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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4ce9O3NIntegrase

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
4ce9O3NIntegrase/1.000
4cifJDXIntegrase/0.688
4cjkH39Integrase/0.688
4ceqQCHIntegrase/0.684
4cfaWOPIntegrase/0.681
4ced9NSIntegrase/0.663
4cigX0PIntegrase/0.658
3zsrO3NIntegrase/0.649
4cezO3NIntegrase/0.649
4cf23GMIntegrase/0.648
4cf0O5UIntegrase/0.643
3zszOM2Integrase/0.639
4cfc7NVIntegrase/0.636
3zswZSWIntegrase/0.634
3zt0ZT0Integrase/0.631
3zsvZSVIntegrase/0.627
4cebZSVIntegrase/0.627
4cfbOM3Integrase/0.627
4cgjNZLIntegrase/0.627
4ceaZSWIntegrase/0.624
4cgd8P3Integrase/0.620
4cefD0TIntegrase/0.613
4ck2NVUIntegrase/0.611
4cj3E4FIntegrase/0.606
4cggK5QIntegrase/0.603
4cerVL4Integrase/0.601
3zsqO4NIntegrase/0.600
4ck1OM1Integrase/0.596
4cesNFWIntegrase/0.595
4cjp4D2Integrase/0.591
4cjfRVNIntegrase/0.590
4chyC5QIntegrase/0.588
4cjrFYMIntegrase/0.586
3zsxN44Integrase/0.583
3zcmPX3Integrase/0.582
4cieY7NIntegrase/0.582
4ceoG0TIntegrase/0.579
4cjuJNSIntegrase/0.577
4cf8V7HIntegrase/0.575
3zt2ZT2Integrase/0.573
4cjsL0YIntegrase/0.572
3zsyOM3Integrase/0.569
4cgiNZLIntegrase/0.569
4cjeQ31Integrase/0.566
4cjqVXOIntegrase/0.566
4ck3K1TIntegrase/0.561
4cf1IY7Integrase/0.556
4cj4S3GIntegrase/0.556
4ceeB0TIntegrase/0.553
4cghLOZIntegrase/0.551
3zt3ZT4Integrase/0.549
4cfdS8YIntegrase/0.548
4cec2SSIntegrase/0.540
4cj54VWIntegrase/0.537
4chqCWUIntegrase/0.516
3zt1OM1Integrase/0.515
1jtvTESEstradiol 17-beta-dehydrogenase 11.1.1.620.497
1ia1NDPDihydrofolate reductase1.5.1.30.491
1q41IXMGlycogen synthase kinase-3 beta2.7.11.260.488
1zemNADXylitol dehydrogenase/0.488
3lqfNADGalactitol dehydrogenase/0.486
4dbzNDPPutative ketoacyl reductase1.3.10.486
2nruT12Interleukin-1 receptor-associated kinase 42.7.11.10.484
2vnjFADNADPH:ferredoxin reductase/0.481
1nqoNADGlyceraldehyde-3-phosphate dehydrogenase/0.479
4mdhNADMalate dehydrogenase, cytoplasmic1.1.1.370.479
1rx8NAPDihydrofolate reductase1.5.1.30.478
2c29NAPDihydroflavonol 4-reductase/0.478
2g1n1IGRenin3.4.23.150.478
2vbdV10Isopenicillin N synthase1.21.3.10.478
2wxvWXVCyclin-dependent kinase 22.7.11.220.478
1n2sNAIdTDP-4-dehydrorhamnose reductase1.1.1.1330.477
2bgjFADNADPH:ferredoxin reductase/0.477
2nrySTUInterleukin-1 receptor-associated kinase 42.7.11.10.477
4p8rNADGlyceraldehyde-3-phosphate dehydrogenase/0.477
4b8wNAPGDP-L-fucose synthase1.1.1.2710.476
2pvnP63Casein kinase II subunit alpha2.7.11.10.475
1hdcCBO3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase1.1.1.530.474
2rh9IGPTryptophan synthase alpha chain/0.474
2znq401Peroxisome proliferator-activated receptor delta/0.474
3fhxPLPPyridoxal kinase2.7.1.350.473
2ylzFADPhenylacetone monooxygenase1.14.13.920.472
4m87NADEnoyl-[acyl-carrier-protein] reductase [NADH]/0.472
4ng2OHNTranscriptional activator protein LasR/0.472
4rrrA3TThreonine--tRNA ligase6.1.1.30.472
1h51FMNPentaerythritol tetranitrate reductase/0.471
1j49NADD-lactate dehydrogenase1.1.1.280.471
4y93746Tyrosine-protein kinase/0.471
1xe65FPPlasmepsin-23.4.23.390.470
2j2pSC2Ficolin-2/0.470
3f1kNAPUncharacterized oxidoreductase YciK10.470
4btjADPTau-tubulin kinase 12.7.11.10.470
4jicFMNGTN Reductase/0.470
5dp2NAPCurF/0.470
2vnkFADNADPH:ferredoxin reductase/0.469
3w0hW12Vitamin D3 receptor/0.469
1kfcIPLTryptophan synthase alpha chain/0.468
2e9uA25Serine/threonine-protein kinase Chk12.7.11.10.468
2znpK55Peroxisome proliferator-activated receptor delta/0.468
3cosNADAlcohol dehydrogenase 41.1.1.10.468
3e5rNADGlyceraldehyde-3-phosphate dehydrogenase 1, cytosolic1.2.1.120.468
3mtfA3FActivin receptor type-12.7.11.300.468
3up4FAD2-oxo-Delta(3)-4,5,5-trimethylcyclopentenylacetyl-CoA monooxygenase1.14.13.1600.468
4enhFVXCholesterol 24-hydroxylase/0.468
3cifNADGlyceraldehyde-3-phosphate dehydrogenase/0.467
3gu83GUDeath-associated protein kinase 12.7.11.10.467
3orfNADDihydropteridine reductase1.5.1.340.467
4fxy0W2Neurolysin, mitochondrial3.4.24.160.467
5a88ADPRiboflavin biosynthesis protein RibF2.7.1.260.467
1bwsNDPGDP-L-fucose synthase/0.466
1fxsNAPGDP-L-fucose synthase/0.466
2vnhFADNADPH:ferredoxin reductase/0.466
3vt8YI3Vitamin D3 receptor/0.466
4c02TAKActivin receptor type-12.7.11.300.466
4dymIYZActivin receptor type-12.7.11.300.466
1drhNAPDihydrofolate reductase1.5.1.30.465
1nzdUPGDNA beta-glucosyltransferase/0.465
1x2hLPALipoate-protein ligase A6.3.1.200.465
2fn7NADLactate dehydrogenase, adjacent gene encodes predicted malate dehydrogenase/0.465
2trtTACTetracycline repressor protein class D/0.465
3otfCMPPotassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4/0.465
1w6hTITPlasmepsin-23.4.23.390.464
3uzwNAP3-oxo-5-beta-steroid 4-dehydrogenase/0.464
3vdqNAD3-hydroxybutyrate dehydrogenase/0.464
4bcrWY1Peroxisome proliferator-activated receptor alpha/0.464
4cgfUJ6Integrase/0.464
4gh5NADShort-chain dehydrogenase/reductase SDR/0.464
4jb1FADUDP-N-acetylenolpyruvoylglucosamine reductase/0.464
4nbtNAD3-oxoacyl-[acyl-carrier-protein] reductase/0.464
1nq5NADGlyceraldehyde-3-phosphate dehydrogenase/0.463
1xe55FEPlasmepsin-23.4.23.390.463
2c1bCQPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.463
2ix5FADAcyl-coenzyme A oxidase 4, peroxisomal1.3.3.60.463
2ovhAS0Progesterone receptor/0.463
2q9fC3SCholesterol 24-hydroxylase/0.463
2zbaZBATrichothecene 3-O-acetyltransferase/0.463
3idsNADGlyceraldehyde-3-phosphate dehydrogenase, glycosomal1.2.1.120.463
4fw8NAI3-oxoacyl-(Acyl-carrier-protein) reductase/0.463
1om1IQACasein kinase II subunit alpha2.7.11.10.462
1p0ySAHRibulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplastic2.1.1.1270.462
3e8xNAPBH1520 protein/0.462
4nd4NADLactate dehydrogenase, adjacent gene encodes predicted malate dehydrogenase/0.462
4q71FADBifunctional protein PutA/0.462
4yqfGDPSeptin-9/0.462
1iolESTEstradiol 17-beta-dehydrogenase 11.1.1.620.461
1kquBR4Phospholipase A2, membrane associated/0.461
2a1tFADMedium-chain specific acyl-CoA dehydrogenase, mitochondrial1.3.8.70.461
2hdhNADHydroxyacyl-coenzyme A dehydrogenase, mitochondrial1.1.1.350.461
2p9gNAID-3-phosphoglycerate dehydrogenase1.1.1.950.461
2xrwANPMitogen-activated protein kinase 82.7.11.240.461
3adaNADSubunit alpha of sarocosine oxidase/0.461
3ekuCY9Actin-5C/0.461
4b4dFADFerredoxin-NADP reductase/0.461
4bkz1WSMaternal embryonic leucine zipper kinase2.7.11.10.461
1dhjMTXDihydrofolate reductase1.5.1.30.460
2v13C40Renin3.4.23.150.460
4a2zVIQGlycylpeptide N-tetradecanoyltransferase/0.460
4mokFADPyranose 2-oxidase/0.460
5ackATP3-phosphoinositide-dependent protein kinase 12.7.11.10.460
1bwlFMNNADPH dehydrogenase 11.6.99.10.459
1fmjRTLRetinol dehydratase/0.459
1h50FMNPentaerythritol tetranitrate reductase/0.459
1u8fNADGlyceraldehyde-3-phosphate dehydrogenase1.2.1.120.459
2ii5CO6Lipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex, mitochondrial2.3.1.1680.459
3eljGS7Mitogen-activated protein kinase 82.7.11.240.459
3iaeD7KBenzaldehyde lyase/0.459
3k31NADEnoyl-[acyl-carrier-protein] reductase [NADH]/0.459
3r5yF42Uncharacterized protein/0.459
4anmWULCasein kinase II subunit alpha2.7.11.10.459
4c7kNAPCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.459
4hbgNDP3-oxoacyl-[acyl-carrier-protein] reductase1.1.1.1000.459
5il2SAHN6-adenosine-methyltransferase 70 kDa subunit/0.459
1e6wNAD3-hydroxyacyl-CoA dehydrogenase type-21.1.1.350.458
1m78NDPDihydrofolate reductase1.5.1.30.458
1rb2FOLDihydrofolate reductase1.5.1.30.458
2f7x4EAcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.458
2pvjP44Casein kinase II subunit alpha2.7.11.10.458
2z54AB1Gag-Pol polyprotein3.4.23.160.458
3be9P04Casein kinase II subunit alpha2.7.11.10.458
3p62FMNPentaerythritol tetranitrate reductase/0.458
3qrsNK8Gag-Pol polyprotein3.4.23.160.458
3vwdACOAlpha-tubulin N-acetyltransferase 1/0.458
4a84DXCMajor pollen allergen Bet v 1-A/0.458
4anx534Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.458
4fcr0TMHeat shock protein HSP 90-alpha/0.458
4g2gTDHMycocyclosin synthase1.14.21.90.458
4u9aSTUInterleukin-1 receptor-associated kinase 42.7.11.10.458
1k8y13PTryptophan synthase alpha chain/0.457
2nnlNAPDihydroflavonol 4-reductase1.1.1.2190.457
2ohvNHLGlutamate racemase/0.457
3nu9478Gag-Pol polyprotein3.4.23.160.457
3nugNADPyridoxal 4-dehydrogenase1.1.1.1070.457
3qlrNDPDihydrofolate reductase1.5.1.30.457
4aqc88ATyrosine-protein kinase JAK2/0.457
4dgnLU2Casein kinase II subunit alpha2.7.11.10.457
4q73FADBifunctional protein PutA/0.457
4ure1PSCyclohexanol dehydrogenase/0.457
5hwrCOAHydroxymethylglutaryl-CoA synthase/0.457
1a8pFADFerredoxin--NADP reductase/0.456
1cjtFOKAdenylate cyclase type 2/0.456
1cjtFOKAdenylate cyclase type 5/0.456
1ps9MDE2,4-dienoyl-CoA reductase1.3.1.340.456
1qorNDPQuinone oxidoreductase 1/0.456
1u4dDBQActivated CDC42 kinase 1/0.456
2cdaNAPGlucose 1-dehydrogenase/0.456
2qd4CHDFerrochelatase, mitochondrial4.99.1.10.456
3bhtMFRCyclin-dependent kinase 22.7.11.220.456
3koo24DBifunctional epoxide hydrolase 23.3.2.100.456
4b13X25Glycylpeptide N-tetradecanoyltransferase/0.456
4geb0LDKynurenine/alpha-aminoadipate aminotransferase, mitochondrial2.6.1.390.456
4kl9NDPDihydrofolate reductase1.5.1.30.456
4nfsNAJAlcohol dehydrogenase E chain1.1.1.10.456
5adhAPRAlcohol dehydrogenase E chain1.1.1.10.456
5b1yNDP3-oxoacyl-[acyl-carrier-protein] reductase/0.456
1a72PADAlcohol dehydrogenase E chain1.1.1.10.455
1fm4DXCMajor pollen allergen Bet v 1-L/0.455
1gd1NADGlyceraldehyde-3-phosphate dehydrogenase/0.455
1jpaANPEphrin type-B receptor 22.7.10.10.455
1uyuCAMCamphor 5-monooxygenase1.14.15.10.455
1vyrFMNPentaerythritol tetranitrate reductase/0.455
2vz6FEFCalcium/calmodulin-dependent protein kinase type II subunit alpha2.7.11.170.455
3ecg065Gag-Pol polyprotein3.4.23.470.455
3lzs017Gag-Pol polyprotein3.4.23.160.455
4a322CDGlycylpeptide N-tetradecanoyltransferase/0.455
4b8zNAPGDP-L-fucose synthase1.1.1.2710.455
4c58824Cyclin-G-associated kinase2.7.11.10.455
4dieC5PCytidylate kinase/0.455
5fwnNAPPutative dehydrogenase/0.455
2eklNADD-3-phosphoglycerate dehydrogenase/0.454
2gsdNADFormate dehydrogenase/0.454
2p5uNADUDP-glucose 4-epimerase/0.454
2rhgIGPTryptophan synthase alpha chain/0.454
2ydjYDJSerine/threonine-protein kinase Chk12.7.11.10.454
2zv2609Calcium/calmodulin-dependent protein kinase kinase 22.7.11.170.454
3a7jADPSerine/threonine-protein kinase 242.7.11.10.454
3atzFMNProstaglandin F2a synthase/0.454
3bgbLJGGag-Pol polyprotein3.4.23.160.454
3c3xNAPEugenol synthase 11.1.1.3180.454
3i5zZ48Mitogen-activated protein kinase 12.7.11.240.454
3nxxNDPDihydrofolate reductase1.5.1.30.454
3p3zP3ZPutative cytochrome P450/0.454
3q43D66M1 family aminopeptidase3.4.110.454
3qt62P0Mevalonate diphosphate decarboxylase/0.454
3s56ROCProtease/0.454
4k9dNADGlyceraldehyde-3-phosphate dehydrogenase1.2.1.120.454
4z63ILE_THR_GLN_TYS_TYSPhytosulfokine receptor 12.7.11.10.454
1jolFFODihydrofolate reductase1.5.1.30.453
1psa0ZLPepsin A3.4.23.10.453
1u4oNDDL-lactate dehydrogenase1.1.1.270.453
2briANPUridylate kinase2.7.4.220.453
2c27ACOMycothiol acetyltransferase2.3.1.1890.453
2d1yNADOxidoreductase, short-chain dehydrogenase/reductase family/0.453
2gnhH52cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.453
2gv8NDPThiol-specific monooxygenase1.14.130.453
3cpsNADGlyceraldehyde-3-phosphate dehydrogenase/0.453
3fun798Leukotriene A-4 hydrolase3.3.2.60.453
3gbuATPUncharacterized sugar kinase PH14592.7.10.453
3gggNADPrephenate dehydrogenase/0.453
3pe2E1BCasein kinase II subunit alpha2.7.11.10.453
3w32W32Epidermal growth factor receptor2.7.10.10.453
3zuyTCHTransporter/0.453
4bbyFADAlkyldihydroxyacetonephosphate synthase, peroxisomal2.5.1.260.453
4ejmNAPPutative zinc-binding dehydrogenase/0.453
4hbm0Y7E3 ubiquitin-protein ligase Mdm26.3.20.453
4qecNAPElxO/0.453
1dyhDZFDihydrofolate reductase1.5.1.30.452
1h74ADPHomoserine kinase2.7.1.390.452
1hdrNADDihydropteridine reductase1.5.1.340.452
1ju9NADAlcohol dehydrogenase E chain1.1.1.10.452
1p0hACOMycothiol acetyltransferase2.3.1.1890.452
1pzhNADLactate dehydrogenase/0.452
2bjhFERFeruloyl esterase A3.1.1.730.452
2e07SAHDiphthine synthase/0.452
2pchSAHDiphthine synthase/0.452
3dbvNADGlyceraldehyde-3-phosphate dehydrogenase/0.452
3k981RCHeat shock protein HSP 90-alpha/0.452
3l0lHC3Nuclear receptor ROR-gamma/0.452
3mvm39PMitogen-activated protein kinase 14/0.452
3o26NDPSalutaridine reductase/0.452
3so9017Pol protein/0.452
3t8oATPRhodopsin kinase/0.452
3vw6IM6Mitogen-activated protein kinase kinase kinase 52.7.11.250.452
3zbsOVE2',3'-cyclic-nucleotide 3'-phosphodiesterase3.1.4.370.452
3zw9NADPeroxisomal bifunctional enzyme1.1.1.350.452
4qenSAHHistone-lysine N-methyltransferase, H3 lysine-9 specific SUVH42.1.1.430.452
5kgpACOPredicted acetyltransferase/0.452
1b8uNADMalate dehydrogenase/0.451
1draMTXDihydrofolate reductase1.5.1.30.451
1fp2HMOIsoflavone-7-O-methyltransferase 82.1.1.1500.451
1gzuNMNNicotinamide/nicotinic acid mononucleotide adenylyltransferase 12.7.7.10.451
1ib0FADNADH-cytochrome b5 reductase 31.6.2.20.451
1snyNAPLD36273p/0.451
2abbFMNPentaerythritol tetranitrate reductase/0.451
2ejvNADL-threonine 3-dehydrogenase/0.451
3bv7NAP3-oxo-5-beta-steroid 4-dehydrogenase/0.451
3mdmFJZCholesterol 24-hydroxylase/0.451
3t3r9PLCytochrome P450 2A61.14.130.451
4c34STUcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.451
4gdy0X1Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial2.6.1.390.451
4gllNADUDP-glucuronic acid decarboxylase 14.1.1.350.451
4l4xNDPAmphI/0.451
4oztP1AEcdysone receptor, putative/0.451
4tuvCPZCytochrome P450 1191.140.451
4z61ILE_THR_GLN_TYS_TYSPhytosulfokine receptor 12.7.11.10.451
5ao1DG3Deoxynucleoside triphosphate triphosphohydrolase SAMHD13.1.50.451
1i7gAZ2Peroxisome proliferator-activated receptor alpha/0.450
1qyw5SDEstradiol 17-beta-dehydrogenase 11.1.1.620.450
1sowNADL-lactate dehydrogenase1.1.1.270.450
1vjy460TGF-beta receptor type-12.7.11.300.450
2e08SAHDiphthine synthase/0.450
2e8hSAHDiphthine synthase/0.450
2uzlC94Cyclin-dependent kinase 22.7.11.220.450
3bg7FADPyranose 2-oxidase/0.450
3cneFMNPutative protease I/0.450
3eheNADUDP-glucose 4-epimerase (GalE-1)/0.450
3mdvCL6Cholesterol 24-hydroxylase/0.450
3nmpPYVAbscisic acid receptor PYL2/0.450
4an4DUDPutative glycosyl transferase/0.450
4bquCLRJapanin/0.450
4cukNAID-lactate dehydrogenase/0.450
4fg8ATPCalcium/calmodulin-dependent protein kinase type 12.7.11.170.450
4gj30XPNon-receptor tyrosine-protein kinase TYK22.7.10.20.450
4jubTPPBenzoylformate decarboxylase4.1.1.70.450
4nd3NADLactate dehydrogenase, adjacent gene encodes predicted malate dehydrogenase/0.450
5c6cCMPcGMP-dependent protein kinase 22.7.11.120.450
1b16NAQAlcohol dehydrogenase1.1.1.10.449
1bvrNADEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.449
1dyjDDFDihydrofolate reductase1.5.1.30.449
1gqtACPRibokinase/0.449
1mj9COAHistone acetyltransferase ESA1/0.449
1qcfPP1Tyrosine-protein kinase HCK2.7.10.20.449
2b37NADEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.449
2clqSTUMitogen-activated protein kinase kinase kinase 52.7.11.250.449
2fznFADBifunctional protein PutA1.5.5.20.449
2h96893Mitogen-activated protein kinase 82.7.11.240.449
2pvhP19Casein kinase II subunit alpha2.7.11.10.449
2w71L23Biotin carboxylase6.3.4.140.449
3kjrNAPBifunctional dihydrofolate reductase-thymidylate synthase/0.449
3mpiFADGlutaryl-CoA dehydrogenase1.3.99.320.449
3nuuJOZ3-phosphoinositide-dependent protein kinase 12.7.11.10.449
3rj5NADAlcohol dehydrogenase1.1.1.10.449
3vrtYS2Vitamin D3 receptor/0.449
3vyfVYFRenin3.4.23.150.449
4bfxZVXPantothenate kinase2.7.1.330.449
4jajXU1Aurora kinase A2.7.11.10.449
4jin1L7RIO-type serine/threonine-protein kinase Rio12.7.11.10.449
4l49CAMCamphor 5-monooxygenase1.14.15.10.449
4mv8ACPBiotin carboxylase6.3.4.140.449
4y1bNAPAntE/0.449
1kkq471Peroxisome proliferator-activated receptor alpha/0.448
1uxjNADMalate dehydrogenase/0.448
2emuSAHDiphthine synthase/0.448
2feuCAMCamphor 5-monooxygenase1.14.15.10.448
2ien017Gag-Pol polyprotein3.4.23.160.448
2oaxSNLMineralocorticoid receptor/0.448
2pa3NAID-3-phosphoglycerate dehydrogenase1.1.1.950.448
2vprTDCTetracycline repressor protein class H/0.448
2xa4AZ5Tyrosine-protein kinase JAK2/0.448
3gegNADShort-chain dehydrogenase/reductase SDR/0.448
3hadNADHydroxyacyl-coenzyme A dehydrogenase, mitochondrial1.1.1.350.448
3i60E86Mitogen-activated protein kinase 12.7.11.240.448
3o9hK2EGag-Pol polyprotein/0.448
3rbvNAPSugar 3-ketoreductase/0.448
3slkNDPPolyketide synthase extender module 2/0.448
3t3c017Gag-Pol polyprotein3.4.23.160.448
3toxNAPPutative oxidoreductase/0.448
4cr8NADN-acylmannosamine 1-dehydrogenase1.1.1.2330.448
4e2dFMNDehydrogenase/0.448
4qmzB49Serine/threonine-protein kinase 242.7.11.10.448
1cbfSAHCobalt-precorrin-4 C(11)-methyltransferase2.1.1.2710.447
1fmlRTLRetinol dehydratase/0.447
1nbiSAMGlycine N-methyltransferase2.1.1.200.447
1nytNAPShikimate dehydrogenase (NADP(+))/0.447
1qx4FADNADH-cytochrome b5 reductase 31.6.2.20.447
2cf6NAPCinnamyl alcohol dehydrogenase 51.1.1.1950.447
2x4f16XMyosin light chain kinase family member 42.7.11.10.447
2ztmNADD(-)-3-hydroxybutyrate dehydrogenase/0.447
3eyhIZATyrosine-protein kinase JAK1/0.447
3gwfFADCyclohexanone monooxygenase/0.447
3oxv478Gag-Pol polyprotein3.4.23.160.447
4bqjXKLHeat shock protein HSP 90-alpha/0.447
4fi1ATPCasein kinase II subunit alpha2.7.11.10.447
4gyzD5MTyrosyl-DNA phosphodiesterase 23.1.40.447
4hxyNDPPlm1/0.447
4mwhATPCasein kinase II subunit alpha2.7.11.10.447
4qnaX11Serine/threonine-protein kinase 242.7.11.10.447
4wda2AM2',3'-cyclic-nucleotide 3'-phosphodiesterase3.1.4.370.447
5da9AGSUncharacterized protein/0.447
1a7kNADGlyceraldehyde-3-phosphate dehydrogenase, glycosomal1.2.1.120.446
1bdlIM1Gag-Pol polyprotein3.4.23.160.446
1dirNADDihydropteridine reductase1.5.1.340.446
1j1cADPGlycogen synthase kinase-3 beta2.7.11.260.446
1nlmUD1UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase/0.446
2fhnBNIAvidin-related protein 4/5/0.446
2o12FMNChorismate synthase/0.446
2o7pNAPRiboflavin biosynthesis protein RibD/0.446
2vigFADShort-chain specific acyl-CoA dehydrogenase, mitochondrial1.3.8.10.446
2y8lADP5'-AMP-activated protein kinase subunit gamma-1/0.446
3c16FOKAdenylate cyclase type 2/0.446
3c16FOKAdenylate cyclase type 5/0.446
3hmm855TGF-beta receptor type-12.7.11.300.446
3junAKDPhenazine biosynthesis protein A/B/0.446
3ksdNADGlyceraldehyde-3-phosphate dehydrogenase 1/0.446
3qroNK9Gag-Pol polyprotein3.4.23.160.446
3r4nFU5Heat shock protein HSP 90-alpha/0.446
3r6sCMPCRP-like cAMP-activated global transcriptional regulator/0.446
3up0D7SaceDAF-12/0.446
3vt5YI2Vitamin D3 receptor/0.446
3zh8C58Protein kinase C iota type2.7.11.130.446
4yt5H4MH(2)-forming methylenetetrahydromethanopterin dehydrogenase-related protein MJ1338/0.446
5ar4SB2Receptor-interacting serine/threonine-protein kinase 22.7.11.10.446
5hwoHMGHydroxymethylglutaryl-CoA synthase/0.446
1gufNDPEnoyl-[acyl-carrier-protein] reductase 1, mitochondrial1.3.1.100.445
1ha3MAUElongation factor Tu-A/0.445
1k74544Peroxisome proliferator-activated receptor gamma/0.445
1rx7FOLDihydrofolate reductase1.5.1.30.445
1szgFNSCytochrome b2, mitochondrial1.1.2.30.445
1tdrMTXDihydrofolate reductase1.5.1.30.445
1tduCB3Thymidylate synthase/0.445
1u7tNAD3-hydroxyacyl-CoA dehydrogenase type-21.1.1.350.445
1y5rC0RCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.445
2bfyH1NAurora kinase B-A2.7.11.10.445
2gmhFADElectron transfer flavoprotein-ubiquinone oxidoreductase, mitochondrial1.5.5.10.445
2ijmADPFocal adhesion kinase 12.7.10.20.445
2npiATPmRNA cleavage and polyadenylation factor CLP1/0.445
2xs0ANPMitogen-activated protein kinase 82.7.11.240.445
3fr8NDPKetol-acid reductoisomerase, chloroplastic1.1.1.860.445
3r04UNQSerine/threonine-protein kinase pim-12.7.11.10.445
3uaxNOSPurine nucleoside phosphorylase DeoD-type/0.445
3vilSA0Beta-glucosidase/0.445
4anv751Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.445
4bcaFADAlkyldihydroxyacetonephosphate synthase, peroxisomal2.5.1.260.445
4dfrMTXDihydrofolate reductase1.5.1.30.445
4dmmNAP3-oxoacyl-[acyl-carrier-protein] reductase/0.445
4f650S9Fibroblast growth factor receptor 1/0.445
4kb81QOCasein kinase I isoform delta2.7.11.10.445
4r9uANPVitamin B12 import ATP-binding protein BtuD/0.445
4trnNADEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.445
4xcvNDPProbable hydroxyacid dehydrogenase protein/0.445
4z64ILE_THR_GLN_TYS_TYSPhytosulfokine receptor 12.7.11.10.445
6cp4CAMCamphor 5-monooxygenase1.14.15.10.445
1dhiMTXDihydrofolate reductase1.5.1.30.444
1h74AGSHomoserine kinase2.7.1.390.444
1kc1NDPdTDP-4-dehydrorhamnose reductase1.1.1.1330.444
1me6IVSPlasmepsin-23.4.23.390.444
1o76CAMCamphor 5-monooxygenase1.14.15.10.444
1pr9NAPL-xylulose reductase1.1.1.100.444
1ra3MTXDihydrofolate reductase1.5.1.30.444
1udaUFGUDP-glucose 4-epimerase5.1.3.20.444
2i4uDJRProtease/0.444
2w9hTOPDihydrofolate reductase1.5.1.30.444
3g5sFADMethylenetetrahydrofolate--tRNA-(uracil-5-)-methyltransferase TrmFO/0.444
3hy7097A disintegrin and metalloproteinase with thrombospondin motifs 53.4.240.444
3mg3ECHOrange carotenoid-binding protein/0.444
3oibFDAPutative acyl-CoA dehydrogenase/0.444
3oqkS52Renin3.4.23.150.444
3vfqAR6Poly [ADP-ribose] polymerase 142.4.2.300.444
3vyeVYERenin3.4.23.150.444
4bibIEOMitogen-activated protein kinase kinase kinase 52.7.11.250.444
4cvmANPUDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase/0.444
4e9aQAPPeptide deformylase/0.444
4eplJAIJasmonic acid-amido synthetase JAR16.3.20.444
4fizCUE17beta-hydroxysteroid dehydrogenase/0.444
4mcc21XtRNA (guanine-N(1)-)-methyltransferase2.1.1.2280.444
4o0wADNAurora kinase A2.7.11.10.444
4o701QKBromodomain-containing protein 4/0.444
4tmcFMNOld yellow enzyme/0.444
5a3bAPRSIR2 family protein/0.444
5e8wSTUTGF-beta receptor type-12.7.11.300.444
5k2dZMAAdenosine receptor A2a/0.444
1cerNADGlyceraldehyde-3-phosphate dehydrogenase/0.443
1gg5FADNAD(P)H dehydrogenase [quinone] 11.6.5.20.443
1h73ANPHomoserine kinase2.7.1.390.443
1j1bANPGlycogen synthase kinase-3 beta2.7.11.260.443
1lrjUD1UDP-glucose 4-epimerase5.1.3.20.443
1ml3NADGlyceraldehyde-3-phosphate dehydrogenase, glycosomal1.2.1.120.443
1svlADPLarge T antigen3.6.40.443
1x27ASP_TYR_VAL_HIS_PTRTyrosine-protein kinase Lck2.7.10.20.443
2c6tDT5Cyclin-dependent kinase 22.7.11.220.443
2e7rSAHDiphthine synthase/0.443
2ehlSAHDiphthine synthase/0.443
2g8yNADHydroxycarboxylate dehydrogenase B/0.443
2j3jHC4NADPH-dependent oxidoreductase 2-alkenal reductase1.3.1.740.443
2qnqQN3Gag-Pol polyprotein3.4.23.160.443
2uxhQUEHTH-type transcriptional regulator TtgR/0.443
2z0ySAMRibosomal RNA small subunit methyltransferase E/0.443
3c15FOKAdenylate cyclase type 2/0.443
3c15FOKAdenylate cyclase type 5/0.443
3ggoNAIPrephenate dehydrogenase/0.443
3o3jBB4Peptide deformylase 1B, chloroplastic/mitochondrial3.5.1.880.443
3otwCOAPhosphopantetheine adenylyltransferase/0.443
3qd03Q43-phosphoinositide-dependent protein kinase 12.7.11.10.443
3qwkX62Cyclin-dependent kinase 22.7.11.220.443
3wrlCAMCamphor 5-monooxygenase1.14.15.10.443
4achKDIGlycogen synthase kinase-3 beta2.7.11.260.443
4biiPYWEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.443
4f9mFCMPeroxisome proliferator-activated receptor gamma/0.443
4fhf0TTSpore photoproduct lyase/0.443
4fhk0U0Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.443
4fv3EK6Mitogen-activated protein kinase 12.7.11.240.443
4hmz18TdTDP-4-dehydro-6-deoxyglucose 3-epimerase5.1.3.270.443
4mq22C4Dual specificity tyrosine-phosphorylation-regulated kinase 1A2.7.12.10.443
4u9zCOAAlpha-tubulin N-acetyltransferase 1/0.443
4wdb2AM2',3'-cyclic-nucleotide 3'-phosphodiesterase3.1.4.370.443
1dfoPLGSerine hydroxymethyltransferase2.1.2.10.442
1dnaCB3Thymidylate synthase/0.442
1jtuLYBThymidylate synthase/0.442
1sbgIM1Gag-Pol polyprotein/0.442
1vbiNADMalate/L-lactate dehydrogenase family protein/0.442
1yszNECEndoplasmin/0.442
2aibERGBeta-elicitin cinnamomin/0.442
2cbrA80Cellular retinoic acid-binding protein 1/0.442
2hwrDRDPeroxisome proliferator-activated receptor gamma/0.442
2qhm7CSSerine/threonine-protein kinase Chk12.7.11.10.442
2zuiCAMCamphor 5-monooxygenase1.14.15.10.442
3dgaNDPBifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.442
3fnlSHALactoperoxidase/0.442
3ijdC2FMethylenetetrahydrofolate reductase/0.442
3lsiFADPyranose 2-oxidase/0.442
3lsmSFDPyranose 2-oxidase/0.442
3qvpFADGlucose oxidase1.1.3.40.442
3rq6APRADP-dependent (S)-NAD(P)H-hydrate dehydratase/0.442
4c36ZO9cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.442
4c73TLH3-oxoacyl-ACP synthase/0.442
4dfn0K1Tyrosine-protein kinase SYK2.7.10.20.442
4du82P0Mevalonate diphosphate decarboxylase/0.442
4fv6E57Mitogen-activated protein kinase 12.7.11.240.442
4iqgNAPShort-chain dehydrogenase/reductase SDR/0.442
4x5iFOLDihydrofolate reductase1.5.1.30.442
5hs1VORLanosterol 14-alpha demethylase/0.442
1e5qNDPSaccharopine dehydrogenase [NADP(+), L-glutamate-forming]1.5.1.100.441
1rx1NAPDihydrofolate reductase1.5.1.30.441
2b4rNADGlyceraldehyde-3-phosphate dehydrogenase/0.441
2bbwGP5Adenylate kinase 4, mitochondrial/0.441
2ckeIQUDeath-associated protein kinase 2/0.441
2drcMTXDihydrofolate reductase1.5.1.30.441
2eh2SAHDiphthine synthase/0.441
2ev9NAPShikimate dehydrogenase (NADP(+))/0.441
2ojg19AMitogen-activated protein kinase 12.7.11.240.441
2owuSAHDiphthine synthase/0.441
2v4lABJPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.441
2w1fL0FAurora kinase A2.7.11.10.441
2xj2985Serine/threonine-protein kinase pim-12.7.11.10.441
2yxuATPPyridoxal kinase2.7.1.350.441
3hrcATP3-phosphoinositide-dependent protein kinase 12.7.11.10.441
3i7eDJRGag-Pol polyprotein/0.441
3jqpA2PFerredoxin--NADP reductase, apicoplast/0.441
3jypNADQuinate/shikimate dehydrogenase (NAD(+))/0.441
3k2bNADGlyceraldehyde-3-phosphate dehydrogenase GAPA1, chloroplastic1.2.1.130.441
3lctADPALK tyrosine kinase receptor2.7.10.10.441
3oqfS51Renin3.4.23.150.441
3qd43Q63-phosphoinositide-dependent protein kinase 12.7.11.10.441
3rni21ZCyclin-dependent kinase 22.7.11.220.441
3w0gW07Vitamin D3 receptor/0.441
4a86H35Major pollen allergen Bet v 1-A/0.441
4bb3KKAIsopenicillin N synthase1.21.3.10.441
4bfzZVZPantothenate kinase2.7.1.330.441
4bieIE6Mitogen-activated protein kinase kinase kinase 52.7.11.250.441
4dptAGSMevalonate diphosphate decarboxylase/0.441
4fr4STUSerine/threonine-protein kinase 32A2.7.11.10.441
4ienCOAPutative acyl-CoA hydrolase/0.441
4zlaBESCytosol aminopeptidase3.4.11.10.441
5a4kFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.441
5iqiGNPBifunctional AAC/APH2.3.10.441
1b14NADAlcohol dehydrogenase1.1.1.10.440
1dq8COA3-hydroxy-3-methylglutaryl-coenzyme A reductase1.1.1.340.440
1dyiFOLDihydrofolate reductase1.5.1.30.440
1f17NAIHydroxyacyl-coenzyme A dehydrogenase, mitochondrial1.1.1.350.440
1nvqUCNSerine/threonine-protein kinase Chk12.7.11.10.440
1ppjANYCytochrome b/0.440
1pqc444Oxysterols receptor LXR-beta/0.440
1txiTX5Vitamin D3 receptor/0.440
1z1rHBHGag-Pol polyprotein3.4.23.160.440
2a7r5GPGMP reductase 2/0.440
2ek7SAHDiphthine synthase/0.440
2gjnFMNNitronate monooxygenase1.13.12.160.440
2ifaFMNUncharacterized protein/0.440
2v9jATP5'-AMP-activated protein kinase subunit gamma-1/0.440
2y3rTIRTamL/0.440
2z52H23Geranylgeranyl pyrophosphate synthase/0.440
2zevB71Geranylgeranyl pyrophosphate synthase/0.440
3b6zCO7Enoyl reductase LovC10.440
3bfb9ODPheromone-binding protein ASP1/0.440
3ieuGDPGTPase Era/0.440
3ndrNADPyridoxal 4-dehydrogenase1.1.1.1070.440
3opxU5PSuppressor of disruption of TFIIS/0.440
3pqbVGPPutative oxidoreductase/0.440
3r9uFADThioredoxin reductase/0.440
3rj9NADAlcohol dehydrogenase1.1.1.10.440
3u4cNDPNADPH-dependent reductase BacG/0.440
3uxyNADShort-chain dehydrogenase/reductase SDR/0.440
3vt65YIVitamin D3 receptor/0.440
3wrmCAMCamphor 5-monooxygenase1.14.15.10.440
4bf2STUMitogen-activated protein kinase kinase kinase 52.7.11.250.440
4ct1ATP3-phosphoinositide-dependent protein kinase 12.7.11.10.440
4de50JDPantothenate synthetase6.3.2.10.440
4j7uNAPSepiapterin reductase1.1.1.1530.440
3emlZMAAdenosine receptor A2a/0.440