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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4c35NU3cAMP-dependent protein kinase catalytic subunit alpha2.7.11.11

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
4c35NU3cAMP-dependent protein kinase catalytic subunit alpha2.7.11.111.000
2e9n76ASerine/threonine-protein kinase Chk12.7.11.10.502
4hle17VPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.494
4ful0VUPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.488
3u9n09HSerine/threonine-protein kinase Chk12.7.11.10.475
2cgv3B3Serine/threonine-protein kinase Chk12.7.11.10.474
4anwO92Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.470
3apfBMWPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.469
3qarQARPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.465
4hyi1AOSerine/threonine-protein kinase Chk12.7.11.10.465
3iodA6DPantothenate synthetase6.3.2.10.463
4ft7H3KSerine/threonine-protein kinase Chk12.7.11.10.462
1stcSTUcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.461
2brgDFYSerine/threonine-protein kinase Chk12.7.11.10.461
2cgw3C3Serine/threonine-protein kinase Chk12.7.11.10.461
3imeBZ2Pantothenate synthetase6.3.2.10.461
4gb90WRPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.461
2c3lIDZSerine/threonine-protein kinase Chk12.7.11.10.458
4ftr5HKSerine/threonine-protein kinase Chk12.7.11.10.457
1nvsUCMSerine/threonine-protein kinase Chk12.7.11.10.456
4ftu7HKSerine/threonine-protein kinase Chk12.7.11.10.456
3tkiS25Serine/threonine-protein kinase Chk12.7.11.10.455
4c34STUcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.452
4hgl0YOCasein kinase I isoform gamma-32.7.11.10.452
2e9uA25Serine/threonine-protein kinase Chk12.7.11.10.451
1ydtIQBcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.449
2e9oA58Serine/threonine-protein kinase Chk12.7.11.10.448
4kz01UJPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.447
1nvqUCNSerine/threonine-protein kinase Chk12.7.11.10.445
2ieaTDPPyruvate dehydrogenase E1 component1.2.4.10.445
4anx534Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.445
4hyh1AMSerine/threonine-protein kinase Chk12.7.11.10.444
2izrBRKCasein kinase I isoform gamma-32.7.11.10.443
4ezl0SEPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.443
2br1PFPSerine/threonine-protein kinase Chk12.7.11.10.442
4djhJDCKappa-type opioid receptor/0.442
2broDF2Serine/threonine-protein kinase Chk12.7.11.10.441
4anuEM7Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.441
4anv751Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.441
2c3kABOSerine/threonine-protein kinase Chk12.7.11.10.440
2pmlANPUncharacterized protein/0.440