sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Cavities are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 4buw | F33 | Tankyrase-2 | 2.4.2.30 |
| PDB ID | HET | Uniprot Name | EC Number | Cavity Similarity |
Align |
|---|---|---|---|---|---|
| 4buw | F33 | Tankyrase-2 | 2.4.2.30 | 1.000 | |
| 4bue | JQF | Tankyrase-2 | 2.4.2.30 | 0.853 | |
| 4bux | F35 | Tankyrase-2 | 2.4.2.30 | 0.825 | |
| 4bs4 | A64 | Tankyrase-2 | 2.4.2.30 | 0.800 | |
| 4bus | 32F | Tankyrase-2 | 2.4.2.30 | 0.779 | |
| 4l2g | 1V4 | Tankyrase-2 | 2.4.2.30 | 0.755 | |
| 4hlh | 20D | Tankyrase-2 | 2.4.2.30 | 0.707 | |
| 4l34 | 1VG | Tankyrase-2 | 2.4.2.30 | 0.688 | |
| 4hlm | 16S | Tankyrase-2 | 2.4.2.30 | 0.662 | |
| 4l0i | 1UW | Tankyrase-2 | 2.4.2.30 | 0.658 | |
| 4l33 | F70 | Tankyrase-2 | 2.4.2.30 | 0.649 | |
| 4hlf | 15Z | Tankyrase-2 | 2.4.2.30 | 0.646 | |
| 4kzl | 20D | Tankyrase-2 | 2.4.2.30 | 0.641 | |
| 4iue | AJ4 | Tankyrase-2 | 2.4.2.30 | 0.639 | |
| 4l0v | 1V1 | Tankyrase-2 | 2.4.2.30 | 0.635 | |
| 4l31 | F08 | Tankyrase-2 | 2.4.2.30 | 0.635 | |
| 4l32 | 1VF | Tankyrase-2 | 2.4.2.30 | 0.635 | |
| 3p0p | NNF | Tankyrase-2 | 2.4.2.30 | 0.631 | |
| 4l0s | 1UZ | Tankyrase-2 | 2.4.2.30 | 0.622 | |
| 4hmh | F94 | Tankyrase-2 | 2.4.2.30 | 0.621 | |
| 4j22 | AJ7 | Tankyrase-2 | 2.4.2.30 | 0.618 | |
| 4buf | F36 | Tankyrase-2 | 2.4.2.30 | 0.617 | |
| 4bj9 | UHB | Tankyrase-2 | 2.4.2.30 | 0.613 | |
| 4l2f | 1V3 | Tankyrase-2 | 2.4.2.30 | 0.612 | |
| 4bu9 | 08C | Tankyrase-2 | 2.4.2.30 | 0.611 | |
| 4hl5 | 15W | Tankyrase-2 | 2.4.2.30 | 0.611 | |
| 4j21 | AJ6 | Tankyrase-2 | 2.4.2.30 | 0.610 | |
| 5aku | 29F | Tankyrase-2 | 2.4.2.30 | 0.610 | |
| 4buu | F38 | Tankyrase-2 | 2.4.2.30 | 0.603 | |
| 4avw | G18 | Tankyrase-2 | 2.4.2.30 | 0.601 | |
| 4l09 | 1UR | Tankyrase-2 | 2.4.2.30 | 0.601 | |
| 4pnr | G18 | Tankyrase-2 | 2.4.2.30 | 0.600 | |
| 4l2k | 1V8 | Tankyrase-2 | 2.4.2.30 | 0.597 | |
| 4krs | 1SX | Tankyrase-1 | 2.4.2.30 | 0.587 | |
| 4hlk | 431 | Tankyrase-2 | 2.4.2.30 | 0.585 | |
| 4buv | 16I | Tankyrase-2 | 2.4.2.30 | 0.584 | |
| 4bui | W2E | Tankyrase-2 | 2.4.2.30 | 0.577 | |
| 4avu | LDR | Tankyrase-2 | 2.4.2.30 | 0.572 | |
| 4hki | FLN | Tankyrase-2 | 2.4.2.30 | 0.569 | |
| 4j3l | AJ5 | Tankyrase-2 | 2.4.2.30 | 0.567 | |
| 4hkk | AGI | Tankyrase-2 | 2.4.2.30 | 0.566 | |
| 4tkg | 09L | Tankyrase-2 | 2.4.2.30 | 0.555 | |
| 4hkn | LU2 | Tankyrase-2 | 2.4.2.30 | 0.554 | |
| 4bjb | P34 | Tankyrase-2 | 2.4.2.30 | 0.530 | |
| 4tjy | 3GN | Tankyrase-2 | 2.4.2.30 | 0.527 | |
| 4msk | 2C8 | Tankyrase-1 | 2.4.2.30 | 0.517 | |
| 4pnm | NU1 | Tankyrase-2 | 2.4.2.30 | 0.515 | |
| 1efy | BZC | Poly [ADP-ribose] polymerase 1 | 2.4.2.30 | 0.506 | |
| 4gv0 | 8ME | Poly [ADP-ribose] polymerase 3 | 2.4.2.30 | 0.505 | |
| 1xs7 | MMI | Beta-secretase 1 | 3.4.23.46 | 0.496 | |
| 2ouu | 35G | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.496 | |
| 4o9c | COA | Acetyl-CoA acetyltransferase | 2.3.1.9 | 0.493 | |
| 3o57 | ZG2 | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.491 | |
| 4xzj | NAD | Putative NAD(+)--arginine ADP-ribosyltransferase Vis | 2.4.2.31 | 0.491 | |
| 3l3m | A92 | Poly [ADP-ribose] polymerase 1 | 2.4.2.30 | 0.488 | |
| 3eku | CY9 | Actin-5C | / | 0.485 | |
| 2wf4 | ZY4 | Beta-secretase 1 | 3.4.23.46 | 0.484 | |
| 3ce0 | P34 | Poly [ADP-ribose] polymerase 3 | 2.4.2.30 | 0.483 | |
| 4hhz | 15S | Poly [ADP-ribose] polymerase 1 | 2.4.2.30 | 0.481 | |
| 3mau | PLR | Putative sphingosine-1-phosphate lyase | / | 0.480 | |
| 1lnm | DTX | Bilin-binding protein | / | 0.479 | |
| 3rsv | 3RS | Beta-secretase 1 | 3.4.23.46 | 0.478 | |
| 1ni4 | TPP | Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial | 1.2.4.1 | 0.477 | |
| 1ni4 | TPP | Pyruvate dehydrogenase E1 component subunit beta, mitochondrial | 1.2.4.1 | 0.477 | |
| 3x2f | NAI | Adenosylhomocysteinase | / | 0.477 | |
| 5a01 | 12V | O-glycosyltransferase | / | 0.477 | |
| 1t57 | FMN | Conserved protein | / | 0.475 | |
| 4k4e | K4E | Tankyrase-1 | 2.4.2.30 | 0.475 | |
| 3k5d | XLI | Beta-secretase 1 | 3.4.23.46 | 0.474 | |
| 3nu0 | 3TU | Dihydrofolate reductase | 1.5.1.3 | 0.473 | |
| 3skg | PB8 | Beta-secretase 1 | 3.4.23.46 | 0.472 | |
| 4lm4 | JPZ | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.471 | |
| 4bjc | RPB | Tankyrase-2 | 2.4.2.30 | 0.470 | |
| 4fcd | 0T6 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.470 | |
| 1dfo | PLG | Serine hydroxymethyltransferase | 2.1.2.1 | 0.469 | |
| 2wey | EV1 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.469 | |
| 3exo | 5MS | Beta-secretase 1 | 3.4.23.46 | 0.469 | |
| 3wd9 | QPC | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.469 | |
| 1c3x | 8IG | Purine nucleoside phosphorylase | 2.4.2.1 | 0.468 | |
| 2rhr | EMO | Putative ketoacyl reductase | 1.3.1 | 0.468 | |
| 2zit | NAD | Exotoxin A | 2.4.2.36 | 0.468 | |
| 3a1n | NAD | NDP-sugar epimerase | / | 0.468 | |
| 3uzw | NAP | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.468 | |
| 4d89 | BXD | Beta-secretase 1 | 3.4.23.46 | 0.468 | |
| 4j0v | 1H7 | Beta-secretase 1 | 3.4.23.46 | 0.468 | |
| 2qta | TDP | Pyruvate dehydrogenase E1 component | 1.2.4.1 | 0.467 | |
| 3gn7 | 3GN | Poly [ADP-ribose] polymerase 1 | 2.4.2.30 | 0.467 | |
| 3o56 | ZG1 | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.467 | |
| 3wv9 | FEG | Hmd co-occurring protein HcgE | / | 0.467 | |
| 4dpf | 0LG | Beta-secretase 1 | 3.4.23.46 | 0.467 | |
| 4fqs | LYA | Thymidylate synthase ThyA | / | 0.467 | |
| 1a26 | CNA | Poly [ADP-ribose] polymerase 1 | 2.4.2.30 | 0.466 | |
| 1y2d | 4DE | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.466 | |
| 1zgc | A2E | Acetylcholinesterase | 3.1.1.7 | 0.466 | |
| 3vf3 | 0GS | Beta-secretase 1 | 3.4.23.46 | 0.466 | |
| 3w5e | NVW | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.466 | |
| 4ajf | F03 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.466 | |
| 4f1y | CNI | Glutamate receptor 3 | / | 0.466 | |
| 1xom | CIO | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.465 | |
| 3uph | 0C1 | Genome polyprotein | 2.7.7.48 | 0.465 | |
| 5epo | TUD | 7-alpha-hydroxysteroid deydrogenase | / | 0.465 | |
| 1soj | IBM | cGMP-inhibited 3',5'-cyclic phosphodiesterase B | 3.1.4.17 | 0.464 | |
| 1trk | TPP | Transketolase 1 | 2.2.1.1 | 0.464 | |
| 2e8u | IPE | Geranylgeranyl pyrophosphate synthase | / | 0.464 | |
| 3tqc | ADP | Pantothenate kinase | / | 0.464 | |
| 4gv2 | 5ME | Poly [ADP-ribose] polymerase 3 | 2.4.2.30 | 0.464 | |
| 2ovv | PFH | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.463 | |
| 3akz | GSU | Glutamate--tRNA ligase 2 | / | 0.463 | |
| 4fco | 0U4 | Beta-secretase 1 | 3.4.23.46 | 0.463 | |
| 4twn | B96 | Ephrin type-A receptor 3 | 2.7.10.1 | 0.463 | |
| 2wwj | Y28 | Lysine-specific demethylase 4A | / | 0.462 | |
| 3sni | 546 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.462 | |
| 4dh6 | 0KN | Beta-secretase 1 | 3.4.23.46 | 0.462 | |
| 4hf4 | 15H | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.462 | |
| 4lxk | 1YT | Beta-secretase 1 | 3.4.23.46 | 0.462 | |
| 5hwq | CAA | Hydroxymethylglutaryl-CoA synthase | / | 0.462 | |
| 1e66 | HUX | Acetylcholinesterase | 3.1.1.7 | 0.461 | |
| 1ro6 | ROL | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.461 | |
| 3iex | GMP | Purine nucleoside phosphorylase | / | 0.461 | |
| 2fm5 | M99 | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.460 | |
| 3d3p | 20A | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.460 | |
| 3dv5 | BAV | Beta-secretase 1 | 3.4.23.46 | 0.460 | |
| 3kjs | NAP | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.460 | |
| 3sqz | COA | Putative hydroxymethylglutaryl-CoA synthase | / | 0.460 | |
| 4g2y | NI5 | cGMP-specific 3',5'-cyclic phosphodiesterase | / | 0.460 | |
| 1xor | ZAR | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.459 | |
| 3c49 | KU8 | Poly [ADP-ribose] polymerase 3 | 2.4.2.30 | 0.459 | |
| 3dv1 | AR9 | Beta-secretase 1 | 3.4.23.46 | 0.459 | |
| 4jtq | NAP | Aldo-keto reductase family 1 member C2 | / | 0.459 | |
| 1uae | UD1 | UDP-N-acetylglucosamine 1-carboxyvinyltransferase | / | 0.458 | |
| 3g4k | ROL | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.458 | |
| 3g58 | 988 | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.458 | |
| 3h4v | DVP | Pteridine reductase 1 | 1.5.1.33 | 0.458 | |
| 3l3l | L3L | Poly [ADP-ribose] polymerase 1 | 2.4.2.30 | 0.458 | |
| 5hwp | COA | Hydroxymethylglutaryl-CoA synthase | / | 0.458 | |
| 3sn6 | P0G | Beta-2 adrenergic receptor | / | 0.458 | |
| 1qyx | ASD | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.457 | |
| 1vbi | NAD | Malate/L-lactate dehydrogenase family protein | / | 0.457 | |
| 2wo7 | ASV | Isopenicillin N synthase | 1.21.3.1 | 0.457 | |
| 3pi5 | 3P5 | Beta-secretase 1 | 3.4.23.46 | 0.457 | |
| 4cf6 | CBD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.457 | |
| 4llk | MEW | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.457 | |
| 5dsy | UHB | Poly [ADP-ribose] polymerase 2 | 2.4.2.30 | 0.457 | |
| 1g8j | MGD | Arsenite oxidase subunit AioA | 1.20.9.1 | 0.456 | |
| 2jgs | BTN | Avidin | / | 0.456 | |
| 3duy | AFJ | Beta-secretase 1 | 3.4.23.46 | 0.456 | |
| 4b1e | 6T6 | Beta-secretase 1 | 3.4.23.46 | 0.456 | |
| 1cjw | COT | Serotonin N-acetyltransferase | / | 0.455 | |
| 1efz | PRF | Queuine tRNA-ribosyltransferase | 2.4.2.29 | 0.455 | |
| 1q5m | NDP | Prostaglandin-E(2) 9-reductase | 1.1.1.189 | 0.455 | |
| 1xf0 | ASD | Aldo-keto reductase family 1 member C3 | / | 0.455 | |
| 2dsh | SAH | Diphthine synthase | / | 0.455 | |
| 2gev | COK | Pantothenate kinase | 2.7.1.33 | 0.455 | |
| 2xup | TZ5 | Acetylcholinesterase | 3.1.1.7 | 0.455 | |
| 5ds3 | 09L | Poly [ADP-ribose] polymerase 1 | 2.4.2.30 | 0.455 | |
| 1geb | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.454 | |
| 1ndh | FAD | NADH-cytochrome b5 reductase 3 | 1.6.2.2 | 0.454 | |
| 1nzq | 162 | Prothrombin | 3.4.21.5 | 0.454 | |
| 1y2b | DEE | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.454 | |
| 2ejz | SAH | Diphthine synthase | / | 0.454 | |
| 2rd6 | 78P | Poly [ADP-ribose] polymerase 1 | 2.4.2.30 | 0.454 | |
| 3tvx | PNX | cAMP-specific 3',5'-cyclic phosphodiesterase 4A | 3.1.4.53 | 0.454 | |
| 4ewo | 996 | Beta-secretase 1 | 3.4.23.46 | 0.454 | |
| 4k9h | 1QU | Beta-secretase 1 | 3.4.23.46 | 0.454 | |
| 1a59 | COA | 2-methylcitrate synthase | / | 0.453 | |
| 1drh | NAP | Dihydrofolate reductase | 1.5.1.3 | 0.453 | |
| 1gae | NAD | Glyceraldehyde-3-phosphate dehydrogenase A | / | 0.453 | |
| 1zdw | FLV | Prenyltransferase | / | 0.453 | |
| 2a0y | DIH | Purine nucleoside phosphorylase | 2.4.2.1 | 0.453 | |
| 2bf7 | HBI | Pteridine reductase 1 | 1.5.1.33 | 0.453 | |
| 2bfp | H4B | Pteridine reductase 1 | 1.5.1.33 | 0.453 | |
| 2f3f | AXF | Beta-secretase 1 | 3.4.23.46 | 0.453 | |
| 3b6p | TMP | Three-prime repair exonuclease 1 | 3.1.11.2 | 0.453 | |
| 4eph | 0RK | Carnitine O-palmitoyltransferase 2, mitochondrial | 2.3.1.21 | 0.453 | |
| 4j0t | 6T9 | Beta-secretase 1 | 3.4.23.46 | 0.453 | |
| 4lxa | 1YS | Beta-secretase 1 | 3.4.23.46 | 0.453 | |
| 5c3j | FAD | Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial | / | 0.453 | |
| 1zkn | IBM | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.452 | |
| 2bfr | ADP | [Protein ADP-ribosylglutamate] hydrolase AF_1521 | 3.2.2 | 0.452 | |
| 2ea1 | GPG | Ribonuclease I | 3.1.27.6 | 0.452 | |
| 2p4j | 23I | Beta-secretase 1 | 3.4.23.46 | 0.452 | |
| 2yy2 | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.452 | |
| 3jsw | JAR | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.452 | |
| 3sl8 | JN7 | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.452 | |
| 4ajm | 3A6 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.452 | |
| 4hhy | 15R | Poly [ADP-ribose] polymerase 1 | 2.4.2.30 | 0.452 | |
| 4kx6 | FAD | Fumarate reductase flavoprotein subunit | 1.3.5.4 | 0.452 | |
| 4nxx | GDP | Mitochondrial dynamics protein MID51 | / | 0.452 | |
| 1odc | A8B | Acetylcholinesterase | 3.1.1.7 | 0.451 | |
| 1rkp | IBM | cGMP-specific 3',5'-cyclic phosphodiesterase | / | 0.451 | |
| 2p8u | COA | Hydroxymethylglutaryl-CoA synthase, cytoplasmic | 2.3.3.10 | 0.451 | |
| 3arv | SAU | Chitinase A | / | 0.451 | |
| 3g1o | RF1 | HTH-type transcriptional regulator EthR | / | 0.451 | |
| 4gv4 | MEJ | Poly [ADP-ribose] polymerase 3 | 2.4.2.30 | 0.451 | |
| 4l6s | 1WQ | Poly [ADP-ribose] polymerase 1 | 2.4.2.30 | 0.451 | |
| 1gpn | HUB | Acetylcholinesterase | 3.1.1.7 | 0.450 | |
| 1i5r | HYC | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.450 | |
| 1me6 | IVS | Plasmepsin-2 | 3.4.23.39 | 0.450 | |
| 1ppj | ANY | Cytochrome b | / | 0.450 | |
| 1so2 | 666 | cGMP-inhibited 3',5'-cyclic phosphodiesterase B | 3.1.4.17 | 0.450 | |
| 2hiz | LIJ | Beta-secretase 1 | 3.4.23.46 | 0.450 | |
| 2o8h | 227 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.450 | |
| 2xlr | FAD | Putative flavin-containing monooxygenase | / | 0.450 | |
| 3a25 | SAM | tRNA(Phe) (4-demethylwyosine(37)-C(7)) aminocarboxypropyltransferase | / | 0.450 | |
| 3dys | 5GP | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.450 | |
| 4frj | DWB | Beta-secretase 1 | 3.4.23.46 | 0.450 | |
| 4h3j | 10W | Beta-secretase 1 | 3.4.23.46 | 0.450 | |
| 4q71 | FAD | Bifunctional protein PutA | / | 0.450 | |
| 1bo4 | COA | Aminoglycoside-(3)-N-acetyltransferase | / | 0.449 | |
| 1lbb | KAI | Glutamate receptor 2 | / | 0.449 | |
| 1muu | GDX | GDP-mannose 6-dehydrogenase | 1.1.1.132 | 0.449 | |
| 2r8p | T6F | Transketolase 1 | / | 0.449 | |
| 2xlp | NAP | Putative flavin-containing monooxygenase | / | 0.449 | |
| 3aiq | HBO | 4-hydroxy-7-methoxy-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-2-yl glucoside beta-D-glucosidase 1b, chloroplastic | 3.2.1.182 | 0.449 | |
| 4b4w | 9L9 | Bifunctional protein FolD | / | 0.449 | |
| 4l5b | 1UX | Deoxycytidine kinase | 2.7.1.74 | 0.449 | |
| 1dr3 | HBI | Dihydrofolate reductase | 1.5.1.3 | 0.448 | |
| 1w6h | TIT | Plasmepsin-2 | 3.4.23.39 | 0.448 | |
| 2b04 | CHO | Phospholipase A2, major isoenzyme | 3.1.1.4 | 0.448 | |
| 2g94 | ZPQ | Beta-secretase 1 | 3.4.23.46 | 0.448 | |
| 3hmv | HBT | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.448 | |
| 3otw | COA | Phosphopantetheine adenylyltransferase | / | 0.448 | |
| 3q3c | NAD | NAD-dependent L-serine dehydrogenase | / | 0.448 | |
| 4exg | 916 | Beta-secretase 1 | 3.4.23.46 | 0.448 | |
| 4imf | SI3 | N-acetylneuraminate lyase | / | 0.448 | |
| 4lez | 1SY | Cyclic GMP-AMP synthase | / | 0.448 | |
| 4q72 | FAD | Bifunctional protein PutA | / | 0.448 | |
| 1hzz | NAP | NAD(P) transhydrogenase subunit beta | 1.6.1.2 | 0.447 | |
| 1ps9 | MDE | 2,4-dienoyl-CoA reductase | 1.3.1.34 | 0.447 | |
| 1q84 | TZ4 | Acetylcholinesterase | 3.1.1.7 | 0.447 | |
| 1uk0 | FRM | Poly [ADP-ribose] polymerase 1 | 2.4.2.30 | 0.447 | |
| 1yry | MSG | Purine nucleoside phosphorylase | 2.4.2.1 | 0.447 | |
| 2pks | G44 | Prothrombin | 3.4.21.5 | 0.447 | |
| 2wez | ZYE | Beta-secretase 1 | 3.4.23.46 | 0.447 | |
| 2wf1 | ZY1 | Beta-secretase 1 | 3.4.23.46 | 0.447 | |
| 2xi4 | AFT | Acetylcholinesterase | 3.1.1.7 | 0.447 | |
| 3dop | NAP | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.447 | |
| 3pvc | FAD | tRNA 5-methylaminomethyl-2-thiouridine biosynthesis bifunctional protein MnmC | / | 0.447 | |
| 4jey | PLP | Acetylornithine/succinyldiaminopimelate aminotransferase | 2.6.1.11 | 0.447 | |
| 4wxf | PLG | Serine hydroxymethyltransferase | / | 0.447 | |
| 1ib0 | FAD | NADH-cytochrome b5 reductase 3 | 1.6.2.2 | 0.446 | |
| 1ut6 | A8N | Acetylcholinesterase | 3.1.1.7 | 0.446 | |
| 1xon | PIL | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.446 | |
| 3b82 | NAD | Exotoxin A | 2.4.2.36 | 0.446 | |
| 4tvj | 09L | Poly [ADP-ribose] polymerase 2 | 2.4.2.30 | 0.446 | |
| 4ynp | SAM | Histone-lysine N-methyltransferase ASH1L | 2.1.1.43 | 0.446 | |
| 5hwr | COA | Hydroxymethylglutaryl-CoA synthase | / | 0.446 | |
| 1oj4 | CDM | 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase | 2.7.1.148 | 0.445 | |
| 1xud | PB4 | Collagenase 3 | 3.4.24 | 0.445 | |
| 1zq5 | E04 | Aldo-keto reductase family 1 member C3 | / | 0.445 | |
| 2hm1 | LIQ | Beta-secretase 1 | 3.4.23.46 | 0.445 | |
| 2ouy | CMP | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.445 | |
| 2r8o | T5X | Transketolase 1 | / | 0.445 | |
| 3g4g | D71 | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.445 | |
| 3nhl | YTR | Ribosyldihydronicotinamide dehydrogenase [quinone] | / | 0.445 | |
| 4dvi | 2IW | Tankyrase-1 | 2.4.2.30 | 0.445 | |
| 4m6j | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.445 | |
| 4n3l | 2FN | Prothrombin | 3.4.21.5 | 0.445 | |
| 5hwo | HMG | Hydroxymethylglutaryl-CoA synthase | / | 0.445 | |
| 1e7q | NAP | GDP-L-fucose synthase | / | 0.444 | |
| 1f3e | DPZ | Queuine tRNA-ribosyltransferase | 2.4.2.29 | 0.444 | |
| 1rft | PXM | Pyridoxal kinase | 2.7.1.35 | 0.444 | |
| 1thn | ADP | Anti-sigma F factor | / | 0.444 | |
| 2cvz | NDP | 3-hydroxyisobutyrate dehydrogenase | / | 0.444 | |
| 2gil | GTP | Ras-related protein Rab-6A | / | 0.444 | |
| 2pg0 | FAD | Acyl-CoA dehydrogenase | / | 0.444 | |
| 2wge | TLM | 3-oxoacyl-[acyl-carrier-protein] synthase 1 | 2.3.1.41 | 0.444 | |
| 2yig | 5EL | Collagenase 3 | 3.4.24 | 0.444 | |
| 3dzk | NMN | ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 | 3.2.2.6 | 0.444 | |
| 3i28 | 34N | Bifunctional epoxide hydrolase 2 | 3.3.2.10 | 0.444 | |
| 3iak | EV1 | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.444 | |
| 3jqb | DX6 | Pteridine reductase, putative | / | 0.444 | |
| 3ox1 | 695 | Ribosyldihydronicotinamide dehydrogenase [quinone] | / | 0.444 | |
| 3qbh | QBH | Beta-secretase 1 | 3.4.23.46 | 0.444 | |
| 3t8v | BTJ | M1 family aminopeptidase | 3.4.11 | 0.444 | |
| 4ara | C56 | Acetylcholinesterase | 3.1.1.7 | 0.444 | |
| 4c72 | TLG | 3-oxoacyl-ACP synthase | / | 0.444 | |
| 4gev | CB3 | Thymidylate synthase | / | 0.444 | |
| 4j0p | 1H8 | Beta-secretase 1 | 3.4.23.46 | 0.444 | |
| 4lcn | GNG | Cytidine and deoxycytidylate deaminase zinc-binding region | / | 0.444 | |
| 4li6 | 1XO | Tankyrase-1 | 2.4.2.30 | 0.444 | |
| 4oew | 5IO | cGMP-specific 3',5'-cyclic phosphodiesterase | / | 0.444 | |
| 1bk0 | ACV | Isopenicillin N synthase | 1.21.3.1 | 0.443 | |
| 1kce | CB3 | Thymidylate synthase | / | 0.443 | |
| 1l2s | STC | Beta-lactamase | 3.5.2.6 | 0.443 | |
| 1trg | CB3 | Thymidylate synthase | / | 0.443 | |
| 2nnl | NAP | Dihydroflavonol 4-reductase | 1.1.1.219 | 0.443 | |
| 2xw7 | NDP | Dihydrofolate reductase | / | 0.443 | |
| 2zev | B71 | Geranylgeranyl pyrophosphate synthase | / | 0.443 | |
| 3exf | TPP | Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial | 1.2.4.1 | 0.443 | |
| 3exf | TPP | Pyruvate dehydrogenase E1 component subunit beta, mitochondrial | 1.2.4.1 | 0.443 | |
| 3k5c | 0BI | Beta-secretase 1 | 3.4.23.46 | 0.443 | |
| 3nx2 | FER | Ferulic acid decarboxylase | / | 0.443 | |
| 4bfz | ZVZ | Pantothenate kinase | 2.7.1.33 | 0.443 | |
| 4fhd | 0TT | Spore photoproduct lyase | / | 0.443 | |
| 4g2j | 0WF | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.443 | |
| 4kp7 | 1UQ | 1-deoxy-D-xylulose 5-phosphate reductoisomerase, apicoplastic | 1.1.1.267 | 0.443 | |
| 4l4x | NDP | AmphI | / | 0.443 | |
| 1aqu | EST | Estrogen sulfotransferase, testis isoform | 2.8.2.4 | 0.442 | |
| 1axw | MTX | Thymidylate synthase | / | 0.442 | |
| 1k21 | IGN | Prothrombin | 3.4.21.5 | 0.442 | |
| 1ld7 | U66 | Protein farnesyltransferase subunit beta | 2.5.1.58 | 0.442 | |
| 1osv | CHC | Bile acid receptor | / | 0.442 | |
| 1rfu | ADP | Pyridoxal kinase | 2.7.1.35 | 0.442 | |
| 1wl4 | COA | Acetyl-CoA acetyltransferase, cytosolic | 2.3.1.9 | 0.442 | |
| 2c1b | CQP | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.442 | |
| 3g4i | D71 | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.442 | |
| 3i6q | NDP | Putative leucoanthocyanidin reductase 1 | / | 0.442 | |
| 3udq | 09E | Beta-secretase 1 | 3.4.23.46 | 0.442 | |
| 4b1h | AR6 | Poly(ADP-ribose) glycohydrolase | 3.2.1.143 | 0.442 | |
| 4b1j | A1R | Poly(ADP-ribose) glycohydrolase | 3.2.1.143 | 0.442 | |
| 4d6q | PD2 | Lysine-specific demethylase 4D | 1.14.11 | 0.442 | |
| 4fcb | 0T7 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.442 | |
| 4i1c | 1BE | Beta-secretase 1 | 3.4.23.46 | 0.442 | |
| 1y2e | 5DE | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.441 | |
| 2ylx | FAD | Phenylacetone monooxygenase | 1.14.13.92 | 0.441 | |
| 3aiv | HBO | 4-hydroxy-7-methoxy-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-2-yl glucoside beta-D-glucosidase, chloroplastic | 3.2.1.182 | 0.441 | |
| 3dva | TPW | Pyruvate dehydrogenase E1 component subunit alpha | 1.2.4.1 | 0.441 | |
| 3dva | TPW | Pyruvate dehydrogenase E1 component subunit beta | 1.2.4.1 | 0.441 | |
| 3q33 | ACO | Histone acetyltransferase RTT109 | 2.3.1.48 | 0.441 | |
| 4f32 | N32 | 3-oxoacyl-[acyl-carrier-protein] synthase 2 | / | 0.441 | |
| 4j0z | 1H5 | Beta-secretase 1 | 3.4.23.46 | 0.441 | |
| 4ks8 | B49 | Serine/threonine-protein kinase PAK 6 | 2.7.11.1 | 0.441 | |
| 4z87 | GDP | Inosine-5'-monophosphate dehydrogenase | / | 0.441 | |
| 5jqh | CAU | Beta-2 adrenergic receptor | / | 0.441 | |
| 1gj5 | 130 | Prothrombin | 3.4.21.5 | 0.440 | |
| 1iwj | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.440 | |
| 1jue | FMN | Dihydroorotate dehydrogenase A (fumarate) | 1.3.98.1 | 0.440 | |
| 1o2g | 696 | Prothrombin | 3.4.21.5 | 0.440 | |
| 1pr4 | MTP | Purine nucleoside phosphorylase DeoD-type | / | 0.440 | |
| 1rgs | CMP | cAMP-dependent protein kinase type I-alpha regulatory subunit | / | 0.440 | |
| 1vbm | YSA | Tyrosine--tRNA ligase | 6.1.1.1 | 0.440 | |
| 2bsx | NOS | Purine nucleoside phosphorylase | / | 0.440 | |
| 2ivf | MGD | Alpha-subunit of ethylbenzene dehydrogenase | / | 0.440 | |
| 2op1 | 8PC | Enoyl-ACP reductase | / | 0.440 | |
| 2p6k | SAH | Diphthine synthase | / | 0.440 | |
| 2wat | COA | Fatty acid synthase subunit alpha | 2.3.1.86 | 0.440 | |
| 2zba | ZBA | Trichothecene 3-O-acetyltransferase | / | 0.440 | |
| 3aez | GDP | Pantothenate kinase | 2.7.1.33 | 0.440 | |
| 3hky | IX6 | Genome polyprotein | 2.7.7.48 | 0.440 | |
| 3itu | IBM | cGMP-dependent 3',5'-cyclic phosphodiesterase | 3.1.4.17 | 0.440 | |
| 3qpo | PFR | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.440 | |
| 3sn7 | 540 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.440 | |
| 4a39 | GEM | Uncharacterized protein | / | 0.440 | |
| 4b66 | NAP | L-ornithine N(5)-monooxygenase | / | 0.440 | |
| 4i9z | 5BA | cGMP-specific 3',5'-cyclic phosphodiesterase | / | 0.440 | |
| 4li8 | 1XQ | Tankyrase-1 | 2.4.2.30 | 0.440 |