sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

Distribution of Cavity similarities measured by Shaper

You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :

PDB ID	HET	Uniprot Name	EC Number
4biw	ANP	Sensor histidine kinase CpxA

Complex with similar cavities

PDB ID	HET	Uniprot Name	EC Number	Cavity Similarity	Align
4biw	ANP	Sensor histidine kinase CpxA	/	1.000
1i59	ANP	Chemotaxis protein CheA	2.7.13.3	0.475
2ewm	NAD	(S)-1-Phenylethanol dehydrogenase	1.1.1.311	0.460
2w6p	OA4	Biotin carboxylase	6.3.4.14	0.448
2cf6	NAP	Cinnamyl alcohol dehydrogenase 5	1.1.1.195	0.445
4cjx	9L9	C-1-tetrahydrofolate synthase, cytoplasmic, putative	/	0.444
1til	ATP	Anti-sigma F factor	/	0.443
1xg5	NAP	Dehydrogenase/reductase SDR family member 11	/	0.442
1llq	NAD	NAD-dependent malic enzyme, mitochondrial	1.1.1.38	0.440
3sl2	ATP	Sensor histidine kinase WalK	/	0.440
4xgx	ADP	FAD:protein FMN transferase	/	0.440