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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4bi0Z0WDual specificity protein kinase TTK2.7.12.1

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
4bi0Z0WDual specificity protein kinase TTK2.7.12.11.000
4bi1ZO6Dual specificity protein kinase TTK2.7.12.10.718
4c4f7CEDual specificity protein kinase TTK2.7.12.10.601
4c4g7RODual specificity protein kinase TTK2.7.12.10.600
4c4iX20Dual specificity protein kinase TTK2.7.12.10.569
4c4h7RODual specificity protein kinase TTK2.7.12.10.553
5ap7SVEDual specificity protein kinase TTK2.7.12.10.513
5ap57RODual specificity protein kinase TTK2.7.12.10.499
2zmd537Dual specificity protein kinase TTK2.7.12.10.487
2o2u738Mitogen-activated protein kinase 102.7.11.240.445
3f69XDRSerine/threonine-protein kinase PknB2.7.11.10.442