sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Cavities are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 4btu | 6XS | Coagulation factor X | 3.4.21.6 |
| PDB ID | HET | Uniprot Name | EC Number | Cavity Similarity |
Align |
|---|---|---|---|---|---|
| 4btu | 6XS | Coagulation factor X | 3.4.21.6 | 1.000 | |
| 2g00 | 4QC | Coagulation factor X | 3.4.21.6 | 0.591 | |
| 4bti | 7R9 | Coagulation factor X | 3.4.21.6 | 0.562 | |
| 1iqg | XME | Coagulation factor X | 3.4.21.6 | 0.523 | |
| 1nfy | RTR | Coagulation factor X | 3.4.21.6 | 0.522 | |
| 2jh5 | 895 | Prothrombin | 3.4.21.5 | 0.521 | |
| 3b6z | CO7 | Enoyl reductase LovC | 1 | 0.513 | |
| 2gde | SN3 | Prothrombin | 3.4.21.5 | 0.511 | |
| 2zi2 | 24U | Prothrombin | 3.4.21.5 | 0.510 | |
| 4fue | 7UP | Urokinase-type plasminogen activator | 3.4.21.73 | 0.504 | |
| 2cji | GSK | Coagulation factor X | 3.4.21.6 | 0.503 | |
| 4ax9 | N5N | Prothrombin | 3.4.21.5 | 0.503 | |
| 1d3p | BT3 | Prothrombin | 3.4.21.5 | 0.502 | |
| 3egk | M18 | Prothrombin | 3.4.21.5 | 0.500 | |
| 3v0x | ANH | Cationic trypsin | 3.4.21.4 | 0.500 | |
| 1uvs | I11 | Prothrombin | 3.4.21.5 | 0.497 | |
| 2anm | CDO | Prothrombin | 3.4.21.5 | 0.495 | |
| 2bvs | 2CE | Prothrombin | 3.4.21.5 | 0.495 | |
| 1gj4 | 132 | Prothrombin | 3.4.21.5 | 0.493 | |
| 1pq9 | 44B | Oxysterols receptor LXR-beta | / | 0.492 | |
| 1zsk | 421 | Coagulation factor XI | 3.4.21.27 | 0.492 | |
| 2a2x | NA9 | Prothrombin | 3.4.21.5 | 0.492 | |
| 1d9i | 00P | Prothrombin | 3.4.21.5 | 0.491 | |
| 1sqt | UI3 | Urokinase-type plasminogen activator | 3.4.21.73 | 0.491 | |
| 1y7l | ASN_LEU_ASN_ILE | Cysteine synthase | 2.5.1.47 | 0.491 | |
| 2jh6 | 894 | Prothrombin | 3.4.21.5 | 0.491 | |
| 4lxb | 7R9 | Prothrombin | 3.4.21.5 | 0.490 | |
| 1zgi | 382 | Prothrombin | 3.4.21.5 | 0.489 | |
| 1nm6 | L86 | Prothrombin | 3.4.21.5 | 0.488 | |
| 3ieu | GDP | GTPase Era | / | 0.488 | |
| 1ypl | RA8 | Prothrombin | 3.4.21.5 | 0.486 | |
| 3te5 | NAI | 5'-AMP-activated protein kinase subunit gamma | / | 0.486 | |
| 4ayv | 9MQ | Prothrombin | 3.4.21.5 | 0.486 | |
| 1gj5 | 130 | Prothrombin | 3.4.21.5 | 0.484 | |
| 1ta6 | 177 | Prothrombin | 3.4.21.5 | 0.484 | |
| 2pzj | NAD | Putative nucleotide sugar epimerase/ dehydratase | / | 0.483 | |
| 3hat | GLY_VAL_ARG_RNG | Prothrombin | 3.4.21.5 | 0.483 | |
| 1ype | UIP | Prothrombin | 3.4.21.5 | 0.481 | |
| 1o5g | CR9 | Prothrombin | 3.4.21.5 | 0.480 | |
| 1ypg | UIR | Prothrombin | 3.4.21.5 | 0.479 | |
| 3dhk | 23U | Prothrombin | 3.4.21.5 | 0.477 | |
| 1u7t | NAD | 3-hydroxyacyl-CoA dehydrogenase type-2 | 1.1.1.35 | 0.476 | |
| 4dbz | NDP | Putative ketoacyl reductase | 1.3.1 | 0.476 | |
| 1iqe | XMB | Coagulation factor X | 3.4.21.6 | 0.475 | |
| 2ewm | NAD | (S)-1-Phenylethanol dehydrogenase | 1.1.1.311 | 0.475 | |
| 1d4p | BPP | Prothrombin | 3.4.21.5 | 0.474 | |
| 3mpi | FAD | Glutaryl-CoA dehydrogenase | 1.3.99.32 | 0.474 | |
| 3toz | NAD | Shikimate dehydrogenase (NADP(+)) | / | 0.474 | |
| 1c4u | IH1 | Prothrombin | 3.4.21.5 | 0.473 | |
| 1ib0 | NAD | NADH-cytochrome b5 reductase 3 | 1.6.2.2 | 0.473 | |
| 1mu6 | CDA | Prothrombin | 3.4.21.5 | 0.473 | |
| 2zc9 | 22U | Prothrombin | 3.4.21.5 | 0.473 | |
| 2zfr | 46U | Prothrombin | 3.4.21.5 | 0.473 | |
| 1qx4 | FAD | NADH-cytochrome b5 reductase 3 | 1.6.2.2 | 0.472 | |
| 1xm1 | GAH | Prothrombin | 3.4.21.5 | 0.472 | |
| 2viv | VG2 | Urokinase-type plasminogen activator | 3.4.21.73 | 0.472 | |
| 3iah | NAP | Putative oxoacyl-(Acyl carrier protein) reductase | / | 0.472 | |
| 1oyt | FSN | Prothrombin | 3.4.21.5 | 0.471 | |
| 1tj0 | FAD | Bifunctional protein PutA | 1.5.5.2 | 0.471 | |
| 2qw0 | 34Z | 4-chlorobenzoyl CoA ligase | / | 0.471 | |
| 2zda | 32U | Prothrombin | 3.4.21.5 | 0.471 | |
| 1kt8 | ILP | Branched-chain-amino-acid aminotransferase, mitochondrial | 2.6.1.42 | 0.470 | |
| 2gmh | FAD | Electron transfer flavoprotein-ubiquinone oxidoreductase, mitochondrial | 1.5.5.1 | 0.470 | |
| 4mok | FAD | Pyranose 2-oxidase | / | 0.470 | |
| 1vja | 7IN | Urokinase-type plasminogen activator | 3.4.21.73 | 0.469 | |
| 3atz | FMN | Prostaglandin F2a synthase | / | 0.469 | |
| 3qt6 | 2P0 | Mevalonate diphosphate decarboxylase | / | 0.469 | |
| 1szg | FNS | Cytochrome b2, mitochondrial | 1.1.2.3 | 0.468 | |
| 2abb | FMN | Pentaerythritol tetranitrate reductase | / | 0.468 | |
| 2fj1 | CTC | Tetracycline repressor protein class D | / | 0.468 | |
| 2ylz | FAD | Phenylacetone monooxygenase | 1.14.13.92 | 0.468 | |
| 5d3q | GDP | Dynamin-1 | 3.6.5.5 | 0.468 | |
| 1lrj | UD1 | UDP-glucose 4-epimerase | 5.1.3.2 | 0.467 | |
| 2v3o | I26 | Prothrombin | 3.4.21.5 | 0.467 | |
| 3dhe | AND | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.467 | |
| 2w3b | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.466 | |
| 2zhe | 13U | Prothrombin | 3.4.21.5 | 0.466 | |
| 3in6 | FMN | Uncharacterized protein | / | 0.466 | |
| 4dd8 | BAT | Disintegrin and metalloproteinase domain-containing protein 8 | 3.4.24 | 0.466 | |
| 1r6u | TYM | Tryptophan--tRNA ligase, cytoplasmic | 6.1.1.2 | 0.465 | |
| 1ra3 | NAP | Dihydrofolate reductase | 1.5.1.3 | 0.465 | |
| 1vi2 | NAD | Quinate/shikimate dehydrogenase | / | 0.465 | |
| 1xe6 | 5FP | Plasmepsin-2 | 3.4.23.39 | 0.465 | |
| 3c1k | T15 | Prothrombin | 3.4.21.5 | 0.465 | |
| 3kqb | LGJ | Coagulation factor X | 3.4.21.6 | 0.465 | |
| 4a8v | 2AN | Major pollen allergen Bet v 1-J | / | 0.465 | |
| 4brg | GNP | Ectonucleoside triphosphate diphosphohydrolase I | / | 0.465 | |
| 4loy | 6XS | Prothrombin | 3.4.21.5 | 0.465 | |
| 2ed4 | NAD | 4-hydroxyphenylacetate 3-monooxygenase reductase component | 1.5.1.36 | 0.464 | |
| 2hfu | MEV | Mevalonate kinase | / | 0.464 | |
| 3ty3 | GGG | Homoisocitrate dehydrogenase | 1.1.1.87 | 0.464 | |
| 4btt | VYR | Coagulation factor X | 3.4.21.6 | 0.464 | |
| 4hfp | 15U | Prothrombin | 3.4.21.5 | 0.464 | |
| 2oap | ANP | Type II secretion system protein (GspE-2) | / | 0.463 | |
| 2rc4 | ACO | Histone acetyltransferase KAT6A | / | 0.463 | |
| 2y0m | ACO | Histone acetyltransferase KAT8 | / | 0.463 | |
| 4eu9 | COA | Succinyl-CoA:acetate CoA-transferase | / | 0.463 | |
| 2q1t | NAD | Putative nucleotide sugar epimerase/ dehydratase | / | 0.462 | |
| 3h3q | H13 | Collagen type IV alpha-3-binding protein | / | 0.462 | |
| 4an4 | DUD | Putative glycosyl transferase | / | 0.462 | |
| 4blr | UTP | NTPase P4 | / | 0.462 | |
| 4n3l | 2FN | Prothrombin | 3.4.21.5 | 0.462 | |
| 1d6w | 00R | Prothrombin | 3.4.21.5 | 0.461 | |
| 2cn0 | F25 | Prothrombin | 3.4.21.5 | 0.461 | |
| 2y05 | NAP | Prostaglandin reductase 1 | / | 0.461 | |
| 3ioc | A5D | Pantothenate synthetase | 6.3.2.1 | 0.461 | |
| 3lqf | NAD | Galactitol dehydrogenase | / | 0.461 | |
| 3own | 3OW | Renin | 3.4.23.15 | 0.461 | |
| 3r3s | NAD | Putative oxidoreductase | / | 0.461 | |
| 4jnk | NAI | L-lactate dehydrogenase A chain | 1.1.1.27 | 0.461 | |
| 1xe5 | 5FE | Plasmepsin-2 | 3.4.23.39 | 0.460 | |
| 2dft | ADP | Shikimate kinase | 2.7.1.71 | 0.460 | |
| 4a83 | DXC | Major pollen allergen Bet v 1-A | / | 0.460 | |
| 1z71 | L17 | Prothrombin | 3.4.21.5 | 0.459 | |
| 2abj | PLP | Branched-chain-amino-acid aminotransferase, cytosolic | 2.6.1.42 | 0.459 | |
| 2c20 | NAD | UDP-glucose 4-epimerase | / | 0.459 | |
| 2fw3 | BUI | Carnitine O-palmitoyltransferase 2, mitochondrial | 2.3.1.21 | 0.459 | |
| 2wyv | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | / | 0.459 | |
| 3pnd | FAD | FAD:protein FMN transferase | / | 0.459 | |
| 1bws | NDP | GDP-L-fucose synthase | / | 0.458 | |
| 2ejv | NAD | L-threonine 3-dehydrogenase | / | 0.458 | |
| 2rlc | CHD | Choloylglycine hydrolase | 3.5.1.24 | 0.458 | |
| 3kjs | NAP | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.458 | |
| 4eag | ATP | 5'-AMP-activated protein kinase subunit gamma-1 | / | 0.458 | |
| 5adh | APR | Alcohol dehydrogenase E chain | 1.1.1.1 | 0.458 | |
| 1mja | COA | Histone acetyltransferase ESA1 | / | 0.457 | |
| 1riw | OSC | Prothrombin | 3.4.21.5 | 0.457 | |
| 3hyo | ADP | Pyridoxal kinase | / | 0.457 | |
| 3rv7 | RVB | Salicylate synthase | / | 0.457 | |
| 5fs7 | FAD | Apoptosis-inducing factor 1, mitochondrial | 1.1.1 | 0.457 | |
| 3etg | NDP | Glutamate dehydrogenase 1, mitochondrial | 1.4.1.3 | 0.456 | |
| 3hlw | CE3 | Beta-lactamase | / | 0.456 | |
| 3nxx | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.456 | |
| 1h63 | FMN | Pentaerythritol tetranitrate reductase | / | 0.455 | |
| 3lsm | SFD | Pyranose 2-oxidase | / | 0.455 | |
| 4e7r | 0NW | Prothrombin | 3.4.21.5 | 0.455 | |
| 4ozt | P1A | Ecdysone receptor, putative | / | 0.455 | |
| 1k4q | FAD | Glutathione reductase, mitochondrial | 1.8.1.7 | 0.454 | |
| 1uma | IN2 | Prothrombin | 3.4.21.5 | 0.454 | |
| 2fzn | FAD | Bifunctional protein PutA | 1.5.5.2 | 0.454 | |
| 2gv8 | NDP | Thiol-specific monooxygenase | 1.14.13 | 0.454 | |
| 2y5h | Y5H | Coagulation factor X | 3.4.21.6 | 0.454 | |
| 2zeb | 11M | Tryptase alpha/beta-1 | 3.4.21.59 | 0.454 | |
| 3gqv | NAP | Enoyl reductase LovC | 1 | 0.454 | |
| 4dfr | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.454 | |
| 4gs4 | ACO | Alpha-tubulin N-acetyltransferase 1 | / | 0.454 | |
| 4loi | 1YC | Stimulator of interferon genes protein | / | 0.454 | |
| 4nd3 | NAD | Lactate dehydrogenase, adjacent gene encodes predicted malate dehydrogenase | / | 0.454 | |
| 4q0k | GA3 | Phytohormone-binding protein | / | 0.454 | |
| 4usr | FAD | Monooxygenase | / | 0.454 | |
| 1bcu | PRL | Prothrombin | 3.4.21.5 | 0.453 | |
| 1kvu | UPG | UDP-glucose 4-epimerase | 5.1.3.2 | 0.453 | |
| 1l7x | 700 | Glycogen phosphorylase, liver form | 2.4.1.1 | 0.453 | |
| 1o2g | 696 | Prothrombin | 3.4.21.5 | 0.453 | |
| 2fn7 | NAD | Lactate dehydrogenase, adjacent gene encodes predicted malate dehydrogenase | / | 0.453 | |
| 2ji6 | TPW | Oxalyl-CoA decarboxylase | 4.1.1.8 | 0.453 | |
| 3d3w | NAP | L-xylulose reductase | 1.1.1.10 | 0.453 | |
| 3img | BZ2 | Pantothenate synthetase | 6.3.2.1 | 0.453 | |
| 4bca | FAD | Alkyldihydroxyacetonephosphate synthase, peroxisomal | 2.5.1.26 | 0.453 | |
| 4gap | NAD | Rotenone-insensitive NADH-ubiquinone oxidoreductase, mitochondrial | 1.6.5.9 | 0.453 | |
| 4i9h | 1E4 | L-lactate dehydrogenase A chain | 1.1.1.27 | 0.453 | |
| 4rel | KMP | Glycosyltransferase | / | 0.453 | |
| 1gmc | PRO_GLY_ALA_TYR | Chymotrypsinogen A | 3.4.21.1 | 0.452 | |
| 1qlh | NAD | Alcohol dehydrogenase E chain | 1.1.1.1 | 0.452 | |
| 2a5h | SAM | L-lysine 2,3-aminomutase | 5.4.3.2 | 0.452 | |
| 2vke | TAC | Tetracycline repressor protein class D | / | 0.452 | |
| 3ai3 | NDP | NADPH-sorbose reductase | / | 0.452 | |
| 3eks | CY9 | Actin-5C | / | 0.452 | |
| 3iqi | ASN_GLU_ASN_ILE | Cysteine synthase | 2.5.1.47 | 0.452 | |
| 3tox | NAP | Putative oxidoreductase | / | 0.452 | |
| 4bkq | NAI | Enoyl-[acyl-carrier-protein] reductase [NADH] | / | 0.452 | |
| 4eua | COA | Succinyl-CoA:acetate CoA-transferase | / | 0.452 | |
| 1cyd | NDP | Carbonyl reductase [NADPH] 2 | 1.1.1.184 | 0.451 | |
| 1g1a | NAD | dTDP-glucose 4,6-dehydratase | / | 0.451 | |
| 1ksz | PGS | Adenylosuccinate synthetase | / | 0.451 | |
| 1me6 | IVS | Plasmepsin-2 | 3.4.23.39 | 0.451 | |
| 2x9d | ITC | Tetracycline repressor protein class D | / | 0.451 | |
| 3iqh | TYR_ASP_ILE | Cysteine synthase | 2.5.1.47 | 0.451 | |
| 3k5c | 0BI | Beta-secretase 1 | 3.4.23.46 | 0.451 | |
| 4c7k | NAP | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.451 | |
| 4fub | 4UP | Urokinase-type plasminogen activator | 3.4.21.73 | 0.451 | |
| 4nbt | NAD | 3-oxoacyl-[acyl-carrier-protein] reductase | / | 0.451 | |
| 4u9y | COA | Alpha-tubulin N-acetyltransferase 1 | / | 0.451 | |
| 8dfr | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.451 | |
| 1civ | NAP | Malate dehydrogenase [NADP], chloroplastic | 1.1.1.82 | 0.450 | |
| 1x1a | SAM | C-20 methyltransferase | / | 0.450 | |
| 1ypj | UIB | Prothrombin | 3.4.21.5 | 0.450 | |
| 2f7x | 4EA | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.450 | |
| 2hma | SAM | tRNA-specific 2-thiouridylase MnmA | / | 0.450 | |
| 2y5g | FJD | Coagulation factor X | 3.4.21.6 | 0.450 | |
| 3ohh | 3HH | Beta-secretase 1 | 3.4.23.46 | 0.450 | |
| 3s1d | ZIR | Cytokinin dehydrogenase 1 | 1.5.99.12 | 0.450 | |
| 4b1r | ITC | Tetracycline repressor protein class D | / | 0.450 | |
| 4g7g | VFV | Lanosterol 14-alpha-demethylase | / | 0.450 | |
| 4m83 | ERY | Oleandomycin glycosyltransferase | 2.4.1 | 0.450 | |
| 1j49 | NAD | D-lactate dehydrogenase | 1.1.1.28 | 0.449 | |
| 1rne | C60 | Renin | 3.4.23.15 | 0.449 | |
| 2f3r | G5P | Guanylate kinase | 2.7.4.8 | 0.449 | |
| 2o23 | NAD | 3-hydroxyacyl-CoA dehydrogenase type-2 | 1.1.1.35 | 0.449 | |
| 2z3n | PHE_ARG_TYR_LEU_GLY | Leucyl/phenylalanyl-tRNA--protein transferase | 2.3.2.6 | 0.449 | |
| 2zhf | 49U | Prothrombin | 3.4.21.5 | 0.449 | |
| 3d91 | REM | Renin | 3.4.23.15 | 0.449 | |
| 3hk1 | B64 | Fatty acid-binding protein, adipocyte | / | 0.449 | |
| 3ime | BZ2 | Pantothenate synthetase | 6.3.2.1 | 0.449 | |
| 3nsh | 957 | Beta-secretase 1 | 3.4.23.46 | 0.449 | |
| 3vwe | COA | Alpha-tubulin N-acetyltransferase 1 | / | 0.449 | |
| 3w5h | FAD | NADH-cytochrome b5 reductase 3 | 1.6.2.2 | 0.449 | |
| 3zei | AWH | O-acetylserine sulfhydrylase | / | 0.449 | |
| 4i0i | 957 | Beta-secretase 1 | 3.4.23.46 | 0.449 | |
| 1adf | TAD | Alcohol dehydrogenase E chain | 1.1.1.1 | 0.448 | |
| 1c3x | 8IG | Purine nucleoside phosphorylase | 2.4.2.1 | 0.448 | |
| 1jqi | FAD | Short-chain specific acyl-CoA dehydrogenase, mitochondrial | / | 0.448 | |
| 1mue | CDD | Prothrombin | 3.4.21.5 | 0.448 | |
| 2a92 | NAI | L-lactate dehydrogenase | / | 0.448 | |
| 2qbu | SAH | Precorrin-2 methyltransferase | / | 0.448 | |
| 2vig | FAD | Short-chain specific acyl-CoA dehydrogenase, mitochondrial | 1.3.8.1 | 0.448 | |
| 2zvb | SAH | Precorrin-3 C17-methyltransferase | / | 0.448 | |
| 3f1k | NAP | Uncharacterized oxidoreductase YciK | 1 | 0.448 | |
| 3phi | NDP | Shikimate dehydrogenase (NADP(+)) | / | 0.448 | |
| 4a86 | 2AN | Major pollen allergen Bet v 1-A | / | 0.448 | |
| 4epl | JAI | Jasmonic acid-amido synthetase JAR1 | 6.3.2 | 0.448 | |
| 4ewo | 996 | Beta-secretase 1 | 3.4.23.46 | 0.448 | |
| 4xr9 | NAD | CalS8 | / | 0.448 | |
| 4yxm | 2BA | DNA integrity scanning protein DisA | / | 0.448 | |
| 1fy7 | COA | Histone acetyltransferase ESA1 | / | 0.447 | |
| 1w4x | FAD | Phenylacetone monooxygenase | 1.14.13.92 | 0.447 | |
| 2rbe | NDP | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.447 | |
| 2wp9 | CBE | Succinate dehydrogenase iron-sulfur subunit | 1.3.5.1 | 0.447 | |
| 2wp9 | CBE | Succinate dehydrogenase cytochrome b556 subunit | / | 0.447 | |
| 2ym1 | FAD | Phenylacetone monooxygenase | 1.14.13.92 | 0.447 | |
| 2ztm | NAD | D(-)-3-hydroxybutyrate dehydrogenase | / | 0.447 | |
| 3h06 | VBP | Glutamate receptor 2 | / | 0.447 | |
| 3ig6 | 438 | Urokinase-type plasminogen activator | 3.4.21.73 | 0.447 | |
| 3oqk | S52 | Renin | 3.4.23.15 | 0.447 | |
| 4b77 | 54M | Beta-secretase 1 | 3.4.23.46 | 0.447 | |
| 4ntd | FAD | Thioredoxin reductase | / | 0.447 | |
| 4nvk | 2NY | Peroxidase | / | 0.447 | |
| 5dw6 | 0T1 | Succinyl-CoA:acetate CoA-transferase | / | 0.447 | |
| 1guy | NAD | Malate dehydrogenase | / | 0.446 | |
| 1t2c | NAI | L-lactate dehydrogenase | 1.1.1.27 | 0.446 | |
| 2dhf | DZF | Dihydrofolate reductase | 1.5.1.3 | 0.446 | |
| 2npx | NAD | NADH peroxidase | 1.11.1.1 | 0.446 | |
| 2v16 | C47 | Renin | 3.4.23.15 | 0.446 | |
| 3ixp | 834 | Ecdysone receptor | / | 0.446 | |
| 4emt | C2E | Stimulator of interferon genes protein | / | 0.446 | |
| 4yj2 | GTP | Tubulin alpha-1B chain | / | 0.446 | |
| 1d4a | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.445 | |
| 1lqd | CMI | Coagulation factor X | 3.4.21.6 | 0.445 | |
| 1owe | 675 | Urokinase-type plasminogen activator | 3.4.21.73 | 0.445 | |
| 1ra8 | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.445 | |
| 2a1h | GBN | Branched-chain-amino-acid aminotransferase, mitochondrial | 2.6.1.42 | 0.445 | |
| 2aa3 | AP0 | L-lactate dehydrogenase | / | 0.445 | |
| 3mdd | FAD | Medium-chain specific acyl-CoA dehydrogenase, mitochondrial | 1.3.8.7 | 0.445 | |
| 3zbr | NAP | 2',3'-cyclic-nucleotide 3'-phosphodiesterase | 3.1.4.37 | 0.445 | |
| 4de0 | 0JB | Beta-lactamase | / | 0.445 | |
| 4frk | DWD | Beta-secretase 1 | 3.4.23.46 | 0.445 | |
| 5c41 | ACP | Ribokinase | / | 0.445 | |
| 1bdb | NAD | Cis-2,3-dihydrobiphenyl-2,3-diol dehydrogenase | / | 0.444 | |
| 1c4v | IH2 | Prothrombin | 3.4.21.5 | 0.444 | |
| 1c9k | 5GP | Bifunctional adenosylcobalamin biosynthesis protein CobU | / | 0.444 | |
| 1kev | NDP | NADP-dependent isopropanol dehydrogenase | 1.1.1.80 | 0.444 | |
| 1nup | NMN | Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 3 | / | 0.444 | |
| 1nuu | NAD | Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 3 | / | 0.444 | |
| 2a94 | AP0 | L-lactate dehydrogenase | 1.1.1.27 | 0.444 | |
| 2jh0 | 701 | Prothrombin | 3.4.21.5 | 0.444 | |
| 2q1u | NAD | Putative nucleotide sugar epimerase/ dehydratase | / | 0.444 | |
| 2zvc | SAH | Precorrin-3 C17-methyltransferase | / | 0.444 | |
| 3djj | FAD | Glutathione reductase, mitochondrial | 1.8.1.7 | 0.444 | |
| 3m1v | COM | Methyl-coenzyme M reductase I subunit alpha | 2.8.4.1 | 0.444 | |
| 3m1v | COM | Methyl-coenzyme M reductase I subunit beta | 2.8.4.1 | 0.444 | |
| 3nut | SAH | Precorrin-3 methylase | / | 0.444 | |
| 3tr0 | 5GP | Guanylate kinase | / | 0.444 | |
| 3u9e | COA | Lmo1369 protein | / | 0.444 | |
| 4az2 | 9MU | Prothrombin | 3.4.21.5 | 0.444 | |
| 4k28 | NAD | Shikimate dehydrogenase family protein | / | 0.444 | |
| 4kx6 | FAD | Fumarate reductase flavoprotein subunit | 1.3.5.4 | 0.444 | |
| 4lhv | GDP | Ras-related protein Rab-8A | / | 0.444 | |
| 5ao1 | DG3 | Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 | 3.1.5 | 0.444 | |
| 1f92 | UKP | Urokinase-type plasminogen activator | 3.4.21.73 | 0.443 | |
| 1g0n | NDP | Tetrahydroxynaphthalene reductase | 1.1.1.252 | 0.443 | |
| 1i5c | ADP | Chemotaxis protein CheA | 2.7.13.3 | 0.443 | |
| 1k22 | MEL | Prothrombin | 3.4.21.5 | 0.443 | |
| 1kvt | UPG | UDP-glucose 4-epimerase | 5.1.3.2 | 0.443 | |
| 1lwi | NAP | 3-alpha-hydroxysteroid dehydrogenase | 1.1.1.50 | 0.443 | |
| 1m75 | CAA | Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial | 1.1.1.35 | 0.443 | |
| 1o9b | NAI | Quinate/shikimate dehydrogenase | / | 0.443 | |
| 1rfv | ADP | Pyridoxal kinase | 2.7.1.35 | 0.443 | |
| 1rx0 | FAD | Isobutyryl-CoA dehydrogenase, mitochondrial | 1.3.99 | 0.443 | |
| 2dc1 | NAD | Probable L-aspartate dehydrogenase | / | 0.443 | |
| 2gcq | DOI | Adenylosuccinate synthetase | / | 0.443 | |
| 2q4b | NAP | Uncharacterized protein At5g02240 | / | 0.443 | |
| 2udp | UPP | UDP-glucose 4-epimerase | 5.1.3.2 | 0.443 | |
| 2vat | COA | Acetyl-CoA--deacetylcephalosporin C acetyltransferase | 2.3.1.175 | 0.443 | |
| 2zgx | 29U | Prothrombin | 3.4.21.5 | 0.443 | |
| 2znn | S44 | Peroxisome proliferator-activated receptor alpha | / | 0.443 | |
| 2ztl | NAD | D(-)-3-hydroxybutyrate dehydrogenase | / | 0.443 | |
| 3dk9 | FAD | Glutathione reductase, mitochondrial | 1.8.1.7 | 0.443 | |
| 4acu | QN7 | Beta-secretase 1 | 3.4.23.46 | 0.443 | |
| 4b4w | 9L9 | Bifunctional protein FolD | / | 0.443 | |
| 4ozn | ATP | Ammonium transporter | / | 0.443 | |
| 4wzh | FMN | Dihydroorotate dehydrogenase (fumarate) | / | 0.443 | |
| 4yag | NAI | C alpha-dehydrogenase | / | 0.443 | |
| 5itz | GTP | Tubulin alpha-1B chain | / | 0.443 | |
| 1mjb | ACO | Histone acetyltransferase ESA1 | / | 0.442 | |
| 1sb8 | UD2 | WbpP | / | 0.442 | |
| 1udb | UFG | UDP-glucose 4-epimerase | 5.1.3.2 | 0.442 | |
| 1w51 | L01 | Beta-secretase 1 | 3.4.23.46 | 0.442 | |
| 1w6h | TIT | Plasmepsin-2 | 3.4.23.39 | 0.442 | |
| 2bkj | FMN | NADPH-flavin oxidoreductase | / | 0.442 | |
| 2gz7 | D3F | Orf1a polyprotein | / | 0.442 | |
| 2xpw | OTC | Tetracycline repressor protein class D | / | 0.442 | |
| 2xx9 | 1NF | Glutamate receptor 2 | / | 0.442 | |
| 3kb1 | ADP | Iron-sulfur cluster carrier protein | / | 0.442 | |
| 3kji | ADP | CO dehydrogenase/acetyl-CoA synthase complex, accessory protein CooC | / | 0.442 | |
| 3lsi | FAD | Pyranose 2-oxidase | / | 0.442 | |
| 4bfx | ZVX | Pantothenate kinase | 2.7.1.33 | 0.442 | |
| 4dyn | 0MR | Nucleoprotein | / | 0.442 | |
| 4e90 | 7RG | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.442 | |
| 4fj2 | NAP | 17beta-hydroxysteroid dehydrogenase | / | 0.442 | |
| 4i10 | 1BS | Beta-secretase 1 | 3.4.23.46 | 0.442 | |
| 4la1 | FAD | Thioredoxin glutathione reductase | / | 0.442 | |
| 4r81 | FMN | Predicted NADH dehydrogenase | / | 0.442 | |
| 1ep1 | FMN | Dihydroorotate dehydrogenase B (NAD(+)), catalytic subunit | 1.3.1.14 | 0.441 | |
| 1ju2 | FAD | (R)-mandelonitrile lyase 2 | 4.1.2.10 | 0.441 | |
| 1l5s | 700 | Glycogen phosphorylase, liver form | 2.4.1.1 | 0.441 | |
| 1npd | NAD | Quinate/shikimate dehydrogenase | / | 0.441 | |
| 2cnd | FAD | Nitrate reductase [NADH] | 1.7.1.1 | 0.441 | |
| 2giv | ACO | Histone acetyltransferase KAT8 | / | 0.441 | |
| 2x0i | NAI | Malate dehydrogenase | / | 0.441 | |
| 3bhi | NAP | Carbonyl reductase [NADPH] 1 | 1.1.1.184 | 0.441 | |
| 3inv | NDP | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.441 | |
| 3p62 | FMN | Pentaerythritol tetranitrate reductase | / | 0.441 | |
| 3qls | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.441 | |
| 4k8s | 1QT | Beta-secretase 1 | 3.4.23.46 | 0.441 | |
| 4udq | FAD | 5-(hydroxymethyl)furfural oxidase | / | 0.441 | |
| 1dj2 | GDP | Adenylosuccinate synthetase, chloroplastic | / | 0.440 | |
| 1h73 | ANP | Homoserine kinase | 2.7.1.39 | 0.440 | |
| 1x1b | SAH | C-20 methyltransferase | / | 0.440 | |
| 2c1b | CQP | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.440 | |
| 2hdh | NAD | Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial | 1.1.1.35 | 0.440 | |
| 3dga | NDP | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.440 | |
| 3fwj | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.440 | |
| 3ik6 | HCZ | Glutamate receptor 2 | / | 0.440 | |
| 3ixk | 929 | Beta-secretase 1 | 3.4.23.46 | 0.440 | |
| 3kjr | NAP | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.440 | |
| 3rpe | FAD | Putative modulator of drug activity | / | 0.440 | |
| 4bb3 | KKA | Isopenicillin N synthase | 1.21.3.1 | 0.440 | |
| 4fkz | UD1 | UDP-N-acetylglucosamine 2-epimerase | 5.1.3.14 | 0.440 | |
| 4fmx | CNL | 1,8-cineole 2-endo-monooxygenase | 1.14.13.156 | 0.440 | |
| 4fuj | 1U9 | Urokinase-type plasminogen activator | 3.4.21.73 | 0.440 | |
| 4l4f | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.440 | |
| 4q73 | FAD | Bifunctional protein PutA | / | 0.440 |