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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4bcmT7ZCyclin-dependent kinase 22.7.11.22

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
4bcmT7ZCyclin-dependent kinase 22.7.11.221.000
3my5RFZCyclin-dependent kinase 22.7.11.220.563
2vu3LZECyclin-dependent kinase 22.7.11.220.560
2fvdLIACyclin-dependent kinase 22.7.11.220.516
1qmzATPCyclin-dependent kinase 22.7.11.220.509
3nux3NVCyclin-dependent kinase 62.7.11.220.503
2cjmATPCyclin-dependent kinase 22.7.11.220.502
1finATPCyclin-dependent kinase 22.7.11.220.499
3qxpX64Cyclin-dependent kinase 22.7.11.220.495
2uzbC75Cyclin-dependent kinase 22.7.11.220.490
1fvv107Cyclin-dependent kinase 22.7.11.220.485
3rak03ZCyclin-dependent kinase 22.7.11.220.485
4jia1K3Tyrosine-protein kinase JAK2/0.481
3ambVX6cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.480
2btsU32Cyclin-dependent kinase 22.7.11.220.479
2w05FRTCyclin-dependent kinase 22.7.11.220.479
3qcx3Q23-phosphoinositide-dependent protein kinase 12.7.11.10.479
4ii5ADPCyclin-dependent kinase 22.7.11.220.477
1jstATPCyclin-dependent kinase 22.7.11.220.476
4ez50RSCyclin-dependent kinase 62.7.11.220.476
3s1h56ZCyclin-dependent kinase 22.7.11.220.473
3r8lZ30Cyclin-dependent kinase 22.7.11.220.472
4flh14KPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.472
4fv9E71Mitogen-activated protein kinase 12.7.11.240.472
1pxmCK5Cyclin-dependent kinase 22.7.11.220.470
3a4oSTUTyrosine-protein kinase Lyn2.7.10.20.470
3amaSKEcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.470
4yzcSTUSerine/threonine-protein kinase/endoribonuclease IRE12.7.11.10.470
2vv9IM9Cyclin-dependent kinase 22.7.11.220.469
2ckeIQUDeath-associated protein kinase 2/0.468
3r1yX76Cyclin-dependent kinase 22.7.11.220.468
3rkb12ZCyclin-dependent kinase 22.7.11.220.468
5av2KMPDeath-associated protein kinase 12.7.11.10.468
4eooATPCyclin-dependent kinase 22.7.11.220.467
3at4CCKCasein kinase II subunit alpha2.7.11.10.465
1gii1PUCyclin-dependent kinase 22.7.11.220.464
1qpjSTUTyrosine-protein kinase Lck2.7.10.20.464
3i4bZ48Glycogen synthase kinase-3 beta2.7.11.260.464
3i60E86Mitogen-activated protein kinase 12.7.11.240.463
3zc6VFCTyrosine-protein kinase JAK32.7.10.20.462
4fsuHK5Serine/threonine-protein kinase Chk12.7.11.10.462
2w17I19Cyclin-dependent kinase 22.7.11.220.461
4grb0XGCasein kinase II subunit alpha2.7.11.10.461
3lltANPProtein serine/threonine kinase-1/0.458
4mq12C3Dual specificity tyrosine-phosphorylation-regulated kinase 1A2.7.12.10.457
3sayOFTGlycogen synthase kinase-3 beta2.7.11.260.455
2ym6YM6Serine/threonine-protein kinase Chk12.7.11.10.454
2vttLZDCyclin-dependent kinase 22.7.11.220.453
3axwTIDCasein kinase II subunit alpha2.7.11.10.453
3tnwF18Cyclin-dependent kinase 22.7.11.220.453
4l7sG7KTyrosine-protein kinase ITK/TSK2.7.10.20.453
3u4uLNHCasein kinase II subunit alpha2.7.11.10.452
4fsnA58Serine/threonine-protein kinase Chk12.7.11.10.452
2uztSS3cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.451
3sw719KCyclin-dependent kinase 22.7.11.220.450
4ftiH7KSerine/threonine-protein kinase Chk12.7.11.10.450
4ic7ANPMitogen-activated protein kinase 72.7.11.240.449
1w0xOLOCyclin-dependent kinase 22.7.11.220.448
4aguD15Cyclin-dependent kinase-like 1/0.448
1pxoCK7Cyclin-dependent kinase 22.7.11.220.447
2vtqLZACyclin-dependent kinase 22.7.11.220.447
2vn9GVDCalcium/calmodulin-dependent protein kinase type II subunit delta2.7.11.170.446
3ezvEZVCyclin-dependent kinase 22.7.11.220.446
3qd43Q63-phosphoinositide-dependent protein kinase 12.7.11.10.446
2pvhP19Casein kinase II subunit alpha2.7.11.10.445
3eb0DRKUncharacterized protein/0.445
2hxl422Serine/threonine-protein kinase Chk12.7.11.10.444
3nynSGVG protein-coupled receptor kinase 62.7.11.160.444
4fv6E57Mitogen-activated protein kinase 12.7.11.240.444
4hvi19STyrosine-protein kinase JAK32.7.10.20.444
4ix6ADPUncharacterized protein/0.444
1q3wATUGlycogen synthase kinase-3 beta2.7.11.260.443
2yaaATPDeath-associated protein kinase 2/0.443
2zjwREFCasein kinase II subunit alpha2.7.11.10.442
4fg7ATPCalcium/calmodulin-dependent protein kinase type 12.7.11.170.442
4dgmAGICasein kinase II subunit alpha2.7.11.10.441
3i5zZ48Mitogen-activated protein kinase 12.7.11.240.440
3qxoX65Cyclin-dependent kinase 22.7.11.220.440
4kz01UJPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.440
4l9i8PRRhodopsin kinase/0.440