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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4c8b0LIReceptor-interacting serine/threonine-protein kinase 22.7.11.1

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
4c8b0LIReceptor-interacting serine/threonine-protein kinase 22.7.11.11.000
2oiqSTIProto-oncogene tyrosine-protein kinase Src2.7.10.20.561
3b8q900Vascular endothelial growth factor receptor 22.7.10.10.542
3lfbZ87Mitogen-activated protein kinase 14/0.522
4o2z046Mitogen-activated protein kinase/0.512
3dtwA96Vascular endothelial growth factor receptor 22.7.10.10.511
4agwNG7Proto-oncogene tyrosine-protein kinase Src2.7.10.20.509
3vnt0JAVascular endothelial growth factor receptor 22.7.10.10.501
4fc00T2Serine/threonine-protein kinase B-raf2.7.11.10.484
2og81N8Tyrosine-protein kinase Lck2.7.10.20.480
4aseAV9Vascular endothelial growth factor receptor 22.7.10.10.480
3c7qXINVascular endothelial growth factor receptor 22.7.10.10.473
3efl706Vascular endothelial growth factor receptor 22.7.10.10.467
2qu6857Vascular endothelial growth factor receptor 22.7.10.10.465
4ksp1SUSerine/threonine-protein kinase B-raf2.7.11.10.463
2xir00JVascular endothelial growth factor receptor 22.7.10.10.455
3hng8STVascular endothelial growth factor receptor 12.7.10.10.455
2hyySTITyrosine-protein kinase ABL12.7.10.20.449
4aa0AA0Mitogen-activated protein kinase 14/0.448
3hv5R24Mitogen-activated protein kinase 14/0.442
4eyjN61Mitogen-activated protein kinase 132.7.11.240.442