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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4c59FEFCyclin-G-associated kinase2.7.11.1

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
4c59FEFCyclin-G-associated kinase2.7.11.11.000
4c58824Cyclin-G-associated kinase2.7.11.10.642
1qpjSTUTyrosine-protein kinase Lck2.7.10.20.493
3b2w9NHTyrosine-protein kinase Lck2.7.10.20.484
2hxl422Serine/threonine-protein kinase Chk12.7.11.10.473
4c57FEFCyclin-G-associated kinase2.7.11.10.471
3a4oSTUTyrosine-protein kinase Lyn2.7.10.20.464
3gu83GUDeath-associated protein kinase 12.7.11.10.462
3i4bZ48Glycogen synthase kinase-3 beta2.7.11.260.460
2vu3LZECyclin-dependent kinase 22.7.11.220.458
2h8hH8HProto-oncogene tyrosine-protein kinase Src2.7.10.20.456
3h0sB38Acetyl-CoA carboxylase/0.452
2qoqANPEphrin type-A receptor 32.7.10.10.450
3lcdBDYMacrophage colony-stimulating factor 1 receptor2.7.10.10.450
4k110J9Proto-oncogene tyrosine-protein kinase Src2.7.10.20.450
4fsnA58Serine/threonine-protein kinase Chk12.7.11.10.449
4oj4DIFPeroxisome proliferator-activated receptor gamma/0.449
2x9fX9FEphrin type-B receptor 42.7.10.10.448
4b4oNDPEpimerase family protein SDR39U1/0.448
1kboFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.445
3vs2VSBTyrosine-protein kinase HCK2.7.10.20.445
4ftiH7KSerine/threonine-protein kinase Chk12.7.11.10.445
3i60E86Mitogen-activated protein kinase 12.7.11.240.444
3k5uPFQAurora kinase A2.7.11.10.444
4c3pACPAurora kinase A2.7.11.10.443
1ojtFADDihydrolipoyl dehydrogenase/0.441
1bygSTUTyrosine-protein kinase CSK/0.440
2o2u738Mitogen-activated protein kinase 102.7.11.240.440