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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4bs4A64Tankyrase-22.4.2.30

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
4bs4A64Tankyrase-22.4.2.301.000
4buxF35Tankyrase-22.4.2.300.868
4bueJQFTankyrase-22.4.2.300.838
4buwF33Tankyrase-22.4.2.300.809
4bus32FTankyrase-22.4.2.300.800
4l2g1V4Tankyrase-22.4.2.300.786
4kzl20DTankyrase-22.4.2.300.652
4iueAJ4Tankyrase-22.4.2.300.648
4hlm16STankyrase-22.4.2.300.642
4l321VFTankyrase-22.4.2.300.640
4l2k1V8Tankyrase-22.4.2.300.639
3p0pNNFTankyrase-22.4.2.300.638
4l0s1UZTankyrase-22.4.2.300.637
4l2f1V3Tankyrase-22.4.2.300.635
4hlh20DTankyrase-22.4.2.300.633
4l33F70Tankyrase-22.4.2.300.628
4bj9UHBTankyrase-22.4.2.300.627
4hlf15ZTankyrase-22.4.2.300.627
4l0v1V1Tankyrase-22.4.2.300.625
4avuLDRTankyrase-22.4.2.300.623
4hl515WTankyrase-22.4.2.300.620
4l31F08Tankyrase-22.4.2.300.617
5aku29FTankyrase-22.4.2.300.612
4l091URTankyrase-22.4.2.300.606
4l0i1UWTankyrase-22.4.2.300.606
4avwG18Tankyrase-22.4.2.300.600
4bufF36Tankyrase-22.4.2.300.598
4buv16ITankyrase-22.4.2.300.594
4hkiFLNTankyrase-22.4.2.300.590
4hmhF94Tankyrase-22.4.2.300.590
4krs1SXTankyrase-12.4.2.300.585
3u9y09LTankyrase-22.4.2.300.584
4bud29FTankyrase-22.4.2.300.584
4j21AJ6Tankyrase-22.4.2.300.583
4but31FTankyrase-22.4.2.300.581
4j3lAJ5Tankyrase-22.4.2.300.556
4tkg09LTankyrase-22.4.2.300.553
4pnrG18Tankyrase-22.4.2.300.536
4pnmNU1Tankyrase-22.4.2.300.518
4tjy3GNTankyrase-22.4.2.300.504
4bjbP34Tankyrase-22.4.2.300.498
2ouu35GcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.493
4dvi2IWTankyrase-12.4.2.300.489
1wl4COAAcetyl-CoA acetyltransferase, cytosolic2.3.1.90.488
3nx2FERFerulic acid decarboxylase/0.486
4msk2C8Tankyrase-12.4.2.300.485
3sqzCOAPutative hydroxymethylglutaryl-CoA synthase/0.480
4o9cCOAAcetyl-CoA acetyltransferase2.3.1.90.477
3a25SAMtRNA(Phe) (4-demethylwyosine(37)-C(7)) aminocarboxypropyltransferase/0.476
1efyBZCPoly [ADP-ribose] polymerase 12.4.2.300.475
1ni4TPPPyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial1.2.4.10.475
1ni4TPPPyruvate dehydrogenase E1 component subunit beta, mitochondrial1.2.4.10.475
2ejzSAHDiphthine synthase/0.474
3dopNAP3-oxo-5-beta-steroid 4-dehydrogenase/0.474
4gv08MEPoly [ADP-ribose] polymerase 32.4.2.300.474
4hf415HcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.472
1lnmDTXBilin-binding protein/0.471
3g1rNAP3-oxo-5-beta-steroid 4-dehydrogenase/0.471
4twnB96Ephrin type-A receptor 32.7.10.10.470
2dw4FADLysine-specific histone demethylase 1A10.467
2zitNADExotoxin A2.4.2.360.467
2vigFADShort-chain specific acyl-CoA dehydrogenase, mitochondrial1.3.8.10.466
1qyxASDEstradiol 17-beta-dehydrogenase 11.1.1.620.465
4lcnGNGCytidine and deoxycytidylate deaminase zinc-binding region/0.465
4k4eK4ETankyrase-12.4.2.300.464
2weyEV1cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.463
3h4vDVPPteridine reductase 11.5.1.330.463
4bjcRPBTankyrase-22.4.2.300.463
2bfaCB3Pteridine reductase 11.5.1.330.462
4g2yNI5cGMP-specific 3',5'-cyclic phosphodiesterase/0.462
2zi63D1Deoxycytidine kinase2.7.1.740.461
3uelA1RPoly(ADP-ribose) glycohydrolase3.2.1.1430.461
3ekuCY9Actin-5C/0.460
2hveADPNucleoside diphosphate kinase A2.7.4.60.459
2ibwCOAAcetyl-CoA acetyltransferase, mitochondrial2.3.1.90.459
4br0AU1Ectonucleoside triphosphate diphosphohydrolase 2/0.459
4li81XQTankyrase-12.4.2.300.459
1dfoPLGSerine hydroxymethyltransferase2.1.2.10.458
1y2d4DEcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.458
4jeyPLPAcetylornithine/succinyldiaminopimelate aminotransferase2.6.1.110.458
4k4fK4FTankyrase-12.4.2.300.458
2bf7HBIPteridine reductase 11.5.1.330.457
3ce0P34Poly [ADP-ribose] polymerase 32.4.2.300.457
4n1gCEIObelin/0.457
1pr4MTPPurine nucleoside phosphorylase DeoD-type/0.456
5hwrCOAHydroxymethylglutaryl-CoA synthase/0.456
1y2bDEEcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.455
2c29NAPDihydroflavonol 4-reductase/0.455
3mauEXTPutative sphingosine-1-phosphate lyase/0.455
3ozc4CTS-methyl-5'-thioadenosine phosphorylase/0.455
3l3mA92Poly [ADP-ribose] polymerase 12.4.2.300.454
3mauPLRPutative sphingosine-1-phosphate lyase/0.454
3x2fNAIAdenosylhomocysteinase/0.454
4xbfFADLysine-specific histone demethylase 1A10.454
5hwqCAAHydroxymethylglutaryl-CoA synthase/0.454
1e92HBIPteridine reductase 11.5.1.330.453
3dhaC6LN-acyl homoserine lactonase AiiA3.1.1.810.452
4pahLNRPhenylalanine-4-hydroxylase1.14.16.10.452
1ut6A8NAcetylcholinesterase3.1.1.70.451
1zgbA1EAcetylcholinesterase3.1.1.70.451
2p8uCOAHydroxymethylglutaryl-CoA synthase, cytoplasmic2.3.3.100.451
3dynPCGHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.451
3fpkFADFerredoxin-NADP reductase/0.451
3sni546cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.451
3to3ATPPetrobactin biosynthesis protein AsbB/0.451
3uph0C1Genome polyprotein2.7.7.480.451
4lm4JPZcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.451
1xomCIOcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.450
4b1iA8PPoly(ADP-ribose) glycohydrolase3.2.1.1430.450
1piwNAPNADP-dependent alcohol dehydrogenase 61.1.1.20.449
3uzxAOM3-oxo-5-beta-steroid 4-dehydrogenase/0.449
1r5hAO2Methionine aminopeptidase 2/0.448
2ovvPFHcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.448
2p6lSAHDiphthine synthase/0.448
2vd0D27Hematopoietic prostaglandin D synthase/0.448
2wd8VGFPteridine reductase/0.448
4ajm3A6cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.448
3rsv3RSBeta-secretase 13.4.23.460.447
4ggzBTNBll1558 protein/0.447
4jtqNAPAldo-keto reductase family 1 member C2/0.447
1q0rAKTAclacinomycin methylesterase RdmC3.1.1.950.446
3c49KU8Poly [ADP-ribose] polymerase 32.4.2.300.446
3jqbDX6Pteridine reductase, putative/0.446
4b1hAR6Poly(ADP-ribose) glycohydrolase3.2.1.1430.446
4hhz15SPoly [ADP-ribose] polymerase 12.4.2.300.446
4i9z5BAcGMP-specific 3',5'-cyclic phosphodiesterase/0.446
1odcA8BAcetylcholinesterase3.1.1.70.445
1rkpIBMcGMP-specific 3',5'-cyclic phosphodiesterase/0.445
1uaeUD1UDP-N-acetylglucosamine 1-carboxyvinyltransferase/0.445
2dshSAHDiphthine synthase/0.445
2dv4SAHDiphthine synthase/0.445
2vcmM11Isopenicillin N synthase1.21.3.10.445
3hkyIX6Genome polyprotein2.7.7.480.445
3qpoPFRcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.445
1e66HUXAcetylcholinesterase3.1.1.70.444
1thnADPAnti-sigma F factor/0.444
2wo7ASVIsopenicillin N synthase1.21.3.10.444
3b6pTMPThree-prime repair exonuclease 13.1.11.20.444
3b78NADExotoxin A2.4.2.360.444
3dy8IBMHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.444
3tqcADPPantothenate kinase/0.444
4c2z646Glycylpeptide N-tetradecanoyltransferase 1/0.444
4g2wNI0cGMP-specific 3',5'-cyclic phosphodiesterase/0.444
4i9i1DYTankyrase-12.4.2.300.444
4j3mAJ8Tankyrase-22.4.2.300.444
4pyoSAHCatechol O-methyltransferase2.1.1.60.444
5arkUMPRibonuclease 43.1.270.444
1c3x8IGPurine nucleoside phosphorylase2.4.2.10.443
1ppjANYCytochrome b/0.443
3eq6BCOAcyl-coenzyme A synthetase ACSM2A, mitochondrial6.2.1.20.443
3k4s0MOcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.443
3o56ZG1cAMP-specific 3',5'-cyclic phosphodiesterase 4B3.1.4.530.443
3q3cNADNAD-dependent L-serine dehydrogenase/0.443
3sl8JN7cAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.443
3wd9QPCcAMP-specific 3',5'-cyclic phosphodiesterase 4B3.1.4.530.443
1fw0KAIGlutamate receptor 2/0.442
1ib1COTSerotonin N-acetyltransferase/0.442
2rgeGNPGTPase HRas/0.442
2y0jAXCcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.442
3a27SAMtRNA(Phe) (4-demethylwyosine(37)-C(7)) aminocarboxypropyltransferase/0.442
3bloQEIQueuine tRNA-ribosyltransferase2.4.2.290.442
3otwCOAPhosphopantetheine adenylyltransferase/0.442
3tfjTHGDimethylsulfonioproprionate demethylase DmdA2.1.1.2690.442
1osvCHCBile acid receptor/0.441
1synF89Thymidylate synthase/0.441
1w6rGNTAcetylcholinesterase3.1.1.70.441
3aiqHBO4-hydroxy-7-methoxy-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-2-yl glucoside beta-D-glucosidase 1b, chloroplastic3.2.1.1820.441
3exfTPPPyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial1.2.4.10.441
3exfTPPPyruvate dehydrogenase E1 component subunit beta, mitochondrial1.2.4.10.441
3tp0FO5HTH-type transcriptional regulator EthR/0.441
3v0p4GWHisto-blood group ABO system transferase/0.441
4bqzGNPEctonucleoside triphosphate diphosphohydrolase 2/0.441
4uajFADNa(+)-translocating NADH-quinone reductase subunit F/0.441
1qtiGNTAcetylcholinesterase3.1.1.70.440
1t57FMNConserved protein/0.440
2bfrADP[Protein ADP-ribosylglutamate] hydrolase AF_15213.2.20.440
2bifANP6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 42.7.1.1050.440
2ea1GPGRibonuclease I3.1.27.60.440
2wn6NDPADP-ribosyltransferase enzymatic component/0.440
3g45988cAMP-specific 3',5'-cyclic phosphodiesterase 4B3.1.4.530.440
3ix4TX1Transcriptional activator protein LasR/0.440
3tvxPNXcAMP-specific 3',5'-cyclic phosphodiesterase 4A3.1.4.530.440
3wv9FEGHmd co-occurring protein HcgE/0.440
4l6s1WQPoly [ADP-ribose] polymerase 12.4.2.300.440
4oztP1AEcdysone receptor, putative/0.440