12.5.1.180.440