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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4bdgP3JSerine/threonine-protein kinase Chk22.7.11.1

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
4bdgP3JSerine/threonine-protein kinase Chk22.7.11.11.000
4bdfH3RSerine/threonine-protein kinase Chk22.7.11.10.644
4bddZ0OSerine/threonine-protein kinase Chk22.7.11.10.601
2ycsNXPSerine/threonine-protein kinase Chk22.7.11.10.597
2w0jZATSerine/threonine-protein kinase Chk22.7.11.10.576
4bdcODHSerine/threonine-protein kinase Chk22.7.11.10.574
4bdbODOSerine/threonine-protein kinase Chk22.7.11.10.567
2yiqYIQSerine/threonine-protein kinase Chk22.7.11.10.551
2yitYITSerine/threonine-protein kinase Chk22.7.11.10.551
2w7xD1ASerine/threonine-protein kinase Chk22.7.11.10.550
2ycrHCWSerine/threonine-protein kinase Chk22.7.11.10.550
2ycqUPXSerine/threonine-protein kinase Chk22.7.11.10.541
4bdiHAUSerine/threonine-protein kinase Chk22.7.11.10.541
3v8w0G2Tyrosine-protein kinase ITK/TSK2.7.10.20.536
4bdhWVISerine/threonine-protein kinase Chk22.7.11.10.528
2xk9XK9Serine/threonine-protein kinase Chk22.7.11.10.524
2yirYIRSerine/threonine-protein kinase Chk22.7.11.10.515
2hxl422Serine/threonine-protein kinase Chk12.7.11.10.514
5av2KMPDeath-associated protein kinase 12.7.11.10.511
2wmqZYQSerine/threonine-protein kinase Chk12.7.11.10.508
3bqr4RBDeath-associated protein kinase 3/0.504
4ftiH7KSerine/threonine-protein kinase Chk12.7.11.10.504
2wtcVGMSerine/threonine-protein kinase Chk22.7.11.10.503
1jklANPDeath-associated protein kinase 12.7.11.10.501
4fsuHK5Serine/threonine-protein kinase Chk12.7.11.10.501
2wtdZZKSerine/threonine-protein kinase Chk22.7.11.10.500
2ycfYCFSerine/threonine-protein kinase Chk22.7.11.10.500
2ckeIQUDeath-associated protein kinase 2/0.496
1qpjSTUTyrosine-protein kinase Lck2.7.10.20.495
3orzBI43-phosphoinositide-dependent protein kinase 12.7.11.10.494
4ks8B49Serine/threonine-protein kinase PAK 62.7.11.10.493
1yolS03Proto-oncogene tyrosine-protein kinase Src2.7.10.20.491
1wvxBD4Death-associated protein kinase 12.7.11.10.489
2cgu3A3Serine/threonine-protein kinase Chk12.7.11.10.489
2hog710Serine/threonine-protein kinase Chk12.7.11.10.486
2y7jB49Phosphorylase b kinase gamma catalytic chain, liver/testis isoform2.7.11.190.485
5av3KMPDeath-associated protein kinase 12.7.11.10.484
2ydiYDISerine/threonine-protein kinase Chk12.7.11.10.483
2xbjXBJSerine/threonine-protein kinase Chk22.7.11.10.482
4l7sG7KTyrosine-protein kinase ITK/TSK2.7.10.20.482
2r0uM54Serine/threonine-protein kinase Chk12.7.11.10.481
3ztxZTXAurora kinase B-A2.7.11.10.479
1nvqUCNSerine/threonine-protein kinase Chk12.7.11.10.477
3a4oSTUTyrosine-protein kinase Lyn2.7.10.20.477
4fg7ATPCalcium/calmodulin-dependent protein kinase type 12.7.11.170.477
2hxq373Serine/threonine-protein kinase Chk12.7.11.10.476
2wtiWTISerine/threonine-protein kinase Chk22.7.11.10.476
3w2sW2REpidermal growth factor receptor2.7.10.10.476
4bfmANPMaternal embryonic leucine zipper kinase2.7.11.10.474
4k1b1OCSerine/threonine-protein kinase pim-12.7.11.10.474
2dq7STUTyrosine-protein kinase Fyn2.7.10.20.473
3vrzVRZTyrosine-protein kinase HCK2.7.10.20.473
4enxZ20Serine/threonine-protein kinase pim-12.7.11.10.473
4fr4STUSerine/threonine-protein kinase 32A2.7.11.10.473
4fsrHKCSerine/threonine-protein kinase Chk12.7.11.10.473
4ftjH8KSerine/threonine-protein kinase Chk12.7.11.10.473
4ftkH9KSerine/threonine-protein kinase Chk12.7.11.10.473
2hy0306Serine/threonine-protein kinase Chk12.7.11.10.471
2objVRVSerine/threonine-protein kinase pim-12.7.11.10.471
4fic0ULProto-oncogene tyrosine-protein kinase Src2.7.10.20.471
4id71G0Activated CDC42 kinase 1/0.471
5d12G97Proto-oncogene tyrosine-protein kinase Src2.7.10.20.471
2brnDF1Serine/threonine-protein kinase Chk12.7.11.10.470
2j7t274Serine/threonine-protein kinase 102.7.11.10.470
4k110J9Proto-oncogene tyrosine-protein kinase Src2.7.10.20.470
1qcfPP1Tyrosine-protein kinase HCK2.7.10.20.469
2h8hH8HProto-oncogene tyrosine-protein kinase Src2.7.10.20.469
2r7b2533-phosphoinositide-dependent protein kinase 12.7.11.10.469
4ftm1HKSerine/threonine-protein kinase Chk12.7.11.10.468
4hyi1AOSerine/threonine-protein kinase Chk12.7.11.10.468
5dr9SKEAurora kinase A2.7.11.10.468
2vrx447Aurora kinase B-A2.7.11.10.467
4enyJ19Serine/threonine-protein kinase pim-12.7.11.10.467
4ft9H4KSerine/threonine-protein kinase Chk12.7.11.10.467
2xm9LWHSerine/threonine-protein kinase Chk22.7.11.10.466
3gu6ADPDeath-associated protein kinase 12.7.11.10.466
3u9n09HSerine/threonine-protein kinase Chk12.7.11.10.466
3vs7KS1Tyrosine-protein kinase HCK2.7.10.20.466
5dt0SKEAurora kinase A2.7.11.10.466
4xx9ATP3-phosphoinositide-dependent protein kinase 12.7.11.10.465
3at4CCKCasein kinase II subunit alpha2.7.11.10.464
3nunJMZ3-phosphoinositide-dependent protein kinase 12.7.11.10.464
4bl1ANPMaternal embryonic leucine zipper kinase2.7.11.10.464
5auwQUEDeath-associated protein kinase 12.7.11.10.464
2ym6YM6Serine/threonine-protein kinase Chk12.7.11.10.463
3hrfATP3-phosphoinositide-dependent protein kinase 12.7.11.10.463
3qd33Q53-phosphoinositide-dependent protein kinase 12.7.11.10.463
3qlfPD5Proto-oncogene tyrosine-protein kinase Src2.7.10.20.463
4ft3H1KSerine/threonine-protein kinase Chk12.7.11.10.463
4bibIEOMitogen-activated protein kinase kinase kinase 52.7.11.250.462
4ysjADPCalmodulin-like domain protein kinase/0.462
3a62STURibosomal protein S6 kinase beta-12.7.11.10.461
3amaSKEcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.461
3f69XDRSerine/threonine-protein kinase PknB2.7.11.10.461
3hrcATP3-phosphoinositide-dependent protein kinase 12.7.11.10.461
3qd03Q43-phosphoinositide-dependent protein kinase 12.7.11.10.461
3qd43Q63-phosphoinositide-dependent protein kinase 12.7.11.10.461
4fsnA58Serine/threonine-protein kinase Chk12.7.11.10.461
4yzcSTUSerine/threonine-protein kinase/endoribonuclease IRE12.7.11.10.461
2bdf24AProto-oncogene tyrosine-protein kinase Src2.7.10.20.460
2pe24643-phosphoinositide-dependent protein kinase 12.7.11.10.460
3jy0LYGSerine/threonine-protein kinase pim-12.7.11.10.460
3zewSTUEphrin type-B receptor 42.7.10.10.460
4a06ATP3-phosphoinositide-dependent protein kinase 12.7.11.10.460
2ijmADPFocal adhesion kinase 12.7.10.20.459
3lcdBDYMacrophage colony-stimulating factor 1 receptor2.7.10.10.459
4jlcSU6Serine/threonine-protein kinase TBK12.7.11.10.459
2cdz23DSerine/threonine-protein kinase PAK 42.7.11.10.458
4fsqHK3Serine/threonine-protein kinase Chk12.7.11.10.458
4mcv29KProto-oncogene tyrosine-protein kinase Src2.7.10.20.458
3nux3NVCyclin-dependent kinase 62.7.11.220.457
4aw1ATP3-phosphoinositide-dependent protein kinase 12.7.11.10.456
4fv1EK4Mitogen-activated protein kinase 12.7.11.240.456
4fv9E71Mitogen-activated protein kinase 12.7.11.240.456
4yhjAN2G protein-coupled receptor kinase 42.7.11.160.456
4dit0KDGlycogen synthase kinase-3 beta2.7.11.260.455
4f640S8Fibroblast growth factor receptor 1/0.455
4ftaH5KSerine/threonine-protein kinase Chk12.7.11.10.455
2pe15173-phosphoinositide-dependent protein kinase 12.7.11.10.454
2x8eX8ESerine/threonine-protein kinase Chk12.7.11.10.454
4b99R4LMitogen-activated protein kinase 72.7.11.240.454
4l425FIRibosomal protein S6 kinase beta-12.7.11.10.454
1okzUCN3-phosphoinositide-dependent protein kinase 12.7.11.10.453
1z5mLI83-phosphoinositide-dependent protein kinase 12.7.11.10.453
2ayp43ASerine/threonine-protein kinase Chk12.7.11.10.453
4g1wG1WMitogen-activated protein kinase 82.7.11.240.453
2yaaATPDeath-associated protein kinase 2/0.452
3cblSTUTyrosine-protein kinase Fes/Fps2.7.10.20.452
4a9uA9USerine/threonine-protein kinase Chk22.7.11.10.452
4ez50RSCyclin-dependent kinase 62.7.11.220.452
4fstHK4Serine/threonine-protein kinase Chk12.7.11.10.452
4ftq4HKSerine/threonine-protein kinase Chk12.7.11.10.452
4hvi19STyrosine-protein kinase JAK32.7.10.20.452
4jbpYPHAurora kinase A2.7.11.10.452
2qhm7CSSerine/threonine-protein kinase Chk12.7.11.10.451
3e8eG98cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.451
3q9xEMOCasein kinase II subunit alpha2.7.11.10.451
3vs2VSBTyrosine-protein kinase HCK2.7.10.20.451
4iebANPCalmodulin-domain protein kinase 1/0.451
1uvrBI83-phosphoinositide-dependent protein kinase 12.7.11.10.450
2wmuZYUSerine/threonine-protein kinase Chk12.7.11.10.450
2xckMH43-phosphoinositide-dependent protein kinase 12.7.11.10.450
5auxKMPDeath-associated protein kinase 12.7.11.10.450
2ivuZD6Proto-oncogene tyrosine-protein kinase receptor Ret2.7.10.10.449
3q92XNBKetohexokinase/0.449
3w33W19Epidermal growth factor receptor2.7.10.10.449
1uu7BI23-phosphoinositide-dependent protein kinase 12.7.11.10.448
1yvj4STTyrosine-protein kinase JAK32.7.10.20.448
2ydjYDJSerine/threonine-protein kinase Chk12.7.11.10.448
3bu5ATPInsulin receptor2.7.10.10.448
4grb0XGCasein kinase II subunit alpha2.7.11.10.448
4ic7ANPMitogen-activated protein kinase 72.7.11.240.448
5auvAGIDeath-associated protein kinase 12.7.11.10.448
1fvv107Cyclin-dependent kinase 22.7.11.220.447
3ckxSTUSerine/threonine-protein kinase 242.7.11.10.447
4ekl0RFRAC-alpha serine/threonine-protein kinase2.7.11.10.447
4fad0TBPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.447
4jq8KJ8Epidermal growth factor receptor2.7.10.10.447
4uyaAGSMitogen-activated protein kinase kinase kinase 212.7.11.250.447
2uzbC75Cyclin-dependent kinase 22.7.11.220.446
3nuuJOZ3-phosphoinositide-dependent protein kinase 12.7.11.10.446
4jajXU1Aurora kinase A2.7.11.10.446
4jik1KOSerine/threonine-protein kinase Chk12.7.11.10.446
3a99ANPSerine/threonine-protein kinase pim-12.7.11.10.445
3i4bZ48Glycogen synthase kinase-3 beta2.7.11.260.445
3qaiXNNKetohexokinase/0.445
3qcs3Q13-phosphoinositide-dependent protein kinase 12.7.11.10.445
3uvqFS8Mitogen-activated protein kinase 14/0.445
4ansVGHALK tyrosine kinase receptor2.7.10.10.445
4ezj0SCPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.445
4ftu7HKSerine/threonine-protein kinase Chk12.7.11.10.445
4gt3ATPMitogen-activated protein kinase 12.7.11.240.445
4i0r1B4Tyrosine-protein kinase SYK2.7.10.20.445
4o0wADNAurora kinase A2.7.11.10.445
2vu3LZECyclin-dependent kinase 22.7.11.220.444
3gc8B45Mitogen-activated protein kinase 112.7.11.240.444
3oogYTPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.444
3qa2XNAKetohexokinase/0.444
3vs5VSGTyrosine-protein kinase HCK2.7.10.20.444
4flh14KPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.444
4o0rX4ZSerine/threonine-protein kinase PAK 12.7.11.10.444
5dpvSKEAurora kinase A2.7.11.10.444
2br1PFPSerine/threonine-protein kinase Chk12.7.11.10.443
2phkATPPhosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform2.7.11.190.443
3kkvB99cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.443
4bcmT7ZCyclin-dependent kinase 22.7.11.220.443
2henADPEphrin type-B receptor 22.7.10.10.442
2nruT12Interleukin-1 receptor-associated kinase 42.7.11.10.442
3wi6YRZMAP kinase-activated protein kinase 22.7.11.10.442
4c34STUcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.442
4fv2EK5Mitogen-activated protein kinase 12.7.11.240.442
4o0uADNAurora kinase A2.7.11.10.442
1ad5ANPTyrosine-protein kinase HCK2.7.10.20.441
2c3lIDZSerine/threonine-protein kinase Chk12.7.11.10.441
2cgw3C3Serine/threonine-protein kinase Chk12.7.11.10.441
2pvmP29Casein kinase II subunit alpha2.7.11.10.441
2znq401Peroxisome proliferator-activated receptor delta/0.441
3gubGUBDeath-associated protein kinase 12.7.11.10.441
3lltANPProtein serine/threonine kinase-1/0.441
3zc6VFCTyrosine-protein kinase JAK32.7.10.20.441
3zlyYSODual specificity mitogen-activated protein kinase kinase 12.7.12.20.441
4rrvATP3-phosphoinositide-dependent protein kinase 12.7.11.10.441
1q8uH52cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.440
2c6eHPMAurora kinase A2.7.11.10.440
2uzuL20cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.440
3cjgKIMVascular endothelial growth factor receptor 22.7.10.10.440
3sc13S13-phosphoinositide-dependent protein kinase 12.7.11.10.440
3tkh07SSerine/threonine-protein kinase Chk12.7.11.10.440
3vs3VSETyrosine-protein kinase HCK2.7.10.20.440
4fmqANPMitogen-activated protein kinase 12.7.11.240.440
4fsmHK1Serine/threonine-protein kinase Chk12.7.11.10.440
4ftt6HKSerine/threonine-protein kinase Chk12.7.11.10.440