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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4bmvNAPShort-chain dehydrogenase

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
4bmvNAPShort-chain dehydrogenase/1.000
4hwkNAPSepiapterin reductase1.1.1.1530.507
4j7uNAPSepiapterin reductase1.1.1.1530.503
4j7xNAPSepiapterin reductase1.1.1.1530.500
1xg5NAPDehydrogenase/reductase SDR family member 11/0.487
2yutNAPPutative short-chain oxidoreductase/0.486
1xkqNDPUncharacterized protein/0.470
2jahNDPClavaldehyde dehydrogenase/0.466
1x7gNAPPutative ketoacyl reductase1.3.10.465
3toxNAPPutative oxidoreductase/0.461
1xseNDPCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.460
3g49NAPCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.458
4c7kNAPCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.455
1x7hNDPPutative ketoacyl reductase1.3.10.454
5idwNAPShort-chain dehydrogenase/reductase SDR/0.447
4i5eNAPAlclohol dehydrogenase/short-chain dehydrogenase/0.441