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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4b8wNAPGDP-L-fucose synthase1.1.1.271

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
4b8wNAPGDP-L-fucose synthase1.1.1.2711.000
4b8zNAPGDP-L-fucose synthase1.1.1.2710.590
4e5yNDPGDP-L-fucose synthase1.1.1.2710.520
3iahNAPPutative oxoacyl-(Acyl carrier protein) reductase/0.473
3gy0NAPNAD(P)-dependent oxidoreductase/0.472
2ydxNAPMethionine adenosyltransferase 2 subunit beta/0.460
2p5uNADUDP-glucose 4-epimerase/0.457
4is3NAD3alpha-hydroxy bile acid-CoA-ester 3-dehydrogenase 21.17.98.10.457
3a4vNADNDP-sugar epimerase/0.456
4j7xNAPSepiapterin reductase1.1.1.1530.450
3d3wNAPL-xylulose reductase1.1.1.100.446
4fj1NAP17beta-hydroxysteroid dehydrogenase/0.446
1vl8NAPOxidoreductase, short chain dehydrogenase/reductase family/0.445
3f1kNAPUncharacterized oxidoreductase YciK10.445
3qwfNAP17beta-hydroxysteroid dehydrogenase/0.445
4fj0NAP17beta-hydroxysteroid dehydrogenase/0.445
4j7uNAPSepiapterin reductase1.1.1.1530.445
5jsfNAD17-beta-hydroxysteroid dehydrogenase 141.1.10.444
4esoNAPPutative oxidoreductase/0.442
5idwNAPShort-chain dehydrogenase/reductase SDR/0.442
1cydNDPCarbonyl reductase [NADPH] 21.1.1.1840.441
1ybmNAPUncharacterized protein At5g02240/0.441
1pr9NAPL-xylulose reductase1.1.1.100.440
1wntNAPL-xylulose reductase1.1.1.100.440