sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Cavities are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 4bb2 | STR | Corticosteroid-binding globulin |
| PDB ID | HET | Uniprot Name | EC Number | Cavity Similarity |
Align |
|---|---|---|---|---|---|
| 4bb2 | STR | Corticosteroid-binding globulin | / | 1.000 | |
| 2vdy | HCY | Corticosteroid-binding globulin | / | 0.560 | |
| 4c49 | HCY | Corticosteroid-binding globulin | / | 0.544 | |
| 3bxo | UPP | dTDP-3-amino-3,4,6-trideoxy-alpha-D-glucopyranose | / | 0.509 | |
| 2v95 | HCY | Corticosteroid-binding globulin | / | 0.502 | |
| 2ejz | SAH | Diphthine synthase | / | 0.496 | |
| 1zdw | FLV | Prenyltransferase | / | 0.488 | |
| 1txt | CAA | HMG-CoA synthase | / | 0.487 | |
| 4j53 | 1J4 | Serine/threonine-protein kinase PLK1 | 2.7.11.21 | 0.487 | |
| 2aba | STR | Pentaerythritol tetranitrate reductase | / | 0.486 | |
| 3q9b | B3N | Acetylpolyamine amidohydrolase | / | 0.486 | |
| 1w6h | TIT | Plasmepsin-2 | 3.4.23.39 | 0.485 | |
| 1gky | 5GP | Guanylate kinase | 2.7.4.8 | 0.484 | |
| 4iar | ERM | 5-hydroxytryptamine receptor 1B | / | 0.484 | |
| 1h61 | PDN | Pentaerythritol tetranitrate reductase | / | 0.482 | |
| 1t7o | 152 | Carnitine O-acetyltransferase | 2.3.1.7 | 0.482 | |
| 2gjl | FMN | Nitronate monooxygenase | 1.13.12.16 | 0.482 | |
| 3fhx | PLP | Pyridoxal kinase | 2.7.1.35 | 0.481 | |
| 1h60 | STR | Pentaerythritol tetranitrate reductase | / | 0.480 | |
| 3wqm | B29 | Diterpene synthase | 3.1.7.8 | 0.480 | |
| 4bfz | ZVZ | Pantothenate kinase | 2.7.1.33 | 0.477 | |
| 3eon | 341 | Glutaryl-CoA dehydrogenase | / | 0.475 | |
| 1ex7 | 5GP | Guanylate kinase | 2.7.4.8 | 0.474 | |
| 3prf | FP3 | Serine/threonine-protein kinase B-raf | 2.7.11.1 | 0.474 | |
| 3zbr | NAP | 2',3'-cyclic-nucleotide 3'-phosphodiesterase | 3.1.4.37 | 0.474 | |
| 1zgb | A1E | Acetylcholinesterase | 3.1.1.7 | 0.473 | |
| 3dys | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.472 | |
| 3uon | QNB | Muscarinic acetylcholine receptor M2 | / | 0.472 | |
| 1mcz | RMN | Benzoylformate decarboxylase | 4.1.1.7 | 0.471 | |
| 1a9p | 9DI | Purine nucleoside phosphorylase | 2.4.2.1 | 0.470 | |
| 2fxu | BID | Actin, alpha skeletal muscle | / | 0.470 | |
| 4dz5 | NAP | Aldo-keto reductase family 1 member C3 | / | 0.470 | |
| 1xl8 | 152 | Peroxisomal carnitine O-octanoyltransferase | 2.3.1.137 | 0.469 | |
| 2ed3 | SAH | Diphthine synthase | / | 0.469 | |
| 2wya | HMG | Hydroxymethylglutaryl-CoA synthase, mitochondrial | 2.3.3.10 | 0.469 | |
| 4psb | GA3 | Cytokinin-specific binding protein | / | 0.469 | |
| 3pqb | VGP | Putative oxidoreductase | / | 0.468 | |
| 3sl2 | ATP | Sensor histidine kinase WalK | / | 0.468 | |
| 4uoh | ADP | Nucleoside diphosphate kinase | / | 0.468 | |
| 1qjf | ACS | Isopenicillin N synthase | 1.21.3.1 | 0.467 | |
| 4gts | 7TP | Geranylgeranyl transferase type-2 subunit beta | 2.5.1.60 | 0.467 | |
| 2vn1 | FK5 | Peptidylprolyl isomerase | / | 0.466 | |
| 3uzw | NAP | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.465 | |
| 4da8 | BG2 | Purine nucleoside phosphorylase DeoD-type | 2.4.2.1 | 0.465 | |
| 4zzj | CNA | NAD-dependent protein deacetylase sirtuin-1 | 3.5.1 | 0.465 | |
| 1nce | CB3 | Thymidylate synthase | / | 0.464 | |
| 1yry | MSG | Purine nucleoside phosphorylase | 2.4.2.1 | 0.464 | |
| 4bft | ZVT | Pantothenate kinase | 2.7.1.33 | 0.464 | |
| 1nqu | RDL | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.463 | |
| 1qv0 | CZH | Obelin | / | 0.463 | |
| 2a9y | 26A | Adenosine kinase | 2.7.1.20 | 0.463 | |
| 2h3w | HC5 | Carnitine O-acetyltransferase | 2.3.1.7 | 0.463 | |
| 3dy8 | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.463 | |
| 3vf6 | 0H6 | Glucokinase | 2.7.1.2 | 0.463 | |
| 3jsi | WTC | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.462 | |
| 4ffl | ADP | Uncharacterized protein | / | 0.462 | |
| 1mcz | TDP | Benzoylformate decarboxylase | 4.1.1.7 | 0.461 | |
| 2e9a | B28 | Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific) | 2.5.1.31 | 0.461 | |
| 3b9x | NOS | Pyrimidine-specific ribonucleoside hydrolase RihB | 3.2.2.8 | 0.461 | |
| 3cmf | PDN | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.461 | |
| 3hbf | MYC | Flavonoid 3-O-glucosyltransferase | 2.4.1 | 0.461 | |
| 4ise | 1FW | Glucokinase | 2.7.1.2 | 0.461 | |
| 4kla | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.461 | |
| 4q0k | GA3 | Phytohormone-binding protein | / | 0.461 | |
| 1pwy | AC2 | Purine nucleoside phosphorylase | 2.4.2.1 | 0.460 | |
| 2wo7 | ASV | Isopenicillin N synthase | 1.21.3.1 | 0.460 | |
| 2yph | QQY | 2',3'-cyclic-nucleotide 3'-phosphodiesterase | 3.1.4.37 | 0.460 | |
| 3eku | CY9 | Actin-5C | / | 0.460 | |
| 3k4s | 0MO | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.460 | |
| 3vt8 | YI3 | Vitamin D3 receptor | / | 0.460 | |
| 4n3r | 2GU | Tankyrase-1 | 2.4.2.30 | 0.460 | |
| 5dp2 | NAP | CurF | / | 0.460 | |
| 1aqu | EST | Estrogen sulfotransferase, testis isoform | 2.8.2.4 | 0.459 | |
| 1odc | A8B | Acetylcholinesterase | 3.1.1.7 | 0.459 | |
| 2re8 | GSU | Glutamine--tRNA ligase | 6.1.1.18 | 0.459 | |
| 3exh | TPP | Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial | 1.2.4.1 | 0.459 | |
| 3exh | TPP | Pyruvate dehydrogenase E1 component subunit beta, mitochondrial | 1.2.4.1 | 0.459 | |
| 4k9o | TPP | Benzoylformate decarboxylase | 4.1.1.7 | 0.459 | |
| 4uug | PXG | Branched-chain amino acid aminotransferase, putative | / | 0.459 | |
| 1yci | NDF | Hypoxia-inducible factor 1-alpha inhibitor | 1.14.11.30 | 0.458 | |
| 2a59 | LMZ | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.458 | |
| 2dsh | SAH | Diphthine synthase | / | 0.458 | |
| 2hve | ADP | Nucleoside diphosphate kinase A | 2.7.4.6 | 0.458 | |
| 2xvi | FAD | Putative flavin-containing monooxygenase | / | 0.458 | |
| 3q8u | ADP | Nucleoside diphosphate kinase | / | 0.458 | |
| 4wda | 2AM | 2',3'-cyclic-nucleotide 3'-phosphodiesterase | 3.1.4.37 | 0.458 | |
| 1if7 | SBR | Carbonic anhydrase 2 | 4.2.1.1 | 0.457 | |
| 1itz | TPP | Transketolase, chloroplastic | 2.2.1.1 | 0.457 | |
| 1w6j | R71 | Lanosterol synthase | 5.4.99.7 | 0.457 | |
| 2dhf | DZF | Dihydrofolate reductase | 1.5.1.3 | 0.457 | |
| 2j3q | TFL | Acetylcholinesterase | 3.1.1.7 | 0.457 | |
| 2xb8 | XNW | 3-dehydroquinate dehydratase | 4.2.1.10 | 0.457 | |
| 3c72 | CX1 | Geranylgeranyl transferase type-2 subunit beta | 2.5.1.60 | 0.457 | |
| 4rel | KMP | Glycosyltransferase | / | 0.457 | |
| 4ure | 1PS | Cyclohexanol dehydrogenase | / | 0.457 | |
| 5std | UNN | Scytalone dehydratase | 4.2.1.94 | 0.457 | |
| 1ez0 | NAP | NADP-dependent fatty aldehyde dehydrogenase | 1.2.1.4 | 0.456 | |
| 2xda | JPS | 3-dehydroquinate dehydratase | 4.2.1.10 | 0.456 | |
| 3uax | NOS | Purine nucleoside phosphorylase DeoD-type | / | 0.456 | |
| 3v0m | 5GW | Histo-blood group ABO system transferase | / | 0.456 | |
| 4ajd | F04 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.456 | |
| 4gh6 | LUO | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.456 | |
| 4jva | 1OR | cAMP-dependent protein kinase type II-beta regulatory subunit | / | 0.456 | |
| 1jtv | TES | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.455 | |
| 1kyx | CRM | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.455 | |
| 1ndz | FR5 | Adenosine deaminase | 3.5.4.4 | 0.455 | |
| 1qs2 | NAD | Vip2Ac | / | 0.455 | |
| 2aou | CQA | Histamine N-methyltransferase | 2.1.1.8 | 0.455 | |
| 2gvd | FKP | Adenylate cyclase type 2 | / | 0.455 | |
| 2gvd | FKP | Adenylate cyclase type 5 | / | 0.455 | |
| 2qim | ZEA | Class 10 plant pathogenesis-related protein | / | 0.455 | |
| 2vbp | VB1 | Isopenicillin N synthase | 1.21.3.1 | 0.455 | |
| 2w3m | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.455 | |
| 4isg | 1FY | Glucokinase | 2.7.1.2 | 0.455 | |
| 1jf0 | CZH | Obelin | / | 0.454 | |
| 1q0z | AKA | Aclacinomycin methylesterase RdmC | 3.1.1.95 | 0.454 | |
| 1u1d | 181 | Uridine phosphorylase | 2.4.2.3 | 0.454 | |
| 1uym | PU3 | Heat shock protein HSP 90-beta | / | 0.454 | |
| 2v59 | LZK | Biotin carboxylase | 6.3.4.14 | 0.454 | |
| 3gnv | XNZ | Genome polyprotein | 2.7.7.48 | 0.454 | |
| 3h0b | B35 | Beta-secretase 1 | 3.4.23.46 | 0.454 | |
| 3uzz | TES | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.454 | |
| 4qem | HC4 | Phospholipase A2 VRV-PL-VIIIa | / | 0.454 | |
| 4wdf | A2P | 2',3'-cyclic-nucleotide 3'-phosphodiesterase | 3.1.4.37 | 0.454 | |
| 1ib0 | FAD | NADH-cytochrome b5 reductase 3 | 1.6.2.2 | 0.453 | |
| 1rsg | FAD | Polyamine oxidase FMS1 | / | 0.453 | |
| 2oli | IOP | Basic phospholipase A2 VRV-PL-VIIIa | 3.1.1.4 | 0.453 | |
| 2reh | FAD | Nitroalkane oxidase | 1.7.3.1 | 0.453 | |
| 2vcm | M11 | Isopenicillin N synthase | 1.21.3.1 | 0.453 | |
| 4gev | CB3 | Thymidylate synthase | / | 0.453 | |
| 1gae | NAD | Glyceraldehyde-3-phosphate dehydrogenase A | / | 0.452 | |
| 2bkt | RPF | Renin | 3.4.23.15 | 0.452 | |
| 3udn | 09B | Beta-secretase 1 | 3.4.23.46 | 0.452 | |
| 3zbz | OVE | 2',3'-cyclic-nucleotide 3'-phosphodiesterase | 3.1.4.37 | 0.452 | |
| 4z5w | ILE_THR_GLN_TYS_TYS | Phytosulfokine receptor 1 | 2.7.11.1 | 0.452 | |
| 1f3e | DPZ | Queuine tRNA-ribosyltransferase | 2.4.2.29 | 0.451 | |
| 1ni4 | TPP | Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial | 1.2.4.1 | 0.451 | |
| 1ni4 | TPP | Pyruvate dehydrogenase E1 component subunit beta, mitochondrial | 1.2.4.1 | 0.451 | |
| 1zkl | IBM | High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A | 3.1.4.53 | 0.451 | |
| 2fw3 | BUI | Carnitine O-palmitoyltransferase 2, mitochondrial | 2.3.1.21 | 0.451 | |
| 2gjn | FMN | Nitronate monooxygenase | 1.13.12.16 | 0.451 | |
| 3c3d | FO1 | 2-phospho-L-lactate transferase | / | 0.451 | |
| 3caq | NDP | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.451 | |
| 3cr0 | 809 | Wee1-like protein kinase | 2.7.10.2 | 0.451 | |
| 3gsi | THG | Dimethylglycine oxidase | 1.5.3.10 | 0.451 | |
| 3jsx | CC2 | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.451 | |
| 3nu0 | 3TU | Dihydrofolate reductase | 1.5.1.3 | 0.451 | |
| 4a32 | 2CD | Glycylpeptide N-tetradecanoyltransferase | / | 0.451 | |
| 1hb1 | OCV | Isopenicillin N synthase | 1.21.3.1 | 0.450 | |
| 1o6q | R17 | Squalene--hopene cyclase | 4.2.1.129 | 0.450 | |
| 2lba | CHO | Fatty acid binding protein 6 | / | 0.450 | |
| 2oci | TYC | Valacyclovir hydrolase | 3.1 | 0.450 | |
| 2poq | ISD | Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase | 1.3.1.20 | 0.450 | |
| 3h3q | H13 | Collagen type IV alpha-3-binding protein | / | 0.450 | |
| 3occ | DIH | Purine nucleoside phosphorylase DeoD-type | / | 0.450 | |
| 1sd2 | MTH | S-methyl-5'-thioadenosine phosphorylase | / | 0.449 | |
| 2hk9 | NAP | Shikimate dehydrogenase (NADP(+)) | / | 0.449 | |
| 2oth | NIM | Basic phospholipase A2 VRV-PL-VIIIa | 3.1.1.4 | 0.449 | |
| 2yp0 | OVE | 2',3'-cyclic-nucleotide 3'-phosphodiesterase | 3.1.4.37 | 0.449 | |
| 3ghw | GHW | Dihydrofolate reductase | 1.5.1.3 | 0.449 | |
| 3q30 | D61 | Squalene synthase | 2.5.1.21 | 0.449 | |
| 3vt9 | YI4 | Vitamin D3 receptor | / | 0.449 | |
| 1eve | E20 | Acetylcholinesterase | 3.1.1.7 | 0.448 | |
| 1icp | FMN | 12-oxophytodienoate reductase 1 | 1.3.1.42 | 0.448 | |
| 1ry8 | RUT | Aldo-keto reductase family 1 member C3 | / | 0.448 | |
| 1s9d | AFB | Cytohesin-2 | / | 0.448 | |
| 1s9d | AFB | ADP-ribosylation factor 1 | / | 0.448 | |
| 2ab8 | MTP | Adenosine kinase | 2.7.1.20 | 0.448 | |
| 2bu9 | HFV | Isopenicillin N synthase | 1.21.3.1 | 0.448 | |
| 2dxd | ANP | Nucleoside diphosphate kinase | 2.7.4.6 | 0.448 | |
| 2p8u | COA | Hydroxymethylglutaryl-CoA synthase, cytoplasmic | 2.3.3.10 | 0.448 | |
| 2rd2 | QSI | Glutamine--tRNA ligase | 6.1.1.18 | 0.448 | |
| 3n76 | CA2 | 3-dehydroquinate dehydratase | 4.2.1.10 | 0.448 | |
| 3nmp | PYV | Abscisic acid receptor PYL2 | / | 0.448 | |
| 4bby | FAD | Alkyldihydroxyacetonephosphate synthase, peroxisomal | 2.5.1.26 | 0.448 | |
| 4br0 | AU1 | Ectonucleoside triphosphate diphosphohydrolase 2 | / | 0.448 | |
| 4kp6 | 1S1 | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.448 | |
| 1fx9 | MJI | Phospholipase A2, major isoenzyme | 3.1.1.4 | 0.447 | |
| 1kbo | 340 | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.447 | |
| 1kru | IPT | Galactoside O-acetyltransferase | 2.3.1.18 | 0.447 | |
| 1re0 | AFB | ADP-ribosylation factor 1 | / | 0.447 | |
| 1re0 | AFB | ARF guanine-nucleotide exchange factor 1 | / | 0.447 | |
| 1y2b | DEE | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.447 | |
| 2a2d | ANP | N-acetylgalactosamine kinase | 2.7.1.157 | 0.447 | |
| 2ea4 | F79 | Methionine aminopeptidase 2 | / | 0.447 | |
| 2gev | COK | Pantothenate kinase | 2.7.1.33 | 0.447 | |
| 2gv8 | NDP | Thiol-specific monooxygenase | 1.14.13 | 0.447 | |
| 2hq9 | FAD | Mll6688 protein | / | 0.447 | |
| 2zev | IPE | Geranylgeranyl pyrophosphate synthase | / | 0.447 | |
| 3dyl | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.447 | |
| 3v2u | ATP | Protein GAL3 | / | 0.447 | |
| 4fhd | 0TT | Spore photoproduct lyase | / | 0.447 | |
| 4h38 | 0YX | Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific) | 2.5.1.31 | 0.447 | |
| 4isf | 1FX | Glucokinase | 2.7.1.2 | 0.447 | |
| 1fdw | EST | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.446 | |
| 1pke | 2FD | Purine nucleoside phosphorylase DeoD-type | / | 0.446 | |
| 1rsz | DIH | Purine nucleoside phosphorylase | 2.4.2.1 | 0.446 | |
| 2e0n | SAH | Precorrin-2 C20-methyltransferase | / | 0.446 | |
| 2g1n | 1IG | Renin | 3.4.23.15 | 0.446 | |
| 2j9f | THV | 2-oxoisovalerate dehydrogenase subunit alpha, mitochondrial | 1.2.4.4 | 0.446 | |
| 2j9f | THV | 2-oxoisovalerate dehydrogenase subunit beta, mitochondrial | 1.2.4.4 | 0.446 | |
| 2vbd | V10 | Isopenicillin N synthase | 1.21.3.1 | 0.446 | |
| 2wzw | FMN | Nitroreductase NfnB | / | 0.446 | |
| 2xup | TZ5 | Acetylcholinesterase | 3.1.1.7 | 0.446 | |
| 2yoz | OVE | 2',3'-cyclic-nucleotide 3'-phosphodiesterase | 3.1.4.37 | 0.446 | |
| 3g70 | A5T | Renin | 3.4.23.15 | 0.446 | |
| 3hxd | BD7 | Geranylgeranyl transferase type-2 subunit beta | 2.5.1.60 | 0.446 | |
| 3sso | SAH | Mycinamicin VI 2''-O-methyltransferase | / | 0.446 | |
| 3ufl | 508 | Beta-secretase 1 | 3.4.23.46 | 0.446 | |
| 3v0o | 4GW | Histo-blood group ABO system transferase | / | 0.446 | |
| 4a81 | DXC | Major pollen allergen Bet v 1-A | / | 0.446 | |
| 4bfu | ZVU | Pantothenate kinase | 2.7.1.33 | 0.446 | |
| 4e90 | 7RG | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.446 | |
| 4kdr | SAH | Ubiquinone biosynthesis O-methyltransferase | / | 0.446 | |
| 4n4v | 2GY | Tankyrase-1 | 2.4.2.30 | 0.446 | |
| 4pnm | NU1 | Tankyrase-2 | 2.4.2.30 | 0.446 | |
| 4qys | PLR | Tryptophan synthase beta chain 2 | 4.2.1.20 | 0.446 | |
| 1c7o | PPG | Hemolysin | / | 0.445 | |
| 1fcb | FMN | Cytochrome b2, mitochondrial | 1.1.2.3 | 0.445 | |
| 1ygj | RMC | Pyridoxal kinase | 2.7.1.35 | 0.445 | |
| 2g24 | 7IG | Renin | 3.4.23.15 | 0.445 | |
| 2vig | FAD | Short-chain specific acyl-CoA dehydrogenase, mitochondrial | 1.3.8.1 | 0.445 | |
| 3biz | 61E | Wee1-like protein kinase | 2.7.10.2 | 0.445 | |
| 3bv7 | NAP | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.445 | |
| 3qfa | FAD | Thioredoxin reductase 1, cytoplasmic | 1.8.1.9 | 0.445 | |
| 3sqz | COA | Putative hydroxymethylglutaryl-CoA synthase | / | 0.445 | |
| 4a83 | DXC | Major pollen allergen Bet v 1-A | / | 0.445 | |
| 4eqw | COA | Coenzyme A disulfide reductase | / | 0.445 | |
| 4fam | 0SZ | Aldo-keto reductase family 1 member C3 | / | 0.445 | |
| 4kby | C2E | Stimulator of interferon genes protein | / | 0.445 | |
| 4llk | MEW | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.445 | |
| 5hwo | HMG | Hydroxymethylglutaryl-CoA synthase | / | 0.445 | |
| 1b8o | IMH | Purine nucleoside phosphorylase | 2.4.2.1 | 0.444 | |
| 1cs4 | FOK | Adenylate cyclase type 2 | / | 0.444 | |
| 1cs4 | FOK | Adenylate cyclase type 5 | / | 0.444 | |
| 1e66 | HUX | Acetylcholinesterase | 3.1.1.7 | 0.444 | |
| 1nw4 | IMH | Purine nucleoside phosphorylase | / | 0.444 | |
| 2fm0 | M98 | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.444 | |
| 2g5w | 8PG | 12-oxophytodienoate reductase 3 | 1.3.1.42 | 0.444 | |
| 2nmt | MIM | Glycylpeptide N-tetradecanoyltransferase | 2.3.1.97 | 0.444 | |
| 2xb9 | XNW | 3-dehydroquinate dehydratase | 4.2.1.10 | 0.444 | |
| 3e6e | DCS | Alanine racemase | / | 0.444 | |
| 3jyo | NAD | Quinate/shikimate dehydrogenase (NAD(+)) | / | 0.444 | |
| 3nxy | D2H | Dihydrofolate reductase | 1.5.1.3 | 0.444 | |
| 3pz3 | PZ3 | Geranylgeranyl transferase type-2 subunit beta | 2.5.1.60 | 0.444 | |
| 4j8t | DOG | Uncharacterized PhzA/B-like protein PA3332 | / | 0.444 | |
| 4ks7 | X4Z | Serine/threonine-protein kinase PAK 6 | 2.7.11.1 | 0.444 | |
| 4z87 | GDP | Inosine-5'-monophosphate dehydrogenase | / | 0.444 | |
| 5il2 | SAH | N6-adenosine-methyltransferase 70 kDa subunit | / | 0.444 | |
| 1a9c | GTP | GTP cyclohydrolase 1 | 3.5.4.16 | 0.443 | |
| 1pqc | 444 | Oxysterols receptor LXR-beta | / | 0.443 | |
| 2a57 | CRM | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.443 | |
| 2cjf | RP4 | 3-dehydroquinate dehydratase | 4.2.1.10 | 0.443 | |
| 2v58 | LZJ | Biotin carboxylase | 6.3.4.14 | 0.443 | |
| 2xuo | TZ4 | Acetylcholinesterase | 3.1.1.7 | 0.443 | |
| 2xvf | FAD | Putative flavin-containing monooxygenase | / | 0.443 | |
| 3dh7 | FMN | Isopentenyl-diphosphate delta-isomerase | / | 0.443 | |
| 3e33 | ED7 | Protein farnesyltransferase subunit beta | 2.5.1.58 | 0.443 | |
| 3fsj | D7K | Benzoylformate decarboxylase | 4.1.1.7 | 0.443 | |
| 3gc5 | 2MQ | Queuine tRNA-ribosyltransferase | 2.4.2.29 | 0.443 | |
| 3h3r | 14H | Collagen type IV alpha-3-binding protein | / | 0.443 | |
| 3tqx | PLP | 2-amino-3-ketobutyrate coenzyme A ligase | / | 0.443 | |
| 3uzx | AOM | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.443 | |
| 3zei | AWH | O-acetylserine sulfhydrylase | / | 0.443 | |
| 3zoi | M2W | Isopenicillin N synthase | 1.21.3.1 | 0.443 | |
| 4iaq | 2GM | 5-hydroxytryptamine receptor 1B | / | 0.443 | |
| 4nh8 | 2LC | Heat shock protein HSP 90-alpha | / | 0.443 | |
| 4oma | LCS | Methionine gamma-lyase | / | 0.443 | |
| 1be4 | PCG | Nucleoside diphosphate kinase A 2 | 2.7.4.6 | 0.442 | |
| 1s3u | TQD | Dihydrofolate reductase | 1.5.1.3 | 0.442 | |
| 1so2 | 666 | cGMP-inhibited 3',5'-cyclic phosphodiesterase B | 3.1.4.17 | 0.442 | |
| 1udt | VIA | cGMP-specific 3',5'-cyclic phosphodiesterase | / | 0.442 | |
| 1z6t | ADP | Apoptotic protease-activating factor 1 | / | 0.442 | |
| 2cek | N8T | Acetylcholinesterase | 3.1.1.7 | 0.442 | |
| 2o1s | TDP | 1-deoxy-D-xylulose-5-phosphate synthase | 2.2.1.7 | 0.442 | |
| 2ouu | 35G | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.442 | |
| 2whq | HI6 | Acetylcholinesterase | 3.1.1.7 | 0.442 | |
| 2wnb | C5P | CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 1 | 2.4.99.4 | 0.442 | |
| 2xlr | FAD | Putative flavin-containing monooxygenase | / | 0.442 | |
| 3d91 | REM | Renin | 3.4.23.15 | 0.442 | |
| 3hxf | BD9 | Geranylgeranyl transferase type-2 subunit beta | 2.5.1.60 | 0.442 | |
| 3ohh | 3HH | Beta-secretase 1 | 3.4.23.46 | 0.442 | |
| 4fk3 | 325 | Serine/threonine-protein kinase B-raf | 2.7.11.1 | 0.442 | |
| 4gtv | 7TR | Geranylgeranyl transferase type-2 subunit beta | 2.5.1.60 | 0.442 | |
| 4kxj | P34 | Nucleoprotein | / | 0.442 | |
| 4rh1 | 0TT | Spore photoproduct lyase | / | 0.442 | |
| 4wh2 | ADP | N-acetylhexosamine 1-kinase | 2.7.1.162 | 0.442 | |
| 1fml | RTL | Retinol dehydratase | / | 0.441 | |
| 1fwm | CB3 | Thymidylate synthase | / | 0.441 | |
| 1lnm | DTX | Bilin-binding protein | / | 0.441 | |
| 1pz1 | NAP | General stress protein 69 | / | 0.441 | |
| 1qyw | 5SD | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.441 | |
| 1vbi | NAD | Malate/L-lactate dehydrogenase family protein | / | 0.441 | |
| 1x1d | SAH | C-20 methyltransferase | / | 0.441 | |
| 2f3m | GTD | Glutathione S-transferase Mu 1 | 2.5.1.18 | 0.441 | |
| 2flh | ZEA | Cytokinin-specific binding protein | / | 0.441 | |
| 2q92 | B23 | Methionine aminopeptidase | / | 0.441 | |
| 2w6p | OA4 | Biotin carboxylase | 6.3.4.14 | 0.441 | |
| 3bi6 | 396 | Wee1-like protein kinase | 2.7.10.2 | 0.441 | |
| 3faz | NOS | Purine nucleoside phosphorylase | / | 0.441 | |
| 3hxc | BD6 | Geranylgeranyl transferase type-2 subunit beta | 2.5.1.60 | 0.441 | |
| 3myt | EQU | Steroid Delta-isomerase | 5.3.3.1 | 0.441 | |
| 3ntz | 3TZ | Dihydrofolate reductase | 1.5.1.3 | 0.441 | |
| 3ppk | FNI | Serine/threonine-protein kinase B-raf | 2.7.11.1 | 0.441 | |
| 3qpn | PFK | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.441 | |
| 3sfy | 3FY | Uncharacterized protein | / | 0.441 | |
| 3ssm | SAH | Mycinamicin VI 2''-O-methyltransferase | / | 0.441 | |
| 3t4e | NAD | Quinate/shikimate dehydrogenase | / | 0.441 | |
| 4a86 | 2AN | Major pollen allergen Bet v 1-A | / | 0.441 | |
| 4b5n | FMN | NAD(P)H:flavin oxidoreductase Sye4 | / | 0.441 | |
| 4b6u | M7G | Eukaryotic translation initiation factor 4E type 3 | / | 0.441 | |
| 4ey6 | GNT | Acetylcholinesterase | 3.1.1.7 | 0.441 | |
| 4opc | FDA | Conserved Archaeal protein | / | 0.441 | |
| 4zqc | F6F | Tryptophan synthase alpha chain | / | 0.441 | |
| 4zwp | M44 | Xaa-Pro dipeptidase | 3.4.13.9 | 0.441 | |
| 5akk | 1P8 | Bifunctional epoxide hydrolase 2 | 3.1.3.76 | 0.441 | |
| 5c1m | CLR | Mu-type opioid receptor | / | 0.441 | |
| 5d7p | AR6 | NAD-dependent protein deacetylase sirtuin-2 | 3.5.1 | 0.441 | |
| 4ami | G90 | Beta-1 adrenergic receptor | / | 0.441 | |
| 1hb3 | SCV | Isopenicillin N synthase | 1.21.3.1 | 0.440 | |
| 1mxf | MTX | Putative pteridine reductase 2 | / | 0.440 | |
| 1w6r | GNT | Acetylcholinesterase | 3.1.1.7 | 0.440 | |
| 2c1z | KMP | Anthocyanidin 3-O-glucosyltransferase 2 | 2.4.1.115 | 0.440 | |
| 2cle | F6F | Tryptophan synthase alpha chain | / | 0.440 | |
| 2fto | CB3 | Thymidylate synthase | / | 0.440 | |
| 2g1s | 4IG | Renin | 3.4.23.15 | 0.440 | |
| 2o1x | TDP | 1-deoxy-D-xylulose-5-phosphate synthase | 2.2.1.7 | 0.440 | |
| 2uag | UMA | UDP-N-acetylmuramoylalanine--D-glutamate ligase | 6.3.2.9 | 0.440 | |
| 2vz0 | D64 | Pteridine reductase | / | 0.440 | |
| 2xi4 | AFT | Acetylcholinesterase | 3.1.1.7 | 0.440 | |
| 3atz | FMN | Prostaglandin F2a synthase | / | 0.440 | |
| 3fhx | PXL | Pyridoxal kinase | 2.7.1.35 | 0.440 | |
| 3oad | LPO | Renin | 3.4.23.15 | 0.440 | |
| 3zec | ANP | Adenosine monophosphate-protein transferase SoFic | 2.7.7.n1 | 0.440 | |
| 4ajm | 3A6 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.440 | |
| 4fll | YZ6 | Methionine aminopeptidase 1 | / | 0.440 | |
| 4h9t | HL4 | Phosphotriesterase | / | 0.440 | |
| 4i6h | 1C8 | Serine/threonine-protein kinase PLK2 | 2.7.11.21 | 0.440 | |
| 4ms1 | 381 | Gamma-aminobutyric acid type B receptor subunit 1 | / | 0.440 | |
| 4std | BFS | Scytalone dehydratase | 4.2.1.94 | 0.440 | |
| 5c1d | 12V | UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit | / | 0.440 | |
| 5hwr | COA | Hydroxymethylglutaryl-CoA synthase | / | 0.440 |