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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4b1bFADThioredoxin reductase1.8.1.9

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
4b1bFADThioredoxin reductase1.8.1.91.000
3dgzFADThioredoxin reductase 2, mitochondrial1.8.1.90.542
2x8gFADThioredoxin glutathione reductase/0.513
2x8hFADThioredoxin glutathione reductase/0.501
4j57FADThioredoxin reductase 21.8.1.90.501
3qfaFADThioredoxin reductase 1, cytoplasmic1.8.1.90.474
1dncFADGlutathione reductase, mitochondrial1.8.1.70.467
2nvkFADThioredoxin reductase 1, mitochondrial1.8.1.90.443
2tprFADTrypanothione reductase1.8.1.120.443
1tytFADTrypanothione reductase1.8.1.120.442