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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4b7tCWTGlycogen synthase kinase-3 beta2.7.11.26

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
4b7tCWTGlycogen synthase kinase-3 beta2.7.11.261.000
4nm0ADPGlycogen synthase kinase-3 beta2.7.11.260.657
4nm7ADPGlycogen synthase kinase-3 beta2.7.11.260.633
4acc7YGGlycogen synthase kinase-3 beta2.7.11.260.593
4acdGR9Glycogen synthase kinase-3 beta2.7.11.260.588
3sd0TSKGlycogen synthase kinase-3 beta2.7.11.260.583
4j711JXGlycogen synthase kinase-3 beta2.7.11.260.577
4afjSJJGlycogen synthase kinase-3 beta2.7.11.260.575
4nm5ADPGlycogen synthase kinase-3 beta2.7.11.260.569
3du8553Glycogen synthase kinase-3 beta2.7.11.260.565
3q3b55EGlycogen synthase kinase-3 beta2.7.11.260.561
3l1sZ92Glycogen synthase kinase-3 beta2.7.11.260.560
4achKDIGlycogen synthase kinase-3 beta2.7.11.260.549
3sayOFTGlycogen synthase kinase-3 beta2.7.11.260.542
3zrkZRKGlycogen synthase kinase-3 beta2.7.11.260.538
4acg6LQGlycogen synthase kinase-3 beta2.7.11.260.534
3gb2G3BGlycogen synthase kinase-3 beta2.7.11.260.531
1q3dSTUGlycogen synthase kinase-3 beta2.7.11.260.530
4dit0KDGlycogen synthase kinase-3 beta2.7.11.260.529
4j1rI5RGlycogen synthase kinase-3 beta2.7.11.260.529
3zrmZRMGlycogen synthase kinase-3 beta2.7.11.260.528
3f7z34OGlycogen synthase kinase-3 beta2.7.11.260.516
1q41IXMGlycogen synthase kinase-3 beta2.7.11.260.514
3i4bZ48Glycogen synthase kinase-3 beta2.7.11.260.513
3f883HTGlycogen synthase kinase-3 beta2.7.11.260.512
1j1bANPGlycogen synthase kinase-3 beta2.7.11.260.510
1q3wATUGlycogen synthase kinase-3 beta2.7.11.260.506
4bchT7ZCyclin-dependent kinase 92.7.11.220.501
4dfn0K1Tyrosine-protein kinase SYK2.7.10.20.501
2e9n76ASerine/threonine-protein kinase Chk12.7.11.10.499
2cchATPCyclin-dependent kinase 22.7.11.220.495
1u59STUTyrosine-protein kinase ZAP-702.7.10.20.494
4qmySTUSerine/threonine-protein kinase 242.7.11.10.494
3zrlZRLGlycogen synthase kinase-3 beta2.7.11.260.493
3tkiS25Serine/threonine-protein kinase Chk12.7.11.10.492
1q4l679Glycogen synthase kinase-3 beta2.7.11.260.491
2hog710Serine/threonine-protein kinase Chk12.7.11.10.487
4qo9627Serine/threonine-protein kinase 242.7.11.10.483
2ittAEEEpidermal growth factor receptor2.7.10.10.481
1nvqUCNSerine/threonine-protein kinase Chk12.7.11.10.479
1uv5BRWGlycogen synthase kinase-3 beta2.7.11.260.479
4nj32KDCyclin-dependent kinase 22.7.11.220.479
3jxwLXGSerine/threonine-protein kinase pim-12.7.11.10.476
4bgg844Activin receptor type-12.7.11.300.476
1m17AQ4Epidermal growth factor receptor2.7.10.10.475
2y6o1N1Ephrin type-A receptor 42.7.10.10.475
1q5kTMUGlycogen synthase kinase-3 beta2.7.11.260.473
2ow3BIMGlycogen synthase kinase-3 beta2.7.11.260.473
3a7hATPSerine/threonine-protein kinase 242.7.11.10.473
3emg685Tyrosine-protein kinase SYK2.7.10.20.473
3vf9477Tyrosine-protein kinase SYK2.7.10.20.472
4wboANWRhodopsin kinase/0.472
2br1PFPSerine/threonine-protein kinase Chk12.7.11.10.471
1j1cADPGlycogen synthase kinase-3 beta2.7.11.260.470
4bcqTJFCyclin-dependent kinase 22.7.11.220.470
2hy81STSerine/threonine-protein kinase PAK 12.7.11.10.469
2i0ePDSProtein kinase C beta type2.7.11.130.469
1szmBI4cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.468
4fg7ATPCalcium/calmodulin-dependent protein kinase type 12.7.11.170.468
4jrvKJVEpidermal growth factor receptor2.7.10.10.468
1q99ANPSerine/threonine-protein kinase SKY12.7.11.10.466
3l9lL9LcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.466
2gcdSTUSerine/threonine-protein kinase TAO22.7.11.10.465
2wpa889Cyclin-dependent kinase 22.7.11.220.465
2jedLG8Protein kinase C theta type2.7.11.130.464
4o0rX4ZSerine/threonine-protein kinase PAK 12.7.11.10.464
1pmeSB2Mitogen-activated protein kinase 12.7.11.240.463
3dtcVINMitogen-activated protein kinase kinase kinase 92.7.11.250.463
3i60E86Mitogen-activated protein kinase 12.7.11.240.463
4bcnT9NCyclin-dependent kinase 22.7.11.220.463
4f4p0SBTyrosine-protein kinase SYK2.7.10.20.463
2ym6YM6Serine/threonine-protein kinase Chk12.7.11.10.462
4fob0USALK tyrosine kinase receptor2.7.10.10.462
4i22IREEpidermal growth factor receptor2.7.10.10.462
2c3kABOSerine/threonine-protein kinase Chk12.7.11.10.461
3bhtMFRCyclin-dependent kinase 22.7.11.220.461
4c02TAKActivin receptor type-12.7.11.300.461
4jia1K3Tyrosine-protein kinase JAK2/0.461
4jr3KJREpidermal growth factor receptor2.7.10.10.461
1nvrSTUSerine/threonine-protein kinase Chk12.7.11.10.460
1pyxANPGlycogen synthase kinase-3 beta2.7.11.260.460
2hxl422Serine/threonine-protein kinase Chk12.7.11.10.460
3c4eC4ESerine/threonine-protein kinase pim-12.7.11.10.460
4bcoT6QCyclin-dependent kinase 22.7.11.220.460
4hyi1AOSerine/threonine-protein kinase Chk12.7.11.10.460
3u9n09HSerine/threonine-protein kinase Chk12.7.11.10.459
4eooATPCyclin-dependent kinase 22.7.11.220.459
4ftu7HKSerine/threonine-protein kinase Chk12.7.11.10.459
4qmnDB8Serine/threonine-protein kinase 242.7.11.10.459
4qmzB49Serine/threonine-protein kinase 242.7.11.10.459
2qkrIXMCdc2-like CDK2/CDC28 like protein kinase/0.458
2xyuQ9GEphrin type-A receptor 42.7.10.10.458
3umxQ18Serine/threonine-protein kinase pim-12.7.11.10.458
4aguD15Cyclin-dependent kinase-like 1/0.458
4ft7H3KSerine/threonine-protein kinase Chk12.7.11.10.458
3zdu38RCyclin-dependent kinase-like 32.7.11.220.457
4fswHK6Serine/threonine-protein kinase Chk12.7.11.10.457
4qmxH8HSerine/threonine-protein kinase 242.7.11.10.457
2c3lIDZSerine/threonine-protein kinase Chk12.7.11.10.456
2itpAEEEpidermal growth factor receptor2.7.10.10.456
3r2b05BMAP kinase-activated protein kinase 22.7.11.10.456
4fz60VGTyrosine-protein kinase SYK2.7.10.20.456
4g2fC07Ephrin type-A receptor 32.7.10.10.456
4k181OBSerine/threonine-protein kinase pim-12.7.11.10.456
1yi3LY2Serine/threonine-protein kinase pim-12.7.11.10.455
2wihP48Cyclin-dependent kinase 22.7.11.220.455
4ezk0SDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.455
4ftt6HKSerine/threonine-protein kinase Chk12.7.11.10.455
1stcSTUcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.454
1yi4ADNSerine/threonine-protein kinase pim-12.7.11.10.454
3cy2MB9Serine/threonine-protein kinase pim-12.7.11.10.453
3t8oATPRhodopsin kinase/0.453
3tnwF18Cyclin-dependent kinase 22.7.11.220.453
3vf80JETyrosine-protein kinase SYK2.7.10.20.453
4ftiH7KSerine/threonine-protein kinase Chk12.7.11.10.453
4gk3L87Ephrin type-A receptor 32.7.10.10.453
4gmy0X5Tyrosine-protein kinase JAK2/0.453
4xx9ATP3-phosphoinositide-dependent protein kinase 12.7.11.10.453
2j2iLY4Serine/threonine-protein kinase pim-12.7.11.10.452
4ic7ANPMitogen-activated protein kinase 72.7.11.240.452
2broDF2Serine/threonine-protein kinase Chk12.7.11.10.451
2objVRVSerine/threonine-protein kinase pim-12.7.11.10.451
2wmxZY6Serine/threonine-protein kinase Chk12.7.11.10.451
3js2VM1Fibroblast growth factor receptor 1/0.451
3oom507Activin receptor type-12.7.11.300.451
4fv9E71Mitogen-activated protein kinase 12.7.11.240.451
4mq22C4Dual specificity tyrosine-phosphorylation-regulated kinase 1A2.7.12.10.451
2brhDFWSerine/threonine-protein kinase Chk12.7.11.10.450
3l9mL9McAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.450
4bcpT3CCyclin-dependent kinase 22.7.11.220.450
4hyh1AMSerine/threonine-protein kinase Chk12.7.11.10.450
2bilBI1Serine/threonine-protein kinase pim-12.7.11.10.449
2qhm7CSSerine/threonine-protein kinase Chk12.7.11.10.449
4dfl0K0Tyrosine-protein kinase SYK2.7.10.20.449
4ftm1HKSerine/threonine-protein kinase Chk12.7.11.10.449
4qms1N1Serine/threonine-protein kinase 242.7.11.10.449
2hy0306Serine/threonine-protein kinase Chk12.7.11.10.448
2qo9ANPEphrin type-A receptor 32.7.10.10.448
4b99R4LMitogen-activated protein kinase 72.7.11.240.448
4c62XWWTyrosine-protein kinase JAK2/0.448
4ix6ADPUncharacterized protein/0.448
4yzcSTUSerine/threonine-protein kinase/endoribonuclease IRE12.7.11.10.448
1oiuN76Cyclin-dependent kinase 22.7.11.220.447
3zep1NXTyrosine-protein kinase JAK32.7.10.20.447
4ft0HK9Serine/threonine-protein kinase Chk12.7.11.10.447
3ambVX6cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.446
4fsnA58Serine/threonine-protein kinase Chk12.7.11.10.446
4fv1EK4Mitogen-activated protein kinase 12.7.11.240.446
4jboWPHAurora kinase A2.7.11.10.446
2itqITQEpidermal growth factor receptor2.7.10.10.445
2itwITQEpidermal growth factor receptor2.7.10.10.445
4eym0RXMitogen-activated protein kinase 132.7.11.240.445
4ii5ADPCyclin-dependent kinase 22.7.11.220.445
4n702HXSerine/threonine-protein kinase pim-12.7.11.10.445
1pkdUCNCyclin-dependent kinase 22.7.11.220.444
1qpjSTUTyrosine-protein kinase Lck2.7.10.20.444
2i40BLZCyclin-dependent kinase 22.7.11.220.444
2vd5BI8Myotonin-protein kinase2.7.11.10.444
3zh8C58Protein kinase C iota type2.7.11.130.444
4dggI76Proto-oncogene tyrosine-protein kinase Src2.7.10.20.444
4g6oE28Mitogen-activated protein kinase 12.7.11.240.444
2bkzSBCCyclin-dependent kinase 22.7.11.220.443
4dymIYZActivin receptor type-12.7.11.300.443
4fv6E57Mitogen-activated protein kinase 12.7.11.240.443
4fz70VHTyrosine-protein kinase SYK2.7.10.20.443
4w9wYDJBMP-2-inducible protein kinase2.7.11.10.443
5ajqDB8Serine/threonine-protein kinase 102.7.11.10.443
2brgDFYSerine/threonine-protein kinase Chk12.7.11.10.442
2wmuZYUSerine/threonine-protein kinase Chk12.7.11.10.442
2xchCKG3-phosphoinositide-dependent protein kinase 12.7.11.10.442
3cxw7CPSerine/threonine-protein kinase pim-12.7.11.10.442
4bbe3O4Tyrosine-protein kinase JAK2/0.442
4bgq38RCyclin-dependent kinase-like 52.7.11.220.442
4c34STUcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.442
4ft9H4KSerine/threonine-protein kinase Chk12.7.11.10.442
4fv3EK6Mitogen-activated protein kinase 12.7.11.240.442
4gk2L66Ephrin type-A receptor 32.7.10.10.442
4qnaX11Serine/threonine-protein kinase 242.7.11.10.442
1fvv107Cyclin-dependent kinase 22.7.11.220.441
2r0uM54Serine/threonine-protein kinase Chk12.7.11.10.441
3c4xATPRhodopsin kinase/0.441
4g170VNCasein kinase I isoform gamma-32.7.11.10.441
4i0t1B6Tyrosine-protein kinase SYK2.7.10.20.441
2itnANPEpidermal growth factor receptor2.7.10.10.440
2wmqZYQSerine/threonine-protein kinase Chk12.7.11.10.440
2wmwZYWSerine/threonine-protein kinase Chk12.7.11.10.440
4fsqHK3Serine/threonine-protein kinase Chk12.7.11.10.440
4gh2HK0Serine/threonine-protein kinase Chk12.7.11.10.440
4gk4L90Ephrin type-A receptor 32.7.10.10.440
4mxxDB8Proto-oncogene tyrosine-protein kinase Src2.7.10.20.440
4nks2M2Fibroblast growth factor receptor 1/0.440