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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4bc6XZNSerine/threonine-protein kinase 102.7.11.1

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
4bc6XZNSerine/threonine-protein kinase 102.7.11.11.000
2j7t274Serine/threonine-protein kinase 102.7.11.10.513
3b2w9NHTyrosine-protein kinase Lck2.7.10.20.486
1qpjSTUTyrosine-protein kinase Lck2.7.10.20.472
3vrzVRZTyrosine-protein kinase HCK2.7.10.20.472
4mxyDB8Proto-oncogene tyrosine-protein kinase Src2.7.10.20.468
4mxzDB8Proto-oncogene tyrosine-protein kinase Src2.7.10.20.468
3uvqFS8Mitogen-activated protein kinase 14/0.467
3zewSTUEphrin type-B receptor 42.7.10.10.467
3js2VM1Fibroblast growth factor receptor 1/0.464
3qlfPD5Proto-oncogene tyrosine-protein kinase Src2.7.10.20.462
4bibIEOMitogen-activated protein kinase kinase kinase 52.7.11.250.459
1w84L12Mitogen-activated protein kinase 14/0.454
3qlg1N1Proto-oncogene tyrosine-protein kinase Src2.7.10.20.454
4dggI76Proto-oncogene tyrosine-protein kinase Src2.7.10.20.453
4l7sG7KTyrosine-protein kinase ITK/TSK2.7.10.20.453
5dr9SKEAurora kinase A2.7.11.10.452
5d12G97Proto-oncogene tyrosine-protein kinase Src2.7.10.20.451
4f640S8Fibroblast growth factor receptor 1/0.450
4nka2K7Fibroblast growth factor receptor 1/0.449
3cjgKIMVascular endothelial growth factor receptor 22.7.10.10.448
3w2sW2REpidermal growth factor receptor2.7.10.10.448
4jia1K3Tyrosine-protein kinase JAK2/0.447
3lcdBDYMacrophage colony-stimulating factor 1 receptor2.7.10.10.445
4bcmT7ZCyclin-dependent kinase 22.7.11.220.445
4eym0RXMitogen-activated protein kinase 132.7.11.240.445
4mcv29KProto-oncogene tyrosine-protein kinase Src2.7.10.20.445
3b8r887Vascular endothelial growth factor receptor 22.7.10.10.441
4k110J9Proto-oncogene tyrosine-protein kinase Src2.7.10.20.440
4xli1N1Abelson tyrosine-protein kinase 22.7.10.20.440