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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4c58824Cyclin-G-associated kinase2.7.11.1

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
4c58824Cyclin-G-associated kinase2.7.11.11.000
4c59FEFCyclin-G-associated kinase2.7.11.10.607
4fv9E71Mitogen-activated protein kinase 12.7.11.240.470
3i4bZ48Glycogen synthase kinase-3 beta2.7.11.260.459
3lcdBDYMacrophage colony-stimulating factor 1 receptor2.7.10.10.457
1qpjSTUTyrosine-protein kinase Lck2.7.10.20.456
4c57FEFCyclin-G-associated kinase2.7.11.10.451
3qd43Q63-phosphoinositide-dependent protein kinase 12.7.11.10.445
4c4f7CEDual specificity protein kinase TTK2.7.12.10.443
4fr4STUSerine/threonine-protein kinase 32A2.7.11.10.441
2xvdAS6Ephrin type-B receptor 42.7.10.10.440