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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4cesNFWIntegrase

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity
Align
4cesNFWIntegrase/1.000
4cjuJNSIntegrase/0.650
4ceoG0TIntegrase/0.634
4cerVL4Integrase/0.632
4cghLOZIntegrase/0.632
4cf23GMIntegrase/0.630
4ceqQCHIntegrase/0.626
4cec2SSIntegrase/0.621
4cefD0TIntegrase/0.619
4cj3E4FIntegrase/0.618
4cf8V7HIntegrase/0.617
4cjfRVNIntegrase/0.617
4cgjNZLIntegrase/0.613
4ceaZSWIntegrase/0.608
3zswZSWIntegrase/0.604
4cgd8P3Integrase/0.604
3zsvZSVIntegrase/0.600
4cebZSVIntegrase/0.600
4cf0O5UIntegrase/0.594
4cfaWOPIntegrase/0.590
4cfdS8YIntegrase/0.589
4cigX0PIntegrase/0.587
4ce9O3NIntegrase/0.586
4cgiNZLIntegrase/0.586
4cifJDXIntegrase/0.586
3zt0ZT0Integrase/0.585
4ck1OM1Integrase/0.585
4ck2NVUIntegrase/0.583
4cjrFYMIntegrase/0.580
4cjkH39Integrase/0.579
3zszOM2Integrase/0.575
4chyC5QIntegrase/0.575
4cjeQ31Integrase/0.575
4ceeB0TIntegrase/0.573
4cjqVXOIntegrase/0.572
3zsyOM3Integrase/0.569
4ck3K1TIntegrase/0.568
4cieY7NIntegrase/0.567
3zsrO3NIntegrase/0.566
4cezO3NIntegrase/0.566
3zt3ZT4Integrase/0.563
4cf1IY7Integrase/0.560
3zsxN44Integrase/0.559
4ced9NSIntegrase/0.559
3zsqO4NIntegrase/0.556
4cjp4D2Integrase/0.556
4cfbOM3Integrase/0.550
3zt1OM1Integrase/0.549
4cj54VWIntegrase/0.549
3zt2ZT2Integrase/0.545
4cfc7NVIntegrase/0.540
4cjsL0YIntegrase/0.539
3zcmPX3Integrase/0.534
4cggK5QIntegrase/0.532
4cj4S3GIntegrase/0.528
4chqCWUIntegrase/0.519
5iu4ZMAAdenosine receptor A2a/0.494
2nrySTUInterleukin-1 receptor-associated kinase 42.7.11.10.493
1rx8NAPDihydrofolate reductase1.5.1.30.491
4d03FADPhenylacetone monooxygenase1.14.13.920.491
4gj30XPNon-receptor tyrosine-protein kinase TYK22.7.10.20.491
2w9hTOPDihydrofolate reductase1.5.1.30.488
4ez30S0Cyclin-dependent kinase 22.7.11.220.485
1di8DTQCyclin-dependent kinase 22.7.11.220.482
1uxjNADMalate dehydrogenase/0.482
2cchATPCyclin-dependent kinase 22.7.11.220.481
3sw418KCyclin-dependent kinase 22.7.11.220.480
3emlZMAAdenosine receptor A2a/0.479
2nruT12Interleukin-1 receptor-associated kinase 42.7.11.10.477
3edjBCDCyclomaltodextrinase/0.476
1e9hINRCyclin-dependent kinase 22.7.11.220.475
4bzo676Serine/threonine-protein kinase pim-12.7.11.10.475
1bdlIM1Gag-Pol polyprotein3.4.23.160.474
1upcTPPN(2)-(2-carboxyethyl)arginine synthase/0.474
2npxNADNADH peroxidase1.11.1.10.473
3hdmMMGSerine/threonine-protein kinase Sgk12.7.11.10.473
1ia1NDPDihydrofolate reductase1.5.1.30.472
2bxmIMNSerum albumin/0.472
3bv3P39Mitogen-activated protein kinase 14/0.472
5hwrCOAHydroxymethylglutaryl-CoA synthase/0.472
3fhxPLPPyridoxal kinase2.7.1.350.471
2vttLZDCyclin-dependent kinase 22.7.11.220.470
3oibFDAPutative acyl-CoA dehydrogenase/0.470
4kip1R9Mitogen-activated protein kinase 14/0.470
5hes032Mitogen-activated protein kinase kinase kinase 202.7.11.250.470
1osvCHCBile acid receptor/0.469
4bcrWY1Peroxisome proliferator-activated receptor alpha/0.469
4fv7E94Mitogen-activated protein kinase 12.7.11.240.469
4l7f1V5Mitogen-activated protein kinase 82.7.11.240.469
1nvqUCNSerine/threonine-protein kinase Chk12.7.11.10.468
1xs7MMIBeta-secretase 13.4.23.460.468
3qziX72Cyclin-dependent kinase 22.7.11.220.468
4eji0QACytochrome P450 2A131.14.14.10.468
5ackATP3-phosphoinositide-dependent protein kinase 12.7.11.10.468
1jpaANPEphrin type-B receptor 22.7.10.10.467
3mvm39PMitogen-activated protein kinase 14/0.467
3s7a684Dihydrofolate reductase1.5.1.30.467
1mvsDTMDihydrofolate reductase1.5.1.30.466
1p0pBCHCholinesterase3.1.1.80.466
2briANPUridylate kinase2.7.4.220.466
4an4DUDPutative glycosyl transferase/0.466
4fko20KCyclin-dependent kinase 22.7.11.220.466
4fv0EK3Mitogen-activated protein kinase 12.7.11.240.466
2cbrA80Cellular retinoic acid-binding protein 1/0.465
2ylzFADPhenylacetone monooxygenase1.14.13.920.465
2zb3NDPProstaglandin reductase 21.3.1.480.465
3bv7NAP3-oxo-5-beta-steroid 4-dehydrogenase/0.465
3i5zZ48Mitogen-activated protein kinase 12.7.11.240.465
4e8wIHAD-beta-D-heptose 7-phosphate kinase/0.465
5iu86DZAdenosine receptor A2a/0.465
1m78NDPDihydrofolate reductase1.5.1.30.464
2ahrNAPPyrroline-5-carboxylate reductase/0.464
2xrwANPMitogen-activated protein kinase 82.7.11.240.464
5iubCLRAdenosine receptor A2a/0.464
1rx8FOLDihydrofolate reductase1.5.1.30.463
1u54ACPActivated CDC42 kinase 1/0.463
3d84NDPDihydrofolate reductase1.5.1.30.463
3pxyJWSCyclin-dependent kinase 22.7.11.220.463
3tqaNDPDihydrofolate reductase/0.463
4jb1FADUDP-N-acetylenolpyruvoylglucosamine reductase/0.463
5iua6DXAdenosine receptor A2a/0.463
2rh9IGPTryptophan synthase alpha chain/0.462
3qlrNDPDihydrofolate reductase1.5.1.30.462
4eiyZMAAdenosine receptor A2a/0.462
4jkyADPAdenylate kinase/0.462
1nq5NADGlyceraldehyde-3-phosphate dehydrogenase/0.461
1szmBI4cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.461
2c3kABOSerine/threonine-protein kinase Chk12.7.11.10.461
2vtjLZ4Cyclin-dependent kinase 22.7.11.220.461
3ddqRRCCyclin-dependent kinase 22.7.11.220.461
3g51ANPRibosomal protein S6 kinase alpha-32.7.11.10.461
4gllNADUDP-glucuronic acid decarboxylase 14.1.1.350.461
4y8wSTRSteroid 21-hydroxylase/0.461
1equEQIEstradiol 17-beta-dehydrogenase 11.1.1.620.460
2drcMTXDihydrofolate reductase1.5.1.30.460
2znq401Peroxisome proliferator-activated receptor delta/0.460
3be9P04Casein kinase II subunit alpha2.7.11.10.460
3ft5MO8Heat shock protein HSP 90-alpha/0.460
4a83DXCMajor pollen allergen Bet v 1-A/0.460
4qmpDKISerine/threonine-protein kinase 242.7.11.10.460
4tvbNADHomospermidine synthase2.5.1.440.460
4u9aSTUInterleukin-1 receptor-associated kinase 42.7.11.10.460
1kt8ILPBranched-chain-amino-acid aminotransferase, mitochondrial2.6.1.420.459
1rx1NAPDihydrofolate reductase1.5.1.30.459
2hxq373Serine/threonine-protein kinase Chk12.7.11.10.459
3gu83GUDeath-associated protein kinase 12.7.11.10.459
3k3hBYEHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.459
3tucFPWTyrosine-protein kinase SYK2.7.10.20.459
3vjoANPEpidermal growth factor receptor2.7.10.10.459
4dfrMTXDihydrofolate reductase1.5.1.30.459
4fhk0U0Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.459
4ks8B49Serine/threonine-protein kinase PAK 62.7.11.10.459
4kvgGTPRas-related protein Rap-1A/0.459
4l5b1UXDeoxycytidine kinase2.7.1.740.459
4z61ILE_THR_GLN_TYS_TYSPhytosulfokine receptor 12.7.11.10.459
5k2bZMAAdenosine receptor A2a/0.459
1fdsESTEstradiol 17-beta-dehydrogenase 11.1.1.620.458
1q43CMPPotassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2/0.458
2w0jZATSerine/threonine-protein kinase Chk22.7.11.10.458
2xckMH43-phosphoinositide-dependent protein kinase 12.7.11.10.458
2ylxFADPhenylacetone monooxygenase1.14.13.920.458
4bkz1WSMaternal embryonic leucine zipper kinase2.7.11.10.458
4hhz15SPoly [ADP-ribose] polymerase 12.4.2.300.458
4imfSI3N-acetylneuraminate lyase/0.458
4xcvNDPProbable hydroxyacid dehydrogenase protein/0.458
2eklNADD-3-phosphoglycerate dehydrogenase/0.457
3kb1ADPIron-sulfur cluster carrier protein/0.457
3qi4IBMHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.457
3t3r9PLCytochrome P450 2A61.14.130.457
4bdbODOSerine/threonine-protein kinase Chk22.7.11.10.457
4jl5ADPAdenylate kinase/0.457
1drhNAPDihydrofolate reductase1.5.1.30.456
1i5rHYCEstradiol 17-beta-dehydrogenase 11.1.1.620.456
1x2hLPALipoate-protein ligase A6.3.1.200.456
1xe65FPPlasmepsin-23.4.23.390.456
2ggsNDPdTDP-4-dehydrorhamnose reductase/0.456
2ix5FADAcyl-coenzyme A oxidase 4, peroxisomal1.3.3.60.456
2np8CC3Aurora kinase A2.7.11.10.456
2w3bNDPDihydrofolate reductase1.5.1.30.456
4bdfH3RSerine/threonine-protein kinase Chk22.7.11.10.456
4c02TAKActivin receptor type-12.7.11.300.456
4nbtNAD3-oxoacyl-[acyl-carrier-protein] reductase/0.456
5ar4SB2Receptor-interacting serine/threonine-protein kinase 22.7.11.10.456
5idwNAPShort-chain dehydrogenase/reductase SDR/0.456
1n2sNAIdTDP-4-dehydrorhamnose reductase1.1.1.1330.455
1nvsUCMSerine/threonine-protein kinase Chk12.7.11.10.455
1zc3GNPRas-related protein Ral-A/0.455
2c29NAPDihydroflavonol 4-reductase/0.455
2j2pSC2Ficolin-2/0.455
2q70DC8Estrogen receptor/0.455
2xk9XK9Serine/threonine-protein kinase Chk22.7.11.10.455
3aosJH2Hemolymph juvenile hormone binding protein/0.455
3dheANDEstradiol 17-beta-dehydrogenase 11.1.1.620.455
4bznUGXSerine/threonine-protein kinase pim-12.7.11.10.455
4ejmNAPPutative zinc-binding dehydrogenase/0.455
4i6gFADCryptochrome-2/0.455
4q71FADBifunctional protein PutA/0.455
5b1yNDP3-oxoacyl-[acyl-carrier-protein] reductase/0.455
1b15NAEAlcohol dehydrogenase1.1.1.10.454
1b16NAQAlcohol dehydrogenase1.1.1.10.454
1fmlRTLRetinol dehydratase/0.454
1sm2STUTyrosine-protein kinase ITK/TSK2.7.10.20.454
1u4oNDDL-lactate dehydrogenase1.1.1.270.454
1ve3SAMUncharacterized protein/0.454
2brgDFYSerine/threonine-protein kinase Chk12.7.11.10.454
2bsmBSMHeat shock protein HSP 90-alpha/0.454
2wmwZYWSerine/threonine-protein kinase Chk12.7.11.10.454
2ym2FADPhenylacetone monooxygenase1.14.13.920.454
3ac3KSHTyrosine-protein kinase Lck2.7.10.20.454
3ansS38Bifunctional epoxide hydrolase 23.3.2.100.454
3b6zCO7Enoyl reductase LovC10.454
3cd3STUTyrosine-protein kinase Fes/Fps2.7.10.20.454
3ijdC2FMethylenetetrahydrofolate reductase/0.454
3nww3NWMitogen-activated protein kinase 14/0.454
3u9n09HSerine/threonine-protein kinase Chk12.7.11.10.454
4dbzNDPPutative ketoacyl reductase1.3.10.454
4ft5H2KSerine/threonine-protein kinase Chk12.7.11.10.454
4jajXU1Aurora kinase A2.7.11.10.454
4mf029ZTyrosine-protein kinase ITK/TSK2.7.10.20.454
5eccNAPDehydrofolate reductase type I/0.454
1b2lNDCAlcohol dehydrogenase1.1.1.10.453
1cjuFOKAdenylate cyclase type 2/0.453
1cjuFOKAdenylate cyclase type 5/0.453
1hb1OCVIsopenicillin N synthase1.21.3.10.453
1msnJE2Gag-Pol polyprotein3.4.23.160.453
1q3ePCGPotassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2/0.453
1qoqIGPTryptophan synthase alpha chain/0.453
2ii5CO6Lipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex, mitochondrial2.3.1.1680.453
2oxwILE_ALA_GLYMacrophage metalloelastase3.4.24.650.453
3gyuDL7Nuclear hormone receptor of the steroid/thyroid hormone receptors superfamily/0.453
3mt817TGlycogen phosphorylase, muscle form2.4.1.10.453
3vt5YI2Vitamin D3 receptor/0.453
4ap1NAPSteroid monooxygenase/0.453
4bdhWVISerine/threonine-protein kinase Chk22.7.11.10.453
4ewn0VRImidazole glycerol phosphate synthase subunit HisF4.1.30.453
4ft7H3KSerine/threonine-protein kinase Chk12.7.11.10.453
4l521ULMitogen-activated protein kinase kinase kinase 72.7.11.250.453
4m6jNDPDihydrofolate reductase1.5.1.30.453
5e8ySTUTGF-beta receptor type-22.7.11.300.453
5k2aZMAAdenosine receptor A2a/0.453
1h74AGSHomoserine kinase2.7.1.390.452
1jtvTESEstradiol 17-beta-dehydrogenase 11.1.1.620.452
1k8y13PTryptophan synthase alpha chain/0.452
1obnASVIsopenicillin N synthase1.21.3.10.452
1xddAAYIntegrin alpha-L/0.452
2ituITQEpidermal growth factor receptor2.7.10.10.452
2nnlNAPDihydroflavonol 4-reductase1.1.1.2190.452
3a14NDP1-deoxy-D-xylulose 5-phosphate reductoisomerase/0.452
3vfqAR6Poly [ADP-ribose] polymerase 142.4.2.300.452
4du82P0Mevalonate diphosphate decarboxylase/0.452
4nfsNAJAlcohol dehydrogenase E chain1.1.1.10.452
4yp7NAPNicotinamide-nucleotide adenylyltransferase2.7.7.10.452
5kgpACOPredicted acetyltransferase/0.452
1p44NADEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.451
1urwI1PCyclin-dependent kinase 22.7.11.220.451
2gjnFMNNitronate monooxygenase1.13.12.160.451
2hog710Serine/threonine-protein kinase Chk12.7.11.10.451
2ycrHCWSerine/threonine-protein kinase Chk22.7.11.10.451
3fklFKLMitogen-activated protein kinase 14/0.451
3h3r14HCollagen type IV alpha-3-binding protein/0.451
3q33ACOHistone acetyltransferase RTT1092.3.1.480.451
4aotGW8Serine/threonine-protein kinase 102.7.11.10.451
4e8yIHAD-beta-D-heptose 7-phosphate kinase/0.451
4gh5NADShort-chain dehydrogenase/reductase SDR/0.451
4xuhSFIPeroxisome proliferator-activated receptor gamma/0.451
4xumIMNPeroxisome proliferator-activated receptor gamma/0.451
1cjkFOKAdenylate cyclase type 2/0.450
1cjkFOKAdenylate cyclase type 5/0.450
1diuBDMDihydrofolate reductase1.5.1.30.450
1qorNDPQuinone oxidoreductase 1/0.450
2ag5NAD3-hydroxybutyrate dehydrogenase type 2/0.450
2broDF2Serine/threonine-protein kinase Chk12.7.11.10.450
2bx8AZQSerum albumin/0.450
2el3SAHDiphthine synthase/0.450
2gyoCOA3-oxoacyl-[acyl-carrier-protein] synthase 3/0.450
2rhgIGPTryptophan synthase alpha chain/0.450
2rqfJH3Hemolymph juvenile hormone binding protein/0.450
2xf04UBSerine/threonine-protein kinase Chk12.7.11.10.450
3exhTPPPyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial1.2.4.10.450
3exhTPPPyruvate dehydrogenase E1 component subunit beta, mitochondrial1.2.4.10.450
3iphG11Mitogen-activated protein kinase 14/0.450
3n3zIBMHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.450
3nxxNDPDihydrofolate reductase1.5.1.30.450
3pe2E1BCasein kinase II subunit alpha2.7.11.10.450
3qtxX43Cyclin-dependent kinase 22.7.11.220.450
4bddZ0OSerine/threonine-protein kinase Chk22.7.11.10.450
4fkr45KCyclin-dependent kinase 22.7.11.220.450
4g1z0VPVitamin D3 receptor A/0.450
4gvjADPNon-receptor tyrosine-protein kinase TYK22.7.10.20.450
1cbfSAHCobalt-precorrin-4 C(11)-methyltransferase2.1.1.2710.449
1kfbIGPTryptophan synthase alpha chain/0.449
1pzhNADLactate dehydrogenase/0.449
2ayp43ASerine/threonine-protein kinase Chk12.7.11.10.449
3ad6KSCTyrosine-protein kinase Lck2.7.10.20.449
3aw9NADNAD-dependent epimerase/dehydratase/0.449
3cjfSAVVascular endothelial growth factor receptor 22.7.10.10.449
3gbuATPUncharacterized sugar kinase PH14592.7.10.449
3gobHXXDdmC/0.449
3iok1P6Tyrosine-protein kinase JAK2/0.449
3lkiATPFructokinase/0.449
3py0SU9Cyclin-dependent kinase 22.7.11.220.449
3r354CO4-hydroxybenzoyl-CoA thioesterase3.1.2.230.449
3rfxNADUronate dehydrogenase/0.449
3rmf20ZCyclin-dependent kinase 22.7.11.220.449
4cukNAID-lactate dehydrogenase/0.449
4djaFAD(6-4) photolyase/0.449
4eplJAIJasmonic acid-amido synthetase JAR16.3.20.449
4f32N323-oxoacyl-[acyl-carrier-protein] synthase 2/0.449
4hjoAQ4Epidermal growth factor receptor2.7.10.10.449
4pd6URINucleoside permease/0.449
4xq9NADHomospermidine synthase2.5.1.440.449
1e6wNAD3-hydroxyacyl-CoA dehydrogenase type-21.1.1.350.448
1q41IXMGlycogen synthase kinase-3 beta2.7.11.260.448
1txtCAAHMG-CoA synthase/0.448
1u2gAPRNAD(P) transhydrogenase subunit alpha part 11.6.1.20.448
1ur5NADMalate dehydrogenase/0.448
2acxANPG protein-coupled receptor kinase 62.7.11.160.448
2d4eNAD5-carboxymethyl-2-hydroxymuconate semialdehyde dehydrogenaseiheyensis HTE831]/0.448
2dv3SAHDiphthine synthase/0.448
2o7pNAPRiboflavin biosynthesis protein RibD/0.448
2wmqZYQSerine/threonine-protein kinase Chk12.7.11.10.448
2wyvNADEnoyl-[acyl-carrier-protein] reductase [NADH]/0.448
2zv9PP2Tyrosine-protein kinase Lyn2.7.10.20.448
3g1rNAP3-oxo-5-beta-steroid 4-dehydrogenase/0.448
3h3t16HCollagen type IV alpha-3-binding protein/0.448
3hk1B64Fatty acid-binding protein, adipocyte/0.448
3iaeD7KBenzaldehyde lyase/0.448
3k4nFADPyranose 2-oxidase/0.448
3rk507ZCyclin-dependent kinase 22.7.11.220.448
3wgnGSPCell division protein FtsZ/0.448
4a81DXCMajor pollen allergen Bet v 1-A/0.448
4bf2STUMitogen-activated protein kinase kinase kinase 52.7.11.250.448
4cr8NADN-acylmannosamine 1-dehydrogenase1.1.1.2330.448
4ix4ADPUncharacterized protein/0.448
1ad3NADAldehyde dehydrogenase, dimeric NADP-preferring/0.447
1cs4FOKAdenylate cyclase type 2/0.447
1cs4FOKAdenylate cyclase type 5/0.447
1me6IVSPlasmepsin-23.4.23.390.447
1pd9CO4Dihydrofolate reductase1.5.1.30.447
1scuCOASuccinate--CoA ligase [ADP-forming] subunit alpha6.2.1.50.447
1sxjADPReplication factor C subunit 5/0.447
2bfyH1NAurora kinase B-A2.7.11.10.447
2bhhRYUCyclin-dependent kinase 22.7.11.220.447
2d52COA5,7-dihydroxy-2-methylchromone synthase2.3.1.2160.447
2feuCAMCamphor 5-monooxygenase1.14.15.10.447
2qhm7CSSerine/threonine-protein kinase Chk12.7.11.10.447
2vnkFADNADPH:ferredoxin reductase/0.447
2y6o1N1Ephrin type-A receptor 42.7.10.10.447
3gfzFMNUncharacterized protein/0.447
3pjcPJCTyrosine-protein kinase JAK32.7.10.20.447
3w0rANPHygromycin-B 4-O-kinase2.7.1.1630.447
4a4vYFDPeroxisome proliferator-activated receptor gamma/0.447
4fsqHK3Serine/threonine-protein kinase Chk12.7.11.10.447
4ienCOAPutative acyl-CoA hydrolase/0.447
4k9dNADGlyceraldehyde-3-phosphate dehydrogenase1.2.1.120.447
4nd3NADLactate dehydrogenase, adjacent gene encodes predicted malate dehydrogenase/0.447
4ng2OHNTranscriptional activator protein LasR/0.447
4u97STUInterleukin-1 receptor-associated kinase 42.7.11.10.447
4zwpM44Xaa-Pro dipeptidase3.4.13.90.447
5e8wSTUTGF-beta receptor type-12.7.11.300.447
1f8gNADNAD(P) transhydrogenase subunit alpha part 11.6.1.20.446
1ozhHE3Acetolactate synthase, catabolic2.2.1.60.446
1ykdCMPAdenylate cyclase/0.446
2bbwGP5Adenylate kinase 4, mitochondrial/0.446
2gtmLIDMitogen-activated protein kinase 14/0.446
2p9gNAID-3-phosphoglycerate dehydrogenase1.1.1.950.446
2pvyACPFibroblast growth factor receptor 2/0.446
2zbaZBATrichothecene 3-O-acetyltransferase/0.446
2zrjAGSProtein RecA/0.446
3c14FOKAdenylate cyclase type 2/0.446
3c14FOKAdenylate cyclase type 5/0.446
3dgaNDPBifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.446
3eljGS7Mitogen-activated protein kinase 82.7.11.240.446
3mknDNBPyrimidine-specific ribonucleoside hydrolase RihB/0.446
3q43D66M1 family aminopeptidase3.4.110.446
3qt62P0Mevalonate diphosphate decarboxylase/0.446
3qtqX35Cyclin-dependent kinase 22.7.11.220.446
3r9nZ68Cyclin-dependent kinase 22.7.11.220.446
3toh079Gag-Pol polyprotein2.7.7.490.446
3triNAPPyrroline-5-carboxylate reductase/0.446
3zlyYSODual specificity mitogen-activated protein kinase kinase 12.7.12.20.446
4acm7YGCyclin-dependent kinase 22.7.11.220.446
4bdcODHSerine/threonine-protein kinase Chk22.7.11.10.446
4bftZVTPantothenate kinase2.7.1.330.446
4boeCLRJapanin/0.446
4e907RGHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.446
4qmwKS1Serine/threonine-protein kinase 242.7.11.10.446
4r8qADPMitotic checkpoint serine/threonine-protein kinase BUB12.7.11.10.446
5dr2ATPAurora kinase A2.7.11.10.446
5fl3ADPPili retraction protein PilT/0.446
1bygSTUTyrosine-protein kinase CSK/0.445
1eh4IC1Casein kinase I homolog 12.7.11.10.445
1eioGCHGastrotropin/0.445
1fp2HMOIsoflavone-7-O-methyltransferase 82.1.1.1500.445
1hbvGANGag-Pol polyprotein/0.445
1jtuLYBThymidylate synthase/0.445
1zys199Serine/threonine-protein kinase Chk12.7.11.10.445
2ahvCOAAcetate CoA-transferase YdiF2.8.3.80.445
2brbPFQSerine/threonine-protein kinase Chk12.7.11.10.445
2g1n1IGRenin3.4.23.150.445
2tpsTPSThiamine-phosphate synthase/0.445
2xnbY8LCyclin-dependent kinase 22.7.11.220.445
2ym3YM3Serine/threonine-protein kinase Chk12.7.11.10.445
3akn11DFatty acid-binding protein, intestinal/0.445
3apfBMWPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.445
3cppCAMCamphor 5-monooxygenase1.14.15.10.445
3dysIBMHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.445
3lsiFADPyranose 2-oxidase/0.445
3mpiFADGlutaryl-CoA dehydrogenase1.3.99.320.445
3n6uTSUHTH-type transcriptional regulator TsaR/0.445
3zos0LIEpithelial discoidin domain-containing receptor 12.7.10.10.445
4c62XWWTyrosine-protein kinase JAK2/0.445
4cgfUJ6Integrase/0.445
4cvmANPUDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase/0.445
4h8nNDPNADPH-dependent conjugated polyketone reductase C2/0.445
4hj2LZ6Glutathione S-transferase A12.5.1.180.445
4iwq1FVSerine/threonine-protein kinase TBK12.7.11.10.445
4k5o1OTM1 family aminopeptidase3.4.110.445
4mf129YTyrosine-protein kinase ITK/TSK2.7.10.20.445
4ea30NNNociceptin receptor/0.445
1ahiCHO7-alpha-hydroxysteroid dehydrogenase1.1.1.1590.444
1draMTXDihydrofolate reductase1.5.1.30.444
1ie8KH1Vitamin D3 receptor/0.444
1m75CAAHydroxyacyl-coenzyme A dehydrogenase, mitochondrial1.1.1.350.444
1ol6ATPAurora kinase A2.7.11.10.444
1zx1CB1Ribosyldihydronicotinamide dehydrogenase [quinone]/0.444
2d3mCOA5,7-dihydroxy-2-methylchromone synthase2.3.1.2160.444
2ejjSAHDiphthine synthase/0.444
2eleSAHDiphthine synthase/0.444
2fhnBNIAvidin-related protein 4/5/0.444
2i5bADPPyridoxine kinase/0.444
2ojg19AMitogen-activated protein kinase 12.7.11.240.444
2wmxZY6Serine/threonine-protein kinase Chk12.7.11.10.444
2xikJ60Serine/threonine-protein kinase 252.7.11.10.444
2xmyCDKCyclin-dependent kinase 22.7.11.220.444
2zevB71Geranylgeranyl pyrophosphate synthase/0.444
2znpK55Peroxisome proliferator-activated receptor delta/0.444
3icsCOACoenzyme A disulfide reductase/0.444
3unk0BYCyclin-dependent kinase 22.7.11.220.444
3vrwYS5Vitamin D3 receptor/0.444
3w0hW12Vitamin D3 receptor/0.444
3w0jT08Vitamin D3 receptor/0.444
4fuyEK2Mitogen-activated protein kinase 12.7.11.240.444
4gk2L66Ephrin type-A receptor 32.7.10.10.444
4kugNAD3-hydroxybutyryl-CoA dehydrogenase/0.444
4mdhNADMalate dehydrogenase, cytoplasmic1.1.1.370.444
4oztP1AEcdysone receptor, putative/0.444
4yt5H4MH(2)-forming methylenetetrahydromethanopterin dehydrogenase-related protein MJ1338/0.444
1n9lFMNPutative blue light receptor/0.443
1nq14HYThyroid hormone receptor beta/0.443
1r6g442Thyroid hormone receptor beta/0.443
1sowNADL-lactate dehydrogenase1.1.1.270.443
1uu8BI13-phosphoinositide-dependent protein kinase 12.7.11.10.443
2clqSTUMitogen-activated protein kinase kinase kinase 52.7.11.250.443
2e8rSAHDiphthine synthase/0.443
2fn7NADLactate dehydrogenase, adjacent gene encodes predicted malate dehydrogenase/0.443
2i4pDRHPeroxisome proliferator-activated receptor gamma/0.443
2p4yC03Peroxisome proliferator-activated receptor gamma/0.443
2qbmCAMCamphor 5-monooxygenase1.14.15.10.443
2uv0OHNTranscriptional activator protein LasR/0.443
2uxhQUEHTH-type transcriptional regulator TtgR/0.443
3ag9A02cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.443
3bi2FADPolyamine oxidase FMS1/0.443
3dopNAP3-oxo-5-beta-steroid 4-dehydrogenase/0.443
3gbk2PQPeroxisome proliferator-activated receptor gamma/0.443
3rk909ZCyclin-dependent kinase 22.7.11.220.443
3zkyWT4Isopenicillin N synthase1.21.3.10.443
4acc7YGGlycogen synthase kinase-3 beta2.7.11.260.443
4cvlACPUDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase/0.443
4hbm0Y7E3 ubiquitin-protein ligase Mdm26.3.20.443
4iacACPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.443
4ixfIXFDihydrofolate reductase1.5.1.30.443
4jazSTLPeroxisome proliferator-activated receptor gamma/0.443
4ly91YYGlucokinase regulatory protein/0.443
4nd4NADLactate dehydrogenase, adjacent gene encodes predicted malate dehydrogenase/0.443
5a88ADPRiboflavin biosynthesis protein RibF2.7.1.260.443
1crbRTLRetinol-binding protein 1/0.442
1fdwESTEstradiol 17-beta-dehydrogenase 11.1.1.620.442
1kqwRTLCellular retinol-binding protein type II/0.442
1p8dCO1Oxysterols receptor LXR-beta/0.442
1rrmAPRLactaldehyde reductase1.1.1.770.442
1upw444Oxysterols receptor LXR-beta/0.442
2ft0ACOdTDP-fucosamine acetyltransferase/0.442
2gilGTPRas-related protein Rab-6A/0.442
2pb6SAHDiphthine synthase/0.442
2q6sPLBPeroxisome proliferator-activated receptor gamma/0.442
3flzFLZMitogen-activated protein kinase 14/0.442
3ral04ZCyclin-dependent kinase 22.7.11.220.442
3unj0BXCyclin-dependent kinase 22.7.11.220.442
4b8wNAPGDP-L-fucose synthase1.1.1.2710.442
4c36ZO9cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.442
4eutBX7Serine/threonine-protein kinase TBK12.7.11.10.442
4fod0UVALK tyrosine kinase receptor2.7.10.10.442
4j7uNAPSepiapterin reductase1.1.1.1530.442
4k6fNAPPutative Acetoacetyl-CoA reductase/0.442
4lva20MNicotinamide phosphoribosyltransferase2.4.2.120.442
4y93746Tyrosine-protein kinase/0.442
5jtbZMAAdenosine receptor A2a/0.442
1ef92CPMethylmalonyl-CoA decarboxylase4.1.1.410.441
1h65GDPTranslocase of chloroplast 343.6.50.441
1rfvADPPyridoxal kinase2.7.1.350.441
1rx7FOLDihydrofolate reductase1.5.1.30.441
1u59STUTyrosine-protein kinase ZAP-702.7.10.20.441
1w0xOLOCyclin-dependent kinase 22.7.11.220.441
1wwkNAD307aa long hypothetical phosphoglycerate dehydrogenase/0.441
1x8lOXRRetinol dehydratase/0.441
1z6tADPApoptotic protease-activating factor 1/0.441
1zrzBI1Protein kinase C iota type2.7.11.130.441
2hr8SAHDiphthine synthase/0.441
2q5oPPYIndole-3-pyruvate decarboxylase4.1.1.740.441
2wo7ASVIsopenicillin N synthase1.21.3.10.441
2wotZZGTGF-beta receptor type-12.7.11.300.441
2yaaATPDeath-associated protein kinase 2/0.441
2yirYIRSerine/threonine-protein kinase Chk22.7.11.10.441
3b8r887Vascular endothelial growth factor receptor 22.7.10.10.441
3ec0GRLGag-Pol polyprotein3.4.23.470.441
3efwAK8Aurora kinase A2.7.11.10.441
3i60E86Mitogen-activated protein kinase 12.7.11.240.441
3lqfNADGalactitol dehydrogenase/0.441
3mteSAM16S rRNA (adenine(1408)-N(1))-methyltransferase2.1.1.1800.441
3qlsNDPDihydrofolate reductase1.5.1.30.441
3s1dZIRCytokinin dehydrogenase 11.5.99.120.441
3s2pPMUCyclin-dependent kinase 22.7.11.220.441
3up4FAD2-oxo-Delta(3)-4,5,5-trimethylcyclopentenylacetyl-CoA monooxygenase1.14.13.1600.441
3w0gW07Vitamin D3 receptor/0.441
3zoiM2WIsopenicillin N synthase1.21.3.10.441
4a322CDGlycylpeptide N-tetradecanoyltransferase/0.441
4a9rRU5Serine/threonine-protein kinase Chk22.7.11.10.441
4awo99BHeat shock protein HSP 90-alpha/0.441
4fszHK8Serine/threonine-protein kinase Chk12.7.11.10.441
4ftn2HKSerine/threonine-protein kinase Chk12.7.11.10.441
4g95OAGDihydrofolate reductase1.5.1.30.441
4jin1L7RIO-type serine/threonine-protein kinase Rio12.7.11.10.441
4kxn6K62'-deoxynucleoside 5'-phosphate N-hydrolase 1/0.441
4loqSB4Mitogen-activated protein kinase 14/0.441
4mv8ACPBiotin carboxylase6.3.4.140.441
4r1lADPPhenylacetate-coenzyme A ligase/0.441
5dhgDGVNociceptin receptor/0.441
5k2dZMAAdenosine receptor A2a/0.441
1f17NAIHydroxyacyl-coenzyme A dehydrogenase, mitochondrial1.1.1.350.440
1fm9570Peroxisome proliferator-activated receptor gamma/0.440
1h1s4SPCyclin-dependent kinase 22.7.11.220.440
1n5dNDPCarbonyl reductase [NADPH] 1/0.440
1nbiSAMGlycine N-methyltransferase2.1.1.200.440
1pjkANPCasein kinase II subunit alpha2.7.11.10.440
1pq944BOxysterols receptor LXR-beta/0.440
2aa0MTPAdenosine kinase2.7.1.200.440
2cf6NAPCinnamyl alcohol dehydrogenase 51.1.1.1950.440
2cgv3B3Serine/threonine-protein kinase Chk12.7.11.10.440
2e07SAHDiphthine synthase/0.440
2g2zCOZMalonyl CoA-acyl carrier protein transacylase2.3.1.390.440
2p8uCOAHydroxymethylglutaryl-CoA synthase, cytoplasmic2.3.3.100.440
2pvnP63Casein kinase II subunit alpha2.7.11.10.440
2xa4AZ5Tyrosine-protein kinase JAK2/0.440
2ydoADNAdenosine receptor A2a/0.440
2ym44YMSerine/threonine-protein kinase Chk12.7.11.10.440
2zva1N1Tyrosine-protein kinase Lyn2.7.10.20.440
3byzH11Corticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.440
3cvuFADRE11660p/0.440
3orfNADDihydropteridine reductase1.5.1.340.440
3p7nFMNLight-activated DNA-binding protein EL222/0.440
3r7eX88Cyclin-dependent kinase 22.7.11.220.440
3sfeFADSuccinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial/0.440
3up5FAD2-oxo-Delta(3)-4,5,5-trimethylcyclopentenylacetyl-CoA monooxygenase1.14.13.1600.440
3zewSTUEphrin type-B receptor 42.7.10.10.440
4bb3KKAIsopenicillin N synthase1.21.3.10.440
4bdiHAUSerine/threonine-protein kinase Chk22.7.11.10.440
4e200MYNon-receptor tyrosine-protein kinase TYK22.7.10.20.440
4fg8ATPCalcium/calmodulin-dependent protein kinase type 12.7.11.170.440
4fkzUD1UDP-N-acetylglucosamine 2-epimerase5.1.3.140.440
4gii0X6Non-receptor tyrosine-protein kinase TYK22.7.10.20.440
4kuhCAA3-hydroxybutyryl-CoA dehydrogenase/0.440
4wda2AM2',3'-cyclic-nucleotide 3'-phosphodiesterase3.1.4.370.440
4z63ILE_THR_GLN_TYS_TYSPhytosulfokine receptor 12.7.11.10.440
5ez7FADProbable FAD-dependent oxidoreductase PA4991/0.440
5kczNAJAlcohol dehydrogenase E chain1.1.1.10.440