scPDB - Distribution of Cavity Similarity values of 4bbg entry / Site 1

Distribution of Cavity similarities measured by Shaper

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Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :

PDB ID	HET	Uniprot Name	EC Number
4bbg	V02	Kinesin-like protein KIF11

Complex with similar cavities

PDB ID	HET	Uniprot Name	EC Number	Cavity Similarity
4bbg	V02	Kinesin-like protein KIF11	/	1.000
2xae	2XA	Kinesin-like protein KIF11	/	0.614
2x7d	EGB	Kinesin-like protein KIF11	/	0.602
2ieh	MOY	Kinesin-like protein KIF11	/	0.584
2x7e	X7E	Kinesin-like protein KIF11	/	0.582
3ken	ZZD	Kinesin-like protein KIF11	/	0.579
2wog	ZZD	Kinesin-like protein KIF11	/	0.577
4a51	DQ8	Kinesin-like protein KIF11	/	0.569
1q0b	NAT	Kinesin-like protein KIF11	/	0.567
1x88	NAT	Kinesin-like protein KIF11	/	0.560
3k3b	L31	Kinesin-like protein KIF11	/	0.552
2gm1	2AZ	Kinesin-like protein KIF11	/	0.551
2q2z	MKK	Kinesin-like protein KIF11	/	0.541
2x2r	X2O	Kinesin-like protein KIF11	/	0.535
3k5e	K5E	Kinesin-like protein KIF11	/	0.528
2fme	3QC	Kinesin-like protein KIF11	/	0.523
4a5y	G7X	Kinesin-like protein KIF11	/	0.500
1ke6	LS2	Cyclin-dependent kinase 2	2.7.11.22	0.482
4as7	6LX	Kinesin-like protein KIF11	/	0.481
3qxo	X65	Cyclin-dependent kinase 2	2.7.11.22	0.473
3o0g	3O0	Cyclin-dependent-like kinase 5	2.7.11.1	0.472
4z34	ON7	Lysophosphatidic acid receptor 1	/	0.472
4lg5	A1O	Abscisic acid receptor PYL2	/	0.469
1qpj	STU	Tyrosine-protein kinase Lck	2.7.10.2	0.468
4cfn	JYM	Cyclin-dependent kinase 2	2.7.11.22	0.468
4kfj	1R0	Dihydrofolate reductase	1.5.1.3	0.468
1fvt	106	Cyclin-dependent kinase 2	2.7.11.22	0.467
2brb	PFQ	Serine/threonine-protein kinase Chk1	2.7.11.1	0.467
3ddq	RRC	Cyclin-dependent kinase 2	2.7.11.22	0.467
1w2x	RCP	Acetyl-CoA carboxylase	/	0.465
2vtq	LZA	Cyclin-dependent kinase 2	2.7.11.22	0.465
3sqq	99Z	Cyclin-dependent kinase 2	2.7.11.22	0.464
1e8w	QUE	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	2.7.1.153	0.463
2hog	710	Serine/threonine-protein kinase Chk1	2.7.11.1	0.463
4fjy	FJY	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	2.7.1.153	0.462
4h4x	FAD	Biphenyl dioxygenase ferredoxin reductase subunit	/	0.461
4z35	ON9	Lysophosphatidic acid receptor 1	/	0.460
2feu	CAM	Camphor 5-monooxygenase	1.14.15.1	0.458
3r1q	X75	Cyclin-dependent kinase 2	2.7.11.22	0.458
4erw	STU	Cyclin-dependent kinase 2	2.7.11.22	0.458
1ke7	LS3	Cyclin-dependent kinase 2	2.7.11.22	0.457
2vr1	ATF	Biotin carboxylase	6.3.4.14	0.457
3rm7	19Z	Cyclin-dependent kinase 2	2.7.11.22	0.456
1os1	ATP	Phosphoenolpyruvate carboxykinase (ATP)	/	0.455
3eem	53V	Uncharacterized protein	/	0.455
3pwr	ROC	Gag-Pol polyprotein	3.4.23.16	0.455
1ke9	LS5	Cyclin-dependent kinase 2	2.7.11.22	0.454
2a1m	CAM	Camphor 5-monooxygenase	1.14.15.1	0.454
2phk	ATP	Phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform	2.7.11.19	0.454
3aid	ARQ	Gag-Pol polyprotein	3.4.23.16	0.454
3qu0	X40	Cyclin-dependent kinase 2	2.7.11.22	0.453
3r7v	Z02	Cyclin-dependent kinase 2	2.7.11.22	0.453
3tiz	3TI	Cyclin-dependent kinase 2	2.7.11.22	0.453
3qqk	X02	Cyclin-dependent kinase 2	2.7.11.22	0.452
3qrt	X14	Cyclin-dependent kinase 2	2.7.11.22	0.452
4a9m	P9M	Bromodomain-containing protein 2	/	0.452
4fjz	4FJ	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	2.7.1.153	0.452
4l4f	CAM	Camphor 5-monooxygenase	1.14.15.1	0.452
4lb2	DM5	Serum albumin	/	0.452
3wrm	CAM	Camphor 5-monooxygenase	1.14.15.1	0.451
4eor	4SP	Cyclin-dependent kinase 2	2.7.11.22	0.451
4nb6	444	Nuclear receptor ROR-gamma	/	0.451
1oiu	N76	Cyclin-dependent kinase 2	2.7.11.22	0.450
2cdu	FAD	NADH oxidase	/	0.450
2r0u	M54	Serine/threonine-protein kinase Chk1	2.7.11.1	0.450
3fwg	CAM	Camphor 5-monooxygenase	1.14.15.1	0.450
3kdi	A8S	Abscisic acid receptor PYL2	/	0.450
4jhz	1KV	Beta-glucuronidase	3.2.1.31	0.450
4l9i	8PR	Rhodopsin kinase	/	0.450
2b55	D31	Cyclin-dependent kinase 2	2.7.11.22	0.449
2iw8	4SP	Cyclin-dependent kinase 2	2.7.11.22	0.449
3dyq	PCG	High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A	/	0.449
3qwk	X62	Cyclin-dependent kinase 2	2.7.11.22	0.449
4fkp	LS5	Cyclin-dependent kinase 2	2.7.11.22	0.449
3r1s	X73	Cyclin-dependent kinase 2	2.7.11.22	0.448
4l4e	CAM	Camphor 5-monooxygenase	1.14.15.1	0.448
1oi9	N20	Cyclin-dependent kinase 2	2.7.11.22	0.447
2cd2	FOL	Dihydrofolate reductase	1.5.1.3	0.447
2qhm	7CS	Serine/threonine-protein kinase Chk1	2.7.11.1	0.447
3cd5	7HI	3-hydroxy-3-methylglutaryl-coenzyme A reductase	1.1.1.34	0.447
3ddp	RC8	Cyclin-dependent kinase 2	2.7.11.22	0.447
3r6x	X84	Cyclin-dependent kinase 2	2.7.11.22	0.447
4c9p	CAM	Cytochrome P450	/	0.447
4ek6	10K	Cyclin-dependent kinase 2	2.7.11.22	0.447
2i40	BLZ	Cyclin-dependent kinase 2	2.7.11.22	0.446
3ns2	PYV	Abscisic acid receptor PYL2	/	0.446
3qgt	CP6	Bifunctional dihydrofolate reductase-thymidylate synthase	/	0.446
4bcm	T7Z	Cyclin-dependent kinase 2	2.7.11.22	0.446
1vyz	N5B	Cyclin-dependent kinase 2	2.7.11.22	0.445
2a1o	CAM	Camphor 5-monooxygenase	1.14.15.1	0.445
3qtz	X42	Cyclin-dependent kinase 2	2.7.11.22	0.445
3rk5	07Z	Cyclin-dependent kinase 2	2.7.11.22	0.445
4fkj	11K	Cyclin-dependent kinase 2	2.7.11.22	0.445
1ogu	ST8	Cyclin-dependent kinase 2	2.7.11.22	0.444
3eej	53R	Uncharacterized protein	/	0.444
3fwf	CAM	Camphor 5-monooxygenase	1.14.15.1	0.444
3rni	21Z	Cyclin-dependent kinase 2	2.7.11.22	0.444
5aab	VGH	ALK tyrosine kinase receptor	2.7.10.1	0.444
3unj	0BX	Cyclin-dependent kinase 2	2.7.11.22	0.443
4asg	814	ATP-dependent molecular chaperone HSP82	/	0.443
4ezk	0SD	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	2.7.1.153	0.443
1eet	BFU	Gag-Pol polyprotein	2.7.7.49	0.442
1ffi	2NC	Gag-Pol polyprotein	3.4.23.16	0.442
1vru	AAP	Gag-Pol polyprotein	2.7.7.49	0.442
2q29	ACO	Oxalyl-CoA decarboxylase	4.1.1.8	0.442
4ez3	0S0	Cyclin-dependent kinase 2	2.7.11.22	0.442
4fsn	A58	Serine/threonine-protein kinase Chk1	2.7.11.1	0.442
4g1z	0VP	Vitamin D3 receptor A	/	0.442
4la7	A1O	Abscisic acid receptor PYL2	/	0.442
5drd	ATP	Aurora kinase A	2.7.11.1	0.442
1h1r	6CP	Cyclin-dependent kinase 2	2.7.11.22	0.441
1ouk	084	Mitogen-activated protein kinase 14	/	0.441
2c6o	4SP	Cyclin-dependent kinase 2	2.7.11.22	0.441
2chw	039	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	2.7.1.153	0.441
2vtl	LZ5	Cyclin-dependent kinase 2	2.7.11.22	0.441
2wip	P49	Cyclin-dependent kinase 2	2.7.11.22	0.441
2ym6	YM6	Serine/threonine-protein kinase Chk1	2.7.11.1	0.441
3a4o	STU	Tyrosine-protein kinase Lyn	2.7.10.2	0.441
3fwj	CAM	Camphor 5-monooxygenase	1.14.15.1	0.441
3haz	FAD	Bifunctional protein PutA	/	0.441
3neg	PYV	Abscisic acid receptor PYL1	/	0.441
4c9o	CAM	Cytochrome P450	/	0.441
4l42	5FI	Ribosomal protein S6 kinase beta-1	2.7.11.1	0.441
1t86	CAM	Camphor 5-monooxygenase	1.14.15.1	0.440
1uu7	BI2	3-phosphoinositide-dependent protein kinase 1	2.7.11.1	0.440
1ykd	CMP	Adenylate cyclase	/	0.440
2c4g	514	Cyclin-dependent kinase 2	2.7.11.22	0.440
3nj0	PYV	Abscisic acid receptor PYL2	/	0.440
3nxr	D2D	Dihydrofolate reductase	1.5.1.3	0.440
3tnw	F18	Cyclin-dependent kinase 2	2.7.11.22	0.440
4nm9	FAD	Bifunctional protein PutA	/	0.440